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CATH domain | Related DB codes (homologues) |
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3.40.50.720 : Rossmann fold | S00543,S00551,S00552,S00553,S00602,S00604,S00605,S00608,S00610,S00625,S00319,S00328,S00329,S00330,S00331,S00332,D00456,D00458,S00324,S00320,S00325,S00326,S00327,D00459,S00335,S00336,S00334,T00219,S00339,D00513,D00001,D00002,D00003,D00005,D00007,D00008,D00010,D00012,D00017,D00018,D00023,D00027,D00028,D00031,D00032,D00033,D00034,D00035,D00037,D00048,D00071,D00476,D00481,D00482,D00490,D00492,D00494,D00545,D00601,D00603,D00604,D00605,D00615,D00845,D00857,D00858,M00161,M00171,M00210,T00002,T00010,T00011,T00015,T00227,T00247,T00408,T00414,D00827,D00262,D00274,D00275,M00035,T00109 |
Enzyme Name | UniProtKB | KEGG |
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| P36234 |
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Protein name | Glycerate dehydrogenase | glycerate dehydrogenaseD-glycerate dehydrogenasehydroxypyruvate reductase |
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Synonyms | GDHEC 1.1.1.29NADH-dependent hydroxypyruvate reductaseHPRHydroxypyruvate dehydrogenaseGlyoxylate reductase |
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Pfam | PF00389 (2-Hacid_dh) PF02826 (2-Hacid_dh_C) [Graphical view]
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KEGG pathways | MAP code | Pathways |
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MAP00260 | Glycine, serine and threonine metabolism | MAP00630 | Glyoxylate and dicarboxylate metabolism |
UniProtKB:Accession Number | P36234 |
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Entry name | DHGY_HYPME |
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Activity | (R)-glycerate + NAD(+) = hydroxypyruvate + NADH. |
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Subunit | Homodimer. |
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Subcellular location |
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Cofactor |
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Compound table: links to PDB-related databases & PoSSuM |
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| Substrates | Products |
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KEGG-id | C00258 | C00003 | C00168 | C00004 |
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Compound | (R)-Glycerate | NAD+ | Hydroxypyruvate | NADH |
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Type | carbohydrate,carboxyl group | amide group,amine group,nucleotide | carbohydrate,carboxyl group | amide group,amine group,nucleotide |
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ChEBI | 32398
| 15846
| 30841
| 16908
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PubChem | 439194
| 5893
| 964
| 439153
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| | | | | | | | | | | |
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1gdhA01 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound |
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1gdhB01 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound |
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1gdhA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound |
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1gdhB02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound |
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References for Catalytic Mechanism | References | Sections | No. of steps in catalysis |
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[1] | p.1549-1551 |
| [5] | p.1133-1136, Fig.12 | 2 |
references | [1] |
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PubMed ID | 14154 |
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Journal | J Biol Chem |
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Year | 1977 |
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Volume | 252 |
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Pages | 1539-51 |
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Authors | Dubrow R, Pizer LI |
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Title | Transient kinetic and deuterium isotope effect studies on the catalytic mechanism of phosphoglycerate dehydrogenase. |
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[2] |
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PubMed ID | 2689175 |
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Journal | Eur J Biochem |
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Year | 1989 |
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Volume | 186 |
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Pages | 355-9 |
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Authors | Van Schaftingen E, Draye JP, Van Hoof F |
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Title | Coenzyme specificity of mammalian liver D-glycerate dehydrogenase. |
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[3] |
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Comments | CHARACTERIZATION |
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Medline ID | 90306024 |
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PubMed ID | 2114287 |
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Journal | Eur J Biochem |
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Year | 1990 |
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Volume | 190 |
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Pages | 279-84 |
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Authors | Izumi Y, Yoshida T, Kanzaki H, Toki S, Miyazaki SS, Yamada H |
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Title | Purification and characterization of hydroxypyruvate reductase from a serine-producing methylotroph, Hyphomicrobium methylovorum GM2. |
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Related UniProtKB | P36234 |
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[4] |
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PubMed ID | 1567457 |
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Journal | Biochem Biophys Res Commun |
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Year | 1992 |
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Volume | 184 |
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Pages | 60-6 |
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Authors | Kochhar S, Hunziker PE, Leong-Morgenthaler P, Hottinger H |
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Title | Evolutionary relationship of NAD(+)-dependent D-lactate dehydrogenase: comparison of primary structure of 2-hydroxy acid dehydrogenases. |
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[5] |
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Comments | X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) |
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Medline ID | 94166078 |
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PubMed ID | 8120891 |
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Journal | J Mol Biol |
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Year | 1994 |
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Volume | 236 |
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Pages | 1123-40 |
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Authors | Goldberg JD, Yoshida T, Brick P |
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Title | Crystal structure of a NAD-dependent D-glycerate dehydrogenase at 2.4 A resolution. |
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Related PDB | 1gdh |
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Related UniProtKB | P36234 |
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comments | This enzyme may have a similar catalytic mechanism to that of lactate dehydrogenase (D00456 in EzCatDB), as they share a similar active-site.
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created | updated |
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2004-03-25 | 2009-02-26 |
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