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CATH domain | Related DB codes (homologues) |
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1.10.510.10 : Transferase(Phosphotransferase); domain 1 | M00125,M00124,M00131,T00224,M00127,M00129,M00130,M00132,M00136,M00196,M00197,M00198,M00304,M00323,M00325,M00326,M00327,M00328,M00329,M00330,M00331,M00332,M00333,M00335,M00339 | 2.30.29.30 : PH-domain like | M00125,M00183,M00118 | 3.30.200.20 : Phosphorylase Kinase; domain 1 | M00125,M00124,M00131,T00224,M00127,M00129,M00130,M00132,M00136,M00196,M00197,M00198,M00304,M00323,M00325,M00326,M00327,M00328,M00329,M00330,M00331,M00332,M00333,M00335,M00339,D00298 | 3.30.505.10 : SHC Adaptor Protein | M00183,M00043,M00130,M00148,T00256,M00304,M00333,M00339,T00221 |
Enzyme Name | UniProtKB | KEGG |
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| P51813 |
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Protein name | Cytoplasmic tyrosine-protein kinase BMX | Non-specific protein-tyrosine kinaseATP:protein-tyrosine O-phosphotransferase (ambiguous)Bruton's tyrosine kinaseBMXCytoplasmic protein tyrosine kinaseETKNtk |
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Synonyms | EC 2.7.10.2Bone marrow tyrosine kinase gene in chromosome X proteinEpithelial and endothelial tyrosine kinaseETKNTK38 |
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RefSeq | NP_001712.1 (Protein) NM_001721.6 (DNA/RNA sequence) NP_975010.1 (Protein) NM_203281.2 (DNA/RNA sequence)
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Pfam | PF00779 (BTK) PF00169 (PH) PF07714 (Pkinase_Tyr) PF00017 (SH2) [Graphical view]
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UniProtKB:Accession Number | P51813 |
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Entry name | BMX_HUMAN |
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Activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
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Subunit | Interacts with BCAR1, CAV1, MYD88, PTK2/FAK1, RUFY1, RUFY2, STAT3, TIRAP and TNFRSF1B. |
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Subcellular location | Cytoplasm. Note: Localizes to the edges of spreading cells when complexed with BCAR1. |
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Cofactor | Binds 1 zinc ion per subunit (By similarity). |
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Compound table: links to PDB-related databases & PoSSuM |
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| Cofactors | Substrates | Products |
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KEGG-id | C00305 | C00002 | C00585 | C00008 | C01167 |
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Compound | Magnesium | ATP | [protein]-L-tyrosine | ADP | [protein]-L-tyrosine phosphate |
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Type | divalent metal (Ca2+, Mg2+) | amine group,nucleotide | aromatic ring (only carbon atom),peptide/protein | amine group,nucleotide | aromatic ring (only carbon atom),peptide/protein,phosphate group/phosphate ion |
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ChEBI | 18420
| 15422
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| 16761
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PubChem | 888
| 5957
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| 6022
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| | | | | | | | | | | | |
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2ys2A |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound |
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2ekxA00 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound |
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3sxrA01 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound |
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3sxrB01 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound |
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3sxsA01 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound |
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3sxrA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound |
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3sxrB02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound |
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3sxsA02 |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | Unbound | Unbound |
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References for Catalytic Mechanism | References | Sections | No. of steps in catalysis |
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[1] | Figure 2 |
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references | [1] |
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Comments | REVIEW ON FUNCTION. |
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PubMed ID | 11114746 |
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Journal | Oncogene |
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Year | 2000 |
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Volume | 19 |
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Pages | 5651-61 |
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Authors | Qiu Y, Kung HJ |
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Title | Signaling network of the Btk family kinases. |
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[2] |
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PubMed ID | 11331870 |
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Journal | Nat Cell Biol |
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Year | 2001 |
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Volume | 3 |
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Pages | 439-44 |
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Authors | Chen R, Kim O, Li M, Xiong X, Guan JL, Kung HJ, Chen H, Shimizu Y, Qiu Y |
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Title | Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. |
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[3] |
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PubMed ID | 14532277 |
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Journal | J Biol Chem |
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Year | 2003 |
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Volume | 278 |
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Pages | 51267-76 |
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Authors | Zhang R, Xu Y, Ekman N, Wu Z, Wu J, Alitalo K, Min W |
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Title | Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathway. |
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[4] |
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PubMed ID | 18292575 |
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Journal | J Immunol |
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Year | 2008 |
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Volume | 180 |
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Pages | 3485-91 |
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Authors | Semaan N, Alsaleh G, Gottenberg JE, Wachsmann D, Sibilia J |
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Title | Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. |
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[5] |
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PubMed ID | 21883956 |
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Journal | Chem Biol Drug Des |
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Year | 2011 |
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Volume | 78 |
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Pages | 739-48 |
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Authors | Muckelbauer J, Sack JS, Ahmed N, Burke J, Chang CY, Gao M, Tino J, Xie D, Tebben AJ |
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Title | X-ray crystal structure of bone marrow kinase in the x chromosome: a Tec family kinase. |
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Related PDB | 3sxr,3sxs |
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Related UniProtKB | P51813 |
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comments | This enzyme belongs to Tec family of non-receptor tyrosine kinases. This enzyme is composed of the N-terminal pleckstrin homology (PH) domain, BTK-type zinc finger motif, an unknown domain, which can be Src homology 3 (SH3) domain, Src homology 2 (SH2) domain, and the C-terminal kinase domain (see [1]). The catalytic domain of this enzyme is homologous to Proto-oncogene tyrosine-protein kinase ABL1 (M00130 in EzCatDB), with common active-site residues.
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created | updated |
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2012-06-19 | 2013-01-30 |
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