References
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[1]
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Resource
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Comments
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Medline ID
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PubMed ID
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6364987
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Journal
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Arch Biochem Biophys
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Year
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1984
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Volume
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228
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Pages
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133-42
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Authors
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Conradt H, Hohmann-Berger M, Hohmann HP, Blaschkowski HP, Knappe J
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Title
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Pyruvate formate-lyase (inactive form) and pyruvate formate-lyase activating enzyme of Escherichia coli
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Related PDB
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Related UniProtKB
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[2]
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Resource
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Comments
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Medline ID
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PubMed ID
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6369325
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Journal
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Proc Natl Acad Sci U S A
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Year
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1984
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Volume
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81
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Pages
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1332-5
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Authors
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Knappe J, Neugebauer FA, Blaschkowski HP, Ganzler M
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Title
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Post-translational activation introduces a free radical into pyruvate formate-lyase
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Related PDB
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Related UniProtKB
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[3]
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Resource
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Comments
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Medline ID
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PubMed ID
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3965391
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Journal
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Infect Immun
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Year
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1985
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Volume
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47
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Pages
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129-34
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Authors
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Yamada T, Takahashi-Abbe S, Abbe K
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Title
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Effects of oxygen on pyruvate formate-lyase in situ and sugar metabolism of Streptococcus mutans and Streptococcus sanguis
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Related PDB
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Related UniProtKB
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[4]
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Resource
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Comments
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Medline ID
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PubMed ID
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3076439
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Journal
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Biofactors
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Year
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1988
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Volume
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1
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Pages
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123-8
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Authors
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Kozarich JW
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Title
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S-adenosylmethionine-dependent enzyme activation
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Related PDB
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Related UniProtKB
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[5]
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Resource
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Comments
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Medline ID
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PubMed ID
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3061816
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Journal
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Eur J Biochem
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Year
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1988
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Volume
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178
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Pages
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445-50
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Authors
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Plaga W, Frank R, Knappe J
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Title
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Catalytic-site mapping of pyruvate formate lyase. Hypophosphite reaction on the acetyl-enzyme intermediate affords carbon-phosphorus bond synthesis (1-hydroxyethylphosphonate)
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Related PDB
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Related UniProtKB
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[6]
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Resource
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Comments
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Medline ID
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PubMed ID
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2553398
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Journal
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Eur J Biochem
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Year
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1989
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Volume
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184
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Pages
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723-8
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Authors
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Unkrig V, Neugebauer FA, Knappe J
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Title
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The free radical of pyruvate formate-lyase. Characterization by EPR spectroscopy and involvement in catalysis as studied with the substrate-analogue hypophosphite
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Related PDB
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Related UniProtKB
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[7]
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Resource
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Comments
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Medline ID
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PubMed ID
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2549003
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Journal
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J Bacteriol
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Year
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1989
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Volume
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171
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Pages
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4900-5
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Authors
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Wong KK, Suen KL, Kwan HS
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Title
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Transcription of pfl is regulated by anaerobiosis, catabolite repression, pyruvate, and oxrA: Mu dA operon fusions of Salmonella typhimurium
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Related PDB
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Related UniProtKB
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[8]
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Resource
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Comments
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X-ray crystallography
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Medline ID
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PubMed ID
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1310545
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Journal
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Proc Natl Acad Sci U S A
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Year
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1992
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Volume
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89
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Pages
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996-1000
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Authors
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Wagner AF, Frey M, Neugebauer FA, Schafer W, Knappe J
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Title
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The free radical in pyruvate formate-lyase is located on glycine-734
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Related PDB
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1cm5
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Related UniProtKB
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[9]
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Resource
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Comments
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Medline ID
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PubMed ID
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8260492
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Journal
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Biochemistry
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Year
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1993
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Volume
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32
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Pages
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14102-10
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Authors
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Wong KK, Murray BW, Lewisch SA, Baxter MK, Ridky TW, Ulissi-DeMario L, Kozarich JW
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Title
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Molecular properties of pyruvate formate-lyase activating enzyme
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Related PDB
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Related UniProtKB
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[10]
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Resource
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Comments
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Medline ID
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PubMed ID
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8175649
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Journal
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J Biol Chem
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Year
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1994
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Volume
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269
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Pages
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12432-7
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Authors
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Frey M, Rothe M, Wagner AF, Knappe J
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Title
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Adenosylmethionine-dependent synthesis of the glycyl radical in pyruvate formate-lyase by abstraction of the glycine C-2 pro-S hydrogen atom. Studies of [2H]glycine-substituted enzyme and peptides homologous to the glycine 734 site.
