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CATH domain | Related DB codes (homologues) |
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3.40.50.720 : Rossmann fold | S00543,S00551,S00552,S00553,S00602,S00604,S00605,S00608,S00610,S00625,S00319,S00328,S00329,S00330,S00331,S00332,D00456,D00457,D00458,S00324,S00320,S00325,S00326,S00327,D00459,S00335,S00336,S00334,T00219,S00339,D00513,D00001,D00002,D00003,D00005,D00007,D00008,D00010,D00012,D00017,D00018,D00023,D00027,D00028,D00031,D00032,D00033,D00034,D00035,D00037,D00048,D00071,D00476,D00482,D00490,D00492,D00494,D00545,D00601,D00603,D00604,D00605,D00615,D00845,D00857,D00858,M00161,M00171,M00210,T00002,T00010,T00011,T00015,T00227,T00247,T00408,T00414,D00827,D00262,D00274,D00275,M00035,T00109 | 3.90.180.10 : Quinone Oxidoreductase; Chain A, domain 1 | D00001,D00002,D00018,D00048,D00482,D00490,D00492,D00615 |
Enzyme Name | UniProtKB | KEGG |
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| Q9QYY9 |
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Protein name | Alcohol dehydrogenase 4 | alcohol dehydrogenasealdehyde reductaseADHalcohol dehydrogenase (NAD)aliphatic alcohol dehydrogenaseethanol dehydrogenaseNAD-dependent alcohol dehydrogenaseNAD-specific aromatic alcohol dehydrogenaseNADH-alcohol dehydrogenaseNADH-aldehyde dehydrogenaseprimary alcohol dehydrogenaseyeast alcohol dehydrogenase |
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Synonyms | EC 1.1.1.1Alcohol dehydrogenase class IIAlcohol dehydrogenase IIADH2 |
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RefSeq | NP_036126.2 (Protein) NM_011996.2 (DNA/RNA sequence)
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Pfam | PF08240 (ADH_N) PF00107 (ADH_zinc_N) [Graphical view]
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KEGG pathways | MAP code | Pathways |
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MAP00010 | Glycolysis / Gluconeogenesis | MAP00071 | Fatty acid metabolism | MAP00120 | Bile acid biosynthesis | MAP00260 | Glycine, serine and threonine metabolism | MAP00350 | Tyrosine metabolism | MAP00624 | 1- and 2-Methylnaphthalene degradation | MAP00641 | 3-Chloroacrylic acid degradation | MAP00830 | Retinol metabolism | MAP00980 | Metabolism of xenobiotics by cytochrome P450 | MAP00982 | Drug metabolism - cytochrome P450 |
UniProtKB:Accession Number | Q9QYY9 |
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Entry name | ADH4_MOUSE |
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Activity | An alcohol + NAD(+) = an aldehyde or ketone + NADH. |
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Subunit | Dimer. |
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Subcellular location | Cytoplasm (By similarity). |
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Cofactor | Binds 2 zinc ions per subunit. |
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References for Catalytic Mechanism | References | Sections | No. of steps in catalysis |
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[7] | p.450-451 |
| [8] | p.346-348 |
| [11] | Figure 3 p.3859 |
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references | [1] |
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PubMed ID | 7484389 |
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Journal | Adv Exp Med Biol |
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Year | 1995 |
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Volume | 372 |
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Pages | 281-94 |
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Authors | Jornvall H, Danielsson O, Hjelmqvist L, Persson B, Shafqat J |
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Title | The alcohol dehydrogenase system. |
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[2] |
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PubMed ID | 7479907 |
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Journal | Proc Natl Acad Sci U S A |
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Year | 1995 |
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Volume | 92 |
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Pages | 10904-8 |
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Authors | Hjelmqvist L, Estonius M, Jornvall H |
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Title | The vertebrate alcohol dehydrogenase system: variable class II type form elucidates separate stages of enzymogenesis. |
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[3] |
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PubMed ID | 9059633 |
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Journal | Adv Exp Med Biol |
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Year | 1997 |
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Volume | 414 |
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Pages | 291-302 |
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Authors | Hurley TD, Steinmetz CG, Xie P, Yang ZN |
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Title | Three-dimensional structures of human alcohol dehydrogenase isoenzymes reveal the molecular basis for their functional diversity. |
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[4] |
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PubMed ID | 9059632 |
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Journal | Adv Exp Med Biol |
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Year | 1997 |
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Volume | 414 |
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Pages | 281-9 |
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Authors | Jornvall H, Shafqat J, el-Ahmad M, Hjelmqvist L, Persson B, Danielsson O |
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Title | Alcohol dehydrogenase variability. Evolutionary and functional conclusions from characterization of further variants. |
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[5] |
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PubMed ID | 9572895 |
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Journal | J Med Chem |
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Year | 1998 |
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Volume | 41 |
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Pages | 1696-701 |
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Authors | Schindler JF, Berst KB, Plapp BV |
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Title | Inhibition of human alcohol dehydrogenases by formamides. |
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[6] |
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PubMed ID | 10352708 |
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Journal | Adv Exp Med Biol |
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Year | 1999 |
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Volume | 463 |
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Pages | 373-7 |
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Authors | Persson B, Nordling E, Kallberg Y, Lundh D, Oppermann UC, Marschall HU, Jornvall H |
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Title | Bioinformatics in studies of SDR and MDR enzymes. |
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[7] |
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Comments | X-ray crystallography |
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PubMed ID | 10970744 |
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Journal | J Mol Biol |
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Year | 2000 |
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Volume | 302 |
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Pages | 441-53 |
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Authors | Svensson S, Hoog JO, Schneider G, Sandalova T |
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Title | Crystal structures of mouse class II alcohol dehydrogenase reveal determinants of substrate specificity and catalytic efficiency. |
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Related PDB | 1e3e,1e3i,1e3l |
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[8] |
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PubMed ID | 11306056 |
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Journal | Chem Biol Interact |
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Year | 2001 |
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Volume | 130-132 |
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Pages | 339-50 |
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Authors | Svensson S, Stromberg P, Sandalova T, Hoog J |
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Title | Class II alcohol dehydrogenase (ADH2)--adding the structure. |
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[9] |
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PubMed ID | 11173978 |
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Journal | J Biomed Sci |
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Year | 2001 |
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Volume | 8 |
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Pages | 71-6 |
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Authors | Hoog JO, Hedberg JJ, Stromberg P, Svensson S |
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Title | Mammalian alcohol dehydrogenase - functional and structural implications. |
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[10] |
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PubMed ID | 11964133 |
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Journal | Cell Mol Life Sci |
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Year | 2002 |
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Volume | 59 |
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Pages | 552-9 |
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Authors | Stromberg P, Svensson S, Hedberg JJ, Nordling E, Hoog JO |
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Title | Identification and characterisation of two allelic forms of human alcohol dehydrogenase 2. |
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[11] |
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PubMed ID | 11942822 |
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Journal | J Am Chem Soc |
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Year | 2002 |
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Volume | 124 |
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Pages | 3858-64 |
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Authors | Kohen A, Jensen JH |
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Title | Boundary conditions for the Swain-Schaad relationship as a criterion for hydrogen tunneling. |
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comments | This enzyme belongs to the zinc-containing alcohol dehydrogenase class II. According to the literature [7] & [8], this enzyme is inefficient, probably due to Pro47, whose mutation to His restores the activity.
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created | updated |
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2005-01-11 | 2009-02-26 |
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