|
CATH domain | Related DB codes (homologues) |
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2.60.40.10 : Immunoglobulin-like | M00131,T00257,T00005,M00127,M00132,M00323,M00325,M00327,M00329,M00330,M00331,M00332,T00307,D00166,D00500,M00112,M00193,T00063,T00065,T00067,T00245 | 2.60.40.1180 : Immunoglobulin-like | T00307,D00165,D00176,D00664,D00665,D00863,D00864,M00112,M00193,M00314,T00057,T00062,T00067 | 3.20.20.80 : TIM Barrel | S00202,S00210,S00748,S00906,S00907,S00911,S00912,S00915,M00134,M00160,D00479,S00204,S00205,S00206,S00207,S00203,S00208,S00209,S00211,S00213,S00214,T00307,D00165,D00166,D00169,D00176,D00501,D00502,D00503,D00844,D00861,D00864,M00026,M00112,M00193,M00346,T00057,T00062,T00063,T00066,T00067 |
Enzyme Name | UniProtKB | KEGG |
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| P05618 | P30920 | P43379 | P31797 | P26827 |
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Protein name | Cyclomaltodextrin glucanotransferase | Cyclomaltodextrin glucanotransferase | Cyclomaltodextrin glucanotransferase | Cyclomaltodextrin glucanotransferase | Cyclomaltodextrin glucanotransferase | cyclomaltodextrin glucanotransferaseBacillus macerans amylasecyclodextrin glucanotransferasealpha-cyclodextrin glucanotransferasealpha-cyclodextrin glycosyltransferasebeta-cyclodextrin glucanotransferasebeta-cyclodextrin glycosyltransferasegamma-cyclodextrin glycosyltransferasecyclodextrin glycosyltransferasecyclomaltodextrin glucotransferasecyclomaltodextrin glycosyltransferasekonchizaimualpha-1,4-glucan 4-glycosyltransferase, cyclizingBMACGTaseneutral-cyclodextrin glycosyltransferase1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase(cyclizing) |
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Synonyms | EC 2.4.1.19Cyclodextrin-glycosyltransferaseCGTase | EC 2.4.1.19Cyclodextrin-glycosyltransferaseCGTase | EC 2.4.1.19Cyclodextrin-glycosyltransferaseCGTase | EC 2.4.1.19Cyclodextrin-glycosyltransferaseCGTase | EC 2.4.1.19Cyclodextrin-glycosyltransferaseCGTase |
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Pfam | PF00128 (Alpha-amylase) PF02806 (Alpha-amylase_C) PF00686 (CBM_20) PF01833 (TIG) [Graphical view]
| PF00128 (Alpha-amylase) PF02806 (Alpha-amylase_C) PF00686 (CBM_20) PF01833 (TIG) [Graphical view]
| PF00128 (Alpha-amylase) PF02806 (Alpha-amylase_C) PF00686 (CBM_20) PF01833 (TIG) [Graphical view]
| PF00128 (Alpha-amylase) PF02806 (Alpha-amylase_C) PF00686 (CBM_20) PF01833 (TIG) [Graphical view]
| PF00128 (Alpha-amylase) PF02806 (Alpha-amylase_C) PF00686 (CBM_20) PF01833 (TIG) [Graphical view]
|
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CAZy | GH13 (Glycoside Hydrolase Family)
| GH13 (Glycoside Hydrolase Family)
| GH13 (Glycoside Hydrolase Family)
| GH13 (Glycoside Hydrolase Family)
| GH13 (Glycoside Hydrolase Family)
|
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UniProtKB:Accession Number | P05618 | P30920 | P43379 | P31797 | P26827 |
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Entry name | CDGT_BACS0 | CDGT1_BACCI | CDGT2_BACCI | CDGT_BACST | CDGT_THETU |
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Activity | Cyclizes part of a (1->4)-alpha-D-glucan chain by formation of a (1->4)-alpha-D-glucosidic bond. | Cyclizes part of a (1->4)-alpha-D-glucan chain by formation of a (1->4)-alpha-D-glucosidic bond. | Cyclizes part of a (1->4)-alpha-D-glucan chain by formation of a (1->4)-alpha-D-glucosidic bond. | Cyclizes part of a (1->4)-alpha-D-glucan chain by formation of a (1->4)-alpha-D-glucosidic bond. | Cyclizes part of a (1->4)-alpha-D-glucan chain by formation of a (1->4)-alpha-D-glucosidic bond. |
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Subunit | Monomer. | Monomer. | Monomer. | Monomer. |
|
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Subcellular location | Secreted (By similarity). | Secreted (By similarity). | Secreted (By similarity). | Secreted (By similarity). | Secreted. |
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Cofactor | Binds 2 calcium ions per subunit. | Binds 2 calcium ions per subunit. | Binds 2 calcium ions per subunit. | Binds 2 calcium ions per subunit. | Binds 2 calcium ions per subunit. |
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Compound table: links to PDB-related databases & PoSSuM |
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| Cofactors | Substrates | Products | intermediates |
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KEGG-id | C00076 | C01935 | C00369 | C00973 | C01935 |
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|
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Compound | Calcium | Maltodextrin | Starch | Cyclomaltodextrin | Maltodextrin | Transition-state-1 | Covalent-bonded intermediate |
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Type | divalent metal (Ca2+, Mg2+) | polysaccharide | polysaccharide | polysaccharide | polysaccharide |
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|
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ChEBI | 29108
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PubChem | 271
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|
| 46173710
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| | | | | | | | | | | | | | |
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1d7fA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1d7fB01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1dedA01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:ACR | Unbound | Unbound | Unbound | Unbound | Unbound |
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1dedB01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:ACR | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1i75A01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:NOJ | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1i75B01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:NOJ | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1pamA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1pamB01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1ukqA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:GLC-ACI-G6D-BGC | Unbound |
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1ukqB01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:GLC-ACI-G6D-BGC | Unbound |
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1uksA01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:GLC-ACI-GLD-GAL | Unbound | Unbound | Unbound | Unbound | Unbound |
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1uksB01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:GLC-ACI-GLD-GAL | Unbound | Unbound | Unbound | Unbound | Unbound |
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1uktA01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:ACI-GLD-GLC-GAL | Unbound | Unbound | Unbound | Unbound | Unbound |
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1uktB01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:ACI-GLD-GLC-GAL | Unbound | Unbound | Unbound | Unbound | Unbound |
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1v3jA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1v3jB01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1v3kA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1v3kB01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1v3lA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:GLC-ACI-GLD-GAL(chain D) | Unbound |
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1v3lB01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:GLC-ACI-GLD-GLC(chain E) | Unbound |
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1v3mA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:GLC-ACI-GLD-GAL(chain D) | Unbound |
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1v3mB01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:GLC-ACI-GLD-GAL(chain H) | Unbound |
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1cgtA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cguA01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:GLC-GLC | Unbound | Unbound | Unbound | Unbound | Unbound |
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3cgtA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Bound:BCD | Unbound | Unbound | Unbound |
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4cgtA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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5cgtA01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:GLC-GLC | Unbound | Unbound | Bound:GLC 711 | Unbound | Unbound |
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6cgtA01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:OPG-DAG-GLC-OPG-DAG-GLC | Unbound | Unbound | Unbound | Unbound | Unbound |
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7cgtA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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8cgtA01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:TM6 | Unbound | Unbound | Unbound | Unbound | Unbound |