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Related PDB
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Related UniProtKB
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[11]
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Resource
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Comments
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Medline ID
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PubMed ID
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7727431
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Journal
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Biochemistry
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Year
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1995
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Volume
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34
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Pages
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5712-7
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Authors
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Parast CV, Wong KK, Kozarich JW, Peisach J, Magliozzo RS
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Title
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Electron paramagnetic resonance evidence for a cysteine-based radical in pyruvate formate-lyase inactivated with mercaptopyruvate.
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Related PDB
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Related UniProtKB
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[12]
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Resource
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Comments
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Medline ID
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PubMed ID
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7873518
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Journal
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Biochemistry
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Year
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1995
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Volume
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34
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Pages
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2393-9
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Authors
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Parast CV, Wong KK, Lewisch SA, Kozarich JW, Peisach J, Magliozzo RS
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Title
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Hydrogen exchange of the glycyl radical of pyruvate formate-lyase is catalyzed by cysteine 419.
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Related PDB
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Related UniProtKB
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[13]
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Resource
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Comments
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Medline ID
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PubMed ID
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8524160
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Journal
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Methods Enzymol
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Year
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1995
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Volume
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258
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Pages
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343-62
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Authors
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Knappe J, Wagner AF
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Title
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Glycyl free radical in pyruvate formate-lyase: synthesis, structure characteristics, and involvement in catalysis.
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Related PDB
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Related UniProtKB
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[14]
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Resource
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Comments
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Medline ID
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PubMed ID
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9425077
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Journal
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Biochemistry
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Year
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1998
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Volume
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37
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Pages
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558-63
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Authors
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Reddy SG, Wong KK, Parast CV, Peisach J, Magliozzo RS, Kozarich JW
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Title
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Dioxygen inactivation of pyruvate formate-lyase: EPR evidence for the formation of protein-based sulfinyl and peroxyl radicals.
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Related PDB
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Related UniProtKB
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[15]
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Resource
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Comments
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Medline ID
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PubMed ID
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9767563
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Journal
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Mol Microbiol
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Year
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1998
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Volume
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29
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Pages
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945-54
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Authors
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Sawers G, Watson G
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Title
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A glycyl radical solution: oxygen-dependent interconversion of pyruvate formate-lyase.
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Related PDB
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Related UniProtKB
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[16]
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Resource
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Comments
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Medline ID
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PubMed ID
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11848913
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Journal
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Chem Rev
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Year
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1998
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Volume
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98
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Pages
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705-762
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Authors
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Stubbe J, van Der Donk WA
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Title
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Protein Radicals in Enzyme Catalysis.
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Related PDB
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Related UniProtKB
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[17]
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Resource
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Comments
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Medline ID
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PubMed ID
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Journal
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J Am Chem Soc
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Year
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1998
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Volume
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120
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Pages
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11449-55
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Authors
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Himo F, Eriksson LA
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Title
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Catalytic mechanism of pyruvate formate-lyase (PFL). A theoretical study
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Related PDB
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Related UniProtKB
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[18]
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Resource
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Comments
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Medline ID
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PubMed ID
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10089368
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Journal
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Acta Crystallogr D Biol Crystallogr
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Year
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1999
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Volume
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55
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Pages
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531-3
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Authors
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Leppanen VM, Parast CV, Wong KK, Kozarich JW, Goldman A
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Title
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Purification and crystallization of a proteolytic fragment of Escherichia coli pyruvate formate-lyase
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Related PDB
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Related UniProtKB
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[19]
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Resource
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Comments
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X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
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Medline ID
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99436526
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PubMed ID
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10504733
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Journal
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Nat Struct Biol
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Year
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1999
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Volume
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6
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Pages
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969-75
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Authors
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Becker A, Fritz-Wolf K, Kabsch W, Knappe J, Schultz S, Volker Wagner AF
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Title
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Structure and mechanism of the glycyl radical enzyme pyruvate formate-lyase
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Related PDB
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2pfl
3pfl
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Related UniProtKB
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P09373
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[20]
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Resource
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Comments
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Medline ID
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PubMed ID
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10574800
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Journal
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Structure Fold Des
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Year
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1999
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Volume
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7
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Pages
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R257-62
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Authors
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Eklund H, Fontecave M
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Title
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Glycyl radical enzymes: a conservative structural basis for radicals.
