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PubMed ID | 3584108 |
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Journal | J Biol Chem |
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Year | 1987 |
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Volume | 262 |
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Pages | 7105-8 |
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Authors | Hill KA, Castellino FJ |
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Title | Topographical relationships between the monovalent and divalent cation binding sites of des-1-41-light chain bovine plasma protein C and des-1-41-light chain-activated bovine plasma protein C. |
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PubMed ID | 3584107 |
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Journal | J Biol Chem |
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Year | 1987 |
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Volume | 262 |
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Pages | 7098-104 |
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Title | 205Tl+ as a spectroscopic probe of the monovalent cation binding sites of bovine plasma activated protein C and des-1-41-light-chain-activated protein C. |
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PubMed ID | 2839161 |
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Journal | Biochem J |
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Year | 1988 |
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Volume | 251 |
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Pages | 229-36 |
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Authors | Hill KA, Steiner SA, Castellino FJ |
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Title | Estimation of the distance between the divalent cation binding site of des-1-41-light chain-activated bovine plasma protein C and a nitroxide spin label attached to the active-site serine residue. |
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PubMed ID | 2538457 |
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Journal | J Biol Chem |
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PubMed ID | 1939075 |
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Journal | J Biol Chem |
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Volume | 266 |
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Pages | 20139-45 |
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PubMed ID | 1761551 |
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Journal | J Biol Chem |
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Year | 1991 |
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Volume | 266 |
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PubMed ID | 1657904 |
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Journal | J Biol Chem |
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Year | 1991 |
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Volume | 266 |
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Pages | 19886-9 |
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Authors | Zushi M, Gomi K, Honda G, Kondo S, Yamamoto S, Hayashi T, Suzuki K |
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Title | Aspartic acid 349 in the fourth epidermal growth factor-like structure of human thrombomodulin plays a role in its Ca(2+)-mediated binding to protein C. |
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PubMed ID | 1317308 |
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Journal | FASEB J |
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Year | 1992 |
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Volume | 6 |
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Pages | 2561-7 |
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Authors | Walker FJ, Fay PJ |
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Title | Regulation of blood coagulation by the protein C system. |
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PubMed ID | 1309772 |
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Journal | J Biol Chem |
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Year | 1992 |
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Volume | 267 |
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Pages | 703-6 |
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Authors | Hogg PJ, Ohlin AK, Stenflo J |
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Title | Identification of structural domains in protein C involved in its interaction with thrombin-thrombomodulin on the surface of endothelial cells. |
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PubMed ID | 1464619 |
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Journal | J Biol Chem |
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Year | 1992 |
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Volume | 267 |
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Pages | 26078-84 |
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Authors | Zhang L, Castellino FJ |
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Title | Influence of specific gamma-carboxyglutamic acid residues on the integrity of the calcium-dependent conformation of human protein C. |
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PubMed ID | 8216224 |
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Journal | Biochem J |
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Year | 1993 |
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Volume | 295 |
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Pages | 239-45 |
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Authors | Hermans JM, Stone SR |
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Title | Interaction of activated protein C with serpins. |
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PubMed ID | 8251484 |
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Journal | Biochemistry |
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Year | 1993 |
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Volume | 32 |
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Pages | 12656-63 |
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Authors | Mesters RM, Heeb MJ, Griffin JH |
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Title | A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va. |
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[13] |
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Comments | VARIANTS TRP-38; CYS-42; HIS-42; GLN-271 AND ASN-294. |
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Medline ID | 93313192 |
