EzCatDB: D00469
Related links:    PDB-formatted query search system Fasta-formatted query search system Fasta-formatted query search system

DB codeD00469
CATH domainDomain 11.25.40.10 : Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Domain 2-.-.-.-
E.C.3.1.3.16

CATH domainRelated DB codes (homologues)
1.25.40.10 : Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatM00184

Enzyme Name
UniProtKBKEGG

P53041
Protein nameSerine/threonine-protein phosphatase 5phosphoprotein phosphatase
protein phosphatase-1
protein phosphatase-2A
protein phosphatase-2B
protein phosphatase-2C
protein D phosphatase
phosphospectrin phosphatase
casein phosphatase
Aspergillus awamori acid protein phosphatase
calcineurin
phosphatase 2A
phosphatase 2B
phosphatase II
phosphatase IB
phosphatase C-II
polycation modulated (PCM-) phosphatase
phosphopyruvate dehydrogenase phosphatase
phosphatase SP
branched-chain alpha-keto acid dehydrogenase phosphatase
BCKDH phosphatase
3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase
HMG-CoA reductase phosphatase
phosphatase H-II
phosphatase III
phosphatase I
protein phosphatase
phosphatase IV
SynonymsPP5
EC 3.1.3.16
Protein phosphatase T
PP-T
PPT
RefSeqNP_006238.1 (Protein)
NM_006247.3 (DNA/RNA sequence)
PfamPF00149 (Metallophos)
PF08321 (PPP5)
PF00515 (TPR_1)
[Graphical view]


UniProtKB:Accession NumberP53041
Entry namePPP5_HUMAN
ActivityA phosphoprotein + H(2)O = a protein + phosphate.
SubunitInteracts with CDC16 and CDC27.
Subcellular locationNucleus. Cytoplasm. Note=Predominantly nuclear. But also present in the cytoplasm.
CofactorBinds 1 iron ion per subunit (By similarity).,Binds 1 manganese ion per subunit (By similarity).

Compound table: links to PDB-related databases & PoSSuM

CofactorsSubstratesProducts
KEGG-idC00076C00391C00023C00034C00562C00001L00078C02734C01976C00017C00009
CompoundCalciumCalmodulinIronManganesePhosphoproteinH2OCaseinPhenolic phosphatePhosphoamideProteinOrthophosphate
Typedivalent metal (Ca2+, Mg2+)peptide/proteinheavy metalheavy metalpeptide/protein,phosphate group/phosphate ionH2Opeptide/protein,phosphate group/phosphate ionaromatic ring (only carbon atom),phosphate group/phosphate ionamine group,phosphate group/phosphate ionpeptide/proteinphosphate group/phosphate ion
ChEBI29108

18248
82664
18291
35154

15377

37548


26078
PubChem271

23925
23930

962
22247451

12793


22486802
1004
                   
1a17AUnboundUnboundUnboundUnboundUnbound UnboundUnboundUnboundUnboundAnalogue:SO4

Active-site residues
pdb
        
1a17A


references
[1]
CommentsX-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 19-177.
PubMed ID9482716
JournalEMBO J
Year1998
Volume17
Pages1192-9.
AuthorsDas AK, Cohen PW, Barford D
TitleThe structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions.
Related PDB1a17
Related UniProtKBP53041
[2]
PubMed ID11881984
JournalJ Med Chem
Year2002
Volume45
Pages1151-75.
AuthorsMcCluskey A, Sim AT, Sakoff JA
TitleSerine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies.

comments
The tertiary structure of the C-terminal catalytic domain has not been determined yet.

createdupdated
2004-03-192012-06-26


Copyright: Nozomi Nagano, JST & CBRC-AIST
Funded by PRESTO/Japan Science and Technology Corporation (JST) (December 2001 - November 2004)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
Funded by BIRD/Japan Science and Technology Corporation (JST) (September 2005 - September 2008)
Funded by BIRD/Japan Science and Technology Corporation (JST) (October 2007 - September 2010)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - )
© Biotechnology Research Institute for Drug Discovery, AIST, 2015-2016 All Rights Reserved.
© Computational Biology Research Center, AIST, 2004-2016 All Rights Reserved.