EzCatDB: D00197
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DB codeD00197
RLCP classification1.13.30000.10 : Hydrolysis
CATH domainDomain 12.40.10.10 : Thrombin, subunit HCatalytic domain
Domain 22.40.10.10 : Thrombin, subunit HCatalytic domain
E.C.3.4.21.4
CSA1a0j

CATH domainRelated DB codes (homologues)
2.40.10.10 : Thrombin, subunit HM00139,D00214,M00167,D00426,M00133,D00428,D00429,D00430,D00431,D00432,D00433,D00434,D00435,M00227,M00209,D00194,D00211,D00212,D00216,M00212,D00224,D00497,M00217,M00216,D00528,D00848,D00850,D00851,D00852,D00855,M00152,M00155,M00157,M00181,M00315,M00316,M00317,M00348,M00349,T00074,T00410,T00411

Enzyme Name
UniProtKBKEGG

P00775P35049P35031P35033P00762P00763P00761P00760P07477
Protein nameTrypsinTrypsinTrypsin-1Trypsin-3Anionic trypsin-1Anionic trypsin-2TrypsinCationic trypsinTrypsin-1trypsin
alpha-trypsin
beta-trypsin
cocoonase
parenzyme
parenzymol
tryptar
trypure
pseudotrypsin
tryptase
tripcellim
sperm receptor hydrolase
SynonymsEC 3.4.21.4
SGT
EC 3.4.21.4
EC 3.4.21.4
Trypsin I
EC 3.4.21.4
Trypsin III
EC 3.4.21.4
Anionic trypsin I
Pretrypsinogen I
Serine protease 1
EC 3.4.21.4
Anionic trypsin II
Pretrypsinogen II
Serine protease 2
EC 3.4.21.4
EC 3.4.21.4
Beta-trypsin
EC 3.4.21.4
Beta-trypsin
Cationic trypsinogen
Serine protease 1
Trypsin I
ContainsNoneNoneNoneNoneNoneNoneNoneAlpha-trypsin chain 1
Alpha-trypsin chain 2
Alpha-trypsin chain 1
Alpha-trypsin chain 2
RefSeq

NP_001117183.1 (Protein)
NM_001123711.1 (DNA/RNA sequence)
NP_001119704.1 (Protein)
NM_001126232.1 (DNA/RNA sequence)

NP_036767.1 (Protein)
NM_012635.1 (DNA/RNA sequence)
NP_036861.1 (Protein)
NM_012729.1 (DNA/RNA sequence)
XP_003749781.1 (Protein)
XM_003749733.1 (DNA/RNA sequence)

NP_001107199.1 (Protein)
NM_001113727.1 (DNA/RNA sequence)
NP_002760.1 (Protein)
NM_002769.4 (DNA/RNA sequence)
MEROPSS01.101 (Serine)
S01.103 (Serine)
S01.125 (Serine)
S01.126 (Serine)
S01.094 (Serine)
S01.119 (Serine)

S01.151 (Serine)
S01.127 (Serine)
PfamPF00089 (Trypsin)
[Graphical view]
PF00089 (Trypsin)
[Graphical view]
PF00089 (Trypsin)
[Graphical view]
PF00089 (Trypsin)
[Graphical view]
PF00089 (Trypsin)
[Graphical view]
PF00089 (Trypsin)
[Graphical view]
PF00089 (Trypsin)
[Graphical view]
PF00089 (Trypsin)
[Graphical view]
PF00089 (Trypsin)
[Graphical view]


UniProtKB:Accession NumberP00775P35049P35031P35033P00762P00763P00761P00760P07477
Entry nameTRYP_STRGRTRYP_FUSOXTRY1_SALSATRY3_SALSATRY1_RATTRY2_RATTRYP_PIGTRY1_BOVINTRY1_HUMAN
ActivityPreferential cleavage: Arg-|-Xaa, Lys-|-Xaa.Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
Subunit








Subcellular location
Secreted.Secreted, extracellular space.Secreted, extracellular space.Secreted, extracellular space.Secreted, extracellular space.Secreted, extracellular space.Secreted, extracellular space.Secreted, extracellular space.
Cofactor

Binds 1 calcium ion per subunit.Binds 1 calcium ion per subunit (By similarity).Binds 1 calcium ion per subunit.Binds 1 calcium ion per subunit.Binds 1 calcium ion per subunit.Binds 1 calcium ion per subunit.Binds 1 calcium ion per subunit.

Compound table: links to PDB-related databases & PoSSuM

SubstratesProductsintermediates
KEGG-idC00012C00001C00012C03253
CompoundPeptideH2OPeptideAmino acid(Arg-, Lys-)
Typepeptide/proteinH2Opeptide/proteinamino acids
ChEBI
15377