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PubMed ID | 8324221 |
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Journal | Blood |
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Year | 1993 |
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Volume | 82 |
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Pages | 159-68 |
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Authors | Gandrille S, Alhenc-Gelas M, Gaussem P, Aillaud MF, Dupuy E, Juhan-Vague I, Aiach M |
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Title | Five novel mutations located in exons III and IX of the protein C gene in patients presenting with defective protein C anticoagulant activity. |
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Related UniProtKB | P04070 |
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[14] |
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PubMed ID | 8130392 |
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Journal | Glycobiology |
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Year | 1993 |
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Volume | 3 |
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Pages | 597-608 |
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Authors | Yan SB, Chao YB, van Halbeek H |
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Title | Novel Asn-linked oligosaccharides terminating in GalNAc beta (1-->4)[Fuc alpha (1-->3)]GlcNAc beta (1-->.) are present in recombinant human protein C expressed in human kidney 293 cells. |
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[15] |
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Comments | NUCLEOTIDE SEQUENCE OF 43-64 FROM NUCLEIC ACID, AND VARIANT GLY-57 (YONAGO). |
---|
Medline ID | 93237511 |
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PubMed ID | 8477066 |
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Journal | Int J Hematol |
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Year | 1993 |
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Volume | 57 |
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Pages | 9-14 |
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Authors | Mimuro J, Muramatsu S, Kaneko M, Yoshitake S, Iijima K, Nakamura K, Sakata Y, Matsuda M |
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Title | An abnormal protein C (protein C Yonago) with an amino acid substitution of Gly for Arg-15 caused by a single base mutation of C to G in codon 57 (CGG-->GGG). Deteriorated calcium-dependent conformation of the gamma-carboxyglutamic acid domain relevant to a thrombotic tendency. |
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Related UniProtKB | P04070 |
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[16] |
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PubMed ID | 8104182 |
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Journal | J Biol Chem |
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Year | 1993 |
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Volume | 268 |
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Pages | 19943-8 |
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Authors | Rezaie AR, Esmon CT |
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Title | Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecular inhibitors. |
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[17] |
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PubMed ID | 8505327 |
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Journal | J Biol Chem |
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Year | 1993 |
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Volume | 268 |
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Pages | 12040-5 |
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Authors | Zhang L, Castellino FJ |
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Title | The contributions of individual gamma-carboxyglutamic acid residues in the calcium-dependent binding of recombinant human protein C to acidic phospholipid vesicles. |
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[18] |
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PubMed ID | 8401232 |
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Journal | Protein Sci |
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Year | 1993 |
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Volume | 2 |
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Pages | 1482-9 |
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Authors | Mesters RM, Heeb MJ, Griffin JH |
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Title | Interactions and inhibition of blood coagulation factor Va involving residues 311-325 of activated protein C. |
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[19] |
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Comments | REVIEW ON PROC VARIANTS. |
---|
Medline ID | 93190290 |
---|
PubMed ID | 8446940 |
---|
Journal | Thromb Haemost |
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Year | 1993 |
---|
Volume | 69 |
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Pages | 77-84 |
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Authors | Reitsma PH, Poort SR, Bernardi F, Gandrille S, Long GL, Sala N, Cooper DN |
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Title | Protein C deficiency: a database of mutations. For the Protein C & S Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. |
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Related UniProtKB | P04070 |
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[20] |
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PubMed ID | 7980464 |
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Journal | Biochem J |
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Year | 1994 |
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Volume | 303 |
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Pages | 929-33 |
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Authors | Grinnell BW, Gerlitz B, Berg DT |
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Title | Identification of a region in protein C involved in thrombomodulin-stimulated activation by thrombin: potential repulsion at anion-binding site I in thrombin. |
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[21] |
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PubMed ID | 8043441 |
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Journal | Br J Haematol |
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Year | 1994 |
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Volume | 86 |
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Pages | 590-600 |