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9cgtA01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:TM5 | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cdgA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cgvA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cgwA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cgxA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cgyA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cxeA01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:GLC-GLC-GLC-GLC | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cxfA01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:GLC-GLC-GLC-GLC | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cxgA01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:ACR | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cxhA01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:GLC-GLC-GLC-GLC | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cxiA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cxkA01 |  |  |  |  |  |  |  | Bound:2x_CA | Bound:GLC-GLC-GLC-GLC-GLC-GLC-GLC-GLC-GLC(chain C) | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cxlA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Intermediate-bound:GLC-GLC-G4D |
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1d3cA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Bound:GLC-GLC-GLC-GLC-GLC-GLC-GLC-GLC(chain C) | Unbound | Unbound | Unbound |
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1dijA01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:GLC-GLC-GLC-GLC-GLC-GLC-ACI-GLC-GLC | Unbound | Unbound | Unbound | Unbound | Unbound |
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1dtuA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:GLC-GLC-GLC-ADH-G6D-GLC(chain C) | Unbound |
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1eo5A01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:GLC-GLC-GLC-GLC-GLC-GLC-GLC(chain B) | Unbound | Unbound | Unbound | Unbound | Unbound |
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1eo7A01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:GLC-GLC-GLC-GLC-GLC-GLC(chain B) | Unbound | Unbound | Unbound | Unbound | Unbound |
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1kckA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:GLC-ADH-G6D-GLC(chain B) | Unbound |
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1kclA01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:GLC-GLC-GLC-GLC(chain B) | Unbound | Unbound | Unbound | Unbound | Unbound |
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1ot1A01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:GLC-GLC-GLC-GLC-GLC-GLC-GLC(chain C) | Unbound | Unbound | Unbound | Unbound | Unbound |
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1ot2A01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:GLC-GLC-GLC-GLC-GLC-GLC-GLC(chain C) | Unbound | Unbound | Unbound | Unbound | Unbound |
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1pezA01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:GLC-GLC(chain C) | Unbound | Unbound | Unbound | Unbound | Unbound |
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1pj9A01 |  |  |  |  |  |  |  | Bound:2x_CA | Analogue:GLC-GLC(chain C) | Unbound | Unbound | Bound:GLC-GLC(chain B) | Unbound | Unbound |
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1tcmA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1tcmB01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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2cxgA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:GLC-ACI-G6D-GLC | Unbound |
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2dijA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:GLC-GLC-GLC-GLC-GLC-GLC-ADH-G6D-GLC | Unbound |
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1cygA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1a47A01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Transition-state-analogue:GTE-GLC-GLC-ACI-G6D-GLC-GLC | Unbound |
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1ciuA01 |  |  |  |  |  |  |  | Bound:2x_CA | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1d7fA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1d7fB02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1dedA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1dedB02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1i75A02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1i75B02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1pamA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1pamB02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1ukqA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1ukqB02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1uksA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1uksB02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1uktA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1uktB02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1v3jA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1v3jB02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1v3kA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1v3kB02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1v3lA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1v3lB02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1v3mA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1v3mB02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cgtA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cguA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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3cgtA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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4cgtA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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5cgtA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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6cgtA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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7cgtA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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8cgtA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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9cgtA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cdgA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cgvA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cgwA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cgxA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cgyA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cxeA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cxfA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cxgA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cxhA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cxiA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cxkA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cxlA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1d3cA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1dijA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1dtuA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1eo5A02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1eo7A02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1kckA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1kclA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1ot1A02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1ot2A02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1pezA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1pj9A02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1tcmA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1tcmB02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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2cxgA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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2dijA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1cygA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1a47A02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
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1ciuA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1d7fA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1d7fB03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1dedA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1dedB03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1i75A03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1i75B03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1pamA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1pamB03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1ukqA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1ukqB03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1uksA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1uksB03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1uktA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1uktB03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1v3jA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1v3jB03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1v3kA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1v3kB03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1v3lA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1v3lB03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1v3mA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1v3mB03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cgtA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cguA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