PubChem
22247451
962



             
1sgtA01Unbound UnboundUnboundUnbound
1fn8A01Unbound Bound:GLY-ALA-ARG(chain B)UnboundUnbound
1fy4A01Unbound UnboundUnboundIntermediate-bound:GLY-ALA-ARG(chain B)
1fy5A01Unbound Bound:GLY-ALA-LYS(chain B)UnboundUnbound
1gdnA01Unbound Bound:GLY-ALA-LYS(chain B)UnboundUnbound
1gdqA01Unbound UnboundUnboundIntermediate-bound:ARG(chain B)
1gduA01Unbound Bound:GLY-ALA-ARG(chain B)UnboundUnbound
1tryA01Unbound UnboundUnboundIntermediate-analogue:ISP
1bitA01Unbound UnboundUnboundUnbound
1bzxE01Bound:LYS 515-ALA 516(chain I) UnboundUnboundUnbound
1tbsA01Unbound UnboundUnboundUnbound
2staE01Bound:ARG 505-ILE 506(chain I) UnboundUnboundUnbound
2stbE01Bound:LYS 505-ILE 506(chain I) UnboundUnboundUnbound
2tbsA01Unbound UnboundUnboundUnbound
1a0jA01Unbound UnboundUnboundUnbound
1a0jB01Unbound UnboundUnboundUnbound
1a0jC01Unbound UnboundUnboundUnbound
1a0jD01Unbound UnboundUnboundUnbound
1braA01Unbound UnboundUnboundUnbound
1brbE01Bound:LYS 15-ALA 16(chain I) UnboundUnboundUnbound
1brcE01Bound:ARG 15-ALA 16(chain I) UnboundUnboundUnbound
1trmA01Unbound UnboundUnboundUnbound
1trmB01Unbound UnboundUnboundUnbound
2trmA01Unbound UnboundUnboundUnbound
1amhA01Unbound UnboundUnboundUnbound
1amhB01Unbound UnboundUnboundUnbound
1anbA01Unbound UnboundUnboundUnbound
1ancA01Unbound UnboundUnboundUnbound
1andA01Unbound UnboundUnboundUnbound
1aneA01Unbound UnboundUnboundUnbound
1dpoA01Unbound UnboundUnboundUnbound
1ezsC01Bound:ARG 284-MET 285(chain B) UnboundUnboundUnbound
1ezsD01Bound:ARG 84-MET 85(chain A) UnboundUnboundUnbound
1ezuC01Analogue:MET 284-MET 285(chain B) UnboundUnboundUnbound
1ezuD01Analogue:MET 84-MET 85(chain A) UnboundUnboundUnbound
1fy8E01Bound:LYS 15-ALA 16(chain I) UnboundUnboundUnbound
1i99E01Bound:LYS 353-SER 354(chain I) UnboundUnboundUnbound
1ql9A01Unbound UnboundUnboundUnbound
1sluB01Analogue:MET 84-MET 85(chain A) UnboundUnboundUnbound
1slvB01Analogue:MET 84-MET 85(chain A) UnboundUnboundUnbound
1slwB01Analogue:MET 84-MET 85(chain A) UnboundUnboundUnbound
1slxB01Analogue:MET 84-MET 85(chain A) UnboundUnboundUnbound
3tgiE01Bound:LYS 15-ALA 16(chain I) UnboundUnboundUnbound
3tgjE01Bound:LYS 15-ALA 16(chain I) UnboundUnboundUnbound
1aksBUnbound UnboundUnboundUnbound
1an1E01Bound:LYS 8-ILE 9(chain I) UnboundUnboundUnbound
1avwA01Bound:ARG 563-ILE 564(chain B) UnboundUnboundUnbound
1avxA01Bound:ARG 563-ILE 564(chain B) UnboundUnboundUnbound
1ejaA01Bound:LYS 34-VAL 35(chain B) UnboundUnboundUnbound
1eptCUnbound UnboundUnboundUnbound
1fmgA01Unbound UnboundUnboundUnbound
1fn6A01Unbound UnboundUnboundUnbound
1fniA01Unbound UnboundUnboundUnbound
1ldtT01Bound:LYS 8-ILE 9(chain L) UnboundUnboundUnbound
1mctA01Bound:ARG 5-ILE 6(chain I) UnboundUnboundUnbound
1qquA01Unbound UnboundUnboundUnbound
1tfxA01Bound:ARG 15-GLY 16(chain C) UnboundUnboundUnbound
1tfxB01Bound:ARG 15-GLY 16(chain D) UnboundUnboundUnbound
1aq7A01Unbound Analogue:AEBUnboundUnbound
1aujA01Unbound UnboundUnboundIntermediate-analogue:PPB
1az8A01Unbound UnboundUnboundUnbound
1bjuA01Unbound UnboundUnboundUnbound
1bjvA01Unbound UnboundUnboundUnbound
1btpA01Unbound UnboundUnboundUnbound
1btwA01Unbound UnboundUnboundIntermediate-analogue:BOC-ALA-VAL-BLY(chain H)
1btxA01Unbound UnboundUnboundIntermediate-analogue:BOC-ALA-VAL-BLY-ETH(chain H)
1btyA01Unbound UnboundUnboundUnbound
1btzA01Unbound UnboundUnboundIntermediate-analogue:BOC-ALA-VAL-BLY-CH3(chain H)
1c1nA01Unbound UnboundUnboundUnbound
1c1oA01Unbound UnboundUnboundUnbound
1c1pA01Unbound UnboundUnboundUnbound
1c1qA01Unbound UnboundUnboundUnbound
1c1rA01Unbound UnboundUnboundUnbound
1c1sA01Unbound UnboundUnboundUnbound
1c1tA01Unbound UnboundUnboundUnbound
1c2dA01Unbound UnboundUnboundUnbound
1c2eA01Unbound UnboundUnboundUnbound
1c2fA01Unbound UnboundUnboundUnbound
1c2gA01Unbound UnboundUnboundUnbound
1c2hA01Unbound UnboundUnboundUnbound
1c2iA01Unbound UnboundUnboundUnbound
1c2jA01Unbound UnboundUnboundUnbound
1c2kA01Unbound UnboundUnboundUnbound
