|
KEGG pathways | MAP code | Pathways |
---|
MAP00040 | Pentose and glucuronate interconversions | MAP00051 | Fructose and mannose metabolism | MAP00052 | Galactose metabolism | MAP00561 | Glycerolipid metabolism | MAP00620 | Pyruvate metabolism |
UniProtKB:Accession Number | O08782 | P45377 | P80276 | P15121 |
---|
Entry name | ALD2_CRIGR | ALD2_MOUSE | ALDR_PIG | ALDR_HUMAN |
---|
Activity | Alditol + NAD(P)(+) = aldose + NAD(P)H. | Alditol + NAD(P)(+) = aldose + NAD(P)H. | Alditol + NAD(P)(+) = aldose + NAD(P)H. | Alditol + NAD(P)(+) = aldose + NAD(P)H. |
---|
Subunit | Monomer (By similarity). | Monomer (By similarity). | Monomer. | Monomer. |
---|
Subcellular location | Cytoplasm (By similarity). | Cytoplasm (By similarity). | Cytoplasm. | Cytoplasm. |
---|
Cofactor |
|
|
|
|
---|
Compound table: links to PDB-related databases & PoSSuM |
---|
| Substrates | Products |
---|
KEGG-id | C00004 | C00005 | C01370 | C00080 | C00003 | C00006 | C00717 |
---|
Compound | NADH | NADPH | Aldose | H+ | NAD+ | NADP+ | Alditol |
---|
Type | amide group,amine group,nucleotide | amide group,amine group,nucleotide | carbohydrate | others | amide group,amine group,nucleotide | amide group,amine group,nucleotide | carbohydrate |
---|
ChEBI | 16908
| 16474
|
| 15378
| 15846
| 18009
|
|
---|
PubChem | 439153
| 5884
|
| 1038
| 5893
| 5886
|
|
---|
| | | | | | | | | | | | | | |
---|
1c9wA |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | | Unbound | Bound:NAP | Unbound |
---|
1frbA |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:ZST | | Unbound | Bound:NAP | Unbound |
---|
1ah0A |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:SBI | | Unbound | Bound:NAP | Unbound |
---|
1ah3A |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:TOL | | Unbound | Bound:NAP | Unbound |
---|
1ah4A |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | | Unbound | Bound:NAP | Unbound |
---|
1ekoA |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:I84 | | Unbound | Bound:NAP | Unbound |
---|
1adsA |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | | Unbound | Bound:NAP | Unbound |
---|
1az1A |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:ALR 317 | | Unbound | Bound:NAP | Unbound |
---|
1az2A |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:CIT | | Unbound | Bound:NAP | Unbound |
---|
1ef3A |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:FID | | Unbound | Bound:NAP | Unbound |
---|
1ef3B |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:FID | | Unbound | Bound:NAP | Unbound |
---|
1el3A |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:I84 | | Unbound | Bound:NAP | Unbound |
---|
1ieiA |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:ZES | | Unbound | Bound:NAP | Unbound |
---|
1pwlA |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:1GL | | Unbound | Bound:NAP | Unbound |
---|
1pwmA |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:FID | | Unbound | Bound:NAP | Unbound |
---|
1t40A |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:ID5 | | Unbound | Bound:NAP | Unbound |
---|
1t41A |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:ID5 | | Unbound | Bound:NAP | Unbound |
---|
1us0A |  |  |  |  |  |  |  | Unbound | Bound:NDP | Analogue:LDT | | Unbound | Unbound | Unbound |