3cgtA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
4cgtA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
5cgtA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
6cgtA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
7cgtA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
8cgtA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
9cgtA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cdgA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cgvA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cgwA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cgxA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cgyA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cxeA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cxfA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cxgA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cxhA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cxiA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cxkA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cxlA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1d3cA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1dijA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1dtuA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1eo5A03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1eo7A03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1kckA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1kclA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1ot1A03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1ot2A03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1pezA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1pj9A03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1tcmA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1tcmB03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
2cxgA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
2dijA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cygA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1a47A03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1ciuA03 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1d7fA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1d7fB04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1dedA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1dedB04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1i75A04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1i75B04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1pamA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1pamB04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1ukqA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1ukqB04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1uksA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1uksB04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1uktA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1uktB04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1v3jA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1v3jB04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1v3kA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1v3kB04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1v3lA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1v3lB04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1v3mA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1v3mB04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cgtA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cguA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
3cgtA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
4cgtA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
5cgtA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
6cgtA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
7cgtA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
8cgtA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
9cgtA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cdgA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cgvA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cgwA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cgxA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cgyA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cxeA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cxfA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cxgA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cxhA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cxiA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cxkA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cxlA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1d3cA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1dijA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1dtuA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1eo5A04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1eo7A04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1kckA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1kclA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1ot1A04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1ot2A04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1pezA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1pj9A04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1tcmA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1tcmB04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
2cxgA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
2dijA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1cygA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1a47A04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
1ciuA04 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound | Unbound |
---|
Active-site residues | resource |
---|
Swiss-prot;P05618, P30920, P43379, P31797, P26827 & literature [8], [11], [16] | pdb | Catalytic residues | Cofactor-binding residues | comment |
---|
| | | | | | | | | | |
---|
1d7fA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199; (Calcium-2)
| mutant H233N
|
---|
1d7fB01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199; (Calcium-2)
| mutant H233N
|
---|
1dedA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199; (Calcium-2)
| mutant H233N
|
---|
1dedB01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199; (Calcium-2)
| mutant H233N
|
---|
1i75A01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
|
|
---|
1i75B01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
|
|
---|
1pamA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
|
|
---|
1pamB01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
|
|
---|
1ukqA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
|
|
---|
1ukqB01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
|
|
---|
1uksA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant F183L, F259L
|
---|
1uksB01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant F183L, F259L
|
---|
1uktA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant Y100L
|
---|
1uktB01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant Y100L
|
---|
1v3jA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant F283L
|
---|
1v3jB01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant F283L
|
---|
1v3kA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant F283Y
|
---|
1v3kB01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant F283Y
|
---|
1v3lA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant F283L
|
---|
1v3lB01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant F283L
|
---|
1v3mA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant F283Y
|
---|
1v3mB01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant F283Y
|
---|
1cgtA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
|
|
---|
1cguA01 |  |  |  |  |  |  |  | ;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant D229A
|
---|
3cgtA01 |  |  |  |  |  |  |  | ASP 229; ;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant E257A
|
---|
4cgtA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant deletion 145-150, F151D
|
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5cgtA01 |  |  |  |  |  |  |  | ;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant D229A
|
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6cgtA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant L194T
|
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7cgtA01 |  |  |  |  |  |  |  | ;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant D229A
|
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8cgtA01 |  |  |  |  |  |  |  | ASP 229; ;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant E257A
|