1c2lA01Unbound UnboundUnboundUnbound
1c2mA01Unbound UnboundUnboundUnbound
1c5pA01Unbound UnboundUnboundUnbound
1c5qA01Unbound UnboundUnboundUnbound
1c5rA01Unbound UnboundUnboundUnbound
1c5sA01Unbound UnboundUnboundUnbound
1c5tA01Unbound UnboundUnboundUnbound
1c5uA01Unbound UnboundUnboundUnbound
1c5vA01Unbound UnboundUnboundUnbound
1c9pA01Bound:LYS 34-VAL 35(chain B) UnboundUnboundUnbound
1ce5A01Unbound UnboundUnboundUnbound
1d6rA01Bound:LYS 16-SER 17(chain I) UnboundUnboundUnbound
1ejmA01Bound:ARG 515-LEU 516(chain B) UnboundUnboundUnbound
1ejmC01Bound:ARG 515-LEU 516(chain D) UnboundUnboundUnbound
1ejmE01Bound:ARG 515-LEU 516(chain F) UnboundUnboundUnbound
1f0tA01Unbound UnboundUnboundUnbound
1f0uA01Unbound UnboundUnboundUnbound
1f2sE01Bound:ARG 305-ILE 306(chain I) UnboundUnboundUnbound
1g3bA01Unbound UnboundUnboundUnbound
1g3cA01Unbound UnboundUnboundUnbound
1g3dA01Unbound UnboundUnboundUnbound
1g3eA01Unbound UnboundUnboundUnbound
1g9iE01Bound:LYS 311-SER 312(chain I) UnboundUnboundUnbound
1gbtA01Unbound UnboundUnboundIntermediate-analogue:GBS
1jrsA01Unbound UnboundUnboundIntermediate-bound:ACE-LEU-LEU-ARG(chain B)
1jrtA01Unbound UnboundUnboundIntermediate-bound:ACE-LEU-LEU-ARG(chain B)
1maxA01Unbound UnboundUnboundIntermediate-analogue:ZAP
1mayA01Unbound UnboundUnboundIntermediate-analogue:ZAP
1mcuE01Bound:ARG 305-ILE 306(chain I) UnboundUnboundUnbound
1mtsA01Unbound UnboundUnboundUnbound
1mtuA01Unbound UnboundUnboundUnbound
1mtvA01Unbound UnboundUnboundUnbound
1mtwA01Unbound UnboundUnboundUnbound
1ntpA01Unbound UnboundUnboundIntermediate-analogue:MIP
1ppcE01Unbound Analogue:NAS-GLY-APH-PIP(chain I)UnboundUnbound
1ppeE01Bound:ARG 5-ILE 6(chain I) UnboundUnboundUnbound
1pphE01Unbound Analogue:TOS-APM-PIP(chain I)UnboundUnbound
1qa0A01Unbound UnboundUnboundUnbound
1qb1A01Unbound UnboundUnboundUnbound
1qb6A01Unbound UnboundUnboundUnbound
1qb9A01Unbound UnboundUnboundUnbound
1qbnA01Unbound UnboundUnboundUnbound
1qboA01Unbound UnboundUnboundUnbound
1ql7A01Unbound UnboundUnboundUnbound
1ql8A01Unbound UnboundUnboundUnbound
1sbwA01Bound:LYS 20-SER 21(chain I) UnboundUnboundUnbound
1sfiA01Bound:LYS 5-SER 6(chain I) UnboundUnboundUnbound
1smfE01Bound:LYS 11-SER 12(chain I) UnboundUnboundUnbound
1tabE01Bound:LYS 26-SER 27(chain I) UnboundUnboundUnbound
1tawA01Bound:ARG 15-ALA 16(chain B) UnboundUnboundUnbound
1tgbA01Unbound UnboundUnboundUnbound
1tgcA01Unbound UnboundUnboundUnbound
1tgnA01Unbound UnboundUnboundUnbound
1tgsZ01Bound:LYS 18-ILE 19(chain I) UnboundUnboundUnbound
1tgtA01Unbound UnboundUnboundUnbound
1tioA01Unbound UnboundUnboundUnbound
1tldA01Unbound UnboundUnboundUnbound
1tngA01Unbound UnboundUnboundUnbound
1tnhA01Unbound UnboundUnboundUnbound
1tniA01Unbound UnboundUnboundUnbound
1tnjA01Unbound UnboundUnboundUnbound
1tnkA01Unbound UnboundUnboundUnbound
1tnlA01Unbound UnboundUnboundUnbound
1tpaE01Bound:LYS 15-ALA 16(chain I) UnboundUnboundUnbound
1tpoA01Unbound UnboundUnboundUnbound
1tppA01Unbound UnboundUnboundIntermediate-analogue:APA
1tpsA01Analogue:A9A UnboundUnboundUnbound
1tynA01Unbound UnboundUnboundIntermediate-analogue:CTA
1xufA01Unbound UnboundUnboundUnbound
1xugA01Unbound UnboundUnboundUnbound
1xuhA01Unbound UnboundUnboundUnbound
1xuiA01Unbound UnboundUnboundUnbound
1xujA01Unbound UnboundUnboundUnbound
1xukA01Unbound UnboundUnboundUnbound
1yyy101Unbound UnboundUnboundIntermediate-analogue:BNS-NVA-GLY-3GA
2btcE01Bound:LYS 505-ILE 506(chain I) UnboundUnboundUnbound
2bzaA01Unbound UnboundUnboundUnbound
2ptcE01Bound:LYS 15-ALA 16(chain I) UnboundUnboundUnbound
2ptnA01Unbound UnboundUnboundUnbound
2tgaA01Unbound UnboundUnboundUnbound
2tgdA01Unbound UnboundUnboundIntermediate-analogue:DFP
2tgpZ01Bound:LYS 15-ALA 16(chain I) UnboundUnboundUnbound
2tgtA01Unbound UnboundUnboundUnbound
2tioA01Unbound UnboundUnboundUnbound
2tpiZ01Bound:LYS 15-ALA 16(chain I) UnboundUnboundUnbound
3btdE01Analogue:ASP 515-ALA 516(chain I) UnboundUnboundUnbound
3bteE01Analogue:GLU 515-ALA 516(chain I) UnboundUnboundUnbound