---|
1x96A |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:CIT 319 | | Unbound | Bound:NAP | Unbound |
---|
1x97A |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:FIR | | Unbound | Bound:NAP | Unbound |
---|
1x98A |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:CIT | | Unbound | Bound:NAP | Unbound |
---|
1xgdA |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | | Unbound | Unbound | Unbound |
---|
2acqA |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | | Unbound | Bound:NAP | Analogue:G6P |
---|
2acrA |  |  |  |  |  |  |  | Unbound | Unbound | Unbound | | Unbound | Bound:NAP | Analogue:CAC |
---|
2acsA |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:CIT | | Unbound | Bound:NAP | Unbound |
---|
2acuA |  |  |  |  |  |  |  | Unbound | Unbound | Analogue:CIT | | Unbound | Bound:NAP | Unbound |
---|
References for Catalytic Mechanism | References | Sections | No. of steps in catalysis |
---|
[9] | p.84 |
| [10] | p.25690-25692 |
| [12] | p.2028-2031 |
| [13] | Fig.2, p.956 |
| [15] | Fig.6 |
| [16] | p.14327 |
| [18] | p.689-690 |
| [32] | Fig.1, p.223-226 |
| [45] | Scheme 1 |
| [48] | Fig.1 |
|
references | [1] |
---|
PubMed ID | 3138530 |
---|
Journal | Mol Pharmacol |
---|
Year | 1988 |
---|
Volume | 34 |
---|
Pages | 377-87 |
---|
Authors | Ishida T, In Y, Ohishi H, Yamamoto D, Inoue M, Tanaka C, Ueno Y, Ohmomo Y, Kanda N, Tanaka A, et al |
---|
Title | Structure-activity relationship of aldose reductase inhibitors based on X-ray crystal structures of oxazolecarbamate derivatives. |
---|
[2] |
---|
PubMed ID | 2125247 |
---|
Journal | Chem Pharm Bull (Tokyo) |
---|
Year | 1990 |
---|
Volume | 38 |
---|
Pages | 1911-9 |
---|
Authors | Ohishi Y, Mukai T, Nagahara M, Yajima M, Kajikawa N, Miyahara K, Takano T |
---|
Title | Preparations of 5-alkylmethylidene-3-carboxymethylrhodanine derivatives and their aldose reductase inhibitory activity. |
---|
[3] |
---|
PubMed ID | 2120443 |
---|
Journal | J Med Chem |
---|
Year | 1990 |
---|
Volume | 33 |
---|
Pages | 2892-9 |
---|
Authors | Ellingboe J, Alessi T, Millen J, Sredy J, King A, Prusiewicz C, Guzzo F, VanEngen D, Bagli J |
---|
Title | (Pyrimidinyloxy)acetic acids and pyrimidineacetic acids as a novel class of aldose reductase inhibitors. |
---|
[4] |
---|
PubMed ID | 1899452 |
---|
Journal | J Med Chem |
---|
Year | 1991 |
---|
Volume | 34 |
---|
Pages | 108-22 |
---|
Authors | Mylari BL, Larson ER, Beyer TA, Zembrowski WJ, Aldinger CE, Dee MF, Siegel TW, Singleton DH |
---|
Title | Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners. |
---|
[5] |
---|
PubMed ID | 1902521 |
---|
Journal | J Mol Biol |
---|
Year | 1991 |
---|
Volume | 218 |
---|
Pages | 695-8 |
---|
Authors | el-Kabbani O, Narayana SV, Babu YS, Moore KM, Flynn TG, Petrash JM, Westbrook EM, DeLucas LJ, Bugg CE |
---|
Title | Purification, crystallization and preliminary crystallographic analysis of porcine aldose reductase. |
---|
[6] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS) |
---|
Medline ID | 93077587 |
---|
PubMed ID | 1447221 |
---|
Journal | J Biol Chem |
---|
Year | 1992 |
---|
Volume | 267 |
---|
Pages | 24841-7 |
---|
Authors | Borhani DW, Harter TM, Petrash JM |
