DB code: T00030

RLCP classification 10.22140.100.10551 : Electron transfer
10.23022.100.10580 : Electron transfer
10.22023.100.10525 : Electron transfer
CATH domain 1.10.645.10 : Cytochrome-c3 Hydrogenase; chain B Catalytic domain
3.40.50.700 : Rossmann fold Catalytic domain
4.10.480.10 : Cytochrome-c3 Hydrogenase; Chain A, domain 2 Catalytic domain
E.C. 1.12.2.1
CSA 1h2r
M-CSA 1h2r
MACiE M0126

CATH domain Related DB codes (homologues)
1.10.645.10 : Cytochrome-c3 Hydrogenase; chain B T00238
3.40.50.700 : Rossmann fold T00238
4.10.480.10 : Cytochrome-c3 Hydrogenase; Chain A, domain 2 T00238

Uniprot Enzyme Name
UniprotKB Protein name Synonyms Pfam RefSeq
P18188 Periplasmic [NiFe] hydrogenase large subunit
EC 1.12.2.1
NiFe hydrogenlyase large chain
PF00374 (NiFeSe_Hases)
[Graphical View]
P12944 Periplasmic [NiFe] hydrogenase large subunit
EC 1.12.2.1
NiFe hydrogenlyase large chain
PF00374 (NiFeSe_Hases)
[Graphical View]
P21852 Periplasmic [NiFe] hydrogenase large subunit
EC 1.12.2.1
NiFe hydrogenlyase large chain
PF00374 (NiFeSe_Hases)
[Graphical View]
YP_002434695.1 (Protein)
NC_011769.1 (DNA/RNA sequence)
P18187 Periplasmic [NiFe] hydrogenase small subunit
EC 1.12.2.1
NiFe hydrogenlyase small chain
PF01058 (Oxidored_q6)
PF10518 (TAT_signal)
[Graphical View]
P12943 Periplasmic [NiFe] hydrogenase small subunit
EC 1.12.2.1
NiFe hydrogenlyase small chain
PF01058 (Oxidored_q6)
[Graphical View]
P21853 Periplasmic [NiFe] hydrogenase small subunit
EC 1.12.2.1
NiFe hydrogenlyase small chain
PF01058 (Oxidored_q6)
[Graphical View]
YP_002434696.1 (Protein)
NC_011769.1 (DNA/RNA sequence)

KEGG enzyme name
cytochrome-c3 hydrogenase
H2:ferricytochrome c3 oxidoreductase
cytochrome c3 reductase
cytochrome hydrogenase
hydrogenase [ambiguous]

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
P18188 PHNL_DESFR 2 H(2) + ferricytochrome c3 = 4 H(+) + ferrocytochrome c3. Heterodimer of a large and a small subunit. Periplasm. Binds 1 nickel ion per subunit.
P12944 PHNL_DESGI 2 H(2) + ferricytochrome c3 = 4 H(+) + ferrocytochrome c3. Heterodimer of a large and a small subunit. Periplasm. Binds 1 nickel ion per subunit.
P21852 PHNL_DESVM 2 H(2) + ferricytochrome c3 = 4 H(+) + ferrocytochrome c3. Heterodimer of a large and a small subunit. Periplasm. Nickel. Iron.
P18187 PHNS_DESFR 2 H(2) + ferricytochrome c3 = 4 H(+) + ferrocytochrome c3. Heterodimer of a large and a small subunit. Periplasm. Binds 2 4Fe-4S clusters. Binds 1 3Fe-4S cluster.
P12943 PHNS_DESGI 2 H(2) + ferricytochrome c3 = 4 H(+) + ferrocytochrome c3. Heterodimer of a large and a small subunit. Periplasm. Binds 2 4Fe-4S clusters. Binds 1 3Fe-4S cluster.
P21853 PHNS_DESVM 2 H(2) + ferricytochrome c3 = 4 H(+) + ferrocytochrome c3. Heterodimer of a large and a small subunit. Periplasm. Binds 2 4Fe-4S clusters. Binds 1 3Fe-4S cluster.

KEGG Pathways
Map code Pathways E.C.

