EzCatDB: T00021
Related links:    PDB-formatted query search system Fasta-formatted query search system Fasta-formatted query search system

DB codeT00021
CATH domainDomain 12.40.180.10 : Catalase HpII, Chain A, domain 1Catalytic domain
Domain 21.10.422.10
Domain 33.40.50.880 : Rossmann fold
E.C.1.11.1.6
CSA1iph

CATH domainRelated DB codes (homologues)
3.40.50.880 : Rossmann foldD00526,M00215,T00114

Enzyme Name
UniProtKBKEGG

P21179
Protein nameCatalase HPIIcatalase
equilase
caperase
optidase
catalase-peroxidase
CAT
SynonymsEC 1.11.1.6
Hydroxyperoxidase II
RefSeqYP_025308.1 (Protein)
NC_000913.2 (DNA/RNA sequence)
YP_489993.1 (Protein)
NC_007779.1 (DNA/RNA sequence)
PfamPF00199 (Catalase)
PF06628 (Catalase-rel)
[Graphical view]

KEGG pathways
MAP codePathways
MAP00380Tryptophan metabolism
MAP00680Methane metabolism

UniProtKB:Accession NumberP21179
Entry nameCATE_ECOLI
Activity2 H(2)O(2) = O(2) + 2 H(2)O.
SubunitHomotetramer.
Subcellular locationCytoplasm (Probable).
CofactorHeme group.

Compound table: links to PDB-related databases & PoSSuM

CofactorsSubstratesProductsintermediates
KEGG-idC00032C00027C00007C00001


CompoundHemeH2O2O2H2OCompound I Covalent-bonded Tyr415-His392Heme hydroxychlorin spirolactone + covalent-bonded Tyr415-His392
Typearomatic ring (with nitrogen atoms),carboxyl group,heavy metalothersothersH2O


