DB code: T00043

RLCP classification 8.113.915310.365 : Isomerization
3.130.90020.2100 : Transfer
CATH domain 3.40.1380.20 : Pyruvate Kinase; Chain
3.20.20.60 : TIM Barrel Catalytic domain
2.40.33.10 : M1 Pyruvate Kinase; Domain 3 Catalytic domain
E.C. 2.7.1.40
CSA 1pkn
M-CSA 1pkn
MACiE M0326

CATH domain Related DB codes (homologues)
3.20.20.60 : TIM Barrel S00241 T00217 S00197 S00242 D00477

Uniprot Enzyme Name
UniprotKB Protein name Synonyms RefSeq Pfam
P0AD61 Pyruvate kinase I
EC 2.7.1.40
PK-1
NP_416191.1 (Protein)
NC_000913.2 (DNA/RNA sequence)
YP_489938.1 (Protein)
NC_007779.1 (DNA/RNA sequence)
PF00224 (PK)
PF02887 (PK_C)
[Graphical View]
P00549 Pyruvate kinase 1
PK 1
EC 2.7.1.40
cell division cycle protein 19
NP_009362.1 (Protein)
NM_001178183.1 (DNA/RNA sequence)
PF00224 (PK)
PF02887 (PK_C)
[Graphical View]
Q27686 Pyruvate kinase
PK
EC 2.7.1.40
PF00224 (PK)
PF02887 (PK_C)
[Graphical View]
P11974 Pyruvate kinase PKM
EC 2.7.1.40
Pyruvate kinase muscle isozyme
NP_001182573.1 (Protein)
NM_001195644.1 (DNA/RNA sequence)
NP_001182574.1 (Protein)
NM_001195645.1 (DNA/RNA sequence)
PF00224 (PK)
PF02887 (PK_C)
[Graphical View]
P11979 Pyruvate kinase PKM
EC 2.7.1.40
Pyruvate kinase muscle isozyme
PF00224 (PK)
PF02887 (PK_C)
[Graphical View]
P30613 Pyruvate kinase PKLR
EC 2.7.1.40
Pyruvate kinase 1
Pyruvate kinase isozymes L/R
R-type/L-type pyruvate kinase
Red cell/liver pyruvate kinase
NP_000289.1 (Protein)
NM_000298.5 (DNA/RNA sequence)
NP_870986.1 (Protein)
NM_181871.3 (DNA/RNA sequence)
PF00224 (PK)
PF02887 (PK_C)
[Graphical View]
P14618 Pyruvate kinase PKM
EC 2.7.1.40
Cytosolic thyroid hormone-binding protein
CTHBP
Opa-interacting protein 3
OIP-3
Pyruvate kinase 2/3
Pyruvate kinase muscle isozyme
Thyroid hormone-binding protein 1
THBP1
Tumor M2-PK
p58
NP_001193725.1 (Protein)
NM_001206796.1 (DNA/RNA sequence)
NP_001193726.1 (Protein)
NM_001206797.1 (DNA/RNA sequence)
NP_001193727.1 (Protein)
NM_001206798.1 (DNA/RNA sequence)
NP_001193728.1 (Protein)
NM_001206799.1 (DNA/RNA sequence)
NP_002645.3 (Protein)
NM_002654.4 (DNA/RNA sequence)
NP_872270.1 (Protein)
NM_182470.2 (DNA/RNA sequence)
NP_872271.1 (Protein)
NM_182471.2 (DNA/RNA sequence)
PF00224 (PK)
PF02887 (PK_C)
[Graphical View]

KEGG enzyme name
pyruvate kinase
phosphoenolpyruvate kinase
phosphoenol transphosphorylase

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
P0AD61 KPYK1_ECOLI ATP + pyruvate = ADP + phosphoenolpyruvate. Homotetramer. Magnesium. Potassium.
P00549 KPYK1_YEAST ATP + pyruvate = ADP + phosphoenolpyruvate. Homotetramer. Magnesium. Potassium.
Q27686 KPYK_LEIME ATP + pyruvate = ADP + phosphoenolpyruvate. Homotetramer. Magnesium. Potassium.
P11974 KPYM_RABIT ATP + pyruvate = ADP + phosphoenolpyruvate. Interacts with HERC1 (By similarity). Homotetramer. Magnesium. Potassium.
P11979 KPYM_FELCA ATP + pyruvate = ADP + phosphoenolpyruvate. Interacts with HERC1 (By similarity). Homotetramer. Magnesium. Potassium.
P30613 KPYR_HUMAN ATP + pyruvate = ADP + phosphoenolpyruvate. Homotetramer. Magnesium. Potassium.
P14618 KPYM_HUMAN ATP + pyruvate = ADP + phosphoenolpyruvate. Homotetramer. Interacts with HERC1. Magnesium. Potassium.

KEGG Pathways
Map code Pathways E.C.
MAP00010 Glycolysis / Gluconeogenesis
MAP00230 Purine metabolism
MAP00620 Pyruvate metabolism
MAP00710 Carbon fixation in photosynthetic organisms

Compound table
Cofactors Substrates Products Intermediates
KEGG-id C00305 C00238 C00008 C00074 C00002 C00022
E.C.