Compound table
Cofactors Substrates Products Intermediates
KEGG-id L00024 L00027 L00028 C00282 C02682 C00080 C02684
E.C. (peroxide bound)
(oxygen atom bound)
Compound [4Fe-4S] [3Fe-4S] Ni--Fe(CN)2(CO) H2 ferricytochrome c3 H+ ferrocytochrome c3 Transition-state Transition-state
Type heavy metal,sulfide group heavy metal,sulfide group heavy metal,others others aromatic ring (with nitrogen atoms),carbohydrate,heavy metal,peptide/protein,sulfide group others aromatic ring (with nitrogen atoms),carbohydrate,heavy metal,peptide/protein,sulfide group
ChEBI 33725
47402
18276
15378
PubChem 58838673
783
1038
1frfL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:_NI-Fe Unbound Unbound Unbound
1yqwQ Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:_NI-FCO Unbound Unbound Unbound Transition-state-bound:PER (Ni-SU status)
1yqwR Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:_NI-FCO Unbound Unbound Unbound Transition-state-bound:PER (Ni-SU status)
1yqwS Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:_NI-FCO Unbound Unbound Unbound Transition-state-bound:PER (Ni-SU status)
1yrqH Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:_NI-FCO Unbound Unbound Unbound
1yrqI Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:_NI-FCO Unbound Unbound Unbound
1yrqJ Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:_NI-FCO Unbound Unbound Unbound
1yrqK Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:_NI-FCO Unbound Unbound Unbound
1yrqM Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:_NI-FCO Unbound Unbound Unbound
1yrqN Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:_NI-FCO Unbound Unbound Unbound
1frvB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:_NI-FEL Unbound Unbound Unbound
1frvD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:_NI-FEL Unbound Unbound Unbound
1yq9H Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:_NI-FCO Unbound Unbound Unbound Transition-state-bound:PER (Ni-A status)
1yq9I Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:_NI-FCO Unbound Unbound Unbound Transition-state-bound:PER (Ni-A status)
2frvB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:_NI-FCO Unbound Unbound Unbound Transition-state-bound:__O (Ni-B state)
2frvD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:_NI-FCO Unbound Unbound Unbound Transition-state-bound:__O (Ni-B state)
2frvF Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:_NI-FCO Unbound Unbound Unbound Transition-state-bound:__O (Ni-B state)
2frvH Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:_NI-FCO Unbound Unbound Unbound Transition-state-bound:__O (Ni-B state)
2frvJ Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:_NI-FCO Unbound Unbound Unbound Transition-state-bound:__O (Ni-B state)
2frvL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:_NI-FCO Unbound Unbound Unbound Transition-state-bound:__O (Ni-B state)
1h2aL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:NFE Unbound Unbound Unbound
1h2rL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:NFE Unbound Unbound Unbound
1ubhL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:FNE-CMO Unbound Unbound Unbound
1ubjL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:FNE-CMO Unbound Unbound Unbound
1ubkL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:FNE-CMO Unbound Unbound Unbound
1ublL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:FNE-CMO Unbound Unbound Unbound
1ubmL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:FNE Unbound Unbound Unbound
1uboL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:FNE-CMO Unbound Unbound Unbound
1ubrL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:FNE-CMO Unbound Unbound Unbound
1ubtL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:FNE Unbound Unbound Unbound
1ubuL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:FNE Unbound Unbound Unbound
1wuhL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:NFC Unbound Unbound Unbound Transition-state-bound:NFC (Ni-A status)
1wuiL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:NFC Unbound Unbound Unbound Transition-state-bound:NFC (Ni-A status)
1wujL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:NFO Unbound Unbound Unbound Transition-state-bound:NFO (Ni-B status)
1wukL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Analogue:NFO Unbound Unbound Unbound Transition-state-bound:NFO (oxidized status)
1wulL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Bound:NFR Unbound Unbound Unbound
1frfS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1yqwA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1yqwB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1yqwC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1yrqA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1yrqB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1yrqC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1yrqD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1yrqF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1yrqG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1frvA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1frvC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1yq9A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1yq9B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
2frvA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
2frvC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
2frvE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
2frvG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
2frvI01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
2frvS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1h2aS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1h2rS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1ubhS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1ubjS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1ubkS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1ublS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1ubmS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1uboS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1ubrS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1ubtS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1ubuS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1wuhS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1wuiS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1wujS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1wukS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1wulS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Unbound Unbound Unbound Unbound Unbound
1frfS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1yqwA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1yqwB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1yqwC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1yrqA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1yrqB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1yrqC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1yrqD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1yrqF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1yrqG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1frvA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1frvC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1yq9A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1yq9B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
2frvA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
2frvC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
2frvE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
2frvG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
2frvI02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
2frvS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1h2aS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1h2rS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1ubhS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1ubjS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1ubkS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1ublS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1ubmS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1uboS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1ubrS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1ubtS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1ubuS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1wuhS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1wuiS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1wujS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1wukS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound
1wulS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:SF4 Bound:F3S Unbound Unbound Unbound Unbound

Reference for Active-site residues
resource references E.C.
