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| Related UniProtKB | P00582 |
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| Related PDB | 1kfd |
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| Related UniProtKB | P00582 |
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| Comments | X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF KLENOW FRAGMENT. |
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| Medline ID | 93227044 |
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| Related PDB | 1kln |
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| Related UniProtKB | P00582 |
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| Comments | Review |
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| Journal | Curr Opin Struct Biol |
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| Year | 1993 |
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| Comments | X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS). |
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| Medline ID | 95364959 |
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| PubMed ID | 7637814 |
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| Year | 1995 |
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| Title | Crystal structure of Thermus aquaticus DNA polymerase. |
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| Related PDB | 1taq |
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| Related UniProtKB | P19821 |
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| Comments | X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 290-832. |
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| Medline ID | 96016150 |
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| PubMed ID | 7568114 |
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| Journal | Proc Natl Acad Sci U S A |
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| Year | 1995 |
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| Volume | 92 |
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| Pages | 9264-8 |
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| Title | Crystal structure of the large fragment of Thermus aquaticus DNA polymerase I at 2.5-A resolution: structural basis for thermostability. |
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| Related PDB | 1ktq |
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| Related UniProtKB | P19821 |
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| PubMed ID | 8679555 |
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| Journal | Biochemistry |
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| Year | 1996 |
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| Volume | 35 |
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| Pages | 7256-66 |
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| Authors | Kaushik N, Pandey VN, Modak MJ |
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| Title | Significance of the O-helix residues of Escherichia coli DNA polymerase I in DNA synthesis: dynamics of the dNTP binding pocket. |
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| Comments | X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS). |
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| Medline ID | 96353982 |
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| PubMed ID | 8717047 |
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| Journal | Nature |
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| Year | 1996 |
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| Volume | 382 |
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| Pages | 278-81 |
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| Title | Structure of Taq ploymerase with DNA at the polymerase active site. |
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| Related PDB | 1tau |
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| Related UniProtKB | P19821 |
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| [20] |
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| PubMed ID | 9214499 |
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| Journal | Nature |
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| Year | 1997 |
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| Volume | 388 |
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| Pages | 33-4 |
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| PubMed ID | 9396823 |
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| Journal | Nucleic Acids Res |
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| Year | 1997 |
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| Volume | 25 |
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| Pages | 5110-8 |
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| Authors | Moser MJ, Holley WR, Chatterjee A, Mian IS |
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| Title | The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains. |
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| Comments | X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 297-876 |