3btfE01Analogue:PHE 515-ALA 516(chain I) UnboundUnboundUnbound
3btgE01Analogue:GLY 515-ALA 516(chain I) UnboundUnboundUnbound
3bthE01Analogue:HIS 515-ALA 516(chain I) UnboundUnboundUnbound
3btkE01Bound:LYS 515-ALA 516(chain I) UnboundUnboundUnbound
3btmE01Analogue:MET 515-ALA 516(chain I) UnboundUnboundUnbound
3btqE01Analogue:GLN 515-ALA 516(chain I) UnboundUnboundUnbound
3bttE01Analogue:THR 515-ALA 516(chain I) UnboundUnboundUnbound
3btwE01Analogue:TRP 515-ALA 516(chain I) UnboundUnboundUnbound
3ptbA01Unbound UnboundUnboundUnbound
3ptnA01Unbound UnboundUnboundUnbound
3tpiZ01Bound:LYS 15-ALA 16(chain I) UnboundUnboundUnbound
4ptpA01Unbound UnboundUnboundIntermediate-analogue:DIP
4tpiZ01Bound:ARG 15-ALA 16(chain I) UnboundUnboundUnbound
5ptpA01Unbound UnboundUnboundIntermediate-analogue:MIS
1ezxC01Unbound Bound:SER 359(chain B)UnboundIntermediate-bound:MET 358(chain A)
1trnA01Unbound UnboundUnboundIntermediate-analogue:ISP
1trnB01Unbound UnboundUnboundIntermediate-analogue:ISP
1sgtA02Unbound UnboundUnboundUnbound
1fn8A02Unbound UnboundUnboundUnbound
1fy4A02Unbound UnboundUnboundUnbound
1fy5A02Unbound UnboundUnboundUnbound
1gdnA02Unbound UnboundUnboundUnbound
1gdqA02Unbound UnboundUnboundUnbound
1gduA02Unbound UnboundUnboundUnbound
1tryA02Unbound UnboundUnboundUnbound
1bitA02Unbound UnboundUnboundUnbound
1bzxE02Unbound UnboundUnboundUnbound
1tbsA02Unbound UnboundUnboundUnbound
2staE02Unbound UnboundUnboundUnbound
2stbE02Unbound UnboundUnboundUnbound
2tbsA02Unbound UnboundUnboundUnbound
1a0jA02Unbound UnboundUnboundUnbound
1a0jB02Unbound UnboundUnboundUnbound
1a0jC02Unbound UnboundUnboundUnbound
1a0jD02Unbound UnboundUnboundUnbound
1braA02Unbound UnboundUnboundUnbound
1brbE02Unbound UnboundUnboundUnbound
1brcE02Unbound UnboundUnboundUnbound
1trmA02Unbound UnboundUnboundUnbound
1trmB02Unbound UnboundUnboundUnbound
2trmA02Unbound UnboundUnboundUnbound
1amhA02Unbound UnboundUnboundUnbound
1amhB02Unbound UnboundUnboundUnbound
1anbA02Unbound UnboundUnboundUnbound
1ancA02Unbound UnboundUnboundUnbound
1andA02Unbound UnboundUnboundUnbound
1aneA02Unbound UnboundUnboundUnbound
1dpoA02Unbound UnboundUnboundUnbound
1ezsC02Unbound UnboundUnboundUnbound
1ezsD02Unbound UnboundUnboundUnbound
1ezuC02Unbound UnboundUnboundUnbound
1ezuD02Unbound UnboundUnboundUnbound
1fy8E02Unbound UnboundUnboundUnbound
1i99E02Unbound UnboundUnboundUnbound
1ql9A02Unbound UnboundUnboundUnbound
1sluB02Unbound UnboundUnboundUnbound
1slvB02Unbound UnboundUnboundUnbound
1slwB02Unbound UnboundUnboundUnbound
1slxB02Unbound UnboundUnboundUnbound
3tgiE02Unbound UnboundUnboundUnbound
3tgjE02Unbound UnboundUnboundUnbound
1aksAUnbound UnboundUnboundUnbound
1an1E02Unbound UnboundUnboundUnbound
1avwA02Unbound UnboundUnboundUnbound
1avxA02Unbound UnboundUnboundUnbound
1ejaA02Unbound UnboundUnboundUnbound
1eptAUnbound UnboundUnboundUnbound
1eptBUnbound UnboundUnboundUnbound
1fmgA02Unbound UnboundUnboundUnbound
1fn6A02Unbound UnboundUnboundUnbound
1fniA02Unbound UnboundUnboundUnbound
1ldtT02Unbound UnboundUnboundUnbound
1mctA02Unbound UnboundUnboundUnbound
1qquA02Unbound UnboundUnboundUnbound
1tfxA02Unbound UnboundUnboundUnbound
1tfxB02Unbound UnboundUnboundUnbound
1aq7A02Unbound UnboundUnboundUnbound
1aujA02Unbound UnboundUnboundUnbound
1az8A02Unbound UnboundUnboundUnbound
1bjuA02Unbound UnboundUnboundUnbound
1bjvA02Unbound UnboundUnboundUnbound
1btpA02Unbound UnboundUnboundUnbound
1btwA02Unbound UnboundUnboundUnbound
1btxA02Unbound UnboundUnboundUnbound
1btyA02Unbound UnboundUnboundUnbound
1btzA02Unbound UnboundUnboundUnbound
1c1nA02Unbound UnboundUnboundUnbound
1c1oA02Unbound UnboundUnboundUnbound
1c1pA02Unbound UnboundUnboundUnbound
1c1qA02Unbound UnboundUnboundUnbound
1c1rA02Unbound UnboundUnboundUnbound
1c1sA02Unbound UnboundUnboundUnbound
1c1tA02Unbound UnboundUnboundUnbound
1c2dA02Unbound UnboundUnboundUnbound
1c2eA02Unbound UnboundUnboundUnbound
1c2fA02Unbound UnboundUnboundUnbound
1c2gA02Unbound UnboundUnboundUnbound
1c2hA02Unbound UnboundUnboundUnbound