---|
Title | The crystal structure of the aldose reductase.NADPH binary complex. |
---|
Related PDB | 1abn |
---|
Related UniProtKB | P15121 |
---|
[7] |
---|
PubMed ID | 1613744 |
---|
Journal | J Med Chem |
---|
Year | 1992 |
---|
Volume | 35 |
---|
Pages | 2169-77 |
---|
Authors | Lipinski CA, Aldinger CE, Beyer TA, Bordner J, Burdi DF, Bussolotti DL, Inskeep PB, Siegel TW |
---|
Title | Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors. |
---|
[8] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) |
---|
Medline ID | 92131138 |
---|
PubMed ID | 1734286 |
---|
Journal | Nature |
---|
Year | 1992 |
---|
Volume | 355 |
---|
Pages | 469-72 |
---|
Authors | Rondeau JM, Tete-Favier F, Podjarny A, Reymann JM, Barth P, Biellmann JF, Moras D |
---|
Title | Novel NADPH-binding domain revealed by the crystal structure of aldose reductase. |
---|
Related PDB | 1dla |
---|
Related UniProtKB | P80276 |
---|
[9] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) |
---|
Medline ID | 92320300 |
---|
PubMed ID | 1621098 |
---|
Journal | Science |
---|
Year | 1992 |
---|
Volume | 257 |
---|
Pages | 81-4 |
---|
Authors | Wilson DK, Bohren KM, Gabbay KH, Quiocho FA |
---|
Title | An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications. |
---|
Related PDB | 1ads |
---|
Related UniProtKB | P15121 |
---|
[10] |
---|
Comments | MUTAGENESIS OF ASP-43; TYR-48; LYS-77 AND HIS-110. |
---|
PubMed ID | 8245005 |
---|
Journal | J Biol Chem |
---|
Year | 1993 |
---|
Volume | 268 |
---|
Pages | 25687-93 |
---|
Authors | Tarle I, Borhani DW, Wilson DK, Quiocho FA, Petrash JM |
---|
Title | Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110. |
---|
Related UniProtKB | P15121 |
---|
[11] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) |
---|
Medline ID | 94052189 |
---|
PubMed ID | 8234324 |
---|
Journal | Proc Natl Acad Sci U S A |
---|
Year | 1993 |
---|
Volume | 90 |
---|
Pages | 9847-51 |
---|
Authors | Wilson DK, Tarle I, Petrash JM, Quiocho FA |
---|
Title | Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat. |
---|
Related PDB | 1mar |
---|
Related UniProtKB | P15121 |
---|
[12] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 8117659 |
---|
Journal | Biochemistry |
---|
Year | 1994 |
---|
Volume | 33 |
---|
Pages | 2021-32 |
---|
Authors | Bohren KM, Grimshaw CE, Lai CJ, Harrison DH, Ringe D, Petsko GA, Gabbay KH |
---|
Title | Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme. |
---|
Related PDB | 2acq,2acr,2acs,2acu |
---|
[13] |
---|
PubMed ID | 8039602 |
---|
Journal | Diabetes |
---|
Year | 1994 |
---|
Volume | 43 |
---|
Pages | 955-9 |
---|
Authors | Petrash JM, Tarle I, Wilson DK, Quiocho FA |
---|
Title | Aldose reductase catalysis and crystallography. Insights from recent advances in enzyme structure and function. |
---|
[14] |
---|
PubMed ID | 7484379 |
---|
Journal | Adv Exp Med Biol |
---|
Year | 1995 |
---|
Volume | 372 |
---|
Pages | 193-201 |
---|
Authors | Flynn TG, Green NC, Bhatia MB, el-Kabbani O |
---|
Title | Structure and mechanism of aldehyde reductase. |
---|
[15] |
---|
PubMed ID | 7599122 |
---|
Journal | Biochemistry |
---|
Year | 1995 |
---|
Volume | 34 |
---|
Pages | 8299-308 |
---|
Authors | De Winter HL, von Itzstein M |
