DB code: S00252

CATH domain 3.30.1330.40 : 60s Ribosomal Protein L30; Chain Catalytic domain
E.C. 5.4.99.5
CSA 1dbf
M-CSA 1dbf
MACiE

CATH domain Related DB codes (homologues)

Uniprot Enzyme Name
UniprotKB Protein name Synonyms RefSeq Pfam
P19080 Chorismate mutase
CM
EC 5.4.99.5
NP_390150.1 (Protein)
NC_000964.3 (DNA/RNA sequence)
PF07736 (CM_1)
[Graphical View]
Q84FH6
Chorismate mutase
EC 5.4.99.5
PF07736 (CM_1)
[Graphical View]

KEGG enzyme name
chorismate mutase
hydroxyphenylpyruvate synthase

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
P19080 CHMU_BACSU Chorismate = prephenate. Homotrimer. Cytoplasm.
Q84FH6 Q84FH6_THETH

KEGG Pathways
Map code Pathways E.C.
MAP00400 Phenylalanine, tyrosine and tryptophan biosynthesis

Compound table
Substrates Products Intermediates
KEGG-id C00251 C00254
E.C.
Compound Chorismate Prephenate
Type carbohydrate,carboxyl group carbohydrate,carboxyl group
ChEBI 17333
84387
PubChem 12039
1comA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Bound:PRE Unbound
1comB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Bound:PRE Unbound
1comC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Bound:PRE Unbound
1comD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Bound:PRE Unbound
1comE Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Bound:PRE Unbound
1comF Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Bound:PRE Unbound
1comG Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Bound:PRE Unbound
1comH Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Bound:PRE Unbound
1comI Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
1comJ Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
1comK Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Bound:PRE Unbound
1comL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
1dbfA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
1dbfB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
1dbfC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
1fnjA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
1fnkA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
2chsA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
2chsB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
2chsC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
2chsD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
2chsE Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
2chsF Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
2chsG Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
2chsH Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
2chsI Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
2chsJ Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
2chsK Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
2chsL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
2chtA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Transition-state-analogue:TSA
2chtB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Transition-state-analogue:TSA
2chtC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Transition-state-analogue:TSA
2chtD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Transition-state-analogue:TSA
2chtE Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Transition-state-analogue:TSA
2chtF Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Transition-state-analogue:TSA
2chtG Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Transition-state-analogue:TSA
2chtH Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Transition-state-analogue:TSA
2chtI Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Transition-state-analogue:TSA
2chtJ Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Transition-state-analogue:TSA
2chtK Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Transition-state-analogue:TSA
2chtL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Transition-state-analogue:TSA
1odeA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
1odeB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
1odeC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound
1ufyA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:MLI Unbound Unbound
1ui9A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound

Reference for Active-site residues
resource references E.C.
literature [5], [12], [14]

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1comA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1comB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1comC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1comD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1comE Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1comF Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1comG Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1comH Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1comI Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1comJ Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1comK Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1comL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1dbfA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1dbfB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1dbfC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1fnjA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain mutant C88S, R90K
1fnkA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain mutant C88K, R90S
2chsA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chsB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chsC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chsD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chsE Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chsF Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chsG Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chsH Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chsI Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chsJ Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chsK Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chsL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chtA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chtB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chtC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chtD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chtE Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chtF Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chtG Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chtH Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chtI Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chtJ Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chtK Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
2chtL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1odeA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 89
1odeB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 89
1odeC Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 89
1ufyA Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 89
1ui9A Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 89

References for Catalytic Mechanism
References Sections No. of steps in catalysis
[3]
1FIG.1, p.8602
[5]
Fig.1, p.494-498
[6]
Fig.1, Fig.6, Fig.7, p.650-651
[7]
Fig.1, Fig.5, Fig.6, p.200-201
[9]
Fig.1, Fig.2, p.5047-5048
[12]
p.678-679, p.681-682
[15]
Fig.1, Fig.4, p.36836-36838
[16]
Scheme 1
[20]
Fig.1
[21]
Fig.2
[22]
Scheme 1
[23]
Scheme 1
[24]
Fig.1, p.3206
[25]
p.5598
[27]
Scheme 1
[28]
Scheme 1