ChEBI17627
26355
16240
27140
26689
15379
15377



PubChem
784
22326046
977
962
22247451



               
1cf9A01Bound:HEMUnboundUnbound  UnboundUnbound
1cf9B01Bound:HEMUnboundUnbound  UnboundUnbound
1cf9C01Bound:HEMUnboundUnbound  UnboundUnbound
1cf9D01Bound:HEMUnboundUnbound  UnboundUnbound
1gg9A01Bound:HEMUnboundUnbound  UnboundUnbound
1gg9B01Bound:HEMUnboundUnbound  UnboundUnbound
1gg9C01Bound:HEMUnboundUnbound  UnboundUnbound
1gg9D01Bound:HEMUnboundUnbound  UnboundUnbound
1ggeA01Analogue:HDDUnboundUnbound  UnboundIntermediate-bound:HDD-TYR 415-HIS 392
1ggeB01Analogue:HDDUnboundUnbound  UnboundIntermediate-bound:HDD-TYR 415-HIS 392
1ggeC01Analogue:HDDUnboundUnbound  UnboundIntermediate-bound:HDD-TYR 415-HIS 392
1ggeD01Analogue:HDDUnboundUnbound  UnboundIntermediate-bound:HDD-TYR 415-HIS 392
1ggfA01Bound:HEMBound:2xPEOUnbound  UnboundUnbound
1ggfB01Bound:HEMBound:2xPEOUnbound  UnboundUnbound
1ggfC01Bound:HEMBound:2xPEOUnbound  UnboundUnbound
1ggfD01Bound:HEMBound:2xPEOUnbound  UnboundUnbound
1gghA01Bound:HEMUnboundUnbound  UnboundUnbound
1gghB01Bound:HEMUnboundUnbound  UnboundUnbound
1gghC01Bound:HEMUnboundUnbound  UnboundUnbound
1gghD01Bound:HEMUnboundUnbound  UnboundUnbound
1ggjA01Analogue:HDDUnboundUnbound  UnboundIntermediate-bound:HDD-TYR 415-HIS 392
1ggjB01Analogue:HDDUnboundUnbound  UnboundIntermediate-bound:HDD-TYR 415-HIS 392
1ggjC01Analogue:HDDUnboundUnbound  UnboundIntermediate-bound:HDD-TYR 415-HIS 392
1ggjD01Analogue:HDDUnboundUnbound  UnboundIntermediate-bound:HDD-TYR 415-HIS 392
1ggkA01Bound:HEMUnboundUnbound  Intermediate-bound:TYR 415-HIS 392Unbound
1ggkB01Bound:HEMUnboundUnbound  Intermediate-bound:TYR 415-HIS 392Unbound
1ggkC01Bound:HEMUnboundUnbound  Intermediate-bound:TYR 415-HIS 392Unbound
1ggkD01Bound:HEMUnboundUnbound  Intermediate-bound:TYR 415-HIS 392Unbound
1iphA01Bound:HEMUnboundUnbound  UnboundUnbound
1iphB01Bound:HEMUnboundUnbound  UnboundUnbound
1iphC01Bound:HEMUnboundUnbound  UnboundUnbound
1iphD01Bound:HEMUnboundUnbound  UnboundUnbound
1p7yA01Bound:HEMUnboundUnbound  UnboundUnbound
1p7yB01Bound:HEMUnboundUnbound  UnboundUnbound
1p7yC01Bound:HEMUnboundUnbound  UnboundUnbound
1p7yD01Bound:HEMUnboundUnbound  UnboundUnbound
1p7zA01Bound:HEMUnboundUnbound  UnboundUnbound
1p7zB01Bound:HEMUnboundUnbound  UnboundUnbound
1p7zC01Bound:HEMUnboundUnbound  UnboundUnbound
1p7zD01Bound:HEMUnboundUnbound  UnboundUnbound
1p80A01Bound:HEMUnboundUnbound  UnboundUnbound
1p80B01Bound:HEMUnboundUnbound  UnboundUnbound
1p80C01Bound:HEMUnboundUnbound  UnboundUnbound
1p80D01Bound:HEMUnboundUnbound  UnboundUnbound
1p81A01Analogue:HDDUnboundUnbound  UnboundIntermediate-bound:HDD-TYR 415-HIS 392
1p81B01Analogue:HDDUnboundUnbound  UnboundIntermediate-bound:HDD-TYR 415-HIS 392
1p81C01Analogue:HDDUnboundUnbound  UnboundIntermediate-bound:HDD-TYR 415-HIS 392