Compound Magnesium Potassium ADP Phosphoenolpyruvate ATP Pyruvate
Type divalent metal (Ca2+, Mg2+) univalent metal (Na+, K+) amine group,nucleotide carboxyl group,phosphate group/phosphate ion amine group,nucleotide carbohydrate,carboxyl group
ChEBI 18420
29103
16761
44897
15422
32816
PubChem 888
813
6022
1005
58114173
59658623
5957
1060
1e0tA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0tB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0tC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0tD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0uA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0uB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0uC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0uD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pkyA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pkyB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pkyC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pkyD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a3wA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a3wB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a3xA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a3xB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a49A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a49B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a49C01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a49D01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a49E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a49F01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a49G01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a49H01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a5uA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a5uB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a5uC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a5uD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a5uE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a5uF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a5uG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a5uH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1aqfA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1aqfB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1aqfC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1aqfD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1aqfE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1aqfF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1aqfG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1aqfH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3wA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3wB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3wC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3wD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3wE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3wF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3wG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3wH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3xA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3xB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3xC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3xD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3xE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3xF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3xG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3xH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pknA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pkmA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liuA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liuB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liuC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liuD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liwA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liwB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liwC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liwD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1lixA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1lixB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1lixC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1lixD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liyA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liyB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liyC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liyD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1t5aA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1t5aB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1t5aC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1t5aD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1zjhA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0tA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0tB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0tC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0tD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0uA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0uB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0uC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0uD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pkyA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pkyB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pkyC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pkyD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a3wA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1a3wB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1a3xA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1a3xB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1pklA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a49A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_MG Bound:__K Unbound Unbound Bound:ATP Analogue:OXL
1a49B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Bound:__K Unbound Unbound Unbound Analogue:OXL
1a49C02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_MG Bound:__K Unbound Unbound Bound:ATP Analogue:OXL
1a49D02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_MG Bound:__K Unbound Unbound Bound:ATP Analogue:OXL
1a49E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_MG Bound:__K Unbound Unbound Bound:ATP Analogue:OXL
1a49F02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_MG Bound:__K Unbound Unbound Bound:ATP Analogue:OXL
1a49G02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_MG Bound:__K Unbound Unbound Bound:ATP Analogue:OXL
1a49H02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Bound:__K Unbound Unbound Unbound Analogue:OXL
1a5uA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_MG Analogue:_NA Unbound Unbound Bound:ATP Analogue:OXL
1a5uB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Analogue:_NA Unbound Unbound Unbound Analogue:OXL
1a5uC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_MG Analogue:_NA Unbound Unbound Bound:ATP Analogue:OXL
1a5uD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_MG Analogue:_NA Unbound Unbound Bound:ATP Analogue:OXL
1a5uE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_MG Analogue:_NA Unbound Unbound Bound:ATP Analogue:OXL
1a5uF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_MG Analogue:_NA Unbound Unbound Bound:ATP Analogue:OXL
1a5uG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:2x_MG Analogue:_NA Unbound Unbound Bound:ATP Analogue:OXL
1a5uH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Analogue:_NA Unbound Unbound Unbound Analogue:OXL
1aqfA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Bound:__K Unbound Bound:PEQ Unbound Unbound
1aqfB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Bound:__K Unbound Bound:PEQ Unbound Unbound
1aqfC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Bound:__K Unbound Bound:PEQ Unbound Unbound
1aqfD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Bound:__K Unbound Bound:PEQ Unbound Unbound
1aqfE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Bound:__K Unbound Bound:PEQ Unbound Unbound
1aqfF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Bound:__K Unbound Bound:PEQ Unbound Unbound
1aqfG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Bound:__K Unbound Bound:PEQ Unbound Unbound
1aqfH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Bound:__K Unbound Bound:PEQ Unbound Unbound
1f3wA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Unbound Unbound Bound:PYR
1f3wB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Unbound Unbound Bound:PYR
1f3wC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Unbound Unbound Bound:PYR
1f3wD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Unbound Unbound Bound:PYR
1f3wE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Unbound Unbound Bound:PYR
1f3wF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Unbound Unbound Bound:PYR
1f3wG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Unbound Unbound Bound:PYR
1f3wH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Unbound Unbound Bound:PYR
1f3xA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Unbound Unbound Bound:PYR
1f3xB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Unbound Unbound Bound:PYR
1f3xC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Unbound Unbound Bound:PYR
1f3xD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Unbound Unbound Bound:PYR
1f3xE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Unbound Unbound Bound:PYR
1f3xF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Unbound Unbound Bound:PYR
1f3xG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Unbound Unbound Bound:PYR
1f3xH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Unbound Unbound Bound:PYR
1pknA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Unbound Unbound Bound:PYR
1pkmA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liuA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1liuB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1liuC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1liuD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1liwA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1liwB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1liwC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1liwD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1lixA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1lixB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1lixC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1lixD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1liyA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1liyB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1liyC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1liyD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:_MN Bound:__K Unbound Analogue:PGA Unbound Unbound
1t5aA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Bound:__K Unbound Unbound Unbound Analogue:OXL
1t5aB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Bound:__K Unbound Unbound Unbound Analogue:OXL
1t5aC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Bound:__K Unbound Unbound Unbound Analogue:OXL
1t5aD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:_MG Bound:__K Unbound Unbound Unbound Analogue:OXL
1zjhA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0tA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0tB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0tC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0tD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0uA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0uB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0uC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1e0uD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pkyA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pkyB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pkyC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pkyD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a3wA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a3wB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a3xA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a3xB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklE03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklF03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklG03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pklH03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a49A03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a49B03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a49C03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a49D03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a49E03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a49F03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a49G03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a49H03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a5uA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a5uB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a5uC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a5uD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a5uE03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a5uF03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a5uG03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1a5uH03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1aqfA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1aqfB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1aqfC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1aqfD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1aqfF03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1aqfG03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1aqfH03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3wA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3wB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3wC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3wD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3wE03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3wF03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3wG03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3wH03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3xA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3xB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3xC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3xD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3xE03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3xF03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3xG03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1f3xH03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pknA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1pkmA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liuA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liuB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liuC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liuD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liwA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liwB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liwC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liwD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1lixA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1lixB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1lixC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1lixD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liyA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liyB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liyC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1liyD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1t5aA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1t5aB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1t5aC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1t5aD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound
1zjhA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound Unbound Unbound Unbound Unbound

Reference for Active-site residues
resource references E.C.