References
[1]
Resource
Comments
Medline ID
PubMed ID 2125470
Journal Biochemistry
Year 1990
Volume 29
Pages 8872-8
Authors Gray JV, Eren D, Knowles JR
Title Monofunctional chorismate mutase from Bacillus subtilis: kinetic and 13C NMR studies on the interactions of the enzyme with its ligands.
Related PDB
Related UniProtKB
[2]
Resource
Comments STRUCTURE BY NMR.
Medline ID 93229495
PubMed ID 8471608
Journal Biochemistry
Year 1993
Volume 32
Pages 3965-72
Authors Rajagopalan JS, Taylor KM, Jaffe EK
Title 13C NMR studies of the enzyme-product complex of Bacillus subtilis chorismate mutase.
Related PDB
Related UniProtKB P19080
[3]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
Medline ID 93391402
PubMed ID 8378335
Journal Proc Natl Acad Sci U S A
Year 1993
Volume 90
Pages 8600-3
Authors Chook YM, Ke H, Lipscomb WN
Title Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog.
Related PDB 2chs 2cht
Related UniProtKB P19080
[4]
Resource
Comments
Medline ID
PubMed ID 8061004
Journal Biochemistry
Year 1994
Volume 33
Pages 9953-9
Authors Gray JV, Knowles JR
Title Monofunctional chorismate mutase from Bacillus subtilis: FTIR studies and the mechanism of action of the enzyme.
Related PDB
Related UniProtKB
[5]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
Medline ID 94322390
PubMed ID 8046752
Journal J Mol Biol
Year 1994
Volume 240
Pages 476-500
Authors Chook YM, Gray JV, Ke H, Lipscomb WN
Title The monofunctional chorismate mutase from Bacillus subtilis. Structure determination of chorismate mutase and its complexes with a transition state analog and prephenate, and implications for the mechanism of the enzymatic reaction.
Related PDB 1com
Related UniProtKB P19080
[6]
Resource
Comments
Medline ID
PubMed ID 8303271
Journal Science
Year 1994
Volume 263
Pages 646-52
Authors Haynes MR, Stura EA, Hilvert D, Wilson IA
Title Routes to catalysis: structure of a catalytic antibody and comparison with its natural counterpart.
Related PDB
Related UniProtKB
[7]
Resource
Comments
Medline ID
PubMed ID 9383421
Journal Chem Biol
Year 1995
Volume 2
Pages 195-203
Authors Lee AY, Stewart JD, Clardy J, Ganem B
Title New insight into the catalytic mechanism of chorismate mutases from structural studies.
Related PDB
Related UniProtKB
[8]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1-109
Medline ID
PubMed ID
Journal J Am Chem Soc
Year 1995
Volume 117
Pages 3627-8
Authors Lee AY, Karplus PA, Ganem B, Clardy J
Title Atomic structure of the buried catalytic pocket of Escherichia coli horismate mutase.
Related PDB
Related UniProtKB
[9]
Resource
Comments
Medline ID
PubMed ID 8643526
Journal Proc Natl Acad Sci U S A
Year 1996
Volume 93
Pages 5043-8
Authors Kast P, Asif-Ullah M, Jiang N, Hilvert D
Title Exploring the active site of chorismate mutase by combinatorial mutagenesis and selection: the importance of electrostatic catalysis.
Related PDB
Related UniProtKB
[10]
Resource
Comments
Medline ID
PubMed ID 9384560
Journal Structure
Year 1997
Volume 5
Pages 1437-52
Authors Strater N, Schnappauf G, Braus G, Lipscomb WN
Title Mechanisms of catalysis and allosteric regulation of yeast chorismate mutase from crystal structures.
Related PDB
Related UniProtKB