---|
Title | Aldose reductase as a target for drug design: molecular modeling calculations on the binding of acyclic sugar substrates to the enzyme. |
---|
[16] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) |
---|
Medline ID | 96062495 |
---|
PubMed ID | 7578036 |
---|
Journal | Biochemistry |
---|
Year | 1995 |
---|
Volume | 34 |
---|
Pages | 14323-30 |
---|
Authors | Wilson DK, Nakano T, Petrash JM, Quiocho FA |
---|
Title | 1.7 A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor. |
---|
Related PDB | 1frb |
---|
Related UniProtKB | P45377 |
---|
[17] |
---|
PubMed ID | 7622427 |
---|
Journal | J Antibiot (Tokyo) |
---|
Year | 1995 |
---|
Volume | 48 |
---|
Pages | 439-46 |
---|
Authors | Matsumoto K, Nagashima K, Kamigauchi T, Kawamura Y, Yasuda Y, Ishii K, Uotani N, Sato T, Nakai H, Terui Y, et al |
---|
Title | Salfredins, new aldose reductase inhibitors produced by Crucibulum sp. RF-3817. I. Fermentation, isolation and structures of salfredins. |
---|
[18] |
---|
PubMed ID | 7552731 |
---|
Journal | Nat Struct Biol |
---|
Year | 1995 |
---|
Volume | 2 |
---|
Pages | 687-92 |
---|
Authors | el-Kabbani O, Judge K, Ginell SL, Myles DA, DeLucas LJ, Flynn TG |
---|
Title | Structure of porcine aldehyde reductase holoenzyme. |
---|
[19] |
---|
PubMed ID | 9059665 |
---|
Journal | Adv Exp Med Biol |
---|
Year | 1997 |
---|
Volume | 414 |
---|
Pages | 579-600 |
---|
Authors | Jez JM, Flynn TG, Penning TM |
---|
Title | A nomenclature system for the aldo-keto reductase superfamily. |
---|
[20] |
---|
PubMed ID | 9059648 |
---|
Journal | Adv Exp Med Biol |
---|
Year | 1997 |
---|
Volume | 414 |
---|
Pages | 435-42 |
---|
Authors | Wilson DK, Nakano T, Petrash JM, Quiocho FA |
---|
Title | Structural studies of aldo-keto reductase inhibition. |
---|
[21] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) |
---|
Medline ID | 98070237 |
---|
PubMed ID | 9405046 |
---|
Journal | Biochemistry |
---|
Year | 1997 |
---|
Volume | 36 |
---|
Pages | 16134-40 |
---|
Authors | Harrison DH, Bohren KM, Petsko GA, Ringe D, Gabbay KH |
---|
Title | The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant. |
---|
Related PDB | 1az1,1az2 |
---|
Related UniProtKB | P15121 |
---|
[22] |
---|
PubMed ID | 9329083 |
---|
Journal | Proteins |
---|
Year | 1997 |
---|
Volume | 29 |
---|
Pages | 186-92 |
---|
Authors | el-Kabbani O, Carper DA, McGowan MH, Devedjiev Y, Rees-Milton KJ, Flynn TG |
---|
Title | Studies on the inhibitor-binding site of porcine aldehyde reductase: crystal structure of the holoenzyme-inhibitor ternary complex. |
---|
[23] |
---|
Comments | X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) |
---|
Medline ID | 97341224 |
---|
PubMed ID | 9195881 |
---|
Journal | Structure |
---|
Year | 1997 |
---|
Volume | 5 |
---|
Pages | 601-12 |
---|
Authors | Urzhumtsev A, Tete-Favier F, Mitschler A, Barbanton J, Barth P, Urzhumtseva L, Biellmann JF, Podjarny A, Moras D |
---|
Title | A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil. |
---|
Related PDB | 1ah0,1ah3,1ah4 |
---|
Related UniProtKB | P80276 |
---|
[24] |
---|
PubMed ID | 9871575 |
---|
Journal | Bioorg Med Chem Lett |
---|
Year | 1998 |
---|
Volume | 8 |
---|
Pages | 641-6 |
---|