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9cgtA01 |  |  |  |  |  |  |  | ASP 229; ;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant E257A
|
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1cdgA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
|
|
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1cgvA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant Y195F
|
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1cgwA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant Y195G
|
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1cgxA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant Y195L
|
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1cgyA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant Y195W
|
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1cxeA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
|
|
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1cxfA01 |  |  |  |  |  |  |  | ; ;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant D229N, E257Q
|
---|
1cxgA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
|
|
---|
1cxhA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
|
|
---|
1cxiA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
|
|
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1cxkA01 |  |  |  |  |  |  |  | ; ;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant D229N, E257Q
|
---|
1cxlA01 |  |  |  |  |  |  |  | ASP 229; ;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant E257Q
|
---|
1d3cA01 |  |  |  |  |  |  |  | ; ;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant D229N, E257Q
|
---|
1dijA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant Y195F
|
---|
1dtuA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant Y89D, S146P
|
---|
1eo5A01 |  |  |  |  |  |  |  | ; ;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant D229A, E257A
|
---|
1eo7A01 |  |  |  |  |  |  |  | ; ;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant D229A, E257A
|
---|
1kckA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant N193G
|
---|
1kclA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant G179L
|
---|
1ot1A01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant D135A
|
---|
1ot2A01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant D135N
|
---|
1pezA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant A230V
|
---|
1pj9A01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant T185S, T186Y, N188D, K192R
|
---|
1tcmA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant W616A
|
---|
1tcmB01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant W616A
|
---|
2cxgA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
|
|
---|
2dijA01 |  |  |  |  |  |  |  | ASP 229;GLU 257;HIS 327;ASP 328
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 139;ILE 190;ASP 199;HIS 233(Calcium-2)
| mutant Y195F
|
---|
1cygA01 |  |  |  |  |  |  |  | ASP 225;GLU 253;HIS 323;ASP 324
| ASP 24;ASN 26;ASN 29;ASN 30;GLY 48;ASP 50(Calcium-1);ASN 135;ILE 186;ASP 195;HIS 229(Calcium-2)
|
|
---|
1a47A01 |  |  |  |  |  |  |  | ASP 230;GLU 258;HIS 328;ASP 329
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 140;ILE 191;ASP 200;HIS 234(Calcium-2)
|
|
---|
1ciuA01 |  |  |  |  |  |  |  | ASP 230;GLU 258;HIS 328;ASP 329
| ASP 27;ASN 29;ASN 32;ASN 33;GLY 51;ASP 53(Calcium-1);ASN 140;ILE 191;ASP 200;HIS 234(Calcium-2)
|
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1d7fA02 |  |  |  |  |  |  |  |
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1d7fB02 |  |  |  |  |  |  |  |
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1dedA02 |  |  |  |  |  |  |  |
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1dedB02 |  |  |  |  |  |  |  |
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1i75A02 |  |  |  |  |  |  |  |
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1i75B02 |  |  |  |  |  |  |  |
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1pamA02 |  |  |  |  |  |  |  |
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1pamB02 |  |  |  |  |  |  |  |
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1ukqA02 |  |  |  |  |  |  |  |
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1ukqB02 |  |  |  |  |  |  |  |
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1uksA02 |  |  |  |  |  |  |  |
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1uksB02 |  |  |  |  |  |  |  |
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1uktA02 |  |  |  |  |  |  |  |
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1uktB02 |  |  |  |  |  |  |  |
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1v3jA02 |  |  |  |  |  |  |  |
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1v3jB02 |  |  |  |  |  |  |  |
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1v3kA02 |  |  |  |  |  |  |  |
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1v3kB02 |  |  |  |  |  |  |  |
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1v3lA02 |  |  |  |  |  |  |  |
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1v3lB02 |  |  |  |  |  |  |  |
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1v3mA02 |  |  |  |  |  |  |  |
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1v3mB02 |  |  |  |  |  |  |  |
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1cgtA02 |  |  |  |  |  |  |  |
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1cguA02 |  |  |  |  |  |  |  |
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3cgtA02 |  |  |  |  |  |  |  |
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4cgtA02 |  |  |  |  |  |  |  |
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5cgtA02 |  |  |  |  |  |  |  |
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6cgtA02 |  |  |  |  |  |  |  |
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7cgtA02 |  |  |  |  |  |  |  |
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8cgtA02 |  |  |  |  |  |  |  |
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9cgtA02 |  |  |  |  |  |  |  |
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1cdgA02 |  |  |  |  |  |  |  |
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1cgvA02 |  |  |  |  |  |  |  |
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1cgwA02 |  |  |  |  |  |  |  |
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1cgxA02 |  |  |  |  |  |  |  |
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1cgyA02 |  |  |  |  |  |  |  |
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1cxeA02 |  |  |  |  |  |  |  |
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1cxfA02 |  |  |  |  |  |  |  |
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1cxgA02 |  |  |  |  |  |  |  |
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1cxhA02 |  |  |  |  |  |  |  |
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1cxiA02 |  |  |  |  |  |  |  |
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1cxkA02 |  |  |  |  |  |  |  |
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1cxlA02 |  |  |  |  |  |  |  |
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1d3cA02 |  |  |  |  |  |  |  |
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1dijA02 |  |  |  |  |  |  |  |
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1dtuA02 |  |  |  |  |  |  |  |
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1eo5A02 |  |  |  |  |  |  |  |
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1eo7A02 |  |  |  |  |  |  |  |
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1kckA02 |  |  |  |  |  |  |  |
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1kclA02 |  |  |  |  |  |  |  |
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1ot1A02 |  |  |  |  |  |  |  |
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1ot2A02 |  |  |  |  |  |  |  |
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1pezA02 |  |  |  |  |  |  |  |
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1pj9A02 |  |  |  |  |  |  |  |
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1tcmA02 |  |  |  |  |  |  |  |
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1tcmB02 |  |  |  |  |  |  |  |
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2cxgA02 |  |  |  |  |  |  |  |
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2dijA02 |  |  |  |  |  |  |  |
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1cygA02 |  |  |  |  |  |  |  |
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1a47A02 |  |  |  |  |  |  |  |
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1ciuA02 |  |  |  |  |  |  |  |
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1d7fA03 |  |  |  |  |  |  |  |
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1d7fB03 |  |  |  |  |  |  |  |
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1dedA03 |  |  |  |  |  |  |  |
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1dedB03 |  |  |  |  |  |  |  |
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1i75A03 |  |  |  |  |  |  |  |
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1i75B03 |  |  |  |  |  |  |  |
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1pamA03 |  |  |  |  |  |  |  |
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1pamB03 |  |  |  |  |  |  |  |
