DB code: U00001

CATH domain -.-.-.- :
1.10.1200.10 : Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A Catalytic domain
E.C. -.-.-.-
CSA
M-CSA
MACiE

CATH domain Related DB codes (homologues)
1.10.1200.10 : Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A M00347

Uniprot Enzyme Name
UniprotKB Protein name Synonyms Pfam RefSeq
O77077 Acyl carrier protein
None PF00550 (PP-binding)
[Graphical View]
O77470 Acyl carrier protein
None PF00550 (PP-binding)
[Graphical View]
XP_002365498.1 (Protein)
XM_002365457.1 (DNA/RNA sequence)
P07854 Acyl carrier protein 1, chloroplastic
Acyl carrier protein I
ACP I
PF00550 (PP-binding)
[Graphical View]

KEGG enzyme name
Acyl carrier protein
ACP

UniprotKB: Accession Number Entry name Activity Subunit Subcellular location Cofactor
O77077 O77077_PLAFA
O77470 O77470_TOXGO
P07854 ACP1_SPIOL Plastid, chloroplast.

KEGG Pathways
Map code Pathways E.C.
MAP00061 Fatty acid biosynthesis
MAP01056 Biosynthesis of type II polyketide backbone
MAP01057 Biosynthesis of type II polyketide products
MAP01066 Biosynthesis of alkaloids derived from terpenoid and polyketide

Compound table
Cofactors Substrates Products Intermediates
KEGG-id C01134 C00229 C00173
E.C.
Compound Pantetheine 4'-phosphate Acyl-carrier protein Acyl-[acyl-carrier protein]
Type carbohydrate,peptide/protein,phosphate group/phosphate ion,sulfhydryl group carbohydrate,peptide/protein,phosphate group/phosphate ion,sulfhydryl group carbohydrate,peptide/protein,phosphate group/phosphate ion,sulfide group
ChEBI 4222
PubChem 115254
2fq0A00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:PNS Unbound
2fq2A00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:PNS Unbound
3gzlA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:PNS Unbound
3gzmA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:PNS Unbound
3gzmB00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:PNS Unbound
2qnwA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound
2avaA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound
2fvaA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:PNS Bound:STE
2fveA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound
2fvfA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Bound:PNS Bound:DKA
2xz0D00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound
2xz1C00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Analogue:PNY Unbound
2xz1D00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain Unbound Unbound

Reference for Active-site residues
resource references E.C.

Active-site residues
PDB Catalytic residues Cofactor-binding residues Modified residues Main-chain involved in catalysis Comment
2fq0A00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 37(Phosphopantetheine binding)
2fq2A00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 37(Phosphopantetheine binding)
3gzlA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 39(Phosphopantetheine binding)
3gzmA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 39(Phosphopantetheine binding)
3gzmB00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 39(Phosphopantetheine binding)
2qnwA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 41(Phosphopantetheine binding)
2avaA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 38(Phosphopantetheine binding)
2fvaA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 38(Phosphopantetheine binding)
2fveA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 38(Phosphopantetheine binding)
2fvfA00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SER 38(Phosphopantetheine binding)
2xz0D00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SEP 38
2xz1C00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SEP 38
2xz1D00 Pdbj logo s Rasmollogo id Rasmollogo chain Mmcif id Mmcif chain SEP 38

References for Catalytic Mechanism
References Sections No. of steps in catalysis

References
[1]
Resource
Comments
Medline ID
PubMed ID 16618110
Journal Biochemistry
Year 2006
Volume 45
Pages 5217-27
Authors Zornetzer GA, Fox BG, Markley JL
Title Solution structures of spinach acyl carrier protein with decanoate and stearate.
Related PDB 2ava 2fva 2fve 2fvf
Related UniProtKB
[2]
Resource
Comments
Medline ID
PubMed ID 16734426
Journal Biochemistry
Year 2006
Volume 45
Pages 6904-16
Authors Sharma AK, Sharma SK, Surolia A, Surolia N, Sarma SP
Title Solution structures of conformationally equilibrium forms of holo-acyl carrier protein (PfACP) from Plasmodium falciparum provides insight into the mechanism of activation of ACPs.
Related PDB 2fq0 2fq2
Related UniProtKB
[3]
Resource
Comments
Medline ID
PubMed ID 19768685
Journal Proteins
Year 2010
Volume 78
Pages 575-88
Authors Gallagher JR, Prigge ST
Title Plasmodium falciparum acyl carrier protein crystal structures in disulfide-linked and reduced states and their prevalence during blood stage growth.
Related PDB 3gzl 3gzm
Related UniProtKB

Comments
Although this protein is not an enzyme, it is involved in various kinds of enzyme reactions as the following substrates/products.
C00173 Acyl-[acyl-carrier protein]
C00229 [acyl-carrier-protein], Acyl-carrier protein
C00685 3-Oxoacyl-[acyl-carrier protein]
C00693 trans-2,3-Dehydroacyl-[acyl-carrier protein]
C01203 Oleoyl-[acyl-carrier protein]
C01209 malonyl-[acyl-carrier protein], malonyl-[acyl-carrier-protein], Malonyl-[acyl-carrier protein]
C01271 (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C04088 Stearoyl-[acyl-carrier protein]
C04180 3-Decanoyl-[acyl-carrier protein]
C04619 (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04688 (R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05744 acetoacetyl-[acyl-carrier protein]
C05754 trans-Dec-2-enoyl-[acyl-carrier protein]
C05757 (R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758 trans-Dodec-2-enoyl-[acyl-carrier protein]
L00039 (Z)-hexadec-11-enoyl-[acyl-carrier protein]
L00040 (Z)-3-oxooctadec-13-enoyl-[acyl-carrier protein]
Thus, this protein is very important in fatty acid metabolism and polyketide synthesis and so on.

Created Updated
2012-07-13 2012-07-17