literature [10], [33], [36]

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
1e0tA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1e0tB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1e0tC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1e0tD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1e0uA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1e0uB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1e0uC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1e0uD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1pkyA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1pkyB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1pkyC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1pkyD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a3wA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a3wB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a3xA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a3xB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1pklA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1pklB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1pklC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1pklD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1pklE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1pklF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1pklG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1pklH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a49A01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a49B01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a49C01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a49D01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a49E01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a49F01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a49G01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a49H01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a5uA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a5uB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a5uC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a5uD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a5uE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a5uF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a5uG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1a5uH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1aqfA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1aqfB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1aqfC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1aqfD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1aqfE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1aqfF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1aqfG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1aqfH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1f3wA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1f3wB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1f3wC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1f3wD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1f3wE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1f3wF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1f3wG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1f3wH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1f3xA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain mutant S402P
1f3xB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain mutant S402P
1f3xC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain mutant S402P
1f3xD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain mutant S402P
1f3xE01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain mutant S402P
1f3xF01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain mutant S402P
1f3xG01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain mutant S402P
1f3xH01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain mutant S402P
1pknA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1pkmA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1liuA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1liuB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1liuC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1liuD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1liwA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1liwB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1liwC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1liwD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1lixA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1lixB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1lixC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1lixD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1liyA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1liyB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1liyC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1liyD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1t5aA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1t5aB01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1t5aC01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1t5aD01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1zjhA01 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain
1e0tA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 32;LYS 220;THR 278;SER 312;GLU 314 ASN 34;SER 36;ASP 66;THR 67(Potassium);GLU 222;ASP 246(Magnesium) mutant Q279M, R292D
1e0tB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 32;LYS 220;THR 278;SER 312;GLU 314 ASN 34;SER 36;ASP 66;THR 67(Potassium);GLU 222;ASP 246(Magnesium) mutant Q279M, R292D
1e0tC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 32;LYS 220;THR 278;SER 312;GLU 314 ASN 34;SER 36;ASP 66;THR 67(Potassium);GLU 222;ASP 246(Magnesium) mutant Q279M, R292D
1e0tD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 32;LYS 220;THR 278;SER 312;GLU 314 ASN 34;SER 36;ASP 66;THR 67(Potassium);GLU 222;ASP 246(Magnesium) mutant Q279M, R292D
1e0uA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 32;LYS 220;THR 278;SER 312;GLU 314 ASN 34;SER 36;ASP 66;THR 67(Potassium);GLU 222;ASP 246(Magnesium) mutant R271L, Q279M
1e0uB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 32;LYS 220;THR 278;SER 312;GLU 314 ASN 34;SER 36;ASP 66;THR 67(Potassium);GLU 222;ASP 246(Magnesium) mutant R271L, Q279M
1e0uC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 32;LYS 220;THR 278;SER 312;GLU 314 ASN 34;SER 36;ASP 66;THR 67(Potassium);GLU 222;ASP 246(Magnesium) mutant R271L, Q279M
1e0uD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 32;LYS 220;THR 278;SER 312;GLU 314 ASN 34;SER 36;ASP 66;THR 67(Potassium);GLU 222;ASP 246(Magnesium) mutant R271L, Q279M
1pkyA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 32;LYS 220;THR 278;SER 312;GLU 314 ASN 34;SER 36;ASP 66;THR 67(Potassium);GLU 222;ASP 246(Magnesium)
1pkyB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 32;LYS 220;THR 278;SER 312;GLU 314 ASN 34;SER 36;ASP 66;THR 67(Potassium);GLU 222;ASP 246(Magnesium)
1pkyC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 32;LYS 220;THR 278;SER 312;GLU 314 ASN 34;SER 36;ASP 66;THR 67(Potassium);GLU 222;ASP 246(Magnesium)
1pkyD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 32;LYS 220;THR 278;SER 312;GLU 314 ASN 34;SER 36;ASP 66;THR 67(Potassium);GLU 222;ASP 246(Magnesium)
1a3wA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 49;LYS 240;THR 298;SER 332;GLU 334 ASN 51;SER 53;ASP 84;THR 85(Potassium);GLU 242;ASP 266(Magnesium)
1a3wB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 49;LYS 240;THR 298;SER 332;GLU 334 ASN 51;SER 53;ASP 84;THR 85(Potassium);GLU 242;ASP 266(Magnesium)
1a3xA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 49;LYS 240;THR 298;SER 332;GLU 334 ASN 51;SER 53;ASP 84;THR 85(Potassium);GLU 242;ASP 266(Magnesium)
1a3xB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 49;LYS 240;THR 298;SER 332;GLU 334 ASN 51;SER 53;ASP 84;THR 85(Potassium);GLU 242;ASP 266(Magnesium)
1pklA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 49;LYS 238;THR 296;SER 330;GLU 332 ASN 51;SER 53;ASP 83;THR 84(Potassium);GLU 240;ASP 264(Magnesium)
1pklB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 49;LYS 238;THR 296;SER 330;GLU 332 ASN 51;SER 53;ASP 83;THR 84(Potassium);GLU 240;ASP 264(Magnesium)
1pklC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 49;LYS 238;THR 296;SER 330;GLU 332 ASN 51;SER 53;ASP 83;THR 84(Potassium);GLU 240;ASP 264(Magnesium)