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1ukqA03 |  |  |  |  |  |  |  |
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1ukqB03 |  |  |  |  |  |  |  |
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1uksA03 |  |  |  |  |  |  |  |
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1uksB03 |  |  |  |  |  |  |  |
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1uktA03 |  |  |  |  |  |  |  |
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1uktB03 |  |  |  |  |  |  |  |
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1v3jA03 |  |  |  |  |  |  |  |
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1v3jB03 |  |  |  |  |  |  |  |
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1v3kA03 |  |  |  |  |  |  |  |
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1v3kB03 |  |  |  |  |  |  |  |
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1v3lA03 |  |  |  |  |  |  |  |
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1v3lB03 |  |  |  |  |  |  |  |
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1v3mA03 |  |  |  |  |  |  |  |
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1v3mB03 |  |  |  |  |  |  |  |
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1cgtA03 |  |  |  |  |  |  |  |
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1cguA03 |  |  |  |  |  |  |  |
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3cgtA03 |  |  |  |  |  |  |  |
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4cgtA03 |  |  |  |  |  |  |  |
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5cgtA03 |  |  |  |  |  |  |  |
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6cgtA03 |  |  |  |  |  |  |  |
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7cgtA03 |  |  |  |  |  |  |  |
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8cgtA03 |  |  |  |  |  |  |  |
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9cgtA03 |  |  |  |  |  |  |  |
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1cdgA03 |  |  |  |  |  |  |  |
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1cgvA03 |  |  |  |  |  |  |  |
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1cgwA03 |  |  |  |  |  |  |  |
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1cgxA03 |  |  |  |  |  |  |  |
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1cgyA03 |  |  |  |  |  |  |  |
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1cxeA03 |  |  |  |  |  |  |  |
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1cxfA03 |  |  |  |  |  |  |  |
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1cxgA03 |  |  |  |  |  |  |  |
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1cxhA03 |  |  |  |  |  |  |  |
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1cxiA03 |  |  |  |  |  |  |  |
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1cxkA03 |  |  |  |  |  |  |  |
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1cxlA03 |  |  |  |  |  |  |  |
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1d3cA03 |  |  |  |  |  |  |  |
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1dijA03 |  |  |  |  |  |  |  |
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1dtuA03 |  |  |  |  |  |  |  |
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1eo5A03 |  |  |  |  |  |  |  |
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1eo7A03 |  |  |  |  |  |  |  |
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1kckA03 |  |  |  |  |  |  |  |
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1kclA03 |  |  |  |  |  |  |  |
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1ot1A03 |  |  |  |  |  |  |  |
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1ot2A03 |  |  |  |  |  |  |  |
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1pezA03 |  |  |  |  |  |  |  |
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1pj9A03 |  |  |  |  |  |  |  |
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1tcmA03 |  |  |  |  |  |  |  |
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1tcmB03 |  |  |  |  |  |  |  |
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2cxgA03 |  |  |  |  |  |  |  |
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2dijA03 |  |  |  |  |  |  |  |
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1cygA03 |  |  |  |  |  |  |  |
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1a47A03 |  |  |  |  |  |  |  |
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1ciuA03 |  |  |  |  |  |  |  |
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1d7fA04 |  |  |  |  |  |  |  |
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1d7fB04 |  |  |  |  |  |  |  |
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1dedA04 |  |  |  |  |  |  |  |
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1dedB04 |  |  |  |  |  |  |  |
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1i75A04 |  |  |  |  |  |  |  |
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1i75B04 |  |  |  |  |  |  |  |
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1pamA04 |  |  |  |  |  |  |  |
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1pamB04 |  |  |  |  |  |  |  |
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1ukqA04 |  |  |  |  |  |  |  |
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1ukqB04 |  |  |  |  |  |  |  |
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1uksA04 |  |  |  |  |  |  |  |
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1uksB04 |  |  |  |  |  |  |  |
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1uktA04 |  |  |  |  |  |  |  |
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1uktB04 |  |  |  |  |  |  |  |
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1v3jA04 |  |  |  |  |  |  |  |
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1v3jB04 |  |  |  |  |  |  |  |
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1v3kA04 |  |  |  |  |  |  |  |
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1v3kB04 |  |  |  |  |  |  |  |
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1v3lA04 |  |  |  |  |  |  |  |
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1v3lB04 |  |  |  |  |  |  |  |
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1v3mA04 |  |  |  |  |  |  |  |
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1v3mB04 |  |  |  |  |  |  |  |
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1cgtA04 |  |  |  |  |  |  |  |
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1cguA04 |  |  |  |  |  |  |  |
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3cgtA04 |  |  |  |  |  |  |  |
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4cgtA04 |  |  |  |  |  |  |  |
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5cgtA04 |  |  |  |  |  |  |  |
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6cgtA04 |  |  |  |  |  |  |  |
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7cgtA04 |  |  |  |  |  |  |  |
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8cgtA04 |  |  |  |  |  |  |  |
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9cgtA04 |  |  |  |  |  |  |  |
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1cdgA04 |  |  |  |  |  |  |  |
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1cgvA04 |  |  |  |  |  |  |  |
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1cgwA04 |  |  |  |  |  |  |  |
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1cgxA04 |  |  |  |  |  |  |  |
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1cgyA04 |  |  |  |  |  |  |  |
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1cxeA04 |  |  |  |  |  |  |  |
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1cxfA04 |  |  |  |  |  |  |  |
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1cxgA04 |  |  |  |  |  |  |  |
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1cxhA04 |  |  |  |  |  |  |  |
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1cxiA04 |  |  |  |  |  |  |  |
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1cxkA04 |  |  |  |  |  |  |  |
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1cxlA04 |  |  |  |  |  |  |  |
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1d3cA04 |  |  |  |  |  |  |  |
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1dijA04 |  |  |  |  |  |  |  |
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1dtuA04 |  |  |  |  |  |  |  |
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1eo5A04 |  |  |  |  |  |  |  |
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1eo7A04 |  |  |  |  |  |  |  |
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1kckA04 |  |  |  |  |  |  |  |
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1kclA04 |  |  |  |  |  |  |  |
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1ot1A04 |  |  |  |  |  |  |  |
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1ot2A04 |  |  |  |  |  |  |  |
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1pezA04 |  |  |  |  |  |  |  |
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1pj9A04 |  |  |  |  |  |  |  |
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1tcmA04 |  |  |  |  |  |  |  |
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1tcmB04 |  |  |  |  |  |  |  |
