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Enzyme Name | UniProtKB | KEGG |
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| Q50925 |
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Protein name | Hydroxylamine oxidoreductase | hydroxylamine oxidaseHAO (ambiguouscf. EC 1.7.99.8, hydroxylamine oxidoreductase)hydroxylamine oxidoreductase (ambiguouscf. EC 1.7.99.8, hydroxylamine oxidoreductase) |
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Synonyms | HAOEC 1.7.3.4 |
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RefSeq | NP_841035.1 (Protein) NC_004757.1 (DNA/RNA sequence) NP_842054.1 (Protein) NP_842336.1 (Protein)
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KEGG pathways | MAP code | Pathways |
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MAP00910 | Nitrogen metabolism |
UniProtKB:Accession Number | Q50925 |
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Entry name | HAO_NITEU |
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Activity | Hydroxylamine + O(2) = nitrite + H(2)O. |
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Subunit | Homotrimer. |
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Subcellular location | Periplasm. |
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Cofactor | Binds 8 heme groups per subunit. One heme group a p-460 type, the remaining 7 are c-type. |
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References for Catalytic Mechanism | References | Sections | No. of steps in catalysis |
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[2] | p.282-283, Fig.6 |
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references | [1] |
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PubMed ID | 1783597 |
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Journal | J Biochem (Tokyo) |
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Year | 1991 |
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Volume | 110 |
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Pages | 681-2 |
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Authors | Mikami T, Tanaka N, Sato T, Moriyama H, Numata M, Fujiwara T, Fukumori Y, Yamanaka T, Sato M, Kakiuchi K, et al |
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Title | Crystallization and preliminary X-ray studies of hydroxylamine oxidoreductase from Nitrosomonas europaea. |
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[2] |
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Comments | X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) |
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Medline ID | 97249290 |
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PubMed ID | 9095195 |
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Journal | Nat Struct Biol |
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Year | 1997 |
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Volume | 4 |
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Pages | 276-84 |
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Authors | Igarashi N, Moriyama H, Fujiwara T, Fukumori Y, Tanaka N |
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Title | The 2.8 A structure of hydroxylamine oxidoreductase from a nitrifying chemoautotrophic bacterium, Nitrosomonas europaea. |
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Related PDB | 1fgj |
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Related UniProtKB | Q50925 |
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[3] |
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PubMed ID | 9425072 |
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Journal | Biochemistry |
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Year | 1998 |
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Volume | 37 |
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Pages | 523-9 |
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Authors | Arciero DM, Golombek A, Hendrich MP, Hooper AB |
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Title | Correlation of optical and EPR signals with the P460 heme of hydroxylamine oxidoreductase from Nitrosomonas europaea. |
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[4] |
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PubMed ID | 11457010 |
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Journal | J Am Chem Soc |
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Year | 2001 |
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Volume | 123 |
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Pages | 2997-3005 |
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Authors | Hendrich MP, Petasis D, Arciero DM, Hooper AB |
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Title | Correlations of structure and electronic properties from EPR spectroscopy of hydroxylamine oxidoreductase. |
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comments | According to the literature [2], this enzyme catalyzes the following reactions: (A) Oxygenation of NH2OH by O2, producing HNO2 and H2O, at heme-P460 (HEC in 1fgi): (B) Electron transfer from heme-P460 to heme-6: (C) Electron transfer from heme-P460 to heme-7: (D) Electron transfer from heme-6 to heme-5: (E) Electron transfer from heme-5 to heme-3: (F) Electron transfer from heme-3 to heme-2: (G) Electron transfer from heme-2 to heme-1: (H) Electron transfer from heme-7 to heme-8: (I) Electron transfer from heme-8 to heme-2 (of adjacent subunit): (J) Electron transfer from heme-1 to cytochrome-c554:
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created | updated |
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2004-03-24 | 2009-02-26 |
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