[11]
Resource
Comments
Medline ID
PubMed ID 10103029
Journal Eur J Biochem
Year 1999
Volume 261
Pages 25-32
Authors Mattei P, Kast P, Hilvert D
Title Bacillus subtilis chorismate mutase is partially diffusion-controlled.
Related PDB
Related UniProtKB
[12]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS).
Medline ID 20280181
PubMed ID 10818343
Journal Acta Crystallogr D Biol Crystallogr
Year 2000
Volume 56
Pages 673-83
Authors Ladner JE, Reddy P, Davis A, Tordova M, Howard AJ, Gilliland GL
Title The 1.30 A resolution structure of the Bacillus subtilis chorismate mutase catalytic homotrimer.
Related PDB 1dbf
Related UniProtKB P19080
[13]
Resource
Comments
Medline ID
PubMed ID 11087356
Journal Biochemistry
Year 2000
Volume 39
Pages 14087-94
Authors Gamper M, Hilvert D, Kast P
Title Probing the role of the C-terminus of Bacillus subtilis chorismate mutase by a novel random protein-termination strategy.
Related PDB
Related UniProtKB
[14]
Resource
Comments
Medline ID
PubMed ID 10815997
Journal Comput Chem
Year 2000
Volume 24
Pages 275-85
Authors Worthington SE, Krauss M
Title Effective fragment potentials and the enzyme active site.
Related PDB
Related UniProtKB
[15]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 10960481
Journal J Biol Chem
Year 2000
Volume 275
Pages 36832-8
Authors Kast P, Grisostomi C, Chen IA, Li S, Krengel U, Xue Y, Hilvert D
Title A strategically positioned cation is crucial for efficient catalysis by chorismate mutase.
Related PDB 1fnj 1fnk
Related UniProtKB
[16]
Resource
Comments
Medline ID
PubMed ID 11456771
Journal J Am Chem Soc
Year 2001
Volume 123
Pages 1709-12
Authors Marti S, Andres J, Moliner V, Silla E, Tunon I, Bertran J, Field MJ
Title A hybrid potential reaction path and free energy study of the chorismate mutase reaction.
Related PDB
Related UniProtKB
[17]
Resource
Comments
Medline ID
PubMed ID 11495249
Journal J Biomol NMR
Year 2001
Volume 20
Pages 177-80
Authors Eletsky A, Kienhofer A, Pervushin K
Title TROSY NMR with partially deuterated proteins.
Related PDB
Related UniProtKB
[18]
Resource
Comments
Medline ID
PubMed ID 12392438
Journal J Am Chem Soc
Year 2002
Volume 124
Pages 12898-902
Authors Pervushin K, Vogeli B, Eletsky A
Title Longitudinal (1)H relaxation optimization in TROSY NMR spectroscopy.
Related PDB
Related UniProtKB
[19]
Resource
Comments
Medline ID
PubMed ID 12449416
Journal J Biomol NMR
Year 2002
Volume 24
Pages 31-9
Authors Eletsky A, Heinz T, Moreira O, Kienhofer A, Hilvert D, Pervushi K
Title Direct NMR observation and DFT calculations of a hydrogen bond at the active site of a 44 kDa enzyme.
Related PDB
Related UniProtKB
[20]
Resource
Comments
Medline ID
PubMed ID 12698486
Journal Angew Chem Int Ed Engl
Year 2003
Volume 42
Pages 1508-11
Authors Guo H, Cui Q, Lipscomb WN, Karplus M
Title Understanding the role of active-site residues in chorismate mutase catalysis from molecular-dynamics simulations.
Related PDB
Related UniProtKB
[21]
Resource
Comments
Medline ID
PubMed ID 12584715
Journal Chemistry
Year 2003
Volume 9
Pages 984-91
Authors Marti S, Andres J, Moliner V, Silla E, Tunon I, Bertran J
Title Preorganization and reorganization as related factors in enzyme catalysis: the chorismate mutase case.