Authors | Rastelli G, Costantino L |
---|
Title | Molecular dynamics simulations of the structure of aldose reductase complexed with the inhibitor tolrestat. |
---|
[25] |
---|
PubMed ID | 9822541 |
---|
Journal | J Med Chem |
---|
Year | 1998 |
---|
Volume | 41 |
---|
Pages | 4706-15 |
---|
Authors | Fresneau P, Cussac M, Morand JM, Szymonski B, Tranqui D, Leclerc G |
---|
Title | Synthesis, activity, and molecular modeling of new 2, 4-dioxo-5-(naphthylmethylene)-3-thiazolidineacetic acids and 2-thioxo analogues as potent aldose reductase inhibitors. |
---|
[26] |
---|
PubMed ID | 9767647 |
---|
Journal | J Med Chem |
---|
Year | 1998 |
---|
Volume | 41 |
---|
Pages | 4118-29 |
---|
Authors | Negoro T, Murata M, Ueda S, Fujitani B, Ono Y, Kuromiya A, Komiya M, Suzuki K, Matsumoto J |
---|
Title | Novel, highly potent aldose reductase inhibitors: (R)-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine -4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) and its congeners. |
---|
[27] |
---|
PubMed ID | 9549756 |
---|
Journal | Pharmacol Rev |
---|
Year | 1998 |
---|
Volume | 50 |
---|
Pages | 21-33 |
---|
Authors | Yabe-Nishimura C |
---|
Title | Aldose reductase in glucose toxicity: a potential target for the prevention of diabetic complications. |
---|
[28] |
---|
PubMed ID | 10089480 |
---|
Journal | Acta Crystallogr D Biol Crystallogr |
---|
Year | 1999 |
---|
Volume | 55 |
---|
Pages | 721-3 |
---|
Authors | Lamour V, Barth P, Rogniaux H, Poterszman A, Howard E, Mitschler A, Van Dorsselaer A, Podjarny A, Moras D |
---|
Title | Production of crystals of human aldose reductase with very high resolution diffraction. |
---|
[29] |
---|
PubMed ID | 10533811 |
---|
Journal | Drug Des Discov |
---|
Year | 1999 |
---|
Volume | 16 |
---|
Pages | 155-63 |
---|
Authors | Nakao K, Asao M, Shirai H, Shimizu R |
---|
Title | 3D-pharmacophore analyses of aldose reductase inhibitory spiroquinazolinones. |
---|
[30] |
---|
PubMed ID | 10384727 |
---|
Journal | J Am Soc Mass Spectrom |
---|
Year | 1999 |
---|
Volume | 10 |
---|
Pages | 635-47 |
---|
Authors | Rogniaux H, Van Dorsselaer A, Barth P, Biellmann JF, Barbanton J, van Zandt M, Chevrier B, Howard E, Mitschler A, Potier N, Urzhumtseva L, Moras D, Podjarny A |
---|
Title | Binding of aldose reductase inhibitors: correlation of crystallographic and mass spectrometric studies. |
---|
[31] |
---|
PubMed ID | 10493777 |
---|
Journal | Mol Vis |
---|
Year | 1999 |
---|
Volume | 5 |
---|
Pages | 20 |
---|
Authors | El-Kabbani O, Old SE, Ginell SL, Carper DA |
---|
Title | Aldose and aldehyde reductases: structure-function studies on the coenzyme and inhibitor-binding sites. |
---|
[32] |
---|
PubMed ID | 10584067 |
---|
Journal | Proteins |
---|
Year | 1999 |
---|
Volume | 37 |
---|
Pages | 218-27 |
---|
Authors | Varnai P, Richards WG, Lyne PD |
---|
Title | Modelling the catalytic reaction in human aldose reductase. |
---|
[33] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 10771421 |
---|
Journal | Acta Crystallogr D Biol Crystallogr |
---|
Year | 2000 |
---|
Volume | 56 |
---|
Pages | 536-40 |
---|
Authors | Calderone V, Chevrier B, Van Zandt M, Lamour V, Howard E, Poterszman A, Barth P, Mitschler A, Lu J, Dvornik DM, Klebe G, Kraemer O, Moorman AR, Moras D, Podjarny A |