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Related PDB
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Related UniProtKB
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[21]
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Resource
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Comments
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X-ray crystallography
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Medline ID
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PubMed ID
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10425676
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Journal
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Structure Fold Des
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Year
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1999
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Volume
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7
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Pages
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733-44
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Authors
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Leppanen VM, Merckel MC, Ollis DL, Wong KK, Kozarich JW, Goldman A
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Title
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Pyruvate formate lyase is structurally homologous to type I ribonucleotide reductase
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Related PDB
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1qhm
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Related UniProtKB
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[22]
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Resource
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Comments
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Medline ID
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PubMed ID
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10648809
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Journal
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FEBS Lett
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Year
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2000
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Volume
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466
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Pages
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45-8
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Authors
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Plaga W, Vielhaber G, Wallach J, Knappe J
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Title
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Modification of Cys-418 of pyruvate formate-lyase by methacrylic acid, based on its radical mechanism
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Related PDB
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Related UniProtKB
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[23]
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Resource
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Comments
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Medline ID
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PubMed ID
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11154425
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Journal
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Oral Microbiol Immunol
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Year
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2000
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Volume
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15
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Pages
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325-8
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Authors
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Iwami Y, Takahashi-Abbe S, Takahashi N, Abbe K, Yamada T
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Title
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Rate-limiting steps of glucose and sorbitol metabolism in Streptococcus mutans cells exposed to air
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Related PDB
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Related UniProtKB
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[24]
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Resource
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Comments
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Medline ID
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PubMed ID
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11665486
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Journal
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Adv Protein Chem
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Year
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2001
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Volume
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58
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Pages
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1-45
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Authors
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Frey PA, Booker SJ
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Title
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Radical mechanisms of S-adenosylmethionine-dependent enzymes
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Related PDB
|
|
Related UniProtKB
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[25]
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Resource
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Comments
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Medline ID
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PubMed ID
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11444864
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Journal
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Biochem Biophys Res Commun
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Year
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2001
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Volume
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285
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Pages
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456-62
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Authors
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Wagner AF, Schultz S, Bomke J, Pils T, Lehmann WD, Knappe J
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Title
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YfiD of Escherichia coli and Y06I of bacteriophage T4 as autonomous glycyl radical cofactors reconstituting the catalytic center of oxygen-fragmented pyruvate formate-lyase.
|
Related PDB
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Related UniProtKB
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[26]
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Resource
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Comments
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Medline ID
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PubMed ID
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11300793
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Journal
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Biochemistry
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Year
|
2001
|
Volume
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40
|
Pages
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4123-30
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Authors
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Zhang W, Wong KK, Magliozzo RS, Kozarich JW
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Title
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Inactivation of pyruvate formate-lyase by dioxygen
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Related PDB
|
|
Related UniProtKB
|
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[27]
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Resource
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Comments
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Medline ID
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PubMed ID
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11278506
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Journal
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J Biol Chem
|
Year
|
2001
|
Volume
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276
|
Pages
|
12924-7
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Authors
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Krieger CJ, Roseboom W, Albracht SP, Spormann AM
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Title
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A stable organic free radical in anaerobic benzylsuccinate synthase of Azoarcus sp. strain T
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Related PDB
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Related UniProtKB
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[28]
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Resource
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Comments
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X-ray crystallography
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Medline ID
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PubMed ID
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12454503
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Journal
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Acta Crystallogr D Biol Crystallogr
|
Year
|
2002
|
Volume
|
58
|
Pages
|
2209-12
|
Authors
|
Lehtio L, Leppanen VM, Kozarich JW, Goldman A
|
Title
|
Structure of Escherichia coli pyruvate formate-lyase with pyruvate.
|
Related PDB
|
1mzo
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Related UniProtKB
|
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[29]
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Resource
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Comments
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Medline ID
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PubMed ID
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12236732
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Journal
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J Am Chem Soc
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Year
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2002
|
Volume
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124
|
Pages
|
11270-1
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Authors
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Walsby CJ, Ortillo D, Broderick WE, Broderick JB, Hoffman BM
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Title
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An anchoring role for FeS clusters: chelation of the amino acid moiety of S-adenosylmethionine to the unique iron site of the [4Fe-4S] cluster of pyruvate formate-lyase activating enzyme.
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Related PDB
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Related UniProtKB
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[30]
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Resource
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Comments
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X-ray crystallography
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Medline ID
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PubMed ID
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12163496
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Journal
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J Biol Chem
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Year
|
2002
|
Volume
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277
|
Pages
|
40036-42
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Authors
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Becker A, Kabsch W
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Title
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X-ray structure of pyruvate formate-lyase in complex with pyruvate and CoA. How the enzyme uses the Cys-418 thiyl radical for pyruvate cleavage.
|
Related PDB
|
1h16
1h17
1h18
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Related UniProtKB
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