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Authors | Murakawa M, Okamura T, Kamura T, Kuroiwa M, Harada M, Niho Y |
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Title | A comparative study of partial primary structures of the catalytic region of mammalian protein C. |
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[22] |
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PubMed ID | 7989361 |
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Journal | J Biol Chem |
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Year | 1994 |
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Volume | 269 |
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Pages | 31869-80 |
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Authors | Kalafatis M, Rand MD, Mann KG |
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Title | The mechanism of inactivation of human factor V and human factor Va by activated protein C. |
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[23] |
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PubMed ID | 7906267 |
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Journal | J Biol Chem |
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Year | 1994 |
---|
Volume | 269 |
---|
Pages | 3151-4 |
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Authors | Rezaie AR, Mather T, Sussman F, Esmon CT |
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Title | Mutation of Glu-80-->Lys results in a protein C mutant that no longer requires Ca2+ for rapid activation by the thrombin-thrombomodulin complex. |
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[24] |
---|
PubMed ID | 8106403 |
---|
Journal | J Biol Chem |
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Year | 1994 |
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Volume | 269 |
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Pages | 3590-5 |
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Authors | Zhang L, Castellino FJ |
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Title | The binding energy of human coagulation protein C to acidic phospholipid vesicles contains a major contribution from leucine 5 in the gamma-carboxyglutamic acid domain. |
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[25] |
---|
Comments | Model |
---|
Medline ID | 94272342 |
---|
PubMed ID | 8003977 |
---|
Journal | Protein Sci |
---|
Year | 1994 |
---|
Volume | 3 |
---|
Pages | 588-99 |
---|
Authors | Fisher CL, Greengard JS, Griffin JH |
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Title | Models of the serine protease domain of the human antithrombotic plasma factor activated protein C and its zymogen. |
---|
Related PDB | 2pct |
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[26] |
---|
PubMed ID | 7548032 |
---|
Journal | Biochemistry |
---|
Year | 1995 |
---|
Volume | 34 |
---|
Pages | 12775-81 |
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Authors | Persson E, Ezban M, Shymko RM |
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Title | Kinetics of the interaction between the human factor VIIIa subunits: effects of pH, ionic strength, Ca2+ concentration, heparin, and activated protein C-catalyzed proteolysis. |
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[27] |
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PubMed ID | 7547963 |
---|
Journal | Biochemistry |
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Year | 1995 |
---|
Volume | 34 |
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Pages | 12221-6 |
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Authors | Rezaie AR, Esmon CT |
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Title | Tryptophans 231 and 234 in protein C report the Ca(2+)-dependent conformational change required for activation by the thrombin-thrombomodulin complex. |
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[28] |
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PubMed ID | 7673148 |
---|
Journal | J Biol Chem |
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Year | 1995 |
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Volume | 270 |
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Pages | 21158-66 |
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Authors | Nicolaes GA, Tans G, Thomassen MC, Hemker HC, Pabinger I, Varadi K, Schwarz HP, Rosing J |
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Title | Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C. |
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[29] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 84-461. |
---|
Medline ID | 97157472 |
---|
PubMed ID | 9003757 |
---|
Journal | EMBO J |
---|
Year | 1996 |
---|
Volume | 15 |
---|
Pages | 6822-31 |
---|
Authors | Mather T, Oganessyan V, Hof P, Huber R, Foundling S, Esmon C, Bode W |
---|
Title | The 2.8 A crystal structure of Gla-domainless activated protein C. |
---|
Related PDB | 1aut |
---|
Related UniProtKB | P04070 |
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[30] |
---|
PubMed ID | 8902996 |
---|
Journal | Thromb Haemost |
---|
Year | 1996 |
---|
Volume | 76 |
---|
Pages | 556-60 |
---|
Authors | De Cristofaro R |
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Title | Effect of thrombomodulin on the molecular recognition and early catalytic events in thrombin-protein C interaction. |
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[31] |
---|
PubMed ID | 8713779 |
---|
Journal | Thromb Haemost |
---|
Year | 1996 |
---|
Volume | 75 |
---|
Pages | 49-55 |
---|
Authors | Mori T, Takeya H, Nishioka J, Gabazza EC, Suzuki K |
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Title | beta 2-Glycoprotein I modulates the anticoagulant activity of activated protein C on the phospholipid surface. |
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[32] |
---|
PubMed ID | 8815576 |
---|
Journal | Thromb Haemost |
---|
Year | 1996 |
---|
Volume | 75 |
---|
Pages | 275-82 |
---|
Authors | Nishioka J, Ido M, Hayashi T, Suzuki K |
---|
Title | The Gla26 residue of protein C is required for the binding of protein C to thrombomodulin and endothelial cell protein C receptor, but not to protein S and factor Va. |
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[33] |
---|
PubMed ID | 9334197 |
---|
Journal | J Biol Chem |
---|
Year | 1997 |
---|
Volume | 272 |
---|
Pages | 26279-84 |
---|
Authors | Regan LM, Mollica JS, Rezaie AR, Esmon CT |
---|
Title | The interaction between the endothelial cell protein C receptor and protein C is dictated by the gamma-carboxyglutamic acid domain of protein C. |
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[34] |