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| Medline ID | 97169447 |
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| PubMed ID | 9016716 |
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| Journal | Structure |
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| Year | 1997 |
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| Volume | 5 |
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| Pages | 95-108 |
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| Authors | Kiefer JR, Mao C, Hansen CJ, Basehore SL, Hogrefe HH, Braman JC, Beese LS |
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| Title | Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution. |
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| Related PDB | 1xwl |
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| Related UniProtKB | P52026 |
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| [23] |
|---|
| Comments | X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 295-832. |
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| Medline ID | 99077817 |
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| PubMed ID | 9857206 |
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| Year | 1998 |
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| Volume | 17 |
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| Pages | 7514-25 |
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| Authors | Li Y, Korolev S, Waksman G |
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| Title | Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation. |
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| Related PDB | 2ktq,3ktq,4ktq |
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| Related UniProtKB | P19821 |
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| [24] |
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| PubMed ID | 9523721 |
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| Journal | Eur J Biochem |
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| Year | 1998 |
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| Volume | 252 |
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| Pages | 124-32 |
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| Authors | Amblar M, Lopez P |
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| Title | Purification and properties of the 5'-3' exonuclease D190-->a mutant of DNA polymerase I from Streptococcus pneumoniae. |
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| PubMed ID | 9571040 |
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| Journal | J Mol Biol |
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| Year | 1998 |
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| Volume | 278 |
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| Pages | 147-65 |
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| Authors | Astatke M, Grindley ND, Joyce CM |
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| Title | How E. coli DNA polymerase I (Klenow fragment) distinguishes between deoxy- and dideoxynucleotides. |
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| [26] |
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| Comments | X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF KLENOW FRAGMENT. |
|---|
| Medline ID | 98181033 |
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| PubMed ID | 9514742 |
|---|
| Journal | J Mol Biol |
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| Year | 1998 |
|---|
| Volume | 277 |
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| Pages | 363-77 |
|---|
| Authors | Brautigam CA, Steitz TA |
|---|
| Title | Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates. |
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| Related PDB | 1kfs,1krp,1ksp |
|---|
| Related UniProtKB | P00582 |
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| [27] |
|---|
| PubMed ID | 9584195 |
|---|
| Journal | Mol Cell Biol |
|---|
| Year | 1998 |
|---|
| Volume | 18 |
|---|
| Pages | 3552-62 |
|---|
| Authors | Mizuno T, Ito N, Yokoi M, Kobayashi A, Tamai K, Miyazawa H, Hanaoka F |
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| Title | The second-largest subunit of the mouse DNA polymerase alpha-primase complex facilitates both production and nuclear translocation of the catalytic subunit of DNA polymerase alpha. |
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| [28] |
|---|
| Comments | X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 297-876 |
|---|
| Medline ID | 98101648 |
|---|
| PubMed ID | 9440698 |
|---|
| Journal | Nature |
|---|
| Year | 1998 |
|---|
| Volume | 391 |
|---|
| Pages | 304-7 |
|---|
| Authors | Kiefer JR, Mao C, Braman JC, Beese LS |
|---|
| Title | Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. |
|---|
| Related PDB | 2bdp,3bdp,4bdp |
|---|
| Related UniProtKB | P52026 |
|---|
| [29] |
|---|
| Comments | X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS). |
|---|
| Medline ID | 98445410 |
|---|