literature [31], [32], [35], [37], [39], [45], [47]

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1frfL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 25;CYS 543 CYS 75;CYS 546(Fe and Nickel);CYS 72;CYS 543(Nickel)
1yqwQ Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 25;CYS 543 CYS 75;CYS 546(Fe and Nickel);CYS 72;CYS 543(Nickel)
1yqwR Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 25;CYS 543 CYS 75;CYS 546(Fe and Nickel);CYS 72;CYS 543(Nickel)
1yqwS Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 25;CYS 543 CYS 75;CYS 546(Fe and Nickel);CYS 72;CYS 543(Nickel)
1yrqH Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 25;CYS 543 CYS 75;CYS 546(Fe and Nickel);CYS 72;CYS 543(Nickel)
1yrqI Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 25;CYS 543 CYS 75;CYS 546(Fe and Nickel);CYS 72;CYS 543(Nickel)
1yrqJ Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 25;CYS 543 CYS 75;CYS 546(Fe and Nickel);CYS 72;CYS 543(Nickel)
1yrqK Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 25;CYS 543 CYS 75;CYS 546(Fe and Nickel);CYS 72;CYS 543(Nickel)
1yrqM Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 25;CYS 543 CYS 75;CYS 546(Fe and Nickel);CYS 72;CYS 543(Nickel)
1yrqN Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 25;CYS 543 CYS 75;CYS 546(Fe and Nickel);CYS 72;CYS 543(Nickel)
1frvB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 18;CYS 530 CYS 68;CYS 533(Fe and Nickel);CYS 65;CYS 530(Nickel)
1frvD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 18;CYS 530 CYS 68;CYS 533(Fe and Nickel);CYS 65;CYS 530(Nickel)
1yq9H Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 18;CYS 530 CYS 68;CYS 533(Fe and Nickel);CYS 65;CYS 530(Nickel)
1yq9I Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 18;CYS 530 CYS 68;CYS 533(Fe and Nickel);CYS 65;CYS 530(Nickel)
2frvB Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 18;CYS 530 CYS 68;CYS 533(Fe and Nickel);CYS 65;CYS 530(Nickel)
2frvD Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 18;CYS 530 CYS 68;CYS 533(Fe and Nickel);CYS 65;CYS 530(Nickel)
2frvF Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 18;CYS 530 CYS 68;CYS 533(Fe and Nickel);CYS 65;CYS 530(Nickel)
2frvH Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 18;CYS 530 CYS 68;CYS 533(Fe and Nickel);CYS 65;CYS 530(Nickel)
2frvJ Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 18;CYS 530 CYS 68;CYS 533(Fe and Nickel);CYS 65;CYS 530(Nickel)
2frvL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 18;CYS 530 CYS 68;CYS 533(Fe and Nickel);CYS 65;CYS 530(Nickel)
1h2aL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 34;CYS 546 CYS 84;CYS 549(Fe and Nickel);CYS 81;CYS 546(Nickel)
1h2rL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 34;CYS 546 CYS 84;CYS 549(Fe and Nickel);CYS 81;CYS 546(Nickel)
1ubhL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 34;CYS 546 CYS 84;CYS 549(Fe and Nickel);CYS 81;CYS 546(Nickel)
1ubjL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 34;CYS 546 CYS 84;CYS 549(Fe and Nickel);CYS 81;CYS 546(Nickel)
1ubkL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 34;CYS 546 CYS 84;CYS 549(Fe and Nickel);CYS 81;CYS 546(Nickel)
1ublL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 34;CYS 546 CYS 84;CYS 549(Fe and Nickel);CYS 81;CYS 546(Nickel)
1ubmL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 34;CYS 546 CYS 84;CYS 549(Fe and Nickel);CYS 81;CYS 546(Nickel)
1uboL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 34;CYS 546 CYS 84;CYS 549(Fe and Nickel);CYS 81;CYS 546(Nickel)
1ubrL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 34;CYS 546 CYS 84;CYS 549(Fe and Nickel);CYS 81;CYS 546(Nickel)
1ubtL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 34;CYS 546 CYS 84;CYS 549(Fe and Nickel);CYS 81;CYS 546(Nickel)
1ubuL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 34;CYS 546 CYS 84;CYS 549(Fe and Nickel);CYS 81;CYS 546(Nickel)
1wuhL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 34; CSO 84;CYS 549(Fe and Nickel);CYS 81;CSO 546(Nickel) CSO 84;CSO 546
1wuiL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 34; CSO 84;CYS 549(Fe and Nickel);CYS 81;CSO 546(Nickel) CSO 84;CSO 546
1wujL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 34; CYS 84;CYS 549(Fe and Nickel);CYS 81;CSO 546(Nickel) ;CSO 546
1wukL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 34; CYS 84;CYS 549(Fe and Nickel);CYS 81;CSO 546(Nickel) ;CSO 546
1wulL Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain GLU 34; CYS 84;CYS 549(Fe and Nickel);CYS 81;CSO 546(Nickel) ;CSO 546
1frfS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 147(4Fe-4S cluster-1)
1yqwA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 147(4Fe-4S cluster-1)
1yqwB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 147(4Fe-4S cluster-1)
1yqwC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 147(4Fe-4S cluster-1)
1yrqA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 147(4Fe-4S cluster-1)
1yrqB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 147(4Fe-4S cluster-1)