---|
PubMed ID | 9300501 |
---|
Journal | Protein Sci |
---|
Year | 1997 |
---|
Volume | 6 |
---|
Pages | 2016-27 |
---|
Authors | Egan JO, Kalafatis M, Mann KG |
---|
Title | The effect of Arg306-->Ala and Arg506-->Gln substitutions in the inactivation of recombinant human factor Va by activated protein C and protein S. |
---|
[35] |
---|
PubMed ID | 9198204 |
---|
Journal | Thromb Haemost |
---|
Year | 1997 |
---|
Volume | 78 |
---|
Pages | 501-11 |
---|
Authors | Bode W, Brandstetter H, Mather T, Stubbs MT |
---|
Title | Comparative analysis of haemostatic proteinases: structural aspects of thrombin, factor Xa, factor IXa and protein C. |
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[36] |
---|
PubMed ID | 9988741 |
---|
Journal | J Biol Chem |
---|
Year | 1999 |
---|
Volume | 274 |
---|
Pages | 4970-6 |
---|
Authors | He X, Rezaie AR |
---|
Title | Identification and characterization of the sodium-binding site of activated protein C. |
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[37] |
---|
PubMed ID | 10096438 |
---|
Journal | Life Sci |
---|
Year | 1999 |
---|
Volume | 64 |
---|
Pages | 879-85 |
---|
Authors | Martinez-Cruz R, Cordoba F, Mireles-Lopez JC, Zenteno E, Perez-Ortega E, Martinez M, Perez-Campos E |
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Title | Effects of concanavalin A on protein-C activity. |
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[38] |
---|
PubMed ID | 10223294 |
---|
Journal | Proteins |
---|
Year | 1999 |
---|
Volume | 35 |
---|
Pages | 218-34 |
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Authors | Knobe KE, Berntsdotter A, Shen L, Morser J, Dahlback B, Villoutreix BO |
---|
Title | Probing the activation of protein C by the thrombin-thrombomodulin complex using structural analysis, site-directed mutagenesis, and computer modeling. |
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[39] |
---|
PubMed ID | 10456457 |
---|
Journal | Thromb Haemost |
---|
Year | 1999 |
---|
Volume | 82 |
---|
Pages | 72-9 |
---|
Authors | Shen L, Villoutreix BO, Dahlback B |
---|
Title | Involvement of Lys 62(217) and Lys 63(218) of human anticoagulant protein C in heparin stimulation of inhibition by the protein C inhibitor. |
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[40] |
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PubMed ID | 10715104 |
---|
Journal | Biochemistry |
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Year | 2000 |
---|
Volume | 39 |
---|
Pages | 2853-60 |
---|
Authors | Shen L, Dahlback B, Villoutreix BO |
---|
Title | Tracking structural features leading to resistance of activated protein C to alpha 1-antitrypsin. |
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[41] |
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PubMed ID | 11106601 |
---|
Journal | Biophys J |
---|
Year | 2000 |
---|
Volume | 79 |
---|
Pages | 2925-43 |
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Authors | Perera L, Foley C, Darden TA, Stafford D, Mather T, Esmon CT, Pedersen LG |
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Title | Modeling zymogen protein C. |
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[42] |
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PubMed ID | 10688829 |
---|
Journal | Blood |
---|
Year | 2000 |
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Volume | 95 |
---|
Pages | 1714-20 |
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Authors | O'Brien LM, Mastri M, Fay PJ |
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Title | Regulation of factor VIIIa by human activated protein C and protein S: inactivation of cofactor in the intrinsic factor Xase. |
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[43] |
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PubMed ID | 11380450 |
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Journal | Br J Haematol |
---|
Year | 2001 |
---|
Volume | 113 |
---|
Pages | 642-8 |
---|
Authors | Lind B, Koefoed P, Thorsen S |
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Title | Symptomatic type 1 protein C deficiency caused by a de novo Ser270Leu mutation in the catalytic domain. |
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[44] |
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PubMed ID | 11309403 |
---|
Journal | J Biol Chem |
---|
Year | 2001 |
---|
Volume | 276 |
---|
Pages | 23105-8 |
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Authors | Friedrich U, Nicolaes GA, Villoutreix BO, Dahlback B |
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Title | Secondary substrate-binding exosite in the serine protease domain of activated protein C important for cleavage at Arg-506 but not at Arg-306 in factor Va. |
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[45] |
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PubMed ID | 11814362 |
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Journal | Biochemistry |
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Year | 2002 |
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Volume | 41 |
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Pages | 1672-80 |
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Authors | Silveira JR, Kalafatis M, Tracy PB |
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Title | Carbohydrate moieties on the procofactor factor V, but not the derived cofactor factor Va, regulate its inactivation by activated protein C. |
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[46] |
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PubMed ID | 11994010 |
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Journal | Biochemistry |
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Year | 2002 |
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Volume | 41 |
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Pages | 6149-57 |
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Authors | Yang L, Manithody C, Rezaie AR |
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Title | Contribution of basic residues of the 70-80-loop to heparin binding and anticoagulant function of activated protein C. |
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[47] |
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PubMed ID | 12034704 |
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Journal | J Biol Chem |
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Year | 2002 |
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Volume | 277 |
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Pages | 24851-4 |
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Authors | Oganesyan V, Oganesyan N, Terzyan S, Qu D, Dauter Z, Esmon NL, Esmon CT |
