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References
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[1]
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Resource
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Comments
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Variant Pycnodysostosis
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Medline ID
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96355650
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PubMed ID
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8703060
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Journal
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Science
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Year
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1996
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Volume
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273
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Pages
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1236-8
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Authors
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Gelb BD, Shi GP, Chapman HA, Desnick RJ
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Title
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Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency.
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Related PDB
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Related UniProtKB
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P43235
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[2]
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Resource
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Comments
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Medline ID
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PubMed ID
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8647860
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Journal
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J Biol Chem
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Year
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1996
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Volume
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271
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Pages
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12517-24
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Authors
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Bossard MJ, Tomaszek TA, Thompson SK, Amegadzie BY, Hanning CR, Jones C, Kurdyla JT, McNulty DE, Drake FH, Gowen M, Levy MA
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Title
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Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification.
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Related PDB
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Related UniProtKB
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[3]
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Resource
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Comments
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Medline ID
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PubMed ID
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Journal
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J Am Chem Soc
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Year
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1997
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Volume
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119
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Pages
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11351-2
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Authors
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D.S.Yamashita,W.W.Smith,B.Zhao,C.A.Janson,T.A.Tomaszek,M.J.Bossard,M.A.Levy,H.-J.Oh,T.J.Carr,S.K.Thompson,C.F.Ijames,S.A.Carr,M.Mcqueney,K.J.D'alessio,B.Y.Amegadzie,C.R.Hanning,S.Abdel-Meguid,R.L.Desjarlais,J.G.Gleason,D.F.Veber
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Title
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Structure and design of potent and selective cathepsin k inhibitors.
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Related PDB
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1au0
1au2
1au3
1au4
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Related UniProtKB
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[4]
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Resource
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Comments
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Medline ID
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PubMed ID
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9033588
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Journal
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Nat Struct Biol
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Year
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1997
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Volume
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4
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Pages
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109-11
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Authors
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Zhao B, Janson CA, Amegadzie BY, D'Alessio K, Griffin C, Hanning CR, Jones C, Kurdyla J, McQueney M, Qiu X, Smith WW, Abdel-Meguid SS
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Title
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Crystal structure of human osteoclast cathepsin K complex with E-64.
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Related PDB
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1atk
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Related UniProtKB
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[5]
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Resource
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Comments
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Medline ID
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PubMed ID
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9033587
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Journal
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Nat Struct Biol
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Year
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1997
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Volume
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4
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Pages
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105-9
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Authors
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McGrath ME, Klaus JL, Barnes MG, Bromme D
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Title
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Crystal structure of human cathepsin K complexed with a potent inhibitor.
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Related PDB
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1mem
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Related UniProtKB
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[6]
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Resource
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Comments
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inhibitor designe (X-ray crystallography, MS, NMR, kinetic studies)
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Medline ID
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PubMed ID
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9405598
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Journal
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Proc Natl Acad Sci U S A
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Year
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1997
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Volume
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94
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Pages
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14249-54
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Authors
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Thompson SK, Halbert SM, Bossard MJ, Tomaszek TA, Levy MA, Zhao B, Smith WW, Abdel-Meguid SS, Janson CA, D'Alessio KJ, McQueney MS, Amegadzie BY, Hanning CR, DesJarlais RL, Briand J, Sarkar SK, Huddleston MJ, Ijames CF, Carr SA, Garnes KT, Shu A, Heys JR, Bradbeer J, Zembryki D, Veber DF, et al
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Title
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Design of potent and selective human cathepsin K inhibitors that span the active site.
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Related PDB
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1ayu
1ayv
1ayw
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Related UniProtKB
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[7]
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Resource
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Comments
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Medline ID
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PubMed ID
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9153258
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Journal
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J Biol Chem
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Year
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1997
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Volume
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272
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|
Pages
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13955-60
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Authors
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McQueney MS, Amegadzie BY, D'Alessio K, Hanning CR, McLaughlin MM, McNulty D, Carr SA, Ijames C, Kurdyla J, Jones CS
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Title
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Autocatalytic activation of human cathepsin K.
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Related PDB
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Related UniProtKB
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[8]
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Resource
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Comments
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Medline ID
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PubMed ID
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Journal
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J Am Chem Soc
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Year
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1998
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Volume
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120
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|
Pages
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9114-5
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Authors
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R.L.Desjarlais, D.S.Yamashita, H.J.Oh, I.N.Uzinskas, K.F.Erhard, A.C.Allen, R.C.Haltiwanger, B.G.Zhao, W.W.Smith, S.S.Abdel-Meguid, K.Dalessio, C.A.Janson, M.S.Mcqueney, T.A.Tomaszek, M.A.Levy, D.F.Veber
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Title
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Use of x-ray co-crystal structures and molecular modeling to design potent and selective non-peptide inhibitors of cathepsin k.
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Related PDB
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1bgo
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Related UniProtKB
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[9]
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Resource
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|
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Comments
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X-ray crystallography (2.8 Angstroms)
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Medline ID
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|
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PubMed ID
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9893980
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Journal
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Biochemistry
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|
Year
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1999
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Volume
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38
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Pages
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862-9
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Authors
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LaLonde JM, Zhao B, Janson CA, D'Alessio KJ, McQueney MS, Orsini MJ, Debouck CM, Smith WW
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Title
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The crystal structure of human procathepsin K.
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Related PDB
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1by8
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Related UniProtKB
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[10]
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Resource
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|
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Comments
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X-ray crystallography (3.2 Angstroms)
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Medline ID
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99156066
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PubMed ID
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10048321
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Journal
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Protein Sci
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Year
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1999
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Volume
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8
|
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Pages
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283-90
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Authors
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Sivaraman J, Lalumiere M, Menard R, Cygler M
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Title
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Crystal structure of wild-type human procathepsin K.
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Related PDB
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Related UniProtKB
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P43235
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[11]
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Resource
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Comments
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Medline ID
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PubMed ID
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10521264
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Journal
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Biochemistry
|
|
Year
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1999
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Volume
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38
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|
Pages
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13574-83
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|
Authors
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Percival MD, Ouellet M, Campagnolo C, Claveau D, Li C
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Title
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Inhibition of cathepsin K by nitric oxide donors: evidence for the formation of mixed disulfides and a sulfenic acid.
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Related PDB
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Related UniProtKB
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[12]
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Resource
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Comments
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Medline ID
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PubMed ID
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12182837
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Journal
|
Protein Expr Purif
|
|
Year
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2002
|
|
Volume
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25
|
|
Pages
|
541-6
|
|
Authors
|
Hwang HS, Chung HS
|
|
Title
|
Preparation of active recombinant cathepsin K expressed in bacteria as inclusion body.
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Related PDB
|
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Related UniProtKB
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