1p81D01Analogue:HDDUnboundUnbound  UnboundIntermediate-bound:HDD-TYR 415-HIS 392
1qf7A01Bound:HEMUnboundUnbound  UnboundUnbound
1qf7B01Bound:HEMUnboundUnbound  UnboundUnbound
1qf7C01Bound:HEMUnboundUnbound  UnboundUnbound
1qf7D01Bound:HEMUnboundUnbound  UnboundUnbound
1qwsA01Bound:HEMUnboundUnbound  Intermediate-bound:TYR 415-HIS 392Unbound
1qwsB01Bound:HEMUnboundUnbound  Intermediate-bound:TYR 415-HIS 392Unbound
1qwsC01Bound:HEMUnboundUnbound  Intermediate-bound:TYR 415-HIS 392Unbound
1qwsD01Bound:HEMUnboundUnbound  Intermediate-bound:TYR 415-HIS 392Unbound
1cf9A02UnboundUnboundUnbound  UnboundUnbound
1cf9B02UnboundUnboundUnbound  UnboundUnbound
1cf9C02UnboundUnboundUnbound  UnboundUnbound
1cf9D02UnboundUnboundUnbound  UnboundUnbound
1gg9A02UnboundUnboundUnbound  UnboundUnbound
1gg9B02UnboundUnboundUnbound  UnboundUnbound
1gg9C02UnboundUnboundUnbound  UnboundUnbound
1gg9D02UnboundUnboundUnbound  UnboundUnbound
1ggeA02UnboundUnboundUnbound  UnboundUnbound
1ggeB02UnboundUnboundUnbound  UnboundUnbound
1ggeC02UnboundUnboundUnbound  UnboundUnbound
1ggeD02UnboundUnboundUnbound  UnboundUnbound
1ggfA02UnboundBound:PEOUnbound  UnboundUnbound
1ggfB02UnboundBound:PEOUnbound  UnboundUnbound
1ggfC02UnboundBound:PEOUnbound  UnboundUnbound
1ggfD02UnboundBound:PEOUnbound  UnboundUnbound
1gghA02UnboundUnboundUnbound  UnboundUnbound
1gghB02UnboundUnboundUnbound  UnboundUnbound
1gghC02UnboundUnboundUnbound  UnboundUnbound
1gghD02UnboundUnboundUnbound  UnboundUnbound
1ggjA02UnboundUnboundUnbound  UnboundUnbound
1ggjB02UnboundUnboundUnbound  UnboundUnbound
1ggjC02UnboundUnboundUnbound  UnboundUnbound
1ggjD02UnboundUnboundUnbound  UnboundUnbound
1ggkA02UnboundUnboundUnbound  UnboundUnbound
1ggkB02UnboundUnboundUnbound  UnboundUnbound
1ggkC02UnboundUnboundUnbound  UnboundUnbound
1ggkD02UnboundUnboundUnbound  UnboundUnbound
1iphA02UnboundUnboundUnbound  UnboundUnbound
1iphB02UnboundUnboundUnbound  UnboundUnbound
1iphC02UnboundUnboundUnbound  UnboundUnbound
1iphD02UnboundUnboundUnbound  UnboundUnbound
1p7yA02UnboundUnboundUnbound  UnboundUnbound
1p7yB02UnboundUnboundUnbound  UnboundUnbound
1p7yC02UnboundUnboundUnbound  UnboundUnbound
1p7yD02UnboundUnboundUnbound  UnboundUnbound
1p7zA02UnboundUnboundUnbound  UnboundUnbound
1p7zB02UnboundUnboundUnbound  UnboundUnbound
1p7zC02UnboundUnboundUnbound  UnboundUnbound
1p7zD02UnboundUnboundUnbound  UnboundUnbound
1p80A02UnboundUnboundUnbound  UnboundUnbound
1p80B02UnboundUnboundUnbound  UnboundUnbound
1p80C02UnboundUnboundUnbound  UnboundUnbound
1p80D02UnboundUnboundUnbound  UnboundUnbound
1p81A02UnboundUnboundUnbound  UnboundUnbound
1p81B02UnboundUnboundUnbound  UnboundUnbound
1p81C02UnboundUnboundUnbound  UnboundUnbound
1p81D02UnboundUnboundUnbound  UnboundUnbound
1qf7A02UnboundUnboundUnbound  UnboundUnbound
1qf7B02UnboundUnboundUnbound  UnboundUnbound