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2cxgA04 |  |  |  |  |  |  |  |
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2dijA04 |  |  |  |  |  |  |  |
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1cygA04 |  |  |  |  |  |  |  |
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1a47A04 |  |  |  |  |  |  |  |
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1ciuA04 |  |  |  |  |  |  |  |
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References for Catalytic Mechanism | References | Sections | No. of steps in catalysis |
---|
[11] | Fig.6, p.9935 |
| [12] | p.70 |
| [15] | p.598 |
| [20] | p.2238-2240 |
| [22] | p.1143-1145 |
| [23] | p.5913-5914 |
| [31] | p.5578-5579 |
| [34] | Fig.1 |
| [35] | Fig.2, p.407-408 |
| [36] | Fig.1, p.432-433 |
| [38] | Fig.1, Fig.6 |
| [39] | Fig.4, p.342 |
| [57] | Scheme 1 |
|
references | [1] |
---|
PubMed ID | 2975653 |
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Journal | J Biochem (Tokyo) |
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Year | 1988 |
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Volume | 104 |
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Pages | 12-3 |
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Authors | Kubota M, Mikami B, Tsujisaka Y, Morita Y |
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Title | Crystallization of and preliminary crystallographic data for Bacillus stearothermophilus cyclodextrin glucanotransferase. |
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PubMed ID | 2967858 |
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Journal | J Biochem Biophys Methods |
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Year | 1988 |
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Volume | 15 |
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Pages | 307-18 |
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Authors | Makela MJ, Korpela TK |
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Title | Determination of the catalytic activity of cyclomaltodextrin glucanotransferase by maltotriose-methylorange assay. |
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[3] |
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PubMed ID | 2524186 |
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Journal | Biochem J |
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Year | 1989 |
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Volume | 259 |
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Pages | 145-52 |
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Authors | MacGregor EA, Svensson B |
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Title | A super-secondary structure predicted to be common to several alpha-1,4-D-glucan-cleaving enzymes. |
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[4] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS). |
---|
Medline ID | 90064533 |
---|
PubMed ID | 2531228 |
---|
Journal | J Mol Biol |
---|
Year | 1989 |
---|
Volume | 209 |
---|
Pages | 793-800 |
---|
Authors | Hofmann BE, Bender H, Schulz GE |
---|
Title | Three-dimensional structure of cyclodextrin glycosyltransferase from Bacillus circulans at 3.4 A resolution. |
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Related UniProtKB | P30920 |
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[5] |
---|
PubMed ID | 2143786 |
---|
Journal | J Mol Biol |
---|
Year | 1990 |
---|
Volume | 214 |
---|
Pages | 807-9 |
---|
Authors | Lawson CL, Bergsma J, Bruinenberg PM, de Vries G, Dijkhuizen L, Dijkstra BW |
---|
Title | Maltodextrin-dependent crystallization of cyclomaltodextrin glucanotransferase from Bacillus circulans. |
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[6] |
---|
PubMed ID | 2149760 |
---|
Journal | Protein Eng |
---|
Year | 1990 |
---|
Volume | 4 |
---|
Pages | 65-7 |
---|
Authors | Klein C, Vogel W, Bender H, Schulz GE |
---|
Title | Engineering a heavy atom derivative for the X-ray structure analysis of cyclodextrin glycosyltransferase. |
---|
[7] |
---|
PubMed ID | 1838375 |
---|
Journal | J Biochem (Tokyo) |
---|
Year | 1991 |
---|
Volume | 110 |
---|
Pages | 756-61 |
---|
Authors | Abe S, Nagamine Y, Omichi K, Ikenaka T |
---|
Title | Investigation of the active site of Bacillus macerans cyclodextrin glucanotransferase by use of modified maltooligosaccharides. |
---|
[8] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS). |
---|
Medline ID | 91171298 |
---|
PubMed ID | 1826034 |
---|
Journal | J Mol Biol |
---|
Year | 1991 |
---|
Volume | 217 |
---|
Pages | 737-50 |
---|
Authors | Klein C, Schulz GE |
---|
Title | Structure of cyclodextrin glycosyltransferase refined at 2.0 A resolution. |
---|
Related PDB | 1cgt |
---|
Related UniProtKB | P30920 |
---|
[9] |
---|
PubMed ID | 1476442 |
---|
Journal | Appl Environ Microbiol |
---|
Year | 1992 |
---|
Volume | 58 |
---|
Pages | 4016-25 |
---|
Authors | Fujiwara S, Kakihara H, Woo KB, Lejeune A, Kanemoto M, Sakaguchi K, Imanaka T |
---|
Title | Cyclization characteristics of cyclodextrin glucanotransferase are conferred by the NH2-terminal region of the enzyme. |
---|
[10] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 1390660 |
---|
Journal | Biochemistry |
---|
Year | 1992 |
---|
Volume | 31 |
---|
Pages | 8740-6 |
---|
Authors | Klein C, Hollender J, Bender H, Schulz GE |
---|
Title | Catalytic center of cyclodextrin glycosyltransferase derived from X-ray structure analysis combined with site-directed mutagenesis. |
---|
Related PDB | 1cgu |
---|
[11] |
---|
PubMed ID | 8061001 |
---|
Journal | Biochemistry |
---|
Year | 1994 |
---|
Volume | 33 |
---|
Pages | 9929-36 |
---|
Authors | Nakamura A, Haga K, Yamane K |
---|
Title | Four aromatic residues in the active center of cyclodextrin glucanotransferase from alkalophilic Bacillus sp. 1011: effects of replacements on substrate binding and cyclization characteristics. |
---|
[12] |
---|
PubMed ID | 8276116 |
---|
Journal | FEBS Lett |
---|
Year | 1994 |
---|
Volume | 337 |
---|
Pages | 66-70 |
---|
Authors | Nakamura A, Haga K, Yamane K |
---|
Title | The transglycosylation reaction of cyclodextrin glucanotransferase is operated by a Ping-Pong mechanism. |
---|
[13] |
---|
PubMed ID | 7764720 |
---|
Journal | J Biotechnol |
---|
Year | 1994 |
---|
Volume | 32 |
---|
Pages | 283-8 |
---|
Authors | Sin KA, Nakamura A, Masaki H, Matsuura Y, Uozumi T |
---|
Title | Replacement of an amino acid residue of cyclodextrin glucanotransferase of Bacillus ohbensis doubles the production of gamma-cyclodextrin. |
---|
[14] |
---|
PubMed ID | 8133516 |
---|
Journal | J Mol Biol |
---|
Year | 1994 |
---|
Volume | 237 |
---|
Pages | 163-4 |
---|
Authors | Haga K, Harata K, Nakamura A, Yamane K |
---|
Title | Crystallization and preliminary X-ray studies of cyclodextrin glucanotransferase from alkalophilic Bacillus sp. 1011. |
---|
[15] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 8107143 |
---|
Journal | J Mol Biol |
---|
Year | 1994 |
---|
Volume | 236 |
---|
Pages | 590-600 |
---|
Authors | Lawson CL, van Montfort R, Strokopytov B, Rozeboom HJ, Kalk KH, de Vries GE, Penninga D, Dijkhuizen L, Dijkstra BW |
---|
Title | Nucleotide sequence and X-ray structure of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 in a maltose-dependent crystal form. |
---|
Related PDB | 1cdg |
---|
[16] |
---|
PubMed ID | 8018865 |
---|
Journal | Plant Mol Biol |
---|
Year | 1994 |
---|
Volume | 25 |
---|
Pages | 141-57 |
---|
Authors | Svensson B |
---|
Title | Protein engineering in the alpha-amylase family: catalytic mechanism, substrate specificity, and stability. |
---|
[17] |
---|
PubMed ID | 7747949 |
---|
Journal | Appl Environ Microbiol |
---|
Year | 1995 |
---|
Volume | 61 |
---|
Pages | 1257-65 |
---|
Authors | Wind RD, Liebl W, Buitelaar RM, Penninga D, Spreinat A, Dijkhuizen L, Bahl H |
---|
Title | Cyclodextrin formation by the thermostable alpha-amylase of Thermoanaerobacterium thermosulfurigenes EM1 and reclassification of the enzyme as a cyclodextrin glycosyltransferase. |
---|
[18] |
---|
PubMed ID | 7832788 |
---|
Journal | Biochem J |
---|
Year | 1995 |
---|
Volume | 305 |
---|
Pages | 685-6 |
---|
Authors | Janecek S, MacGregor EA, Svensson B |
---|
Title | Characteristic differences in the primary structure allow discrimination of cyclodextrin glucanotransferases from alpha-amylases. |
---|
[19] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 7880832 |
---|
Journal | Biochemistry |
---|
Year | 1995 |
---|
Volume | 34 |
---|
Pages | 3368-76 |
---|
Authors | Penninga D, Strokopytov B, Rozeboom HJ, Lawson CL, Dijkstra BW, Bergsma J, Dijkhuizen L |
---|
Title | Site-directed mutations in tyrosine 195 of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 affect activity and product specificity. |
---|
Related PDB | 1cgv,1cgw,1cgx,1cgy |
---|
[20] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 7857935 |
---|
Journal | Biochemistry |
---|
Year | 1995 |
---|
Volume | 34 |
---|
Pages | 2234-40 |
---|
Authors | Strokopytov B, Penninga D, Rozeboom HJ, Kalk KH, Dijkhuizen L, Dijkstra BW. X-ray structure of cyclodextrin glycosyltransferase complexed with acarbose |
