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CATH domain | Related DB codes (homologues) |
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3.40.50.720 : Rossmann fold | S00543,S00551,S00552,S00553,S00602,S00604,S00605,S00608,S00610,S00625,S00319,S00328,S00329,S00330,S00331,S00332,D00456,D00457,D00458,S00324,S00320,S00325,S00326,S00327,D00459,S00335,S00336,S00334,T00219,S00339,D00513,D00001,D00002,D00003,D00005,D00007,D00008,D00010,D00012,D00017,D00018,D00023,D00027,D00028,D00031,D00032,D00033,D00034,D00035,D00037,D00071,D00476,D00481,D00482,D00490,D00492,D00494,D00545,D00601,D00603,D00604,D00605,D00615,D00845,D00857,D00858,M00161,M00171,M00210,T00002,T00010,T00011,T00015,T00227,T00247,T00408,T00414,D00827,D00262,D00274,D00275,M00035,T00109 | 3.90.180.10 : Quinone Oxidoreductase; Chain A, domain 1 | D00001,D00002,D00018,D00481,D00482,D00490,D00492,D00615 |
UniProtKB:Accession Number | P28304 | Q8L3C8 |
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Entry name | QOR_ECOLI | Q8L3C8_THETH |
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Activity | NADPH + 2 quinone = NADP(+) + 2 semiquinone. |
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Subunit | Homodimer. |
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Subcellular location |
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Cofactor |
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Compound table: links to PDB-related databases & PoSSuM |
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| Substrates | Products |
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KEGG-id | C00005 | C00472 | C00006 | C05309 |
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Compound | NADPH | Quinone | NADP+ | Semiquinone |
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Type | amide group,amine group,nucleotide | aromatic ring (only carbon atom) | amide group,amine group,nucleotide | aromatic ring (only carbon atom) |
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ChEBI | 16474
| 16509
| 18009
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PubChem | 5884
| 4650
| 5886
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1qorA01 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound |
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1qorB01 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound |
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1iyzA01 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound |
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1iz0A01 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound |
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1qorA02 |  |  |  |  |  |  |  | Unbound | Unbound | Bound:NAP | Unbound |
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1qorB02 |  |  |  |  |  |  |  | Unbound | Unbound | Bound:NAP | Unbound |
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1iyzA02 |  |  |  |  |  |  |  | Bound:NDP | Unbound | Unbound | Unbound |
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1iz0A02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound |
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references | [1] |
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PubMed ID | 1370456 |
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Journal | J Biol Chem |
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Year | 1992 |
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Volume | 267 |
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Pages | 96-102 |
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Authors | Rao PV, Krishna CM, Zigler JS Jr |
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Title | Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase. |
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[2] |
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PubMed ID | 8046753 |
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Journal | J Mol Biol |
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Year | 1994 |
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Volume | 240 |
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Pages | 501-3 |
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Authors | Edwards KJ, Thorn JM, Daniher JA, Dixon NE, Ollis DL |
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Title | Crystallization and preliminary X-ray diffraction studies on a soluble Escherichia coli quinone oxidoreductase. |
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[3] |
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Comments | X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) |
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Medline ID | 95326140 |
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PubMed ID | 7602590 |
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Journal | J Mol Biol |
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Year | 1995 |
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Volume | 249 |
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Pages | 785-99 |
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Authors | Thorn JM, Barton JD, Dixon NE, Ollis DL, Edwards KJ |
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Title | Crystal structure of Escherichia coli QOR quinone oxidoreductase complexed with NADPH. |
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Related PDB | 1qor |
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Related UniProtKB | P28304 |
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[4] |
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PubMed ID | 8638928 |
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Journal | Arch Biochem Biophys |
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Year | 1996 |
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Volume | 328 |
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Pages | 173-83 |
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Authors | Edwards KJ, Barton JD, Rossjohn J, Thorn JM, Taylor GL, Ollis DL |
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Title | Structural and sequence comparisons of quinone oxidoreductase, zeta-crystallin, and glucose and alcohol dehydrogenases. |
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[5] |
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PubMed ID | 8804573 |
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Journal | J Protein Chem |
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Year | 1996 |
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Volume | 15 |
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Pages | 261-4 |
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Authors | Duhaiman AS |
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Title | Inhibition of zeta-crystallin by Coumarins: a structure-activity study. |
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[6] |
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PubMed ID | 9774726 |
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Journal | Biochim Biophys Acta |
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Year | 1998 |
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Volume | 1388 |
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Pages | 175-80 |
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Authors | Rabbani N, Duhaiman AS |
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Title | Inhibition of camel lens zeta-crystallin/NADPH:quinone oxidoreductase by pyridoxal-5'-phosphate. |
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[7] |
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PubMed ID | 12199705 |
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Journal | Eur J Biochem |
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Year | 2002 |
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Volume | 269 |
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Pages | 4267-76 |
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Authors | Nordling E, Jornvall H, Persson B |
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Title | Medium-chain dehydrogenases/reductases (MDR). Family characterizations including genome comparisons and active site modeling. |
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[8] |
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PubMed ID | 12837796 |
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Journal | J Bacteriol |
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Year | 2003 |
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Volume | 185 |
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Pages | 4211-8 |
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Authors | Shimomura Y, Kakuta Y, Fukuyama K |
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Title | Crystal structures of the quinone oxidoreductase from Thermus thermophilus HB8 and its complex with NADPH: implication for NADPH and substrate recognition. |
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Related PDB | 1iyz,1iz0 |
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comments | This enzyme belongs to medium-chain alcohol dehydrogenase family. Although the other homologous enzymes utilize zinc ion, this enzyme does not possess metal ions (see [5], [7]). Although the tertiary structure of this enzyme has been determined, the detailed catalytic mechanism has not been elucidated yet.
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created | updated |
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2004-10-25 | 2009-03-30 |
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