1pklD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 49;LYS 238;THR 296;SER 330;GLU 332 ASN 51;SER 53;ASP 83;THR 84(Potassium);GLU 240;ASP 264(Magnesium)
1pklE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 49;LYS 238;THR 296;SER 330;GLU 332 ASN 51;SER 53;ASP 83;THR 84(Potassium);GLU 240;ASP 264(Magnesium)
1pklF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 49;LYS 238;THR 296;SER 330;GLU 332 ASN 51;SER 53;ASP 83;THR 84(Potassium);GLU 240;ASP 264(Magnesium)
1pklG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 49;LYS 238;THR 296;SER 330;GLU 332 ASN 51;SER 53;ASP 83;THR 84(Potassium);GLU 240;ASP 264(Magnesium)
1pklH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 49;LYS 238;THR 296;SER 330;GLU 332 ASN 51;SER 53;ASP 83;THR 84(Potassium);GLU 240;ASP 264(Magnesium)
1a49A02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1a49B02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 672;LYS 869;THR 927;SER 961;GLU 963 ASN 674;SER 676;ASP 712;THR 713(Potassium);GLU 871;ASP 895(Magnesium)
1a49C02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 1272;LYS 1469;THR 1527;SER 1561;GLU 1563 ASN 1274;SER 1276;ASP 1312;THR 1313(Potassium);GLU 1471;ASP 1495(Magnesium)
1a49D02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 1872;LYS 2069;THR 2127;SER 2161;GLU 2163 ASN 1874;SER 1876;ASP 1912;THR 1913(Potassium);GLU 2071;ASP 2095(Magnesium)
1a49E02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 3072;LYS 3269;THR 3327;SER 3361;GLU 3363 ASN 3074;SER 3076;ASP 3112;THR 3113(Potassium);GLU 3271;ASP 3295(Magnesium)
1a49F02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 3672;LYS 3869;THR 3927;SER 3961;GLU 3963 ASN 3674;SER 3676;ASP 3712;THR 3713(Potassium);GLU 3871;ASP 3895(Magnesium)
1a49G02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 4272;LYS 4469;THR 4527;SER 4561;GLU 4563 ASN 4274;SER 4276;ASP 4312;THR 4313(Potassium);GLU 4471;ASP 4495(Magnesium)
1a49H02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 4872;LYS 5069;THR 5127;SER 5161;GLU 5163 ASN 4874;SER 4876;ASP 4912;THR 4913(Potassium);GLU 5071;ASP 5095(Magnesium)
1a5uA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1a5uB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 672;LYS 869;THR 927;SER 961;GLU 963 ASN 674;SER 676;ASP 712;THR 713(Potassium);GLU 871;ASP 895(Magnesium)
1a5uC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 1272;LYS 1469;THR 1527;SER 1561;GLU 1563 ASN 1274;SER 1276;ASP 1312;THR 1313(Potassium);GLU 1471;ASP 1495(Magnesium)
1a5uD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 1872;LYS 2069;THR 2127;SER 2161;GLU 2163 ASN 1874;SER 1876;ASP 1912;THR 1913(Potassium);GLU 2071;ASP 2095(Magnesium)
1a5uE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 3072;LYS 3269;THR 3327;SER 3361;GLU 3363 ASN 3074;SER 3076;ASP 3112;THR 3113(Potassium);GLU 3271;ASP 3295(Magnesium)
1a5uF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 3672;LYS 3869;THR 3927;SER 3961;GLU 3963 ASN 3674;SER 3676;ASP 3712;THR 3713(Potassium);GLU 3871;ASP 3895(Magnesium)
1a5uG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 4272;LYS 4469;THR 4527;SER 4561;GLU 4563 ASN 4274;SER 4276;ASP 4312;THR 4313(Potassium);GLU 4471;ASP 4495(Magnesium)
1a5uH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 4872;LYS 5069;THR 5127;SER 5161;GLU 5163 ASN 4874;SER 4876;ASP 4912;THR 4913(Potassium);GLU 5071;ASP 5095(Magnesium)
1aqfA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1aqfB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1aqfC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1aqfD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1aqfE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1aqfF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1aqfG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1aqfH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1f3wA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1f3wB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1f3wC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1f3wD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1f3wE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1f3wF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1f3wG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1f3wH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1f3xA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Manganese)
1f3xB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Manganese)
1f3xC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Manganese)
1f3xD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Manganese)
1f3xE02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Manganese)
1f3xF02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Manganese)
1f3xG02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Manganese)
1f3xH02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Manganese)
1pknA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Manganese)
1pkmA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1liuA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 116;LYS 313;THR 371;SER 405;GLU 407 ASN 118;SER 120;ASP 156;THR 157(Potassium);GLU 315;ASP 339(Magnesium)
1liuB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 116;LYS 313;THR 371;SER 405;GLU 407 ASN 118;SER 120;ASP 156;THR 157(Potassium);GLU 315;ASP 339(Magnesium)
1liuC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 116;LYS 313;THR 371;SER 405;GLU 407 ASN 118;SER 120;ASP 156;THR 157(Potassium);GLU 315;ASP 339(Magnesium)
1liuD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 116;LYS 313;THR 371;SER 405;GLU 407 ASN 118;SER 120;ASP 156;THR 157(Potassium);GLU 315;ASP 339(Magnesium)
1liwA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 116;LYS 313;THR 371;SER 405;GLU 407 ASN 118;SER 120;ASP 156;THR 157(Potassium);GLU 315;ASP 339(Magnesium)
1liwB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 116;LYS 313;THR 371;SER 405;GLU 407 ASN 118;SER 120;ASP 156;THR 157(Potassium);GLU 315;ASP 339(Magnesium)
1liwC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 116;LYS 313;THR 371;SER 405;GLU 407 ASN 118;SER 120;ASP 156;THR 157(Potassium);GLU 315;ASP 339(Magnesium)
1liwD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 116;LYS 313;THR 371;SER 405;GLU 407 ASN 118;SER 120;ASP 156;THR 157(Potassium);GLU 315;ASP 339(Magnesium)
1lixA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 116;LYS 313;THR 371;SER 405;GLU 407 ASN 118;SER 120;ASP 156;THR 157(Potassium);GLU 315;ASP 339(Magnesium)
1lixB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 116;LYS 313;THR 371;SER 405;GLU 407 ASN 118;SER 120;ASP 156;THR 157(Potassium);GLU 315;ASP 339(Magnesium)
1lixC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 116;LYS 313;THR 371;SER 405;GLU 407 ASN 118;SER 120;ASP 156;THR 157(Potassium);GLU 315;ASP 339(Magnesium)
1lixD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 116;LYS 313;THR 371;SER 405;GLU 407 ASN 118;SER 120;ASP 156;THR 157(Potassium);GLU 315;ASP 339(Magnesium)
1liyA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 116;LYS 313;THR 371;SER 405;GLU 407 ASN 118;SER 120;ASP 156;THR 157(Potassium);GLU 315;ASP 339(Magnesium)
1liyB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 116;LYS 313;THR 371;SER 405;GLU 407 ASN 118;SER 120;ASP 156;THR 157(Potassium);GLU 315;ASP 339(Magnesium)
1liyC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 116;LYS 313;THR 371;SER 405;GLU 407 ASN 118;SER 120;ASP 156;THR 157(Potassium);GLU 315;ASP 339(Magnesium)
1liyD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 116;LYS 313;THR 371;SER 405;GLU 407 ASN 118;SER 120;ASP 156;THR 157(Potassium);GLU 315;ASP 339(Magnesium)
1t5aA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 73;LYS 270;THR 328;SER 362;GLU 364 ASN 75;SER 77;ASP 113;THR 114(Potassium);GLU 272;ASP 296(Magnesium)
1t5aB02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 73;LYS 270;THR 328;SER 362;GLU 364 ASN 75;SER 77;ASP 113;THR 114(Potassium);GLU 272;ASP 296(Magnesium)
1t5aC02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 73;LYS 270;THR 328;SER 362;GLU 364 ASN 75;SER 77;ASP 113;THR 114(Potassium);GLU 272;ASP 296(Magnesium)
1t5aD02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 73;LYS 270;THR 328;SER 362;GLU 364 ASN 75;SER 77;ASP 113;THR 114(Potassium);GLU 272;ASP 296(Magnesium)
1zjhA02 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 72;LYS 269;THR 327;SER 361;GLU 363 ASN 74;SER 76;ASP 112;THR 113(Potassium);GLU 271;ASP 295(Magnesium)