---|
Title | Implications for the catalytic mechanism of glycosidases. |
---|
Related PDB | 1cxg,2cxg |
---|
[21] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS). |
---|
Medline ID | 96094317 |
---|
PubMed ID | 7493956 |
---|
Journal | J Biol Chem |
---|
Year | 1995 |
---|
Volume | 270 |
---|
Pages | 29256-64 |
---|
Authors | Knegtel RM, Strokopytov B, Penninga D, Faber OG, Rozeboom HJ, Kalk KH, Dijkhuizen L, Dijkstra BW |
---|
Title | Crystallographic studies of the interaction of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 with natural substrates and products. |
---|
Related PDB | 1cxe,1cxf,1cxh,1cxi |
---|
Related UniProtKB | P43379 |
---|
[22] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS). |
---|
Journal | Acta Crystallogr D Biol Crystallogr |
---|
Year | 1996 |
---|
Volume | 52 |
---|
Pages | 1136-45 |
---|
Authors | Harata K, Haga K, Nakamura A, Aoyagi M, Yamane K |
---|
Title | X-ray structure of cyclodextrin glucanotransferase from alkalophilic Bacillus Sp. 1011. Comparison of two independent molecules at 1.8-A resolution. |
---|
Related PDB | 1pam |
---|
Related UniProtKB | P05618 |
---|
[23] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF COMPLEX WITH INHIBITOR. |
---|
Medline ID | 96264806 |
---|
PubMed ID | 8672460 |
---|
Journal | Biochemistry |
---|
Year | 1996 |
---|
Volume | 35 |
---|
Pages | 4241-9 |
---|
Authors | Strokopytov B, Knegtel RM, Penninga D, Rozeboom HJ, Kalk KH, Dijkhuizen L, Dijkstra BW |
---|
Title | Structure of cyclodextrin glycosyltransferase complexed with a maltononaose inhibitor at 2.6 angstrom resolution. Implications for product specificity. |
---|
Related PDB | 1dij,2dij |
---|
Related UniProtKB | P43379 |
---|
[24] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS). |
---|
Medline ID | 97115811 |
---|
PubMed ID | 8955113 |
---|
Journal | J Biol Chem |
---|
Year | 1996 |
---|
Volume | 271 |
---|
Pages | 32777-84 |
---|
Authors | Penninga D, van der Veen BA, Knegtel RM, van Hijum SA, Rozeboom HJ, Kalk KH, Dijkstra BW, Dijkhuizen L |
---|
Title | The raw starch binding domain of cyclodextrin glycosyltransferase from Bacillus circulans strain 251. |
---|
Related PDB | 1tcm |
---|
Related UniProtKB | P43379 |
---|
[25] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS). |
---|
Medline ID | 96177766 |
---|
PubMed ID | 8604143 |
---|
Journal | J Mol Biol |
---|
Year | 1996 |
---|
Volume | 256 |
---|
Pages | 611-22 |
---|
Authors | Knegtel RM, Wind RD, Rozeboom HJ, Kalk KH, Buitelaar RM, Dijkhuizen L, Dijkstra BW |
---|
Title | Crystal structure at 2.3 A resolution and revised nucleotide sequence of the thermostable cyclodextrin glycosyltransferase from Thermonanaerobacterium thermosulfurigenes EM1. |
---|
Related PDB | 1ciu |
---|
Related UniProtKB | P26827 |
---|
[26] |
---|
PubMed ID | 9401418 |
---|
Journal | Prog Biophys Mol Biol |
---|
Year | 1997 |
---|
Volume | 67 |
---|
Pages | 67-97 |
---|
Authors | Janecek S |
---|
Title | alpha-Amylase family: molecular biology and evolution. |
---|
[27] |
---|
PubMed ID | 9860832 |
---|
Journal | Biochemistry |
---|
Year | 1998 |
---|
Volume | 37 |
---|
Pages | 17192-8 |
---|
Authors | Mosi R, Sham H, Uitdehaag JC, Ruiterkamp R, Dijkstra BW, Withers SG |
---|
Title | Reassessment of acarbose as a transition state analogue inhibitor of cyclodextrin glycosyltransferase. |
---|
[28] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS). |
---|
Medline ID | 98226626 |
---|
PubMed ID | 9558324 |
---|
Journal | Biochemistry |
---|
Year | 1998 |
---|
Volume | 37 |
---|
Pages | 5909-15 |
---|
Authors | Schmidt AK, Cottaz S, Driguez H, Schulz GE |
---|
Title | Structure of cyclodextrin glycosyltransferase complexed with a derivative of its main product beta-cyclodextrin. |
---|
Related PDB | 3cgt |
---|
Related UniProtKB | P30920 |
---|
[29] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS). |
---|
Medline ID | 98409292 |
---|
PubMed ID | 9738912 |
---|
Journal | Eur J Biochem |
---|
Year | 1998 |
---|
Volume | 255 |
---|
Pages | 710-7 |
---|
Authors | Parsiegla G, Schmidt AK, Schulz GE |
---|
Title | Substrate binding to a cyclodextrin glycosyltransferase and mutations increasing the gamma-cyclodextrin production. |
---|
Related PDB | 4cgt,5cgt,6cgt,7cgt,8cgt,9cgt |
---|
Related UniProtKB | P30920 |
---|
[30] |
---|
PubMed ID | 9654055 |
---|
Journal | Eur J Biochem |
---|
Year | 1998 |
---|
Volume | 253 |
---|
Pages | 598-605 |
---|
Authors | Wind RD, Buitelaar RM, Dijkhuizen L |
---|
Title | Engineering of factors determining alpha-amylase and cyclodextrin glycosyltransferase specificity in the cyclodextrin glycosyltransferase from Thermoanaerobacterium thermosulfurigenes EM1. |
---|
[31] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (2.56 ANGSTROMS). |
---|
Medline ID | 98157977 |
---|
PubMed ID | 9488711 |
---|
Journal | J Biol Chem |
---|
Year | 1998 |
---|
Volume | 273 |
---|
Pages | 5771-9 |
---|
Authors | Wind RD, Uitdehaag JC, Buitelaar RM, Dijkstra BW, Dijkhuizen L |
---|
Title | Engineering of cyclodextrin product specificity and pH optima of the thermostable cyclodextrin glycosyltransferase from Thermoanaerobacterium thermosulfurigenes EM1. |
---|
Related PDB | 1a47 |
---|
Related UniProtKB | P26827 |
---|
[32] |
---|
PubMed ID | 9828462 |
---|
Journal | J Biotechnol |
---|
Year | 1998 |
---|
Volume | 65 |
---|
Pages | 191-202 |
---|
Authors | Chang HY, Irwin PM, Nikolov ZL |
---|
Title | Effects of mutations in the starch-binding domain of Bacillus macerans cyclodextrin glycosyltransferase. |
---|
[33] |
---|
PubMed ID | 10094484 |
---|
Journal | FEBS Lett |
---|
Year | 1999 |
---|
Volume | 445 |
---|
Pages | 333-7 |
---|
Authors | Alcalde M, Plou FJ, Andersen C, Martin MT, Pedersen S, Ballesteros A |
---|
Title | Chemical modification of lysine side chains of cyclodextrin glycosyltransferase from Thermoanaerobacter causes a shift from cyclodextrin glycosyltransferase to alpha-amylase specificity. |
---|
[34] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 10574960 |
---|
Journal | J Biol Chem |
---|
Year | 1999 |
---|
Volume | 274 |
---|
Pages | 34868-76 |
---|
Authors | Uitdehaag JC, Kalk KH, van Der Veen BA, Dijkhuizen L, Dijkstra BW |
---|
Title | The cyclization mechanism of cyclodextrin glycosyltransferase (CGTase) as revealed by a gamma-cyclodextrin-CGTase complex at 1.8-A resolution. |
---|
Related PDB | 1d3c |
---|
[35] |
---|
PubMed ID | 10331861 |
---|
Journal | Nat Struct Biol |
---|
Year | 1999 |
---|
Volume | 6 |
---|
Pages | 406-8 |
---|
Authors | Davies GJ, Wilson KS |
---|
Title | Trapped in the act of catalysis. |
---|
[36] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 10331869 |
---|
Journal | Nat Struct Biol |
---|
Year | 1999 |
---|
Volume | 6 |
---|
Pages | 432-6 |
---|
Authors | Uitdehaag JC, Mosi R, Kalk KH, van der Veen BA, Dijkhuizen L, Withers SG, Dijkstra BW |
---|
Title | X-ray structures along the reaction pathway of cyclodextrin glycosyltransferase elucidate catalysis in the alpha-amylase family. |
---|
Related PDB | 1cxk,1cxl |
---|
[37] |
---|
PubMed ID | 10877806 |
---|
Journal | Appl Environ Microbiol |
---|
Year | 2000 |
---|
Volume | 66 |
---|
Pages | 3058-64 |
---|
Authors | Ohdan K, Kuriki T, Takata H, Kaneko H, Okada S |
---|
Title | Introduction of raw starch-binding domains into Bacillus subtilis alpha-amylase by fusion with the starch-binding domain of Bacillus cyclomaltodextrin glucanotransferase. |
---|
[38] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 10869182 |
---|
Journal | Biochemistry |
---|
Year | 2000 |
---|
Volume | 39 |
---|
Pages | 7772-80 |
---|
Authors | Uitdehaag JC, van Alebeek GJ, van Der Veen BA, Dijkhuizen L, Dijkstra BW |
---|
Title | Structures of maltohexaose and maltoheptaose bound at the donor sites of cyclodextrin glycosyltransferase give insight into the mechanisms of transglycosylation activity and cyclodextrin size specificity. |
---|
Related PDB | 1eo5,1eo7 |
---|
[39] |
---|
PubMed ID | 11150613 |
---|
Journal | Biochim Biophys Acta |
---|
Year | 2000 |
---|
Volume | 1543 |
---|
Pages | 336-360 |
---|
Authors | van der Veen BA, Uitdehaag JC, Dijkstra BW, Dijkhuizen L |
---|
Title | Engineering of cyclodextrin glycosyltransferase reaction and product specificity. |
---|
[40] |
---|
PubMed ID | 10651801 |
---|
Journal | Eur J Biochem |
---|
Year | 2000 |
---|
Volume | 267 |
---|
Pages | 658-65 |
---|
Authors | van der Veen BA, van Alebeek GJ, Uitdehaag JC, Dijkstra BW, Dijkhuizen L |
---|
Title | The three transglycosylation reactions catalyzed by cyclodextrin glycosyltransferase from Bacillus circulans (strain 251) proceed via different kinetic mechanisms. |
---|
[41] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 10731709 |
---|
Journal | J Biochem (Tokyo) |
---|
Year | 2000 |
---|
Volume | 127 |
---|
Pages | 383-91 |
---|
Authors | Ishii N, Haga K, Yamane K, Harata K |
---|
Title | Crystal structure of alkalophilic asparagine 233-replaced cyclodextrin glucanotransferase complexed with an inhibitor, acarbose, at 2.0 A resolution. |
---|
Related PDB | 1ded |