Related PDB
Related UniProtKB
[22]
Resource
Comments
Medline ID
PubMed ID 12783541
Journal J Am Chem Soc
Year 2003
Volume 125
Pages 6892-9
Authors Guimaraes CR, Repasky MP, Chandrasekhar J, Tirado-Rives J, Jorgensen WL
Title Contributions of conformational compression and preferential transition state stabilization to the rate enhancement by chorismate mutase.
Related PDB
Related UniProtKB
[23]
Resource
Comments
Medline ID
PubMed ID 12940735
Journal J Am Chem Soc
Year 2003
Volume 125
Pages 10540-2
Authors Hur S, Bruice TC
Title Just a near attack conformer for catalysis (chorismate to prephenate rearrangements in water, antibody, enzymes, and their mutants).
Related PDB
Related UniProtKB
[24]
Resource
Comments
Medline ID
PubMed ID 12630863
Journal J Am Chem Soc
Year 2003
Volume 125
Pages 3206-7
Authors Kienhofer A, Kast P, Hilvert D
Title Selective stabilization of the chorismate mutase transition state by a positively charged hydrogen bond donor.
Related PDB
Related UniProtKB
[25]
Resource
Comments
Medline ID
PubMed ID 12733875
Journal J Am Chem Soc
Year 2003
Volume 125
Pages 5598-9
Authors Mandal A, Hilvert D
Title Charge optimization increases the potency and selectivity of a chorismate mutase inhibitor.
Related PDB
Related UniProtKB
[26]
Resource
Comments
Medline ID
PubMed ID 12766412
Journal J Biomol NMR
Year 2003
Volume 26
Pages 167-79
Authors Eletsky A, Moreira O, Kovacs H, Pervushin K
Title A novel strategy for the assignment of side-chain resonances in completely deuterated large proteins using 13C spectroscopy.
Related PDB
Related UniProtKB
[27]
Resource
Comments
Medline ID
PubMed ID 12926249
Journal Org Biomol Chem
Year 2003
Volume 1
Pages 483-7
Authors Marti S, Moliner V, Tunon I, Williams IH
Title QM/MM calculations of kinetic isotope effects in the chorismate mutase active site.
Related PDB
Related UniProtKB
[28]
Resource
Comments
Medline ID
PubMed ID 14523243
Journal Proc Natl Acad Sci U S A
Year 2003
Volume 100
Pages 12015-20
Authors Hur S, Bruice TC
Title The near attack conformation approach to the study of the chorismate to prephenate reaction.
Related PDB
Related UniProtKB
[29]
Resource
Comments
Medline ID
PubMed ID 14727008
Journal Arch Microbiol
Year 2004
Volume 181
Pages 195-203
Authors Helmstaedt K, Heinrich G, Merkl R, Braus GH
Title Chorismate mutase of Thermus thermophilus is a monofunctional AroH class enzyme inhibited by tyrosine.
Related PDB
Related UniProtKB Q84FH6
[30]
Resource
Comments
Medline ID
PubMed ID 15136856
Journal Chem Commun (Camb)
Year 2004
Volume (10)
Pages 1238-9
Authors Ranaghan KE, Mulholland AJ
Title Conformational effects in enzyme catalysis: QM/MM free energy calculation of the 'NAC' contribution in chorismate mutase.
Related PDB
Related UniProtKB
[31]
Resource
Comments
Medline ID
PubMed ID 15096202
Journal Eur J Biochem
Year 2004
Volume 271
Pages 1630-7
Authors Woycechowsky KJ, Hilvert D
Title Deciphering enzymes. Genetic selection as a probe of structure and mechanism.
Related PDB
Related UniProtKB

Comments
This enzyme catalyzes Claisen rearrangement (or concerted addition and elimination).

Created Updated
2005-07-11 2009-02-26