---|
Title | The structure of human aldose reductase bound to the inhibitor IDD384. |
---|
Related PDB | 1eko,1el3 |
---|
[34] |
---|
PubMed ID | 10882025 |
---|
Journal | Bioorg Med Chem |
---|
Year | 2000 |
---|
Volume | 8 |
---|
Pages | 1151-8 |
---|
Authors | Rastelli G, Antolini L, Benvenuti S, Costantino L |
---|
Title | Structural bases for the inhibition of aldose reductase by phenolic compounds. |
---|
[35] |
---|
PubMed ID | 10764810 |
---|
Journal | J Biol Chem |
---|
Year | 2000 |
---|
Volume | 275 |
---|
Pages | 21587-95 |
---|
Authors | Dixit BL, Balendiran GK, Watowich SJ, Srivastava S, Ramana KV, Petrash JM, Bhatnagar A, Srivastava SK |
---|
Title | Kinetic and structural characterization of the glutathione-binding site of aldose reductase. |
---|
[36] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 10882376 |
---|
Journal | J Med Chem |
---|
Year | 2000 |
---|
Volume | 43 |
---|
Pages | 2479-83 |
---|
Authors | Oka M, Matsumoto Y, Sugiyama S, Tsuruta N, Matsushima M |
---|
Title | A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography. |
---|
Related PDB | 1ef3 |
---|
[37] |
---|
PubMed ID | 10737739 |
---|
Journal | J Med Chem |
---|
Year | 2000 |
---|
Volume | 43 |
---|
Pages | 1062-70 |
---|
Authors | Singh SB, Malamas MS, Hohman TC, Nilakantan R, Carper DA, Kitchen D |
---|
Title | Molecular modeling of the aldose reductase-inhibitor complex based on the X-ray crystal structure and studies with single-site-directed mutants. |
---|
[38] |
---|
PubMed ID | 11025551 |
---|
Journal | Proteins |
---|
Year | 2000 |
---|
Volume | 41 |
---|
Pages | 407-14 |
---|
Authors | El-Kabbani O, Rogniaux H, Barth P, Chung RP, Fletcher EV, Van Dorsselaer A, Podjarny A |
---|
Title | Aldose and aldehyde reductases: correlation of molecular modeling and mass spectrometric studies on the binding of inhibitors to the active site. |
---|
[39] |
---|
PubMed ID | 10651037 |
---|
Journal | Proteins |
---|
Year | 2000 |
---|
Volume | 38 |
---|
Pages | 41-8 |
---|
Authors | Ye Q, Hyndman D, Li X, Flynn TG, Jia Z |
---|
Title | Crystal structure of CHO reductase, a member of the aldo-keto reductase superfamily. |
---|
Related PDB | 1c9w |
---|
[40] |
---|
PubMed ID | 11444967 |
---|
Journal | Biochemistry |
---|
Year | 2001 |
---|
Volume | 40 |
---|
Pages | 8216-26 |
---|
Authors | Kurono M, Fujiwara I, Yoshida K |
---|
Title | Stereospecific interaction of a novel spirosuccinimide type aldose reductase inhibitor, AS-3201, with aldose reductase. |
---|
[41] |
---|
PubMed ID | 11306077 |
---|
Journal | Chem Biol Interact |
---|
Year | 2001 |
---|
Volume | 130-132 |
---|
Pages | 583-95 |
---|
Authors | Nidetzky B, Mayr P, Neuhauser W, Puchberger M |
---|
Title | Structural and functional properties of aldose xylose reductase from the D-xylose-metabolizing yeast Candida tenuis. |
---|
[42] |
---|
PubMed ID | 11306083 |
---|
Journal | Chem Biol Interact |
---|
Year | 2001 |
---|
Volume | 130-132 |
---|
Pages | 651-8 |
---|
Authors | Ye Q, Hyndman D, Green NC, Li L, Jia Z, Flynn TG |
---|
Title | The crystal structure of an aldehyde reductase Y50F mutant-NADP complex and its implications for substrate binding. |
---|
[43] |