1e0tA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 73
1e0tB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 73
1e0tC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 73
1e0tD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 73
1e0uA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 73
1e0uB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 73
1e0uC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 73
1e0uD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 73
1pkyA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 73
1pkyB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 73
1pkyC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 73
1pkyD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 73
1a3wA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 91
1a3wB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 91
1a3xA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 91
1a3xB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 91
1pklA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1pklB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1pklC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1pklD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1pklE03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1pklF03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1pklG03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1pklH03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 90
1a49A03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1a49B03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 719
1a49C03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 1319
1a49D03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 1919
1a49E03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 3119
1a49F03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 3719
1a49G03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 4319
1a49H03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 4919
1a5uA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1a5uB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 719
1a5uC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 1319
1a5uD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 1919
1a5uE03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 3119
1a5uF03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 3719
1a5uG03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 4319
1a5uH03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 4919
1aqfA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1aqfB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1aqfC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1aqfD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1aqfF03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1aqfG03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1aqfH03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1f3wA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1f3wB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1f3wC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1f3wD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1f3wE03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1f3wF03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1f3wG03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1f3wH03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1f3xA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1f3xB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1f3xC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1f3xD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1f3xE03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1f3xF03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1f3xG03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1f3xH03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1pknA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1pkmA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119
1liuA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 163
1liuB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 163
1liuC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 163
1liuD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 163
1liwA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 163
1liwB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 163
1liwC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 163
1liwD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 163
1lixA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 163
1lixB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 163
1lixC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 163
1lixD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 163
1liyA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 163
1liyB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 163
1liyC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 163
1liyD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 163
1t5aA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 120
1t5aB03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 120
1t5aC03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 120
1t5aD03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 120
1zjhA03 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain ARG 119

References for Catalytic Mechanism
References Sections No. of steps in catalysis
[10]
Fig.5, p.478-480
[13]
Fig.7
[28]
p.731-734, p.737
[33]
[36]
p.6253-6254
[39]
p.201-204
[40]
p.9142-9144
[41]
p.623-624
[52]
[53]
Fig.1, p.9423-9424
[1]
Fig.4, Fig.12, p.204
[4]
Fig.3, p.629
[8]
Scheme II

References
[1]
Resource
Comments
Medline ID
PubMed ID 4522427
Journal Ann N Y Acad Sci
Year 1973
Volume 222
Pages 192-210
Authors Mildvan AS, Nowak T, Fung CH
Title Nuclear relaxation studies of the role of the divalent cation in the mechanism of pyruvate kinase and enolase: inner sphere and second sphere complexes.
Related PDB
Related UniProtKB
[2]
Resource
Comments X-RAY CRYSTALLOGRAPHY (6 ANGSTROMS)
Medline ID 76048760
PubMed ID 1185780
Journal J Mol Biol
Year 1975
Volume 95
Pages 213-25
Authors Stammers DK, Muirhead H
Title Three-dimensional structure of cat muscle pyruvate kinase at 6 Angstrom resolution.
Related PDB
Related UniProtKB P11979
[3]
Resource
Comments X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS)
Medline ID 77209973
PubMed ID 875020
Journal J Mol Biol
Year 1977
Volume 112
Pages 309-16
Authors Stammers DK, Muirhead H
Title Three-dimensional structure of cat muscle pyruvate kinase at 3-1 A resolution.
Related PDB
Related UniProtKB P11979
[4]
Resource
Comments
Medline ID
PubMed ID 625331
Journal Nature
Year 1978
Volume 271
Pages 626-30
Authors Levine M, Muirhead H, Stammers DK, Stuart DI
Title Structure of pyruvate kinase and similarities with other enzymes: possible implications for protein taxonomy and evolution.
Related PDB
Related UniProtKB
[5]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS)
Medline ID 80140448
PubMed ID 537059
Journal J Mol Biol
Year 1979
Volume 134
Pages 109-42
Authors Stuart DI, Levine M, Muirhead H, Stammers DK
Title Crystal structure of cat muscle pyruvate kinase at a resolution of 2.6 A.
Related PDB
Related UniProtKB P11979
[6]
Resource
Comments
Medline ID
PubMed ID 7274544
Journal Biochem Soc Trans
Year 1981
Volume 9
Pages 212-3
Authors Muirhead H, Grant JP, Lawton MA, Midwinter CA, Nocton JC, Stuart DI
Title The structure and function of pyruvate kinase.
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Related UniProtKB
[7]
Resource
Comments
Medline ID
PubMed ID 6723988
Journal FEBS Lett
Year 1984
Volume 171
Pages 293-6
Authors Hoar CG, Nicoll GW, Schiltz E, Schmitt W, Bloxham DP, Byford MF, Dunbar B, Fothergill LA
Title Muscle and liver pyruvate kinases are closely related: amino acid sequence comparisons.
Related PDB
Related UniProtKB
[8]
Resource
Comments
Medline ID
PubMed ID 3910092
Journal Biochemistry
Year 1985
Volume 24
Pages 6163-9
Authors Hoving H, Crysell B, Leadlay PF
Title Fluorine NMR studies on stereochemical aspects of reactions catalyzed by transcarboxylase, pyruvate kinase, and enzyme I.
Related PDB
Related UniProtKB
[9]
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Comments
Medline ID
PubMed ID 2997192
Journal J Biol Chem
Year 1985
Volume 260
Pages 14060-9
Authors Van Divender JM, Grisham CM
Title 7Li, 31P, and 1H NMR studies of interactions between ATP, monovalent cations, and divalent cation sites on rabbit muscle pyruvate kinase.