1yrqC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 147(4Fe-4S cluster-1)
1yrqD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 147(4Fe-4S cluster-1)
1yrqF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 147(4Fe-4S cluster-1)
1yrqG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 147(4Fe-4S cluster-1)
1frvA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 112;CYS 148(4Fe-4S cluster-1)
1frvC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 112;CYS 148(4Fe-4S cluster-1)
1yq9A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 112;CYS 148(4Fe-4S cluster-1)
1yq9B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 112;CYS 148(4Fe-4S cluster-1)
2frvA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 112;CYS 148(4Fe-4S cluster-1)
2frvC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 112;CYS 148(4Fe-4S cluster-1)
2frvE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 112;CYS 148(4Fe-4S cluster-1)
2frvG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 112;CYS 148(4Fe-4S cluster-1)
2frvI01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 112;CYS 148(4Fe-4S cluster-1)
2frvS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 112;CYS 148(4Fe-4S cluster-1)
1h2aS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 150(4Fe-4S cluster-1)
1h2rS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 150(4Fe-4S cluster-1)
1ubhS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 150(4Fe-4S cluster-1)
1ubjS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 150(4Fe-4S cluster-1)
1ubkS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 150(4Fe-4S cluster-1)
1ublS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 150(4Fe-4S cluster-1)
1ubmS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 150(4Fe-4S cluster-1)
1uboS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 150(4Fe-4S cluster-1)
1ubrS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 150(4Fe-4S cluster-1)
1ubtS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 150(4Fe-4S cluster-1)
1ubuS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 150(4Fe-4S cluster-1)
1wuhS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 150(4Fe-4S cluster-1)
1wuiS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 150(4Fe-4S cluster-1)
1wujS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 150(4Fe-4S cluster-1)
1wukS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 150(4Fe-4S cluster-1)
1wulS01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain THR 18 CYS 17;CYS 20;CYS 114;CYS 150(4Fe-4S cluster-1)
1frfS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 184;CYS 187;CYS 212;CYS 218(4Fe-4S cluster-2);CYS 227;CYS 245;CYS 248(3Fe-4S cluster)
1yqwA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 184;CYS 187;CYS 212;CYS 218(4Fe-4S cluster-2);CYS 227;CYS 245;CYS 248(3Fe-4S cluster)
1yqwB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 184;CYS 187;CYS 212;CYS 218(4Fe-4S cluster-2);CYS 227;CYS 245;CYS 248(3Fe-4S cluster)
1yqwC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 184;CYS 187;CYS 212;CYS 218(4Fe-4S cluster-2);CYS 227;CYS 245;CYS 248(3Fe-4S cluster)
1yrqA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 184;CYS 187;CYS 212;CYS 218(4Fe-4S cluster-2);CYS 227;CYS 245;CYS 248(3Fe-4S cluster)
1yrqB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 184;CYS 187;CYS 212;CYS 218(4Fe-4S cluster-2);CYS 227;CYS 245;CYS 248(3Fe-4S cluster)
1yrqC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 184;CYS 187;CYS 212;CYS 218(4Fe-4S cluster-2);CYS 227;CYS 245;CYS 248(3Fe-4S cluster)
1yrqD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 184;CYS 187;CYS 212;CYS 218(4Fe-4S cluster-2);CYS 227;CYS 245;CYS 248(3Fe-4S cluster)
1yrqF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 184;CYS 187;CYS 212;CYS 218(4Fe-4S cluster-2);CYS 227;CYS 245;CYS 248(3Fe-4S cluster)
1yrqG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 184;CYS 187;CYS 212;CYS 218(4Fe-4S cluster-2);CYS 227;CYS 245;CYS 248(3Fe-4S cluster)
1frvA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 185;CYS 188;CYS 213;CYS 219(4Fe-4S cluster-2);CYS 228;CYS 246;CYS 249(3Fe-4S cluster)
1frvC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 185;CYS 188;CYS 213;CYS 219(4Fe-4S cluster-2);CYS 228;CYS 246;CYS 249(3Fe-4S cluster)
1yq9A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 185;CYS 188;CYS 213;CYS 219(4Fe-4S cluster-2);CYS 228;CYS 246;CYS 249(3Fe-4S cluster)
1yq9B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 185;CYS 188;CYS 213;CYS 219(4Fe-4S cluster-2);CYS 228;CYS 246;CYS 249(3Fe-4S cluster)
2frvA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 185;CYS 188;CYS 213;CYS 219(4Fe-4S cluster-2);CYS 228;CYS 246;CYS 249(3Fe-4S cluster)
2frvC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 185;CYS 188;CYS 213;CYS 219(4Fe-4S cluster-2);CYS 228;CYS 246;CYS 249(3Fe-4S cluster)
2frvE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 185;CYS 188;CYS 213;CYS 219(4Fe-4S cluster-2);CYS 228;CYS 246;CYS 249(3Fe-4S cluster)
2frvG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 185;CYS 188;CYS 213;CYS 219(4Fe-4S cluster-2);CYS 228;CYS 246;CYS 249(3Fe-4S cluster)