1qf7C02UnboundUnboundUnbound  UnboundUnbound
1qf7D02UnboundUnboundUnbound  UnboundUnbound
1qwsA02UnboundUnboundUnbound  UnboundUnbound
1qwsB02UnboundUnboundUnbound  UnboundUnbound
1qwsC02UnboundUnboundUnbound  UnboundUnbound
1qwsD02UnboundUnboundUnbound  UnboundUnbound
1cf9A03UnboundUnboundUnbound  UnboundUnbound
1cf9B03UnboundUnboundUnbound  UnboundUnbound
1cf9C03UnboundUnboundUnbound  UnboundUnbound
1cf9D03UnboundUnboundUnbound  UnboundUnbound
1gg9A03UnboundUnboundUnbound  UnboundUnbound
1gg9B03UnboundUnboundUnbound  UnboundUnbound
1gg9C03UnboundUnboundUnbound  UnboundUnbound
1gg9D03UnboundUnboundUnbound  UnboundUnbound
1ggeA03UnboundUnboundUnbound  UnboundUnbound
1ggeB03UnboundUnboundUnbound  UnboundUnbound
1ggeC03UnboundUnboundUnbound  UnboundUnbound
1ggeD03UnboundUnboundUnbound  UnboundUnbound
1ggfA03UnboundUnboundUnbound  UnboundUnbound
1ggfB03UnboundUnboundUnbound  UnboundUnbound
1ggfC03UnboundUnboundUnbound  UnboundUnbound
1ggfD03UnboundUnboundUnbound  UnboundUnbound
1gghA03UnboundUnboundUnbound  UnboundUnbound
1gghB03UnboundUnboundUnbound  UnboundUnbound
1gghC03UnboundUnboundUnbound  UnboundUnbound
1gghD03UnboundUnboundUnbound  UnboundUnbound
1ggjA03UnboundUnboundUnbound  UnboundUnbound
1ggjB03UnboundUnboundUnbound  UnboundUnbound
1ggjC03UnboundUnboundUnbound  UnboundUnbound
1ggjD03UnboundUnboundUnbound  UnboundUnbound
1ggkA03UnboundUnboundUnbound  UnboundUnbound
1ggkB03UnboundUnboundUnbound  UnboundUnbound
1ggkC03UnboundUnboundUnbound  UnboundUnbound
1ggkD03UnboundUnboundUnbound  UnboundUnbound
1iphA03UnboundUnboundUnbound  UnboundUnbound
1iphB03UnboundUnboundUnbound  UnboundUnbound
1iphC03UnboundUnboundUnbound  UnboundUnbound
1iphD03UnboundUnboundUnbound  UnboundUnbound
1p7yA03UnboundUnboundUnbound  UnboundUnbound
1p7yB03UnboundUnboundUnbound  UnboundUnbound
1p7yC03UnboundUnboundUnbound  UnboundUnbound
1p7yD03UnboundUnboundUnbound  UnboundUnbound
1p7zA03UnboundUnboundUnbound  UnboundUnbound
1p7zB03UnboundUnboundUnbound  UnboundUnbound
1p7zC03UnboundUnboundUnbound  UnboundUnbound
1p7zD03UnboundUnboundUnbound  UnboundUnbound
1p80A03UnboundUnboundUnbound  UnboundUnbound
1p80B03UnboundUnboundUnbound  UnboundUnbound
1p80C03UnboundUnboundUnbound  UnboundUnbound
1p80D03UnboundUnboundUnbound  UnboundUnbound
1p81A03UnboundUnboundUnbound  UnboundUnbound
1p81B03UnboundUnboundUnbound  UnboundUnbound
1p81C03UnboundUnboundUnbound  UnboundUnbound
1p81D03UnboundUnboundUnbound  UnboundUnbound
1qf7A03UnboundUnboundUnbound  UnboundUnbound
1qf7B03UnboundUnboundUnbound  UnboundUnbound
1qf7C03UnboundUnboundUnbound  UnboundUnbound
1qf7D03UnboundUnboundUnbound  UnboundUnbound
1qwsA03UnboundUnboundUnbound  UnboundUnbound
1qwsB03UnboundUnboundUnbound  UnboundUnbound
1qwsC03UnboundUnboundUnbound  UnboundUnbound
1qwsD03UnboundUnboundUnbound  UnboundUnbound

