EzCatDB: M00138
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DB codeM00138
CATH domainDomain 1-.-.-.-
Domain 2-.-.-.-
Domain 33.90.56.10 : Phenol Hydroxylase P2 Protein
Domain 4-.-.-.-
Domain 5-.-.-.-
Domain 6-.-.-.-
E.C.1.14.13.7


Enzyme Name
UniProtKBKEGG

P19731
Protein namePhenol hydroxylase P2 proteinphenol 2-monooxygenase
phenol hydroxylase
phenol o-hydroxylase
SynonymsEC 1.14.13.7
Phenol 2-monooxygenase P2 component
PfamPF02406 (MmoB_DmpM)
[Graphical view]

KEGG pathways
MAP codePathways
MAP00361gamma-Hexachlorocyclohexane degradation
MAP00622Toluene and xylene degradation
MAP00626Naphthalene and anthracene degradation

UniProtKB:Accession NumberP19731
Entry nameDMPM_PSEUF
ActivityPhenol + NADPH + O(2) = catechol + NADP(+) + H(2)O.
SubunitThe multicomponent enzyme phenol hydroxylase is formed by P0, P1, P2, P3, P4 and P5 polypeptides.
Subcellular location
CofactorFAD.,Fe(2+).

Compound table: links to PDB-related databases & PoSSuM

CofactorsSubstratesProducts
KEGG-idC00016C00146C00005C00007C00090C00006C00001
CompoundFADPhenolNADPHO2CatecholNADP+H2O
Typeamide group,amine group,aromatic ring (only carbon atom),aromatic ring (with nitrogen atoms),carbohydrate,nucleotidearomatic ring (only carbon atom)amide group,amine group,nucleotideothersaromatic ring (only carbon atom)amide group,amine group,nucleotideH2O
ChEBI16238
15882
16474
27140
26689
15379
18135
18009
15377
PubChem643975
996
20488062
5884
977
289
5886
962
22247451
               
1hqiAUnboundUnboundUnboundUnboundUnboundUnboundUnbound

Active-site residues
pdb
        
1hqiA


references
[1]
PubMed ID8145253
JournalJ Mol Biol
Year1994
Volume238
Pages128-30
AuthorsEnroth C, Huang W, Waters S, Neujahr H, Lindqvist Y, Schneider G
TitleCrystallization and preliminary X-ray analysis of phenol hydroxylase from Trichosporon cutaneum.
[2]
CommentsSTRUCTURE BY NMR
Medline ID97164903
PubMed ID9012665
JournalBiochemistry
Year1997
Volume36
Pages495-504
AuthorsQian H, Edlund U, Powlowski J, Shingler V, Sethson I
TitleSolution structure of phenol hydroxylase protein component P2 determined by NMR spectroscopy.
Related PDB1hqi
Related UniProtKBP19731

comments
This enzyme is composed of six different chains, P0(Swiss-prot;P19729), P1(Swiss-prot;P19730), P2(Swiss-prot;P19731), P3(Swiss-prot;P19732), P4(Swiss-prot;P19733) and P5(Swiss-prot;P19734). PDB structre, 1hqi, corresponds to the structure of P2 component.

createdupdated
2004-02-042009-02-26


Copyright: Nozomi Nagano, JST & CBRC-AIST
Funded by PRESTO/Japan Science and Technology Corporation (JST) (December 2001 - November 2004)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
Funded by BIRD/Japan Science and Technology Corporation (JST) (September 2005 - September 2008)
Funded by BIRD/Japan Science and Technology Corporation (JST) (October 2007 - September 2010)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - )
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