1c2iA02Unbound UnboundUnboundUnbound
1c2jA02Unbound UnboundUnboundUnbound
1c2kA02Unbound UnboundUnboundUnbound
1c2lA02Unbound UnboundUnboundUnbound
1c2mA02Unbound UnboundUnboundUnbound
1c5pA02Unbound UnboundUnboundUnbound
1c5qA02Unbound UnboundUnboundUnbound
1c5rA02Unbound UnboundUnboundUnbound
1c5sA02Unbound UnboundUnboundUnbound
1c5tA02Unbound UnboundUnboundUnbound
1c5uA02Unbound UnboundUnboundUnbound
1c5vA02Unbound UnboundUnboundUnbound
1c9pA02Unbound UnboundUnboundUnbound
1ce5A02Unbound UnboundUnboundUnbound
1d6rA02Unbound UnboundUnboundUnbound
1ejmA02Unbound UnboundUnboundUnbound
1ejmC02Unbound UnboundUnboundUnbound
1ejmE02Unbound UnboundUnboundUnbound
1f0tA02Unbound UnboundUnboundUnbound
1f0uA02Unbound UnboundUnboundUnbound
1f2sE02Unbound UnboundUnboundUnbound
1g3bA02Unbound UnboundUnboundUnbound
1g3cA02Unbound UnboundUnboundUnbound
1g3dA02Unbound UnboundUnboundUnbound
1g3eA02Unbound UnboundUnboundUnbound
1g9iE02Unbound UnboundUnboundUnbound
1gbtA02Unbound UnboundUnboundUnbound
1jrsA02Unbound UnboundUnboundUnbound
1jrtA02Unbound UnboundUnboundUnbound
1maxA02Unbound UnboundUnboundUnbound
1mayA02Unbound UnboundUnboundUnbound
1mcuE02Unbound UnboundUnboundUnbound
1mtsA02Unbound UnboundUnboundUnbound
1mtuA02Unbound UnboundUnboundUnbound
1mtvA02Unbound UnboundUnboundUnbound
1mtwA02Unbound UnboundUnboundUnbound
1ntpA02Unbound UnboundUnboundUnbound
1ppcE02Unbound UnboundUnboundUnbound
1ppeE02Unbound UnboundUnboundUnbound
1pphE02Unbound UnboundUnboundUnbound
1qa0A02Unbound UnboundUnboundUnbound
1qb1A02Unbound UnboundUnboundUnbound
1qb6A02Unbound UnboundUnboundUnbound
1qb9A02Unbound UnboundUnboundUnbound
1qbnA02Unbound UnboundUnboundUnbound
1qboA02Unbound UnboundUnboundUnbound
1ql7A02Unbound UnboundUnboundUnbound
1ql8A02Unbound UnboundUnboundUnbound
1sbwA02Unbound UnboundUnboundUnbound
1sfiA02Unbound UnboundUnboundUnbound
1smfE02Unbound UnboundUnboundUnbound
1tabE02Unbound UnboundUnboundUnbound
1tawA02Unbound UnboundUnboundUnbound
1tgbA02Unbound UnboundUnboundUnbound
1tgcA02Unbound UnboundUnboundUnbound
1tgnA02Unbound UnboundUnboundUnbound
1tgsZ02Unbound UnboundUnboundUnbound
1tgtA02Unbound UnboundUnboundUnbound
1tioA02Unbound UnboundUnboundUnbound
1tldA02Unbound UnboundUnboundUnbound
1tngA02Unbound UnboundUnboundUnbound
1tnhA02Unbound UnboundUnboundUnbound
1tniA02Unbound UnboundUnboundUnbound
1tnjA02Unbound UnboundUnboundUnbound
1tnkA02Unbound UnboundUnboundUnbound
1tnlA02Unbound UnboundUnboundUnbound
1tpaE02Unbound UnboundUnboundUnbound
1tpoA02Unbound UnboundUnboundUnbound
1tppA02Unbound UnboundUnboundUnbound
1tpsA02Unbound UnboundUnboundUnbound
1tynA02Unbound UnboundUnboundUnbound
1xufA02Unbound UnboundUnboundUnbound
1xugA02Unbound UnboundUnboundUnbound
1xuhA02Unbound UnboundUnboundUnbound
1xuiA02Unbound UnboundUnboundUnbound
1xujA02Unbound UnboundUnboundUnbound
1xukA02Unbound UnboundUnboundUnbound
1yyy102Unbound UnboundUnboundUnbound
2btcE02Unbound UnboundUnboundUnbound
2bzaA02Unbound UnboundUnboundUnbound
2ptcE02Unbound UnboundUnboundUnbound
2ptnA02Unbound UnboundUnboundUnbound
2tgaA02Unbound UnboundUnboundUnbound
2tgdA02Unbound UnboundUnboundUnbound
2tgpZ02Unbound UnboundUnboundUnbound
2tgtA02Unbound UnboundUnboundUnbound
2tioA02Unbound UnboundUnboundUnbound
2tpiZ02Unbound UnboundUnboundUnbound
3btdE02Unbound UnboundUnboundUnbound
3bteE02Unbound UnboundUnboundUnbound
3btfE02Unbound UnboundUnboundUnbound
3btgE02Unbound UnboundUnboundUnbound
3bthE02Unbound UnboundUnboundUnbound
3btkE02Unbound UnboundUnboundUnbound
3btmE02Unbound UnboundUnboundUnbound
3btqE02Unbound UnboundUnboundUnbound
3bttE02Unbound UnboundUnboundUnbound
3btwE02Unbound UnboundUnboundUnbound
3ptbA02Unbound UnboundUnboundUnbound
3ptnA02Unbound UnboundUnboundUnbound
3tpiZ02Unbound UnboundUnboundUnbound
4ptpA02Unbound UnboundUnboundUnbound
4tpiZ02Unbound UnboundUnboundUnbound
5ptpA02Unbound UnboundUnboundUnbound
1ezxC02Unbound UnboundUnboundUnbound
1trnA02Unbound UnboundUnboundUnbound
1trnB02Unbound UnboundUnboundUnbound