Active-site residues
resource
Swiss-prot;P21179 & literature [4], [5], [7], [9], [11], [13], [16]
pdbCatalytic residuesCofactor-binding residuescomment
           
1cf9A01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant V169C
1cf9B01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant V169C
1cf9C01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant V169C
1cf9D01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant V169C
1gg9A01       ;ASN 201;HIS 392
TYR 415(Heme binding)
mutant H128N
1gg9B01       ;ASN 201;HIS 392
TYR 415(Heme binding)
mutant H128N
1gg9C01       ;ASN 201;HIS 392
TYR 415(Heme binding)
mutant H128N
1gg9D01       ;ASN 201;HIS 392
TYR 415(Heme binding)
mutant H128N
1ggeA01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
 
1ggeB01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
 
1ggeC01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
 
1ggeD01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
 
1ggfA01       ;ASN 201;HIS 392
TYR 415(Heme binding)
mutant H128N
1ggfB01       ;ASN 201;HIS 392
TYR 415(Heme binding)
mutant H128N
1ggfC01       ;ASN 201;HIS 392
TYR 415(Heme binding)
mutant H128N
1ggfD01       ;ASN 201;HIS 392
TYR 415(Heme binding)
mutant H128N
1gghA01       ;ASN 201;HIS 392
TYR 415(Heme binding)
mutant H128A
1gghB01       ;ASN 201;HIS 392
TYR 415(Heme binding)
mutant H128A
1gghC01       ;ASN 201;HIS 392
TYR 415(Heme binding)
mutant H128A
1gghD01       ;ASN 201;HIS 392
TYR 415(Heme binding)
mutant H128A
1ggjA01HIS 128;       ;HIS 392
TYR 415(Heme binding)
mutant N201A
1ggjB01HIS 128;       ;HIS 392
TYR 415(Heme binding)
mutant N201A
1ggjC01HIS 128;       ;HIS 392
TYR 415(Heme binding)
mutant N201A
1ggjD01HIS 128;       ;HIS 392
TYR 415(Heme binding)
mutant N201A
1ggkA01HIS 128;       ;HIS 392
TYR 415(Heme binding)
mutant N201H
1ggkB01HIS 128;       ;HIS 392
TYR 415(Heme binding)
mutant N201H
1ggkC01HIS 128;       ;HIS 392
TYR 415(Heme binding)
mutant N201H
1ggkD01HIS 128;       ;HIS 392
TYR 415(Heme binding)
mutant N201H
1iphA01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
 
1iphB01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
 
1iphC01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
 
1iphD01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
 
1p7yA01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181A
1p7yB01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181A
1p7yC01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181A
1p7yD01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181A
1p7zA01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181S
1p7zB01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181S
1p7zC01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181S
1p7zD01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181S
1p80A01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181Q
1p80B01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181Q
1p80C01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181Q
1p80D01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181Q
1p81A01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181E
1p81B01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181E
1p81C01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181E
1p81D01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181E
1qf7A01HIS 128;ASN 201;       
TYR 415(Heme binding)
mutant H392Q
1qf7B01HIS 128;ASN 201;       
TYR 415(Heme binding)
mutant H392Q
1qf7C01HIS 128;ASN 201;       
TYR 415(Heme binding)
mutant H392Q
1qf7D01HIS 128;ASN 201;       
TYR 415(Heme binding)
mutant H392Q
1qwsA01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181N
1qwsB01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181N
1qwsC01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181N
1qwsD01HIS 128;ASN 201;HIS 392
TYR 415(Heme binding)
mutant D181N
1cf9A02               
 