2frvI02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 185;CYS 188;CYS 213;CYS 219(4Fe-4S cluster-2);CYS 228;CYS 246;CYS 249(3Fe-4S cluster)
2frvS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 185;CYS 188;CYS 213;CYS 219(4Fe-4S cluster-2);CYS 228;CYS 246;CYS 249(3Fe-4S cluster)
1h2aS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 188;CYS 191;CYS 216;CYS 222(4Fe-4S cluster-2);CYS 231;CYS 249;CYS 252(3Fe-4S cluster)
1h2rS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 188;CYS 191;CYS 216;CYS 222(4Fe-4S cluster-2);CYS 231;CYS 249;CYS 252(3Fe-4S cluster)
1ubhS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 188;CYS 191;CYS 216;CYS 222(4Fe-4S cluster-2);CYS 231;CYS 249;CYS 252(3Fe-4S cluster)
1ubjS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 188;CYS 191;CYS 216;CYS 222(4Fe-4S cluster-2);CYS 231;CYS 249;CYS 252(3Fe-4S cluster)
1ubkS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 188;CYS 191;CYS 216;CYS 222(4Fe-4S cluster-2);CYS 231;CYS 249;CYS 252(3Fe-4S cluster)
1ublS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 188;CYS 191;CYS 216;CYS 222(4Fe-4S cluster-2);CYS 231;CYS 249;CYS 252(3Fe-4S cluster)
1ubmS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 188;CYS 191;CYS 216;CYS 222(4Fe-4S cluster-2);CYS 231;CYS 249;CYS 252(3Fe-4S cluster)
1uboS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 188;CYS 191;CYS 216;CYS 222(4Fe-4S cluster-2);CYS 231;CYS 249;CYS 252(3Fe-4S cluster)
1ubrS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 188;CYS 191;CYS 216;CYS 222(4Fe-4S cluster-2);CYS 231;CYS 249;CYS 252(3Fe-4S cluster)
1ubtS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 188;CYS 191;CYS 216;CYS 222(4Fe-4S cluster-2);CYS 231;CYS 249;CYS 252(3Fe-4S cluster)
1ubuS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 188;CYS 191;CYS 216;CYS 222(4Fe-4S cluster-2);CYS 231;CYS 249;CYS 252(3Fe-4S cluster)
1wuhS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 188;CYS 191;CYS 216;CYS 222(4Fe-4S cluster-2);CYS 231;CYS 249;CYS 252(3Fe-4S cluster)
1wuiS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 188;CYS 191;CYS 216;CYS 222(4Fe-4S cluster-2);CYS 231;CYS 249;CYS 252(3Fe-4S cluster)
1wujS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 188;CYS 191;CYS 216;CYS 222(4Fe-4S cluster-2);CYS 231;CYS 249;CYS 252(3Fe-4S cluster)
1wukS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 188;CYS 191;CYS 216;CYS 222(4Fe-4S cluster-2);CYS 231;CYS 249;CYS 252(3Fe-4S cluster)
1wulS02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain HIS 188;CYS 191;CYS 216;CYS 222(4Fe-4S cluster-2);CYS 231;CYS 249;CYS 252(3Fe-4S cluster)

References for Catalytic Mechanism
References Sections No. of steps in catalysis
[7]
p.987-988
[9]
Fig.5, Fig.9, Fig.10, p.14346-14348
[10]
p.825-828
[12]
Fig.5, p.582-585
[14]
Fig.7, p.12995-12996
[16]
Fig.4, p.7850-7854
[17]
Fig.2, p.664-665
[20]
p.1675-1677
[21]
p.399-400
[22]
p.11628-11630
[23]
p.298
[24]
p.3336-3337
[25]
Fig.3, p.553-554
[31]
Scheme 1, Fig.2, p.6202-6203
[32]
Scheme 1, p.5840 2
[33]
Table 1, p.469-472
[34]
p.457-458
[35]
p.71-73, p.77-80
[36]
p.156-157, p.158-159
[37]
Fig.4, p.4432-4434
[38]
Fig.7, p.11634-11635
[42]
Fig.8, p.92
[44]
Fig.2, p.134-138
[45]
p.10511-10513
[47]
Fig.1, p.641-642
[48]
Fig3., Fig.4, p.872-875
[50]
Fig.6, p.246-248
[51]
Fig.3, p.1637-1640

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Medline ID
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Medline ID
PubMed ID 2987196
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Related UniProtKB
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Medline ID
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Related UniProtKB P18187 P18188
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Medline ID
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Related UniProtKB
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Medline ID
PubMed ID 1558764
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Medline ID
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Medline ID
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Related UniProtKB
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Medline ID
PubMed ID 8501043
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Related UniProtKB
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Comments
Medline ID
PubMed ID 7947844
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Title Analysis of oxidative titrations of Desulfovibrio gigas hydrogenase; implications for the catalytic mechanism.
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Related UniProtKB
[10]
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Comments
Medline ID
PubMed ID 8174562
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Year 1994
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Related UniProtKB
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Medline ID
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Comments X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS).