Active-site residues
pdbCatalytic residuesModified residuesMain-chain involved in catalysiscomment
            
1sgtA01SER 195
 
GLY 193;SER 195
 
1fn8A01SER 195
 
GLY 193;SER 195
 
1fy4A01SER 195
 
GLY 193;SER 195
 
1fy5A01SER 195
 
GLY 193;SER 195
 
1gdnA01SER 195
 
GLY 193;SER 195
 
1gdqA01SER 195
 
GLY 193;SER 195
 
1gduA01SER 195
 
GLY 193;SER 195
 
1tryA01SER 195
 
GLY 193;SER 195
 
1bitA01SER 195
 
GLY 193;SER 195
 
1bzxE01SER 195
 
GLY 193;SER 195
 
1tbsA01SER 195
 
GLY 193;SER 195
 
2staE01SER 195
 
GLY 193;SER 195
 
2stbE01SER 195
 
GLY 193;SER 195
 
2tbsA01SER 195
 
GLY 193;SER 195
 
1a0jA01SER 195
 
GLY 193;SER 195
 
1a0jB01SER 195
 
GLY 193;SER 195
 
1a0jC01SER 195
 
GLY 193;SER 195
 
1a0jD01SER 195
 
GLY 193;SER 195
 
1braA01SER 195
 
GLY 193;SER 195
mutant D189G, G226D
1brbE01SER 195
 
GLY 193;SER 195
mutant D189G, G226D
1brcE01SER 195
 
GLY 193;SER 195
mutant D189G, G226D
1trmA01SER 195
 
GLY 193;SER 195
 
1trmB01SER 195
 
GLY 193;SER 195
 
2trmA01SER 195
 
GLY 193;SER 195
 
1amhA01SER 195
 
GLY 193;SER 195
mutant D189S
1amhB01SER 195
 
GLY 193;SER 195
mutant D189S
1anbA01SER 195
 
GLY 193;SER 195
mutant S214E
1ancA01SER 195
 
GLY 193;SER 195
mutant S214K
1andA01SER 195
 
GLY 193;SER 195
 
1aneA01SER 195
 
GLY 193;SER 195
 
1dpoA01       
 
GLY 193;       
mutant S195C
1ezsC01SER 595
 
GLY 593;SER 595
 
1ezsD01SER 895
 
GLY 893;SER 895
 
1ezuC01SER 595
 
GLY 593;SER 595
 
1ezuD01SER 895
 
GLY 893;SER 895
 
1fy8E01SER 195
 
GLY 193;SER 195
 
1i99E01       
 
GLY 193;       
mutant S195A
1ql9A01SER 195
 
GLY 193;SER 195
 
1sluB01SER 195
 
GLY 193;SER 195
mutant N143H, E151H
1slvB01SER 195
 
GLY 193;SER 195
mutant N143H, E151H
1slwB01SER 195
 
GLY 193;SER 195
mutant V121I, N143H, E151H
1slxB01SER 195
 
GLY 193;SER 195
mutant N143H, E151H
3tgiE01SER 195
 
GLY 193;SER 195
 
3tgjE01       
 
GLY 193;       
mutant S195A
1aksBSER 195
 
GLY 193;SER 195
 
1an1E01SER 195
 
GLY 193;SER 195
 
1avwA01SER 195
 
GLY 193;SER 195
 
1avxA01SER 195
 
GLY 193;SER 195
 
1ejaA01SER 195
 
GLY 193;SER 195
 
1eptCSER 195
 
GLY 193;SER 195
 
1fmgA01SER 195
 
GLY 193;SER 195
 
1fn6A01SER 195
 
GLY 193;SER 195
 
1fniA01SER 195
 
GLY 193;SER 195
 
1ldtT01SER 195
 
GLY 193;SER 195
 
1mctA01SER 195
 
GLY 193;SER 195
 
1qquA01SER 195
 
GLY 193;SER 195
 
1tfxA01SER 195
 
GLY 193;SER 195
 
1tfxB01SER 195
 
GLY 193;SER 195
 
1aq7A01SER 195
 
GLY 193;SER 195
 
1aujA01SER 195
 
GLY 193;SER 195
 
1az8A01SER 195
 
GLY 193;SER 195
 
1bjuA01SER 195
 
GLY 193;SER 195
 
1bjvA01SER 195
 
GLY 193;SER 195
 
1btpA01SER 195
 
GLY 193;SER 195
 
1btwA01SER 195
 
GLY 193;SER 195
 
1btxA01SER 195
 
GLY 193;SER 195
 
1btyA01SER 195
 
GLY 193;SER 195
 
1btzA01SER 195
 
GLY 193;SER 195
 
1c1nA01SER 195
 
GLY 193;SER 195
 
1c1oA01SER 195
 
GLY 193;SER 195
 
1c1pA01SER 195
 
GLY 193;SER 195
 
1c1qA01SER 195
 
GLY 193;SER 195
 
1c1rA01SER 195
 
GLY 193;SER 195
 
1c1sA01SER 195
 
GLY 193;SER 195
 
1c1tA01SER 195
 
GLY 193;SER 195
 
1c2dA01SER 195
 
GLY 193;SER 195
 
1c2eA01SER 195
 
GLY 193;SER 195
 
1c2fA01SER 195
 
GLY 193;SER 195
 
1c2gA01SER 195
 
GLY 193;SER 195
 
1c2hA01SER 195
 