---|
PubMed ID | 11278684 |
---|
Journal | J Biol Chem |
---|
Year | 2001 |
---|
Volume | 276 |
---|
Pages | 19132-40 |
---|
Authors | Crosas B, Cederlund E, Torres D, Jornvall H, Farres J, Pares X |
---|
Title | A vertebrate aldo-keto reductase active with retinoids and ethanol. |
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[44] |
---|
PubMed ID | 11356107 |
---|
Journal | J Med Chem |
---|
Year | 2001 |
---|
Volume | 44 |
---|
Pages | 1718-28 |
---|
Authors | Iwata Y, Arisawa M, Hamada R, Kita Y, Mizutani MY, Tomioka N, Itai A, Miyamoto S |
---|
Title | Discovery of novel aldose reductase inhibitors using a protein structure-based approach: 3D-database search followed by design and synthesis. |
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[45] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 11914486 |
---|
Journal | Acta Crystallogr D Biol Crystallogr |
---|
Year | 2002 |
---|
Volume | 58 |
---|
Pages | 622-6 |
---|
Authors | Kinoshita T, Miyake H, Fujii T, Takakura S, Goto T |
---|
Title | The structure of human recombinant aldose reductase complexed with the potent inhibitor zenarestat. |
---|
Related PDB | 1iei |
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[46] |
---|
PubMed ID | 12003638 |
---|
Journal | Biochem J |
---|
Year | 2002 |
---|
Volume | 366 |
---|
Pages | 889-99 |
---|
Authors | Mayr P, Nidetzky B |
---|
Title | Catalytic reaction profile for NADH-dependent reduction of aromatic aldehydes by xylose reductase from Candida tenuis. |
---|
[47] |
---|
PubMed ID | 12102621 |
---|
Journal | Biochemistry |
---|
Year | 2002 |
---|
Volume | 41 |
---|
Pages | 8785-95 |
---|
Authors | Kavanagh KL, Klimacek M, Nidetzky B, Wilson DK |
---|
Title | The structure of apo and holo forms of xylose reductase, a dimeric aldo-keto reductase from Candida tenuis. |
---|
Related PDB | 1jez,1k8c |
---|
[48] |
---|
PubMed ID | 12413844 |
---|
Journal | Bioorg Med Chem |
---|
Year | 2002 |
---|
Volume | 10 |
---|
Pages | 3923-31 |
---|
Authors | Costantino L, Ferrari AM, Gamberini MC, Rastelli G |
---|
Title | Nitrophenyl derivatives as aldose reductase inhibitors. |
---|
[49] |
---|
PubMed ID | 12007809 |
---|
Journal | FEMS Microbiol Lett |
---|
Year | 2002 |
---|
Volume | 209 |
---|
Pages | 223-8 |
---|
Authors | Jeong EY, Kim IS, Lee H |
---|
Title | Identification of lysine-78 as an essential residue in the Saccharomyces cerevisiae xylose reductase. |
---|
[50] |
---|
PubMed ID | 11839745 |
---|
Journal | J Biol Chem |
---|
Year | 2002 |
---|
Volume | 277 |
---|
Pages | 16285-93 |
---|
Authors | Kozma E, Brown E, Ellis EM, Lapthorn AJ |
---|
Title | The crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamily. |
---|
[51] |
---|
PubMed ID | 12193020 |
---|
Journal | J Nat Prod |
---|
Year | 2002 |
---|
Volume | 65 |
---|
Pages | 1151-5 |
---|
Authors | Yoshikawa M, Murakami T, Ishiwada T, Morikawa T, Kagawa M, Higashi Y, Matsuda H |
---|
Title | New flavonol oligoglycosides and polyacylated sucroses with inhibitory effects on aldose reductase and platelet aggregation from the flowers of Prunus mume. |
---|
[52] |
---|
PubMed ID | 12604217 |
---|
Journal | Chem Biol Interact |
---|
Year | 2003 |
---|
Volume | 143-144 |
---|
Pages | 307-16 |
---|