| PubMed ID | 9770525 |
|---|
| Journal | Proc Natl Acad Sci U S A |
|---|
| Year | 1998 |
|---|
| Volume | 95 |
|---|
| Pages | 12562-7 |
|---|
| Authors | Murali R, Sharkey DJ, Daiss JL, Murthy HM |
|---|
| Title | Crystal structure of Taq DNA polymerase in complex with an inhibitory Fab: the Fab is directed against an intermediate in the helix-coil dynamics of the enzyme. |
|---|
| Related PDB | 1bgx |
|---|
| Related UniProtKB | P19821 |
|---|
| [30] |
|---|
| Comments | X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 290-832. |
|---|
| Medline ID | 98266352 |
|---|
| PubMed ID | 9605316 |
|---|
| Journal | Protein Sci |
|---|
| Year | 1998 |
|---|
| Volume | 7 |
|---|
| Pages | 1116-23 |
|---|
| Authors | Li Y, Kong Y, Korolev S, Waksman G |
|---|
| Title | Crystal structures of the Klenow fragment of Thermus aquaticus DNA polymerase I complexed with deoxyribonucleoside triphosphates. |
|---|
| Related PDB | 5ktq |
|---|
| Related UniProtKB | P19821 |
|---|
| [31] |
|---|
| Comments | X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS). |
|---|
| Medline ID | 20133099 |
|---|
| PubMed ID | 10666572 |
|---|
| Journal | Acta Crystallogr D Biol Crystallogr |
|---|
| Year | 1999 |
|---|
| Volume | 55 |
|---|
| Pages | 1971-7 |
|---|
| Authors | Urs UK, Murali R, Krishna Murthy HM |
|---|
| Title | Structure of taq DNA polymerase shows a new orientation for the structure-specific nuclease domain. |
|---|
| Related PDB | 1cmw |
|---|
| Related UniProtKB | P19821 |
|---|
| [32] |
|---|
| Comments | X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF KLENOW FRAGMENT. |
|---|
| Medline ID | 99105820 |
|---|
| PubMed ID | 9888810 |
|---|
| Journal | Biochemistry |
|---|
| Year | 1999 |
|---|
| Volume | 38 |
|---|
| Pages | 696-704 |
|---|
| Authors | Brautigam CA, Sun S, Piccirilli JA, Steitz TA |
|---|
| Title | Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli. |
|---|
| Related PDB | 2kfn,2kfz,2kzm,2kzz |
|---|
| Related UniProtKB | P00582 |
|---|
| [33] |
|---|
| Comments | X-ray crystallography |
|---|
| PubMed ID | 10631518 |
|---|
| Journal | Chem Biol |
|---|
| Year | 1999 |
|---|
| Volume | 6 |
|---|
| Pages | 901-8 |
|---|
| Authors | Brautigam CA, Aschheim K, Steitz TA |
|---|
| Title | Structural elucidation of the binding and inhibitory properties of lanthanide (III) ions at the 3'-5' exonucleolytic active site of the Klenow fragment. |
|---|
| Related PDB | 1qsl |
|---|
| [34] |
|---|
| PubMed ID | 9915846 |
|---|
| Journal | J Biol Chem |
|---|
| Year | 1999 |
|---|
| Volume | 274 |
|---|
| Pages | 3067-75 |
|---|
| Authors | Minnick DT, Bebenek K, Osheroff WP, Turner RM Jr, Astatke M, Liu L, Kunkel TA, Joyce CM |
|---|
| Title | Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment). |
|---|
| [35] |
|---|
| Comments | X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 293-831. |
|---|
| Medline ID | 99380545 |
|---|
| PubMed ID | 10449720 |
|---|
| Journal | Proc Natl Acad Sci U S A |
|---|
| Year | 1999 |
|---|
| Volume | 96 |
|---|
| Pages | 9491-6 |
|---|
| Authors | Li Y, Mitaxov V, Waksman G |
|---|
| Title | Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation. |
|---|
| Related PDB | 1qss,1qsy,1qtm |
|---|
| Related UniProtKB | P19821 |
|---|
| [36] |
|---|
| Comments | X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS) OF KLENOW FRAGMENT. |
|---|
| Medline ID | 20056229 |
|---|
| PubMed ID | 10588690 |
|---|
| Journal | Proc Natl Acad Sci U S A |
|---|
| Year | 1999 |
|---|
| Volume | 96 |
|---|
| Pages | 14240-5 |
|---|
| Authors | Teplova M, Wallace ST, Tereshko V, Minasov G, Symons AM, Cook PD, Manoharan M, Egli M |
|---|
| Title | Structural origins of the exonuclease resistance of a zwitterionic RNA. |
|---|
| Related PDB | 1d8y,1d9d,1d9f |
|---|
| Related UniProtKB | P00582 |
|---|
| [37] |
|---|
| PubMed ID | 10924147 |
|---|
| Journal | Biochemistry |
|---|
| Year | 2000 |
|---|
| Volume | 39 |
|---|
| Pages | 9508-13 |
|---|
| Authors | Kamiya H, Maki H, Kasai H |
|---|
| Title | Two DNA polymerases of Escherichia coli display distinct misinsertion specificities for 2-hydroxy-dATP during DNA synthesis. |
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| [38] |
|---|
| PubMed ID | 11004506 |
|---|
| Journal | Biochim Biophys Acta |
|---|
| Year | 2000 |
|---|
| Volume | 1492 |
|---|
| Pages | 341-52 |
|---|
| Authors | Izumi M, Yokoi M, Nishikawa NS, Miyazawa H, Sugino A, Yamagishi M, Yamaguchi M, Matsukage A, Yatagai F, Hanaoka F |
|---|
| Title | Transcription of the catalytic 180-kDa subunit gene of mouse DNA polymerase alpha is controlled by E2F, an Ets-related transcription factor, and Sp1. |
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| [39] |
|---|
| PubMed ID | 10779513 |
|---|
| Journal | J Biol Chem |
|---|
| Year | 2000 |
|---|
| Volume | 275 |
|---|
| Pages | 19685-92 |
|---|
| Authors | Gangurde R, Kaushik N, Singh K, Modak MJ |
|---|
| Title | A carboxylate triad is essential for the polymerase activity of Escherichia coli DNA polymerase I (Klenow fragment). Presence of two functional triads at the catalytic center. |