GLY 193;SER 195
 
1c2iA01SER 195
 
GLY 193;SER 195
 
1c2jA01SER 195
 
GLY 193;SER 195
 
1c2kA01SER 195
 
GLY 193;SER 195
 
1c2lA01SER 195
 
GLY 193;SER 195
 
1c2mA01SER 195
 
GLY 193;SER 195
 
1c5pA01SER 195
 
GLY 193;SER 195
 
1c5qA01SER 195
 
GLY 193;SER 195
 
1c5rA01SER 195
 
GLY 193;SER 195
 
1c5sA01SER 195
 
GLY 193;SER 195
 
1c5tA01SER 195
 
GLY 193;SER 195
 
1c5uA01SER 195
 
GLY 193;SER 195
 
1c5vA01SER 195
 
GLY 193;SER 195
 
1c9pA01SER 195
 
GLY 193;SER 195
 
1ce5A01SER 195
 
GLY 193;SER 195
 
1d6rA01SER 195
 
GLY 193;SER 195
 
1ejmA01SER 195
 
GLY 193;SER 195
mutant A16L
1ejmC01SER 195
 
GLY 193;SER 195
mutant A16L
1ejmE01SER 195
 
GLY 193;SER 195
mutant A16L
1f0tA01SER 195
 
GLY 193;SER 195
 
1f0uA01SER 195
 
GLY 193;SER 195
 
1f2sE01SER 195
 
GLY 193;SER 195
 
1g3bA01SER 195
 
GLY 193;SER 195
 
1g3cA01SER 195
 
GLY 193;SER 195
 
1g3dA01SER 195
 
GLY 193;SER 195
 
1g3eA01SER 195
 
GLY 193;SER 195
 
1g9iE01SER 195
 
GLY 193;SER 195
 
1gbtA01SER 195
 
GLY 193;SER 195
 
1jrsA01SER 195
 
GLY 193;SER 195
 
1jrtA01SER 195
 
GLY 193;SER 195
 
1maxA01SER 195
 
GLY 193;SER 195
 
1mayA01SER 195
 
GLY 193;SER 195
 
1mcuE01SER 195
 
GLY 193;SER 195
 
1mtsA01SER 195
 
GLY 193;SER 195
 
1mtuA01SER 195
 
GLY 193;SER 195
 
1mtvA01SER 195
 
GLY 193;SER 195
 
1mtwA01SER 195
 
GLY 193;SER 195
 
1ntpA01SER 195
 
GLY 193;SER 195
 
1ppcE01SER 195
 
GLY 193;SER 195
 
1ppeE01SER 195
 
GLY 193;SER 195
 
1pphE01SER 195
 
GLY 193;SER 195
 
1qa0A01SER 183
 
GLY 181;SER 183
 
1qb1A01SER 183
 
GLY 181;SER 183
 
1qb6A01SER 183
 
GLY 181;SER 183
 
1qb9A01SER 183
 
GLY 181;SER 183
 
1qbnA01SER 183
 
GLY 181;SER 183
 
1qboA01SER 183
 
GLY 181;SER 183
 
1ql7A01SER 195
 
GLY 193;SER 195
 
1ql8A01SER 195
 
GLY 193;SER 195
 
1sbwA01SER 195
 
GLY 193;SER 195
 
1sfiA01SER 195
 
GLY 193;SER 195
 
1smfE01SER 195
 
GLY 193;SER 195
 
1tabE01SER 195
 
GLY 193;SER 195
 
1tawA01SER 195
 
GLY 193;SER 195
 
1tgbA01SER 195
 
GLY 193;SER 195
 
1tgcA01SER 195
 
GLY 193;SER 195
 
1tgnA01SER 195
 
GLY 193;SER 195
 
1tgsZ01SER 195
 
GLY 193;SER 195
 
1tgtA01SER 195
 
GLY 193;SER 195
 
1tioA01SER 195
 
GLY 193;SER 195
 
1tldA01SER 195
 
GLY 193;SER 195
 
1tngA01SER 195
 
GLY 193;SER 195
 
1tnhA01SER 195
 
GLY 193;SER 195
 
1tniA01SER 195
 
GLY 193;SER 195
 
1tnjA01SER 195
 
GLY 193;SER 195
 
1tnkA01SER 195
 
GLY 193;SER 195
 
1tnlA01SER 195
 
GLY 193;SER 195
 
1tpaE01SER 195
 
GLY 193;SER 195
 
1tpoA01SER 195
 
GLY 193;SER 195
 
1tppA01SER 195
 
GLY 193;SER 195
 
1tpsA01SER 195
 
GLY 193;SER 195
 
1tynA01SER 195
 
GLY 193;SER 195
 
1xufA01SER 195
 
GLY 193;SER 195
 
1xugA01SER 195
 
GLY 193;SER 195
 
1xuhA01SER 195
 
GLY 193;SER 195
 
1xuiA01SER 195
 
GLY 193;SER 195
 
1xujA01SER 195
 
GLY 193;SER 195
 
1xukA01SER 195
 
GLY 193;SER 195
 
1yyy101SER 195
 
GLY 193;SER 195
 
2btcE01SER 195
 
GLY 193;SER 195
 
2bzaA01SER 195
 
GLY 193;SER 195
 
2ptcE01SER 195
 
GLY 193;SER 195
 
2ptnA01SER 195
 
GLY 193;SER 195
 
2tgaA01SER 195
 
GLY 193;SER 195
 
2tgdA01SER 195
 
GLY 193;SER 195
 
2tgpZ01SER 195
 
GLY 193;SER 195
 
2tgtA01SER 195
 
GLY 193;SER 195
 
2tioA01SER 195
 
GLY 193;SER 195
 
2tpiZ01SER 195
 