 
1cf9B02               
 
 
1cf9C02               
 
 
1cf9D02               
 
 
1gg9A02               
 
 
1gg9B02               
 
 
1gg9C02               
 
 
1gg9D02               
 
 
1ggeA02               
 
 
1ggeB02               
 
 
1ggeC02               
 
 
1ggeD02               
 
 
1ggfA02               
 
 
1ggfB02               
 
 
1ggfC02               
 
 
1ggfD02               
 
 
1gghA02               
 
 
1gghB02               
 
 
1gghC02               
 
 
1gghD02               
 
 
1ggjA02               
 
 
1ggjB02               
 
 
1ggjC02               
 
 
1ggjD02               
 
 
1ggkA02               
 
 
1ggkB02               
 
 
1ggkC02               
 
 
1ggkD02               
 
 
1iphA02               
 
 
1iphB02               
 
 
1iphC02               
 
 
1iphD02               
 
 
1p7yA02               
 
 
1p7yB02               
 
 
1p7yC02               
 
 
1p7yD02               
 
 
1p7zA02               
 
 
1p7zB02               
 
 
1p7zC02               
 
 
1p7zD02               
 
 
1p80A02               
 
 
1p80B02               
 
 
1p80C02               
 
 
1p80D02               
 
 
1p81A02               
 
 
1p81B02               
 
 
1p81C02               
 
 
1p81D02               
 
 
1qf7A02               
 
 
1qf7B02               
 
 
1qf7C02               
 
 
1qf7D02               
 
 
1qwsA02               
 
 
1qwsB02               
 
 
1qwsC02               
 
 
1qwsD02               
 
 
1cf9A03               
 
 
1cf9B03               
 
 
1cf9C03               
 
 
1cf9D03               
 
 
1gg9A03               
 
 
1gg9B03               
 
 
1gg9C03               
 
 
1gg9D03               
 
 
1ggeA03               
 
 
1ggeB03               
 
 
1ggeC03               
 
 
1ggeD03               
 
 
1ggfA03               
 
 
1ggfB03               
 
 
1ggfC03               
 
 
1ggfD03               
 
 
1gghA03               
 
 
1gghB03               
 
 
1gghC03               
 
 
1gghD03               
 
 
1ggjA03               
 
 
1ggjB03               
 
 
1ggjC03               
 
 
1ggjD03               
 
 
1ggkA03               
 
 
1ggkB03               
 
 
1ggkC03               
 
 
1ggkD03               
 
 
1iphA03               
 
 
1iphB03               
 
 
1iphC03               
 
 
1iphD03               
 
 
1p7yA03               
 
 
1p7yB03               
 
 
1p7yC03               
 
 
1p7yD03               
 
 
1p7zA03               
 
 
1p7zB03               
 
 
1p7zC03               
 
 
1p7zD03               
 
 
1p80A03               
 
 
1p80B03               
 
 
1p80C03               
 
 
1p80D03               
 
 
1p81A03               
 
 
1p81B03               
 
 
1p81C03               
 
 
1p81D03               
 
 
1qf7A03               
 
 
1qf7B03               
 
 
1qf7C03               
 
 
1qf7D03               
 
 
1qwsA03               
 
 
1qwsB03               
 
 
1qwsC03               
 
 
1qwsD03               
 
 

References for Catalytic Mechanism
ReferencesSectionsNo. of steps in catalysis
[9]Fig.6, Fig.7, p.1017-1021
[11]Fig.6
[17]