Authors | Lee YS, Hodoscek M, Kador PF, Sugiyama K |
---|
Title | Hydrogen bonding interactions between aldose reductase complexed with NADP(H) and inhibitor tolrestat studied by molecular dynamics simulations and binding assay. |
---|
[53] |
---|
PubMed ID | 12855766 |
---|
Journal | Proc Natl Acad Sci U S A |
---|
Year | 2003 |
---|
Volume | 100 |
---|
Pages | 8742-7 |
---|
Authors | Muzet N, Guillot B, Jelsch C, Howard E, Lecomte C |
---|
Title | Electrostatic complementarity in an aldose reductase complex from ultra-high-resolution crystallography and first-principles calculations. |
---|
[54] |
---|
PubMed ID | 15095003 |
---|
Journal | Cell Mol Life Sci |
---|
Year | 2004 |
---|
Volume | 61 |
---|
Pages | 783-93 |
---|
Authors | Klebe G, Kramer O, Sotriffer C |
---|
Title | Strategies for the design of inhibitors of aldose reductase, an enzyme showing pronounced induced-fit adaptations. |
---|
[55] |
---|
PubMed ID | 15146478 |
---|
Journal | Proteins |
---|
Year | 2004 |
---|
Volume | 55 |
---|
Pages | 792-804 |
---|
Authors | Howard EI, Sanishvili R, Cachau RE, Mitschler A, Chevrier B, Barth P, Lamour V, Van Zandt M, Sibley E, Bon C, Moras D, Schneider TR, Joachimiak A, Podjarny A |
---|
Title | Ultrahigh resolution drug design I: details of interactions in human aldose reductase-inhibitor complex at 0.66 A. |
---|
Related PDB | 1us0 |
---|
[56] |
---|
Comments | X-ray crystallography |
---|
PubMed ID | 15146479 |
---|
Journal | Proteins |
---|
Year | 2004 |
---|
Volume | 55 |
---|
Pages | 805-13 |
---|
Authors | El-Kabbani O, Darmanin C, Schneider TR, Hazemann I, Ruiz F, Oka M, Joachimiak A, Schulze-Briese C, Tomizaki T, Mitschler A, Podjarny A |
---|
Title | Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors. |
---|
Related PDB | 1pwl,1pwm |
---|
[57] |
---|
PubMed ID | 15272156 |
---|
Journal | Acta Crystallogr D Biol Crystallogr |
---|
Year | 2004 |
---|
Volume | 60 |
---|
Pages | 1347-54 |
---|
Authors | Ruiz F, Hazemann I, Mitschler A, Joachimiak A, Schneider T, Karplus M, Podjarny A |
---|
Title | The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48. |
---|
Related PDB | 1t40,1t41 |
---|
[58] |
---|
PubMed ID | 15317464 |
---|
Journal | J Med Chem |
---|
Year | 2004 |
---|
Volume | 47 |
---|
Pages | 4530-7 |
---|
Authors | El-Kabbani O, Darmanin C, Oka M, Schulze-Briese C, Tomizaki T, Hazemann I, Mitschler A, Podjarny A |
---|
Title | High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor. |
---|
Related PDB | 1x96,1x97,1x98 |
---|
[59] |
---|
PubMed ID | 15769597 |
---|
Journal | Biochim Biophys Acta |
---|
Year | 2005 |
---|
Volume | 1748 |
---|
Pages | 201-12 |
---|
Authors | Bohren KM, Brownlee JM, Milne AC, Gabbay KH, Harrison DH |
---|
Title | The structure of Apo R268A human aldose reductase: hinges and latches that control the kinetic mechanism. |
---|
Related PDB | 1xgd |
---|
comments | This enzyme catalyzes the following reaction: (A) Hydride transfer from nicotinamide ring of NAD(P)H to the carbonyl group of substrate (aldose):
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created | updated |
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2004-08-12 | 2009-09-28 |
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