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PubMed ID 7854413
Journal Nature
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Related UniProtKB P12943 P12944
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Medline ID
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Related UniProtKB
[14]
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Comments X-ray crystallography
Medline ID
PubMed ID
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Medline ID
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Medline ID
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Related UniProtKB
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Medline ID
PubMed ID 9479448
Journal Biochimie
Year 1997
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Title Hydrogenase: a hydrogen-metabolizing enzyme. What do the crystal structures tell us about its mode of action?
Related PDB
Related UniProtKB
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Medline ID
PubMed ID 9228943
Journal Nat Struct Biol
Year 1997
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Related PDB
Related UniProtKB
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Medline ID
PubMed ID 8990114
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Year 1997
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Related UniProtKB
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Comments X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 19-552.
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PubMed ID 9438867
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Title Unusual ligand structure in Ni-Fe active center and an additional Mg site in hydrogenase revealed by high resolution X-ray structure analysis.
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Related UniProtKB P21852 P21853
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Medline ID
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Volume 26
Pages 396-401
Authors Garcin E, Montet Y, Volbeda A, Hatchikian C, Frey M, Fontecilla-Camps JC
Title Structural bases for the catalytic mechanism of [NiFe] hydrogenases.
Related PDB
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[22]
Resource
Comments X-ray Diffraction
Medline ID
PubMed ID 9751716
Journal Proc Natl Acad Sci U S A
Year 1998
Volume 95
Pages 11625-30
Authors Rousset M, Montet Y, Guigliarelli B, Forget N, Asso M, Bertrand P, Fontecilla-Camps JC, Hatchikian EC
Title [3Fe-4S] to [4Fe-4S] cluster conversion in Desulfovibrio fructosovorans [NiFe] hydrogenase by site-directed mutagenesis.
Related PDB 1frf
Related UniProtKB
[23]
Resource
Comments
Medline ID
PubMed ID 10049702
Journal Biochem Biophys Res Commun
Year 1999
Volume 255
Pages 295-9
Authors Higuchi Y, Yagi T
Title Liberation of hydrogen sulfide during the catalytic action of Desulfovibrio hydrogenase under the atmosphere of hydrogen.
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[24]
Resource
Comments
Medline ID
PubMed ID 9920874
Journal J Biol Chem
Year 1999
Volume 274
Pages 3331-7
Authors Pierik AJ, Roseboom W, Happe RP, Bagley KA, Albracht SP
Title Carbon monoxide and cyanide as intrinsic ligands to iron in the active site of [NiFe]-hydrogenases. NiFe(CN)2CO, Biology's way to activate H2.
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[25]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS).
Medline ID
PubMed ID 10378274
Journal Structure Fold Des
Year 1999
Volume 7
Pages 549-56
Authors Higuchi Y, Ogata H, Miki K, Yasuoka N, Yagi T
Title Removal of the bridging ligand atom at the Ni-Fe active site of [NiFe] hydrogenase upon reduction with H2, as revealed by X-ray structure analysis at 1.4 A resolution.
Related PDB 1h2r
Related UniProtKB P21852 P21853
[26]
Resource
Comments
Medline ID
PubMed ID 11128995
Journal J Biol Inorg Chem
Year 2000
Volume 5
Pages 682-91
Authors Bertrand P, Dole F, Asso M, Guigliarelli B
Title Is there a rate-limiting step in the catalytic cycle of Ni-Fe hydrogenases?
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[27]
Resource
Comments
Medline ID
PubMed ID 10766434
Journal J Biol Inorg Chem
Year 2000
Volume 5
Pages 36-44
Authors Trofanchuk O, Stein M, Gessner C, Lendzian F, Higuchi Y, Lubitz W
Title Single crystal EPR studies of the oxidized active site of [NiFe] hydrogenase from Desulfovibrio vulgaris Miyazaki F.
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[28]
Resource
Comments
Medline ID
PubMed ID 11001090
Journal J Inorg Biochem
Year 2000
Volume 80
Pages 205-11
Authors Higuchi Y, Toujou F, Tsukamoto K, Yagi T
Title The presence of a SO molecule in [NiFe] hydrogenase from Desulfovibrio vulgaris Miyazaki as detected by mass spectrometry.
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[29]
Resource
Comments
Medline ID
PubMed ID 11170458
Journal Biochemistry
Year 2001
Volume 40
Pages 1317-24
Authors Fritz G, Griesshaber D, Seth O, Kroneck PM
Title Nonaheme cytochrome c, a new physiological electron acceptor for [Ni,Fe] hydrogenase in the sulfate-reducing bacterium Desulfovibrio desulfuricans Essex: primary sequence, molecular parameters, and redox properties..
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[30]
Resource
Comments
Medline ID
PubMed ID 11195380
Journal Inorg Chem
Year 2001
Volume 40
Pages 18-24
Authors Li S, Hall MB
Title Modeling the active sites of metalloenzymes. 4. Predictions of the unready states of [NiFe] Desulfovibrio gigas hydrogenase from density functional theory.