Related PDB
Related UniProtKB
[10]
Resource
Comments
Medline ID
PubMed ID 3519210
Journal EMBO J
Year 1986
Volume 5
Pages 475-81
Authors Muirhead H, Clayden DA, Barford D, Lorimer CG, Fothergill-Gilmore LA, Schiltz E, Schmitt W
Title The structure of cat muscle pyruvate kinase.
Related PDB
Related UniProtKB
[11]
Resource
Comments
Medline ID
PubMed ID 3082867
Journal J Biol Chem
Year 1986
Volume 261
Pages 4499-503
Authors DeCamp DL, Colman RF
Title Identification of tyrosine and lysine peptides labeled by 5'-p-fluorosulfonylbenzoyl adenosine in the active site of pyruvate kinase.
Related PDB
Related UniProtKB
[12]
Resource
Comments
Medline ID
PubMed ID 3691955
Journal Biochem Soc Trans
Year 1987
Volume 15
Pages 996-9
Authors Muirhead H, Clayden DA, Cuffe SP, Davies C
Title Crystallographic studies on the structure and catalytic activity of pyruvate kinase from skeletal muscle.
Related PDB
Related UniProtKB
[13]
Resource
Comments
Medline ID
PubMed ID 3040085
Journal Biochemistry
Year 1987
Volume 26
Pages 2243-50
Authors Lodato DT, Reed GH
Title Structure of the oxalate-ATP complex with pyruvate kinase: ATP as a bridging ligand for the two divalent cations.
Related PDB
Related UniProtKB
[14]
Resource
Comments
Medline ID
PubMed ID 3498511
Journal Biochemistry
Year 1987
Volume 26
Pages 3487-93
Authors Rosevear PR, Fox TL, Mildvan AS
Title Nuclear Overhauser effect studies of the conformations of MgATP bound to the active and secondary sites of muscle pyruvate kinase.
Related PDB
Related UniProtKB
[15]
Resource
Comments
Medline ID
PubMed ID 3143610
Journal Int J Biochem
Year 1988
Volume 20
Pages 1001-8
Authors Imarai M, Hinrichsen P, Bazaes S, Wilkens M, Eyzaguirre J
Title Yeast pyruvate kinase: essential lysine residues in the active site.
Related PDB
Related UniProtKB
[16]
Resource
Comments
Medline ID
PubMed ID 3343233
Journal J Biol Chem
Year 1988
Volume 263
Pages 2794-801
Authors Consler TG, Uberbacher EC, Bunick GJ, Liebman MN, Lee JC
Title Domain interaction in rabbit muscle pyruvate kinase. II. Small angle neutron scattering and computer simulation.
Related PDB
Related UniProtKB
[17]
Resource
Comments
Medline ID
PubMed ID 3343233
Journal J Biol Chem
Year 1988
Volume 263
Pages 2794-801
Authors Consler TG, Uberbacher EC, Bunick GJ, Liebman MN, Lee JC
Title Domain interaction in rabbit muscle pyruvate kinase. II. Small angle neutron scattering and computer simulation.
Related PDB
Related UniProtKB
[18]
Resource
Comments
Medline ID
PubMed ID 3374614
Journal Nature
Year 1988
Volume 333
Pages 683-6
Authors Lebioda L, Stec B
Title Crystal structure of enolase indicates that enolase and pyruvate kinase evolved from a common ancestor.
Related PDB
Related UniProtKB
[19]
Resource
Comments
Medline ID
PubMed ID 2489027
Journal J Biol Chem
Year 1989
Volume 264
Pages 8430-41
Authors DeCamp DL, Colman RF
Title 2-[(4-Bromo-2,3-dioxobutyl)thio]-1,N6-ethenoadenosine 5'-diphosphate. A new fluorescent affinity label of a tyrosyl residue in the active site of rabbit muscle pyruvate kinase.
Related PDB
Related UniProtKB
[20]
Resource
Comments
Medline ID
PubMed ID 2334678
Journal Biochemistry
Year 1990
Volume 29
Pages 2495-501
Authors Vollmer SH, Colman RF
Title Cysteinyl peptides of rabbit muscle pyruvate kinase labeled by the affinity label 8-[(4-bromo-2,3-dioxobutyl)thio]adenosine 5'-triphosphate.
Related PDB
Related UniProtKB
[21]
Resource
Comments
Medline ID
PubMed ID 1658780
Journal Proteins
Year 1991
Volume 11
Pages 153-7
Authors Schmidt-Base K, Buchbinder JL, Reed GH, Rayment I
Title Crystallization and preliminary analysis of enzyme-substrate complexes of pyruvate kinase from rabbit muscle.
Related PDB
Related UniProtKB
[22]
Resource
Comments
Medline ID
PubMed ID 1396575
Journal EMBO J
Year 1992
Volume 11
Pages 3811-4
Authors Murcott TH, Gutfreund H, Muirhead H
Title The cooperative binding of fructose-1,6-bisphosphate to yeast pyruvate kinase.
Related PDB
Related UniProtKB
[23]
Resource
Comments
Medline ID
PubMed ID 1555604
Journal Eur J Biochem
Year 1992
Volume 205
Pages 59-69
Authors Landy SB, Ray BD, Plateau P, Lipkowitz KB, Rao BD
Title Conformation of MgATP bound to nucleotidyl and phosphoryl transfer enzymes 1H-transferred NOE measurements on complexes of methionyl tRNA synthetase and pyruvate kinase.
Related PDB
Related UniProtKB
[24]
Resource
Comments
Medline ID
PubMed ID 1304366
Journal Protein Sci
Year 1992
Volume 1
Pages 678-87
Authors Vollmer SH, Colman RF
Title Cysteinyl peptides labeled by dibromobutanedione in reaction with rabbit muscle pyruvate kinase.
Related PDB
Related UniProtKB
[25]
Resource
Comments
Medline ID
PubMed ID 8260493
Journal Biochemistry
Year 1993
Volume 32
Pages 14111-6
Authors Buchbinder JL, Baraniak J, Frey PA, Reed GH
Title Stereochemistry of metal ion coordination to the terminal thiophosphoryl group of adenosine 5'-O-(3-thiotriphosphate) at the active site of pyruvate kinase.