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| [40] |
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| PubMed ID | 10818095 |
|---|
| Journal | J Biol Chem |
|---|
| Year | 2000 |
|---|
| Volume | 275 |
|---|
| Pages | 23759-68 |
|---|
| Authors | Tuske S, Singh K, Kaushik N, Modak MJ |
|---|
| Title | The J-helix of Escherichia coli DNA polymerase I (Klenow fragment) regulates polymerase and 3'- 5'-exonuclease functions. |
|---|
| [41] |
|---|
| PubMed ID | 11329298 |
|---|
| Journal | Biochemistry |
|---|
| Year | 2001 |
|---|
| Volume | 40 |
|---|
| Pages | 2282-90 |
|---|
| Authors | Alekseyev YO, Dzantiev L, Romano LJ |
|---|
| Title | Effects of benzo[a]pyrene DNA adducts on Escherichia coli DNA polymerase I (Klenow fragment) primer-template interactions: evidence for inhibition of the catalytically active ternary complex formation. |
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| [42] |
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| PubMed ID | 11506573 |
|---|
| Journal | J Am Chem Soc |
|---|
| Year | 2001 |
|---|
| Volume | 123 |
|---|
| Pages | 8125-6 |
|---|
| Authors | Kuhn U, Warzeska S, Pritzkow H, Kramer R |
|---|
| Title | A bioinspired dicopper(II) catalyst for the transesterification of dimethyl phosphate. |
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| [43] |
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| PubMed ID | 11278428 |
|---|
| Journal | J Biol Chem |
|---|
| Year | 2001 |
|---|
| Volume | 276 |
|---|
| Pages | 19172-81 |
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| Authors | Amblar M, de Lacoba MG, Corrales MA, Lopez P |
|---|
| Title | Biochemical analysis of point mutations in the 5'-3' exonuclease of DNA polymerase I of Streptococcus pneumoniae. Functional and structural implications. |
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| [44] |
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| PubMed ID | 11278911 |
|---|
| Journal | J Biol Chem |
|---|
| Year | 2001 |
|---|
| Volume | 276 |
|---|
| Pages | 18836-42 |
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| Authors | Shinkai A, Patel PH, Loeb LA |
|---|
| Title | The conserved active site motif A of Escherichia coli DNA polymerase I is highly mutable. |
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| [45] |
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| PubMed ID | 11346641 |
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| Journal | J Biol Chem |
|---|
| Year | 2001 |
|---|
| Volume | 276 |
|---|
| Pages | 27562-7 |
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| Authors | Tosaka A, Ogawa M, Yoshida S, Suzuki M |
|---|
| Title | O-helix mutant T664P of Thermus aquaticus DNA polymerase I: altered catalytic properties for incorporation of incorrect nucleotides but not correct nucleotides. |
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| [46] |
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| PubMed ID | 11536367 |
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| Journal | Mol Carcinog |
|---|
| Year | 2001 |
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| Volume | 31 |
|---|
| Pages | 171-83 |
|---|
| Authors | Popanda O, Flohr C, Dai JC, Hunzicker A, Thielmann HW |
|---|
| Title | A mutation in subunit B of the DNA polymerase alpha-primase complex from Novikoff hepatoma cells concomitant with a conformational change and abnormal catalytic properties of the DNA polymerase alpha-primase complex. |
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| [47] |
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| PubMed ID | 11677239 |
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| Journal | J Biol Chem |
|---|
| Year | 2002 |
|---|
| Volume | 277 |
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| Pages | 1653-61 |
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| Authors | Arrigo CJ, Singh K, Modak MJ |
|---|
| Title | DNA polymerase I of Mycobacterium tuberculosis: functional role of a conserved aspartate in the hinge joining the M and N helices. |
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| [48] |
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| PubMed ID | 12364611 |
|---|
| Journal | Nucleic Acids Res |
|---|
| Year | 2002 |
|---|
| Volume | 30 |
|---|
| Pages | 4314-20 |
|---|
| Authors | Yang SW, Astatke M, Potter J, Chatterjee DK |
|---|
| Title | Mutant Thermotoga neapolitana DNA polymerase I: altered catalytic properties for non-templated nucleotide addition and incorporation of correct nucleotides. |
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| [49] |
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| PubMed ID | 12649320 |
|---|
| Journal | Proc Natl Acad Sci U S A |
|---|
| Year | 2003 |
|---|
| Volume | 100 |
|---|
| Pages | 3895-900 |
|---|
| Authors | Johnson SJ, Taylor JS, Beese LS |
|---|
| Title | Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations. |
|---|
| Related PDB | 1l3s,1l3t,1l3u,1l3v,1l5u,1lv5 |
|---|
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