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[31]
Resource
Comments
Medline ID
PubMed ID 11703120
Journal Inorg Chem
Year 2001
Volume 40
Pages 6201-3
Authors Niu S, Hall MB
Title Modeling the active sites in metalloenzymes 5. The heterolytic bond cleavage of H(2) in the [NiFe] hydrogenase of desulfovibrio gigas by a nucleophilic addition mechanism.
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[32]
Resource
Comments
Medline ID
PubMed ID 11403633
Journal J Am Chem Soc
Year 2001
Volume 123
Pages 5839-40
Authors Stein M, van Lenthe E, Baerends EJ, Lubitz W
Title Relativistic DFT calculations of the paramagnetic intermediates of [NiFe] hydrogenase. Implications for the enzymatic mechanism.
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[33]
Resource
Comments
Medline ID
PubMed ID 11372206
Journal J Biol Inorg Chem
Year 2001
Volume 6
Pages 467-73
Authors Fan HJ, Hall MB
Title Recent theoretical predictions of the active site for the observed forms in the catalytic cycle of Ni-Fe hydrogenase.
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[34]
Resource
Comments
Medline ID
PubMed ID 11372204
Journal J Biol Inorg Chem
Year 2001
Volume 6
Pages 453-9
Authors Maroney MJ, Bryngelson PA
Title Spectroscopic and model studies of the Ni-Fe hydrogenase reaction mechanism.
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[35]
Resource
Comments
Medline ID
PubMed ID 11191224
Journal J Biol Inorg Chem
Year 2001
Volume 6
Pages 63-81
Authors Matias PM, Soares CM, Saraiva LM, Coelho R, Morais J, Le Gall J, Carrondo MA
Title [NiFe] hydrogenase from Desulfovibrio desulfuricans ATCC 27774: gene sequencing, three-dimensional structure determination and refinement at 1.8 A and modelling studies of its interaction with the tetrahaem cytochrome c3.
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[36]
Resource
Comments
Medline ID
PubMed ID 11921392
Journal Chembiochem
Year 2002
Volume 3
Pages 153-60
Authors Frey M
Title Hydrogenases: hydrogen-activating enzymes.
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[37]
Resource
Comments
Medline ID
PubMed ID 12184759
Journal Inorg Chem
Year 2002
Volume 41
Pages 4424-34
Authors Stadler C, de Lacey AL, Montet Y, Volbeda A, Fontecilla-Camps JC, Conesa JC, Fernandez VM
Title Density functional calculations for modeling the active site of nickel-iron hydrogenases. 2. Predictions for the unready and ready States and the corresponding activation processes.
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[38]
Resource
Comments
Medline ID
PubMed ID 11782180
Journal J Am Chem Soc
Year 2002
Volume 124
Pages 281-6
Authors Carepo M, Tierney DL, Brondino CD, Yang TC, Pamplona A, Telser J, Moura I, Moura JJ, Hoffman BM
Title 17O ENDOR detection of a solvent-derived Ni-(OH(x))-Fe bridge that is lost upon activation of the hydrogenase from Desulfovibrio gigas.
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[39]
Resource
Comments X-ray Diffraction
Medline ID
PubMed ID 12296727
Journal J Am Chem Soc
Year 2002
Volume 124
Pages 11628-35
Authors Ogata H, Mizoguchi Y, Mizuno N, Miki K, Adachi S, Yasuoka N, Yagi T, Yamauchi O, Hirota S, Higuchi Y
Title Structural studies of the carbon monoxide complex of [NiFe]hydrogenase from Desulfovibrio vulgaris Miyazaki F: suggestion for the initial activation site for dihydrogen.
Related PDB 1ubh 1ubj 1ubk 1ubl 1ubm 1ubo 1ubr 1ubt
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[40]
Resource
Comments
Medline ID
PubMed ID 11935356
Journal J Biol Inorg Chem
Year 2002
Volume 7
Pages 318-26
Authors De Lacey AL, Stadler C, Fernandez VM, Hatchikian EC, Fan HJ, Li S, Hall MB
Title IR spectroelectrochemical study of the binding of carbon monoxide to the active site of Desulfovibrio fructosovorans Ni-Fe hydrogenase.
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[41]
Resource
Comments
Medline ID
PubMed ID 11862554
Journal J Biol Inorg Chem
Year 2002
Volume 7
Pages 177-94
Authors Muller A, Tscherny I, Kappl R, Hatchikian C, Huttermann J, Cammack R
Title Hydrogenases in the "active" state: determination of g-matrix axes and electron spin distribution at the active site by 1H ENDOR spectroscopy.
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[42]
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Comments
Medline ID
PubMed ID 12515509
Journal J Am Chem Soc
Year 2003
Volume 125
Pages
Authors Foerster S, Stein M, Brecht M, Ogata H, Higuchi Y, Lubitz W
Title Single crystal EPR studies of the reduced active site of [NiFe] hydrogenase from Desulfovibrio vulgaris Miyazaki F.
