EzCatDB: S00307
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DB codeS00307
CATH domainDomain 13.40.50.300 : Rossmann foldCatalytic domain
E.C.2.7.4.10

CATH domainRelated DB codes (homologues)
3.40.50.300 : Rossmann foldS00527,S00547,S00548,S00550,S00554,S00555,S00671,S00672,S00676,S00680,S00682,S00913,S00914,S00301,S00302,S00303,S00304,S00308,S00305,S00306,S00309,S00310,S00311,M00114,M00199,D00129,D00130,D00540,M00186

Enzyme Name
UniProtKBKEGG

P08760
Protein nameGTP:AMP phosphotransferase mitochondrialnucleoside-triphosphate---adenylate kinase
guanosine triphosphate-adenylate kinase
nucleoside triphosphate-adenosine monophosphate transphosphorylase
GTP:AMP phosphotransferase
isozyme 3 of adenylate kinase
SynonymsEC 2.7.4.10
Adenylate kinase 3
AK 3
Adenylate kinase 3 alpha-like 1
RefSeqNP_776662.1 (Protein)
NM_174237.2 (DNA/RNA sequence)
PfamPF00406 (ADK)
PF05191 (ADK_lid)
[Graphical view]

KEGG pathways
MAP codePathways
MAP00240Pyrimidine metabolism

UniProtKB:Accession NumberP08760
Entry nameKAD3_BOVIN
ActivityNTP + AMP = NDP + ADP.
SubunitMonomer.
Subcellular locationMitochondrion matrix.
Cofactor

Compound table: links to PDB-related databases & PoSSuM

SubstratesProducts
KEGG-idC00044C00020C00035C00008
CompoundGTPAMPGDPADP
Typeamide group,amine group,nucleotideamine group,nucleotideamide group,amine group,nucleotideamine group,nucleotide
ChEBI15996
16027
17552
16761
PubChem6830
6083
8977
6022
            
1ak3AUnboundBound:AMPUnboundUnbound
1ak3BUnboundBound:AMPUnboundUnbound
2ak3AUnboundBound:AMPUnboundUnbound
2ak3BUnboundBound:AMPUnboundUnbound

Active-site residues
resource
similar to S00305
pdbCatalytic residues
         
1ak3ALYS 18;ARG 122
1ak3BLYS 18;ARG 122
2ak3ALYS 18;ARG 122
2ak3BLYS 18;ARG 122


references
[1]
PubMed ID3013690
JournalFEBS Lett
Year1986
Volume202
Pages303-8
AuthorsTomasselli AG, Frank R, Schiltz E
TitleThe complete primary structure of GTP:AMP phosphotransferase from beef heart mitochondria.
[2]
PubMed ID2175649
JournalBiochemistry
Year1990
Volume29
Pages8138-44
AuthorsDiederichs K, Schulz GE
TitleThree-dimensional structure of the complex between the mitochondrial matrix adenylate kinase and its substrate AMP.
Related PDB1ak3
Related UniProtKBP08760
[3]
PubMed ID1994037
JournalJ Mol Biol
Year1991
Volume217
Pages541-9
AuthorsDiederichs K, Schulz GE
TitleThe refined structure of the complex between adenylate kinase from beef heart mitochondrial matrix and its substrate AMP at 1.85 A resolution.
Related PDB2ak3
Related UniProtKBP08760
[4]
PubMed ID8537371
JournalJ Biol Chem
Year1995
Volume270
Pages31103-10
AuthorsSchricker R, Magdolen V, Strobel G, Bogengruber E, Breitenbach M, Bandlow W
TitleStrain-dependent occurrence of functional GTP:AMP phosphotransferase (AK3) in Saccharomyces cerevisiae.
[5]
PubMed ID9665856
JournalJ Mol Biol
Year1998
Volume280
Pages551-8
AuthorsYamada M, Sugahara M, Hishitani Y, Nobumoto M, Nakazawa A
TitleIsolation and characterization of mutated mitochondrial GTP:AMP phosphotransferase.

comments
This enzyme belongs to the adenylate kinase family.
This enzyme, adenylate kinase isozyme-3 (GTP:AMP phosphotransferase), is related to other adenylate kinases (see S00305).

createdupdated
2002-05-312009-02-26


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