Related PDB
Related UniProtKB
[26]
Resource
Comments
Medline ID
PubMed ID 8204612
Journal Biochemistry
Year 1994
Volume 33
Pages 6784-91
Authors Jarori GK, Murali N, Rao BD
Title Two-dimensional transferred nuclear Overhauser effect spectroscopy study of the confirmation of MgATP bound at the active and ancillary sites of rabbit muscle pyruvate kinase.
Related PDB
Related UniProtKB
[27]
Resource
Comments
Medline ID
PubMed ID 8193145
Journal Biochemistry
Year 1994
Volume 33
Pages 6301-9
Authors Larsen TM, Laughlin LT, Holden HM, Rayment I, Reed GH
Title Structure of rabbit muscle pyruvate kinase complexed with Mn2+, K+, and pyruvate.
Related PDB
Related UniProtKB
[28]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
Medline ID 96000862
PubMed ID 8591049
Journal Structure
Year 1995
Volume 3
Pages 729-41
Authors Mattevi A, Valentini G, Rizzi M, Speranza ML, Bolognesi M, Coda A
Title Crystal structure of Escherichia coli pyruvate kinase type I: molecular basis of the allosteric transition.
Related PDB 1pky
Related UniProtKB P0AD61
[29]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS)
Medline ID
PubMed ID
Journal Acta Crystallogr D Biol Crystallogr
Year 1996
Volume 52
Pages 499-504
Authors Allen SC, Muirhead H
Title Refined three-dimensional structure of cat-muscle (M1) pyruvate kinase at a resolution of 2.6 A.
Related PDB 1pkm
Related UniProtKB P11979
[30]
Resource
Comments
Medline ID
PubMed ID 8682196
Journal FEBS Lett
Year 1996
Volume 389
Pages 15-9
Authors Mattevi A, Bolognesi M, Valentini G
Title The allosteric regulation of pyruvate kinase.
Related PDB
Related UniProtKB
[31]
Resource
Comments
Medline ID
PubMed ID 8626426
Journal J Biol Chem
Year 1996
Volume 271
Pages 6313-21
Authors Cheng X, Friesen RH, Lee JC
Title Effects of conserved residues on the regulation of rabbit muscle pyruvate kinase.
Related PDB
Related UniProtKB
[32]
Resource
Comments
Medline ID
PubMed ID 9010934
Journal Protein Eng
Year 1996
Volume 9
Pages 1203-10
Authors Collins RA, Kelly SM, Price NC, Fothergill-Gilmore LA, Muirhead H
Title Ligand-induced conformational changes in wild-type and mutant yeast pyruvate kinase.
Related PDB
Related UniProtKB
[33]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS)
Medline ID 97452476
PubMed ID 9308890
Journal Arch Biochem Biophys
Year 1997
Volume 345
Pages 199-206
Authors Larsen TM, Benning MM, Wesenberg GE, Rayment I, Reed GH
Title Ligand-induced domain movement in pyruvate kinase: structure of the enzyme from rabbit muscle with Mg2+, K+, and L-phospholactate at 2.7 A resolution.
Related PDB 1aqf 1pkn
Related UniProtKB P11974
[34]
Resource
Comments
Medline ID
PubMed ID 9434737
Journal Arch Biochem Biophys
Year 1997
Volume 348
Pages 262-7
Authors Laughlin LT, Reed GH
Title The monovalent cation requirement of rabbit muscle pyruvate kinase is eliminated by substitution of lysine for glutamate 117.
Related PDB
Related UniProtKB
[35]
Resource
Comments
Medline ID
PubMed ID 9799487
Journal Biochemistry
Year 1998
Volume 37
Pages 15266-76
Authors Friesen RH, Castellani RJ, Lee JC, Braun W
Title Allostery in rabbit pyruvate kinase: development of a strategy to elucidate the mechanism.
Related PDB
Related UniProtKB
[36]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS)
Medline ID 98241346
PubMed ID 9572839
Journal Biochemistry
Year 1998
Volume 37
Pages 6247-55
Authors Larsen TM, Benning MM, Rayment I, Reed GH
Title Structure of the bis(Mg2+)-ATP-oxalate complex of the rabbit muscle pyruvate kinase at 2.1 A resolution: ATP binding over a barrel.
Related PDB 1a49 1a5u
Related UniProtKB P11974
[37]
Resource
Comments
Medline ID
PubMed ID 9578583
Journal Biochemistry
Year 1998
Volume 37
Pages 6967-74
Authors Loria JP, Nowak T
Title Conformational changes in yeast pyruvate kinase studied by 205Tl+ NMR.
Related PDB
Related UniProtKB
[38]
Resource
Comments
Medline ID
PubMed ID 9500921
Journal J Mol Biol
Year 1998
Volume 276
Pages 839-51
Authors Lovell SC, Mullick AH, Muirhead H
Title Cooperativity in Bacillus stearothermophilus pyruvate kinase.
Related PDB
Related UniProtKB
[39]
Resource
Comments X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS)
Medline ID 98179936
PubMed ID 9519410
Journal Structure
Year 1998
Volume 6
Pages 195-210
Authors Jurica MS, Mesecar A, Heath PJ, Shi W, Nowak T, Stoddard BL
Title The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate.
Related PDB 1a3w 1a3x
Related UniProtKB P00549
[40]
Resource
Comments
Medline ID
PubMed ID 10413488
Journal Biochemistry
Year 1999
Volume 38
Pages 9137-45
Authors Bollenbach TJ, Mesecar AD, Nowak T
Title Role of lysine 240 in the mechanism of yeast pyruvate kinase catalysis.
Related PDB
Related UniProtKB
[41]
Resource
Comments X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS)
Medline ID 99380407
PubMed ID 10448041
Journal J Mol Biol
Year 1999
Volume 291
Pages 615-35
Authors Rigden DJ, Phillips SE, Michels PA, Fothergill-Gilmore LA
Title The structure of pyruvate kinase from Leishmania mexicana reveals details of the allosteric transition and unusual effector specificity.
Related PDB 1pkl
Related UniProtKB Q27686
[42]
Resource
Comments
Medline ID
PubMed ID 11019825
Journal Arch Biochem Biophys
Year 2000
Volume 381
Pages 99-110
Authors Edwin F, Jagannadham MV
Title Anion-induced folding of rabbit muscle pyruvate kinase: existence of multiple intermediate conformations at low pH.