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Title | The crystal structure of the endothelial protein C receptor and a bound phospholipid. |
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[48] |
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PubMed ID | 12029084 |
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Journal | J Biol Chem |
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Year | 2002 |
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Volume | 277 |
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Pages | 28987-95 |
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Authors | Schmidt AE, Padmanabhan K, Underwood MC, Bode W, Mather T, Bajaj SP |
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Title | Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC). Sodium ion in the APC crystal structure is coordinated to four carbonyl groups from two separate loops. |
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[49] |
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PubMed ID | 12595311 |
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Journal | Blood |
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Year | 2003 |
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Volume | 101 |
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Pages | 4802-7 |
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Authors | Manithody C, Fay PJ, Rezaie AR |
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Title | Exosite-dependent regulation of factor VIIIa by activated protein C. |
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[50] |
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PubMed ID | 12393635 |
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Journal | Blood |
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Year | 2003 |
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Volume | 101 |
---|
Pages | 20-30 |
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Authors | Mann KG, Kalafatis M |
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Title | Factor V: a combination of Dr Jekyll and Mr Hyde. |
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[51] |
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PubMed ID | 12446455 |
---|
Journal | Blood |
---|
Year | 2003 |
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Volume | 101 |
---|
Pages | 2277-84 |
---|
Authors | Sun YH, Shen L, Dahlback B |
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Title | Gla domain-mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding. |
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[52] |
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PubMed ID | 12970121 |
---|
Journal | Chest |
---|
Year | 2003 |
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Volume | 124 |
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Pages | 26S-32S |
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Authors | Esmon CT |
---|
Title | The protein C pathway. |
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[53] |
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PubMed ID | 12554095 |
---|
Journal | Trends Cardiovasc Med |
---|
Year | 2003 |
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Volume | 13 |
---|
Pages | 8-15 |
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Authors | Rezaie AR |
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Title | Exosite-dependent regulation of the protein C anticoagulant pathway. |
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[54] |
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PubMed ID | 15337738 |
---|
Journal | J Biol Chem |
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Year | 2004 |
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Volume | 279 |
---|
Pages | 47528-35 |
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Authors | Sun YH, Tran S, Norstrom EA, Dahlback B |
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Title | Enhanced rate of cleavage at Arg-306 and Arg-506 in coagulation factor Va by Gla domain-mutated human-activated protein C. |
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[55] |
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PubMed ID | 14660667 |
---|
Journal | J Biol Chem |
---|
Year | 2004 |
---|
Volume | 279 |
---|
Pages | 6567-75 |
---|
Authors | van der Neut Kolfschoten M, Dirven RJ, Vos HL, Tans G, Rosing J, Bertina RM |
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Title | Factor Va is inactivated by activated protein C in the absence of cleavage sites at Arg-306, Arg-506, and Arg-679. |
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[56] |
---|
PubMed ID | 15254039 |
---|
Journal | J Biol Chem |
---|
Year | 2004 |
---|
Volume | 279 |
---|
Pages | 38519-24 |
---|
Authors | Yang L, Prasad S, Di Cera E, Rezaie AR |
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Title | The conformation of the activation peptide of protein C is influenced by Ca2+ and Na+ binding. |
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[57] |
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PubMed ID | 15943976 |
---|
Journal | FEBS Lett |
---|
Year | 2005 |
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Volume | 579 |
---|
Pages | 3310-6 |
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Authors | Dahlback B, Villoutreix BO |
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Title | The anticoagulant protein C pathway. |
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[58] |
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PubMed ID | 16113785 |
---|
Journal | Thromb Haemost |
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Year | 2005 |
---|
Volume | 94 |
---|
Pages | 60-8 |
---|
Authors | Yang L, Manithody C, Rezaie AR |
---|
Title | The functional significance of the autolysis loop in protein C and activated protein C. |
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[59] |
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PubMed ID | 16418283 |
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Journal | Proc Natl Acad Sci U S A |
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Year | 2006 |
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Volume | 103 |
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Pages | 879-84 |
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Authors | Yang L, Manithody C, Rezaie AR |
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Title | Activation of protein C by the thrombin-thrombomodulin complex: Cooperative roles of Arg-35 of thrombin and Arg-67 of protein C. |
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