---|
[42] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 10686101 |
---|
Journal | J Mol Biol |
---|
Year | 2000 |
---|
Volume | 296 |
---|
Pages | 1027-38 |
---|
Authors | van der Veen BA, Uitdehaag JC, Penninga D, van Alebeek GJ, Smith LM, Dijkstra BW, Dijkhuizen L |
---|
Title | Rational design of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 to increase alpha-cyclodextrin production. |
---|
Related PDB | 1dtu |
---|
[43] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 10679895 |
---|
Journal | J Mol Recognit |
---|
Year | 2000 |
---|
Volume | 13 |
---|
Pages | 35-43 |
---|
Authors | Ishii N, Haga K, Yamane K, Harata K |
---|
Title | Crystal structure of asparagine 233-replaced cyclodextrin glucanotransferase from alkalophilic Bacillus sp. 1011 determined at 1.9 A resolution. |
---|
Related PDB | 1d7f |
---|
[44] |
---|
PubMed ID | 11675025 |
---|
Journal | Carbohydr Res |
---|
Year | 2001 |
---|
Volume | 336 |
---|
Pages | 47-53 |
---|
Authors | Lee SB, Robyt JF |
---|
Title | Trapping of a covalent enzyme intermediate in the reaction of Bacillus macerans cyclomaltodextrin glucanyltransferase with cyclomaltohexaose. |
---|
[45] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 11275559 |
---|
Journal | J Biochem (Tokyo) |
---|
Year | 2001 |
---|
Volume | 129 |
---|
Pages | 593-8 |
---|
Authors | Kanai R, Haga K, Yamane K, Harata K |
---|
Title | Crystal structure of cyclodextrin glucanotransferase from alkalophilic Bacillus sp. 1011 complexed with 1-deoxynojirimycin at 2.0 A resolution. |
---|
Related PDB | 1i75 |
---|
[46] |
---|
PubMed ID | 11555657 |
---|
Journal | J Biol Chem |
---|
Year | 2001 |
---|
Volume | 276 |
---|
Pages | 44557-62 |
---|
Authors | van der Veen BA, Leemhuis H, Kralj S, Uitdehaag JC, Dijkstra BW, Dijkhuizen L |
---|
Title | Hydrophobic amino acid residues in the acceptor binding site are main determinants for reaction mechanism and specificity of cyclodextrin-glycosyltransferase. |
---|
[47] |
---|
PubMed ID | 11288183 |
---|
Journal | Proteins |
---|
Year | 2001 |
---|
Volume | 43 |
---|
Pages | 327-35 |
---|
Authors | Uitdehaag JC, van der Veen BA, Dijkhuizen L, Elber R, Dijkstra BW |
---|
Title | Enzymatic circularization of a malto-octaose linear chain studied by stochastic reaction path calculations on cyclodextrin glycosyltransferase. |
---|
[48] |
---|
PubMed ID | 11943149 |
---|
Journal | FEBS Lett |
---|
Year | 2002 |
---|
Volume | 514 |
---|
Pages | 189-92 |
---|
Authors | Leemhuis H, Dijkstra BW, Dijkhuizen L |
---|
Title | Mutations converting cyclodextrin glycosyltransferase from a transglycosylase into a starch hydrolase. |
---|
[49] |
---|
PubMed ID | 11879012 |
---|
Journal | J Agric Food Chem |
---|
Year | 2002 |
---|
Volume | 50 |
---|
Pages | 1411-5 |
---|
Authors | Lee SH, Kim YW, Lee S, Auh JH, Yoo SS, Kim TJ, Kim JW, Kim ST, Rho HJ, Choi JH, Kim YB, Park KH |
---|
Title | Modulation of cyclizing activity and thermostability of cyclodextrin glucanotransferase and its application as an antistaling enzyme. |
---|
[50] |
---|
PubMed ID | 11790748 |
---|
Journal | J Bacteriol |
---|
Year | 2002 |
---|
Volume | 184 |
---|
Pages | 777-84 |
---|
Authors | Rashid N, Cornista J, Ezaki S, Fukui T, Atomi H, Imanaka T |
---|
Title | Characterization of an archaeal cyclodextrin glucanotransferase with a novel C-terminal domain. |
---|
[51] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 11696539 |
---|
Journal | J Biol Chem |
---|
Year | 2002 |
---|
Volume | 277 |
---|
Pages | 1113-9 |
---|
Authors | Leemhuis H, Uitdehaag JC, Rozeboom HJ, Dijkstra BW, Dijkhuizen L |
---|
Title | The remote substrate binding subsite -6 in cyclodextrin-glycosyltransferase controls the transferase activity of the enzyme via an induced-fit mechanism. |
---|
Related PDB | 1kck,1kcl |
---|
[52] |
---|
PubMed ID | 12554949 |
---|
Journal | Acta Crystallogr D Biol Crystallogr |
---|
Year | 2003 |
---|
Volume | 59 |
---|
Pages | 348-9 |
---|
Authors | Choe HW, Park KS, Labahn J, Granzin J, Kim CJ, Buldt G |
---|
Title | Crystallization and preliminary X-ray diffraction studies of alpha-cyclodextrin glucanotransferase isolated from Bacillus macerans. |
---|
[53] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 12809508 |
---|
Journal | Biochemistry |
---|
Year | 2003 |
---|
Volume | 42 |
---|
Pages | 7518-26 |
---|
Authors | Leemhuis H, Rozeboom HJ, Wilbrink M, Euverink GJ, Dijkstra BW, Dijkhuizen L |
---|
Title | Conversion of cyclodextrin glycosyltransferase into a starch hydrolase by directed evolution: the role of alanine 230 in acceptor subsite +1. |
---|
Related PDB | 1pez |
---|
[54] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 12706817 |
---|
Journal | FEBS Lett |
---|
Year | 2003 |
---|
Volume | 541 |
---|
Pages | 47-51 |
---|
Authors | Leemhuis H, Rozeboom HJ, Dijkstra BW, Dijkhuizen L |
---|
Title | The fully conserved Asp residue in conserved sequence region I of the alpha-amylase family is crucial for the catalytic site architecture and activity. |
---|
Related PDB | 1ot1,1ot2 |
---|
[55] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 14769878 |
---|
Journal | J Biochem (Tokyo) |
---|
Year | 2003 |
---|
Volume | 134 |
---|
Pages | 881-91 |
---|
Authors | Haga K, Kanai R, Sakamoto O, Aoyagi M, Harata K, Yamane K |
---|
Title | Effects of essential carbohydrate/aromatic stacking interaction with Tyr100 and Phe259 on substrate binding of cyclodextrin glycosyltransferase from alkalophilic Bacillus sp. 1011. |
---|
Related PDB | 1ukq,1uks,1ukt |
---|
[56] |
---|
PubMed ID | 12890607 |
---|
Journal | J Biotechnol |
---|
Year | 2003 |
---|
Volume | 103 |
---|
Pages | 203-12 |
---|
Authors | Leemhuis H, Kragh KM, Dijkstra BW, Dijkhuizen L |
---|
Title | Engineering cyclodextrin glycosyltransferase into a starch hydrolase with a high exo-specificity. |
---|
[57] |
---|
PubMed ID | 15023061 |
---|
Journal | Biochemistry |
---|
Year | 2004 |
---|
Volume | 43 |
---|
Pages | 3104-10 |
---|
Authors | Jensen MH, Mirza O, Albenne C, Remaud-Simeon M, Monsan P, Gajhede M, Skov LK |
---|
Title | Crystal structure of the covalent intermediate of amylosucrase from Neisseria polysaccharea. |
---|
[58] |
---|
PubMed ID | 15476414 |
---|
Journal | Biochemistry |
---|
Year | 2004 |
---|
Volume | 43 |
---|
Pages | 13204-13 |
---|
Authors | Leemhuis H, Wehmeier UF, Dijkhuizen L |
---|
Title | Single amino acid mutations interchange the reaction specificities of cyclodextrin glycosyltransferase and the acarbose-modifying enzyme acarviosyl transferase. |
---|
[59] |
---|
PubMed ID | 15096580 |
---|
Journal | Protein Eng Des Sel |
---|
Year | 2004 |
---|
Volume | 17 |
---|
Pages | 205-11 |
---|
Authors | Shim JH, Kim YW, Kim TJ, Chae HY, Park JH, Cha H, Kim JW, Kim YR, Schaefer T, Spendler T, Moon TW, Park KH |
---|
Title | Improvement of cyclodextrin glucanotransferase as an antistaling enzyme by error-prone PCR. |
---|
[60] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 14739329 |
---|
Journal | Protein Sci |
---|
Year | 2004 |
---|
Volume | 13 |
---|
Pages | 457-65 |
---|
Authors | Kanai R, Haga K, Akiba T, Yamane K, Harata K |
---|
Title | Role of Phe283 in enzymatic reaction of cyclodextrin glycosyltransferase from alkalophilic Bacillus sp.1011: Substrate binding and arrangement of the catalytic site. |
---|
Related PDB | 1v3j,1v3k,1v3l,1v3m |
---|
[61] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 14705029 |
---|
Journal | Proteins |
---|
Year | 2004 |
---|
Volume | 54 |
---|
Pages | 128-34 |
---|
Authors | Leemhuis H, Rozeboom HJ, Dijkstra BW, Dijkhuizen L |
---|
Title | Improved thermostability of bacillus circulans cyclodextrin glycosyltransferase by the introduction of a salt bridge. |
---|
Related PDB | 1pj9 |
---|
comments | This enzyme belongs to the glycosidase family-13 (or family of alpha-amylase). Although this enzyme binds two calcium ions on the catalytic domain, they are not involved in catalytic reaction. According to the literature [20], [31], [34], [35], [36] & [39], the reaction proceeds as follows: (1) Asp328 (and/or His327) modulate(s) the activity of Glu257 by raising its pKa, so that the carboxylate of Glu257 is protonated to act as a general acid. (2) Glu257 acts as a general acid, to protonate the leaving O4 atom, leading to the formation of oxocarbonium transition-state (SN1-like reaction). This transition state is stabilized by Asp328 and His327. (3) Asp229 acts as a nucleophile, attacking the C1 atom to form a covalent bond with it, which is an intermediate. (4) The acceptor group, O4 hydroxyl group of the non-reducing end, approaches the active site. (5) Glu257 acts as a general base to deprotonate the acceptor, O4 hydroxyl group. (6) The O4 hydroxyl group makes a nucleophilic attack on the C1 atom, leading to the formation of oxocarbonium transition-state (SN1-like reaction). This transition state is stabilized by Asp328 and His327. (7) Finally, Asp229 is releaased.
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created | updated |
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2005-10-05 | 2011-12-01 |
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