Related PDB
Related UniProtKB
[43]
Resource
Comments
Medline ID
PubMed ID 10816124
Journal Biochem Soc Trans
Year 2000
Volume 28
Pages 186-90
Authors Fothergill-Gillmore LA, Rigden DJ, Michels PA, Phillips SE
Title Leishmania pyruvate kinase: the crystal structure reveals the structural basis of its unique regulatory properties.
Related PDB
Related UniProtKB
[44]
Resource
Comments X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS)
Medline ID 20309762
PubMed ID 10751408
Journal J Biol Chem
Year 2000
Volume 275
Pages 18145-52
Authors Valentini G, Chiarelli L, Fortin R, Speranza ML, Galizzi A, Mattevi A
Title The allosteric regulation of pyruvate kinase.
Related PDB 1e0t 1e0u
Related UniProtKB P0AD61
[45]
Resource
Comments
Medline ID
PubMed ID 11389729
Journal Eur J Biochem
Year 2001
Volume 268
Pages 3267-74
Authors Ramirez-Silva L, Ferreira ST, Nowak T, Tuena de Gomez-Puyou M, Gomez-Puyou A
Title Dimethylsulfoxide promotes K+-independent activity of pyruvate kinase and the acquisition of the active catalytic conformation.
Related PDB
Related UniProtKB
[46]
Resource
Comments X-ray crystallography
Medline ID
PubMed ID 11563914
Journal J Mol Biol
Year 2001
Volume 312
Pages 525-40
Authors Wooll JO, Friesen RH, White MA, Watowich SJ, Fox RO, Lee JC, Czerwinski EW
Title Structural and functional linkages between subunit interfaces in mammalian pyruvate kinase.
Related PDB 1f3w 1f3x
Related UniProtKB
[47]
Resource
Comments
Medline ID
PubMed ID 11747307
Journal Arch Biochem Biophys
Year 2002
Volume 397
Pages 28-39
Authors Fenton AW, Blair JB
Title Kinetic and allosteric consequences of mutations in the subunit and domain interfaces and the allosteric site of yeast pyruvate kinase.
Related PDB
Related UniProtKB
[48]
Resource
Comments
Medline ID
PubMed ID 11913971
Journal Arch Biochem Biophys
Year 2002
Volume 400
Pages 54-62
Authors Plaxton WC, Smith CR, Knowles VL
Title Molecular and regulatory properties of leucoplast pyruvate kinase from Brassica napus (rapeseed) suspension cells.
Related PDB
Related UniProtKB
[49]
Resource
Comments
Medline ID
PubMed ID 11960989
Journal J Biol Chem
Year 2002
Volume 277
Pages 23807-14
Authors Valentini G, Chiarelli LR, Fortin R, Dolzan M, Galizzi A, Abraham DJ, Wang C, Bianchi P, Zanella A, Mattevi A
Title Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia.
Related PDB 1liu 1liw 1lix 1liy
Related UniProtKB
[50]
Resource
Comments
Medline ID
PubMed ID 12504250
Journal Biophys Chem
Year 2003
Volume 103
Pages 1-11
Authors Yu S, Lee LL, Lee JC
Title Effects of metabolites on the structural dynamics of rabbit muscle pyruvate kinase.
Related PDB
Related UniProtKB
[51]
Resource
Comments
Medline ID
PubMed ID 12882975
Journal J Biol Chem
Year 2003
Volume 278
Pages 40943-52
Authors Susan-Resiga D, Nowak T
Title Monitoring active site alterations upon mutation of yeast pyruvate kinase using 205Tl+ NMR.
Related PDB
Related UniProtKB
[52]
Resource
Comments
Medline ID
PubMed ID 15568816
Journal Biochemistry
Year 2004
Volume 43
Pages 15230-45
Authors Susan-Resiga D, Nowak T
Title Proton donor in yeast pyruvate kinase: chemical and kinetic properties of the active site Thr 298 to Cys mutant.
Related PDB
Related UniProtKB
[53]
Resource
Comments
Medline ID
PubMed ID 15996096
Journal Biochemistry
Year 2005
Volume 44
Pages 9417-29
Authors Dombrauckas JD, Santarsiero BD, Mesecar AD
Title Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.
Related PDB 1t5a
Related UniProtKB

Comments
This enzyme binds a potassium ion and two magnesium ions as cofactors. The first magnesium ion is bound to usbtrate, phosphoenolpyruvate, and acidic residues, whereas the second magnesium ion is bound to phosphate groups of the second substrate, ADP, without any interaction with protein residues. Thus, the second magnesium gets bound to the enzyme along with ADP binding. The potassium ion is bound to the transferred group, phosphate group of phosphoenolpyruvate.
This enzyme catalyzes two reactions, firstly phoshoryl transfer and secondly isomerization, as follows (see [36], [39], [40] & [52]):
(A) Transfer of phosphate group from phosphenolpyruvate to ADP:
(A1) The negative charge of the acceptor group, the beta-phosphate of ADP, is stabilized by the second magnesium ion along with Arg119 (of 1a49;PDB). The negative charge of the transferred group is stabilized by the potassium ion and the two magnesium ion, along with Arg72, Lys269 and Arg119. The leaving oxygen atom of phosphoenolpyruvate is stabilized by the first magnesium ion and Lys269.
(A2) The acceptor group, makes a nucleophilic attack on the transferred group, phosphate group of phosphoenolpyruvate, forming enolate intermediate. (This reaction seems associative (or SN2-like), according to the literature [39]).
(B) Isomerization; Shift of double-bond (from C=C-O to C-C=O):
(B1) The first magnesium ion binds the enolate oxygen atom of the intermediate, and stabilizes the negative charge on it. Lys269 also may stabilize it.
(B2) A general acid must protonate the C3 atom (sp2 carbon atom) of the enolate intermediate, changing it to the methyl group (sp3 carbon). Initially, Lys269 was thought to be the general acid (see [10]). However, according to the more recent literature [36], a conserved acidic residue, Glu363, act as a general acid to protonate the sp2 carbon of the intermediate, through water molecules, Ser361 and Thr327. (The carbon atom interacts with a water molecule, which in turn interacts with Thr327. Thr327 interacts with Ser361 through a water, and Ser361 interacts with Glu363 through a water)

Created Updated
2004-03-25 2009-02-26