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[43]
Resource
Comments
Medline ID
PubMed ID 12459907
Journal J Biol Inorg Chem
Year 2003
Volume 8
Pages 129-34
Authors DeLacey AL, Fernandez VM, Rousset M, Cavazza C, Hatchikian EC
Title Spectroscopic and kinetic characterization of active site mutants of Desulfovibrio fructosovoransNi-Fe hydrogenase.
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[44]
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Comments
Medline ID
PubMed ID 15062773
Journal Curr Opin Chem Biol
Year 2004
Volume 8
Pages 133-40
Authors Armstrong FA
Title Hydrogenases: active site puzzles and progress.
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[45]
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PubMed ID 14688251
Journal J Biol Chem
Year 2004
Volume 279
Pages 10508-13
Authors Dementin S, Burlat B, De Lacey AL, Pardo A, Adryanczyk-Perrier G, Guigliarelli B, Fernandez VM, Rousset M
Title A glutamate is the essential proton transfer gate during the catalytic cycle of the [NiFe] hydrogenase.
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[46]
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Comments
Medline ID
PubMed ID 15365900
Journal J Biol Inorg Chem
Year 2004
Volume 9
Pages 873-84
Authors Bruschi M, De Gioia L, Zampella G, Reiher M, Fantucci P, Stein M
Title A theoretical study of spin states in Ni-S4 complexes and models of the [NiFe] hydrogenase active site.
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[47]
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Comments
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PubMed ID 15175937
Journal J Biol Inorg Chem
Year 2004
Volume 9
Pages 636-42
Authors De Lacey AL, Pardo A, Fernandez VM, Dementin S, Adryanczyk-Perrier G, Hatchikian EC, Rousset M
Title FTIR spectroelectrochemical study of the activation and inactivation processes of [NiFe] hydrogenases: effects of solvent isotope replacement and site-directed mutagenesis.
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[48]
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Comments
Medline ID
PubMed ID 15134933
Journal J Inorg Biochem
Year 2004
Volume 98
Pages 862-77
Authors Stein M, Lubitz W
Title Relativistic DFT calculation of the reaction cycle intermediates of [NiFe] hydrogenase: a contribution to understanding the enzymatic mechanism.
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[49]
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Comments
Medline ID
PubMed ID 15667250
Journal Biochem Soc Trans
Year 2005
Volume 33
Pages 7-11
Authors van Gastel M, Fichtner C, Neese F, Lubitz W
Title EPR experiments to elucidate the structure of the ready and unready states of the [NiFe] hydrogenase of Desulfovibrio vulgaris Miyazaki F.
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[50]
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Comments
Medline ID
PubMed ID 15803334
Journal J Biol Inorg Chem
Year 2005
Volume 10
Pages 239-49
Authors Volbeda A, Martin L, Cavazza C, Matho M, Faber BW, Roseboom W, Albracht SP, Garcin E, Rousset M, Fontecilla-Camps JC
Title Structural differences between the ready and unready oxidized states of [NiFe] hydrogenases.
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[51]
Resource
Comments
Medline ID
PubMed ID 16271886
Journal Structure
Year 2005
Volume 13
Pages 1635-42
Authors Ogata H, Hirota S, Nakahara A, Komori H, Shibata N, Kato T, Kano K, Higuchi Y
Title Activation process of [NiFe] hydrogenase elucidated by high-resolution X-Ray analyses: conversion of the ready to the unready state.
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Comments
This enzyme catalyzes the following reactions:
(A) Electron transfer from heme iron of cytochrome c3 to [4Fe-4S] cluster-2 located on the surface of small subunit:
(A1) His184 (1frf) bound to Fe4-S4, is exposed to the surface of the S subunit. This residue might interact with cytochrome c3, for electron transfer (see [12]).
(B) Electron transfer from [4Fe-4S] cluster-2 to [3Fe-4S] cluster:
(B1) Indirect transfer from [4Fe-4S] cluster-2 to [3Fe-4S] cluster through Cys218 (bound to [4Fe-4S] cluster-2) and Cys245 (bound to [3Fe-4S]) (see [12]).
(C) Electron transfer from [3Fe-4S] cluster to [4Fe-4S] cluster-1:
(C1) Indirect transfer from [3Fe-4S] cluster to [4Fe-4S] cluster-1 through Cys248 (bound to [3Fe-4S]) and Cys147 (bound to [4Fe-4S] cluster-1) (see [12]).
(D) Electron transfer from [4Fe-4S] cluster-1 to the Nickel-Iron cluster (reaction center):
(D1) Indirect transfer from [4Fe-4S] cluster-1 to Nickel-Iron cluster through Cys17 (bound to [4Fe-4S] cluster-1) and Cys72 of Large subunit (bound to Nickel-Iron cluster) (see [12]).
(E) Hydrogenation at the Nickel-Iron cluster (reaction center):

Created Updated
2005-08-12 2009-02-26