GLY 193;SER 195
 
3btdE01SER 195
 
GLY 193;SER 195
 
3bteE01SER 195
 
GLY 193;SER 195
 
3btfE01SER 195
 
GLY 193;SER 195
 
3btgE01SER 195
 
GLY 193;SER 195
 
3bthE01SER 195
 
GLY 193;SER 195
 
3btkE01SER 195
 
GLY 193;SER 195
 
3btmE01SER 195
 
GLY 193;SER 195
 
3btqE01SER 195
 
GLY 193;SER 195
 
3bttE01SER 195
 
GLY 193;SER 195
 
3btwE01SER 195
 
GLY 193;SER 195
 
3ptbA01SER 195
 
GLY 193;SER 195
 
3ptnA01SER 195
 
GLY 193;SER 195
 
3tpiZ01SER 195
 
GLY 193;SER 195
 
4ptpA01SER 195
 
GLY 193;SER 195
 
4tpiZ01SER 195
 
GLY 193;SER 195
 
5ptpA01       
MIS 195(monoisopropyl-phosphorylated)
GLY 193;MIS 195
 
1ezxC01SER 195
 
GLY 193;SER 195
 
1trnA01SER 195
 
GLY 193;SER 195
 
1trnB01SER 195
 
GLY 193;SER 195
 
1sgtA02HIS  57;ASP 102
 
 
 
1fn8A02HIS  57;ASP 102
 
 
 
1fy4A02HIS  57;ASP 102
 
 
 
1fy5A02HIS  57;ASP 102
 
 
 
1gdnA02HIS  57;ASP 102
 
 
 
1gdqA02HIS  57;ASP 102
 
 
 
1gduA02HIS  57;ASP 102
 
 
 
1tryA02HIS  57;ASP 102
 
 
 
1bitA02HIS  57;ASP 102
 
 
 
1bzxE02HIS  57;ASP 102
 
 
 
1tbsA02HIS  57;ASP 102
 
 
 
2staE02HIS  57;ASP 102
 
 
 
2stbE02HIS  57;ASP 102
 
 
 
2tbsA02HIS  57;ASP 102
 
 
 
1a0jA02HIS  57;ASP 102
 
 
 
1a0jB02HIS  57;ASP 102
 
 
 
1a0jC02HIS  57;ASP 102
 
 
 
1a0jD02HIS  57;ASP 102
 
 
 
1braA02HIS  57;ASP 102
 
 
 
1brbE02HIS  57;ASP 102
 
 
 
1brcE02HIS  57;ASP 102
 
 
 
1trmA02HIS  57;       
 
 
mutant D102N
1trmB02HIS  57;       
 
 
mutant D102N
2trmA02HIS  57;       
 
 
mutant D102N
1amhA02HIS  57;ASP 102
 
 
 
1amhB02HIS  57;ASP 102
 
 
 
1anbA02HIS  57;ASP 102
 
 
 
1ancA02HIS  57;ASP 102
 
 
 
1andA02HIS  57;ASP 102
 
 
mutant R96H
1aneA02HIS  57;ASP 102
 
 
 
1dpoA02HIS  57;ASP 102
 
 
 
1ezsC02HIS 457;       
 
 
mutant D502N
1ezsD02HIS 757;       
 
 
mutant D802N
1ezuC02HIS 457;       
 
 
mutant D502N
1ezuD02HIS 757;       
 
 
mutant D802N
1fy8E02HIS  57;ASP 102
 
 
 
1i99E02HIS  57;ASP 102
 
 
 
1ql9A02HIS  57;ASP 102
 
 
 
1sluB02HIS  57;ASP 102
 
 
 
1slvB02HIS  57;ASP 102
 
 
 
1slwB02HIS  57;ASP 102
 
 
 
1slxB02HIS  57;ASP 102
 
 
 
3tgiE02HIS  57;ASP 102
 
 
 
3tgjE02HIS  57;ASP 102
 
 
 
1aksAHIS  57;ASP 102
 
 
 
1an1E02HIS  57;ASP 102
 
 
 
1avwA02HIS  57;ASP 102
 
 
 
1avxA02HIS  57;ASP 102
 
 
 
1ejaA02HIS  57;ASP 102
 
 
 
1eptAHIS  57;       
 
 
 
1eptB       ;ASP 102
 
 
 
1fmgA02HIS  57;ASP 102
 
 
 
1fn6A02HIS  57;ASP 102
 
 
 
1fniA02HIS  57;ASP 102
 
 
 
1ldtT02HIS  57;ASP 102
 
 
 
1mctA02HIS  57;ASP 102
 
 
 
1qquA02HIS  57;ASP 102
 
 
 
1tfxA02HIS  57;ASP 102
 
 
 
1tfxB02HIS  57;ASP 102
 
 
 
1aq7A02HIS  57;ASP 102
 
 
 
1aujA02HIS  57;ASP 102
 
 
 
1az8A02HIS  57;ASP 102
 
 
 
1bjuA02HIS  57;ASP 102
 
 
 
1bjvA02HIS  57;ASP 102
 
 
 
1btpA02HIS  57;ASP 102
 
 
 
1btwA02HIS  57;ASP 102
 
 
 
1btxA02HIS  57;ASP 102
 
 
 
1btyA02HIS  57;ASP 102
 
 
 
1btzA02HIS  57;ASP 102
 
 
 
1c1nA02HIS  57;ASP 102
 
 
 
1c1oA02HIS  57;ASP 102
 
 
 
1c1pA02HIS  57;ASP 102
 
 
 
1c1qA02HIS  57;ASP 102
 
 
 
1c1rA02HIS  57;ASP 102
 
 
 
1c1sA02HIS  57;ASP 102
 
 
 
1c1tA02HIS  57;ASP 102
 
 
 
1c2dA02HIS  57;ASP 102
 
 
 
1c2eA02HIS  57;ASP 102
 
 
 
1c2fA02HIS  57;ASP 102
 
 
 
1c2gA02