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CATH domain | Related DB codes (homologues) |
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2.40.40.20 : Barwin-like endoglucanases | M00007 |
Enzyme Name | UniProtKB | KEGG |
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| P0A790 |
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Protein name | Aspartate 1-decarboxylase | aspartate 1-decarboxylaseaspartate alpha-decarboxylaseL-aspartate alpha-decarboxylaseaspartic alpha-decarboxylaseL-aspartate 1-carboxy-lyase |
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Synonyms | EC 4.1.1.11Aspartate alpha-decarboxylase |
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Contains | Aspartate 1-decarboxylase beta chainAspartate 1-decarboxylase alpha chain |
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RefSeq | NP_414673.1 (Protein) NC_000913.2 (DNA/RNA sequence) YP_488434.1 (Protein) NC_007779.1 (DNA/RNA sequence)
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Pfam | PF02261 (Asp_decarbox) [Graphical view]
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KEGG pathways | MAP code | Pathways |
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MAP00252 | Alanine and aspartate metabolism | MAP00410 | beta-Alanine metabolism |
UniProtKB:Accession Number | P0A790 |
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Entry name | PAND_ECOLI |
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Activity | L-aspartate = beta-alanine + CO(2). |
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Subunit | Heterooctamer of four alpha and four beta subunits. |
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Subcellular location | Cytoplasm. |
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Cofactor | Pyruvoyl group. |
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Active-site residues | resource |
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PDB;1aw8 & Swiss-prot;P0A790 & literature;[1],[2],[5] | pdb | Catalytic residues | Modified residues |
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| | | | | | | | | |
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1aw8A |  |  |  |  |  |  |  | LYS 9
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1aw8D |  |  |  |  |  |  |  | LYS 9
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1aw8B |  |  |  |  |  |  |  | TYR 58
| PYR 25(Pyruvoyl Ser)
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1aw8E |  |  |  |  |  |  |  | TYR 58
| PYR 25(Pyruvoyl Ser)
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References for Catalytic Mechanism | References | Sections | No. of steps in catalysis |
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[1] | Scheme 2, p.312 | 2 | [2] | Fig.1b, p.290-291 |
| [5] | Scheme 1 | p.1760 |
references | [1] |
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PubMed ID | 9765870 |
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Journal | Biochem Soc Trans |
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Year | 1998 |
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Volume | 26 |
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Pages | 310-5 |
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Authors | Abell C |
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Title | Enzymes that exploit imines--one way or the other. |
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[2] |
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Comments | X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS). |
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Medline ID | 98206295 |
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PubMed ID | 9546220 |
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Journal | Nat Struct Biol |
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Year | 1998 |
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Volume | 5 |
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Pages | 289-93 |
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Authors | Albert A, Dhanaraj V, Genschel U, Khan G, Ramjee MK, Pulido R, Sibanda BL, von Delft F, Witty M, Blundell TL, Smith AG, Abell C |
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Title | Crystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processing. |
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Related PDB | 1aw8 |
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Related UniProtKB | P0A790 |
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[3] |
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PubMed ID | 10368289 |
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Journal | Structure Fold Des |
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Year | 1999 |
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Volume | 7 |
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Pages | 227-36 |
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Authors | Castillo RM, Mizuguchi K, Dhanaraj V, Albert A, Blundell TL, Murzin AG |
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Title | A six-stranded double-psi beta barrel is shared by several protein superfamilies. |
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[4] |
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PubMed ID | 10610264 |
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Journal | Structure Fold Des |
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Year | 1999 |
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Volume | 7 |
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Pages | R215-6 |
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Authors | Mizuguchi K, Dhanaraj V, Blundell TL, Murzin AG |
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Title | N-ethylmaleimide-sensitive fusion protein (NSF) and CDC48 confirmed as members of the double-psi beta-barrel aspartate decarboxylase/formate dehydrogenase family. |
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[5] |
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PubMed ID | 12240302 |
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Journal | Chem Commun (Camb) |
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Year | 2001 |
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Volume | (18) |
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Pages | 1760-1 |
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Authors | Saldanha SA, Birch LM, Webb ME, Nabbs BK, von Delft F, Smith AG, Abell C |
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Title | Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction. |
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[6] |
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PubMed ID | 12182836 |
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Journal | Protein Expr Purif |
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Year | 2002 |
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Volume | 25 |
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Pages | 533-40 |
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Authors | Chopra S, Pai H, Ranganathan A |
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Title | Expression, purification, and biochemical characterization of Mycobacterium tuberculosis aspartate decarboxylase, PanD. |
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created | updated |
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2004-03-25 | 2009-02-26 |
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