EzCatDB: M00007
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DB codeM00007
CATH domainDomain 13.40.50.740 : Rossmann fold
Domain 23.40.228.10 : Dimethylsulfoxide Reductase; domain 2Catalytic domain
Domain 33.90.55.10 : Dimethylsulfoxide Reductase; domain 3
Domain 42.40.40.20 : Barwin-like endoglucanases
E.C.1.7.2.3
CSA1tmo

CATH domainRelated DB codes (homologues)
2.40.40.20 : Barwin-like endoglucanasesS00101

Enzyme Name
UniProtKBKEGG

O87948
Protein nameTrimethylamine-N-oxide reductasetrimethylamine-N-oxide reductase (cytochrome c)
TMAO reductase
TOR
SynonymsTMAO reductase
Trimethylamine oxidase
EC 1.7.2.3
PfamPF00384 (Molybdopterin)
PF01568 (Molydop_binding)
[Graphical view]


UniProtKB:Accession NumberO87948
Entry nameTORA_SHEMA
ActivityTrimethylamine + 2 (ferricytochrome c)-subunit + H(2)O = trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H(+).
Subunit
Subcellular locationPeriplasm.
Cofactor

Compound table: links to PDB-related databases & PoSSuM

CofactorsSubstratesProducts
KEGG-idC00150C00126C01104C00080C00125C00565C00001
CompoundMolybdenumFerrocytochrome cTrimethylamine N-oxideH+Ferricytochrome cTrimethylamineH2O
Typeheavy metalamide group,amine group,aromatic ring (with nitrogen atoms),carboxyl group,heavy metal,sulfide groupamine groupothersamide group,amine group,aromatic ring (with nitrogen atoms),carboxyl group,heavy metal,sulfide groupamine groupH2O
ChEBI28685

15724
15378

18139
15377
PubChem23932

1145
1038

1146
962
22247451
               
1tmoA01UnboundUnboundUnbound UnboundUnbound 
1tmoA02Bound:2MOUnboundUnbound UnboundUnbound 
1tmoA03UnboundUnboundUnbound UnboundUnbound 
1tmoA04UnboundUnboundUnbound UnboundUnbound 

Active-site residues
resource
PDB;1tmo
pdbCofactor-binding residues
         
1tmoA01 
1tmoA02SER 149 (Molybdenum binding)
1tmoA03 
1tmoA04 


references
[1]
CommentsX-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
Medline ID99033057
PubMed ID9813128
JournalJ Mol Biol
Year1998
Volume284
Pages435-47
AuthorsCzjzek M, Dos Santos JP, Pommier J, Giordano G, Mejean V, Haser R
TitleCrystal structure of oxidized trimethylamine N-oxide reductase from Shewanella massilia at 2.5 A resolution.
Related PDB1tmo
Related UniProtKBO87948
[2]
PubMed ID11781311
JournalJ Biol Chem
Year2002
Volume277
Pages10362-6
AuthorsAllen SC, Barrett CM, Ray N, Robinson C
TitleEssential cytoplasmic domains in the Escherichia coli TatC protein.


createdupdated
2004-03-252009-02-26


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