references
[1]
PubMed ID2543292
JournalArch Biochem Biophys
Year1989
Volume271
Pages323-31
AuthorsSchellhorn HE, Pou S, Moody C, Hassan HM
TitleAn electron spin resonance study of oxyradical generation in superoxide dismutase- and catalase-deficient mutants of Escherichia coli K-12.
[2]
PubMed ID2187997
JournalJ Mol Biol
Year1990
Volume213
Pages219-20
AuthorsTormo J, Fita I, Switala J, Loewen PC
TitleCrystallization and preliminary X-ray diffraction analysis of catalase HPII from Escherichia coli.
[3]
PubMed ID1662642
JournalFEBS Lett
Year1991
Volume295
Pages123-6
AuthorsDawson JH, Bracete AM, Huff AM, Kadkhodayan S, Zeitler CM, Sono M, Chang CK, Loewen PC
TitleThe active site structure of E. coli HPII catalase. Evidence favoring coordination of a tyrosinate proximal ligand to the chlorin iron.
[4]
CommentsX-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
Medline ID95393020
PubMed ID7663946
JournalStructure
Year1995
Volume3
Pages491-502
AuthorsBravo J, Verdaguer N, Tormo J, Betzel C, Switala J, Loewen PC, Fita I
TitleCrystal structure of catalase HPII from Escherichia coli.
Related PDB1iph
Related UniProtKBP21179
[5]
PubMed ID8955627
JournalGene
Year1996
Volume179
Pages39-44
AuthorsLoewen P
TitleProbing the structure of catalase HPII of Escherichia coli--a review.
[6]
PubMed ID8621527
JournalJ Biol Chem
Year1996
Volume271
Pages8863-8
AuthorsMurshudov GN, Grebenko AI, Barynin V, Dauter Z, Wilson KS, Vainshtein BK, Melik-Adamyan W, Bravo J, Ferran JM, Ferrer JC, Switala J, Loewen PC, Fita I
TitleStructure of the heme d of Penicillium vitale and Escherichia coli catalases.
[7]
PubMed ID9185614
JournalArch Biochem Biophys
Year1997
Volume342
Pages58-67
AuthorsObinger C, Maj M, Nicholls P, Loewen P
TitleActivity, peroxide compound formation, and heme d synthesis in Escherichia coli HPII catalase.
[8]
PubMed ID9479449
JournalBiochimie
Year1997
Volume79
Pages667-71
AuthorsJouve HM, Andreoletti P, Gouet P, Hajdu J, Gagnon J
TitleStructural analysis of compound I in hemoproteins: study on Proteus mirabilis catalase.
[9]
PubMed ID9144772
JournalProtein Sci
Year1997
Volume6
Pages1016-23
AuthorsBravo J, Fita I, Ferrer JC, Ens W, Hillar A, Switala J, Loewen PC
TitleIdentification of a novel bond between a histidine and the essential tyrosine in catalase HPII of Escherichia coli.
[10]
PubMed ID9659382
JournalBiochim Biophys Acta
Year1998
Volume1384
Pages209-22
AuthorsMaj M, Loewen P, Nicholls P
TitleE. coli HPII catalase interaction with high spin ligands: formate and fluoride as active site probes.
[11]
CommentsX-ray crystallography
PubMed ID10488114
JournalJ Biol Chem
Year1999
Volume274
Pages27717-25
AuthorsMate MJ, Sevinc MS, Hu B, Bujons J, Bravo J, Switala J, Ens W, Loewen PC, Fita I
TitleMutants that alter the covalent structure of catalase hydroperoxidase II from Escherichia coli.
Related PDB1cf9
[12]
CommentsX-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
Medline ID99190072
PubMed ID10091651
JournalProtein Sci
Year1999
Volume8
Pages490-8
AuthorsSevinc MS, Mate MJ, Switala J, Fita I, Loewen PC
TitleRole of the lateral channel in catalase HPII of Escherichia coli.
Related UniProtKBP21179
[13]
PubMed ID10022351
JournalProteins
Year1999
Volume34
Pages155-66
AuthorsBravo J, Mate MJ, Schneider T, Switala J, Wilson K, Loewen PC, Fita I
TitleStructure of catalase HPII from Escherichia coli at 1.9 A resolution.
[14]
PubMed ID11275470
JournalFree Radic Biol Med
Year2001
Volume30
Pages709-14
AuthorsBrunelli L, Yermilov V, Beckman JS
TitleModulation of catalase peroxidatic and catalatic activity by nitric oxide.
[15]
PubMed ID11119647
JournalProteins
Year2001
Volume42
Pages230-6
AuthorsHorvath MM, Grishin NV
TitleThe C-terminal domain of HPII catalase is a member of the type I glutamine amidotransferase superfamily.
[16]
CommentsX-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS).
Medline ID21348730
PubMed ID11455600
JournalProteins
Year2001
Volume44
Pages270-81
AuthorsMelik-Adamyan W, Bravo J, Carpena X, Switala J, Mate MJ, Fita I, Loewen PC
TitleSubstrate flow in catalases deduced from the crystal structures of active site variants of HPII from Escherichia coli.
Related PDB1gg9,1gge,1ggf,1ggh,1ggj,1ggk,1qf7
Related UniProtKBP21179
[17]
CommentsX-ray crystallography
PubMed ID12777389
JournalJ Biol Chem
Year2003
Volume278
Pages31290-6
AuthorsChelikani P, Carpena X, Fita I, Loewen PC
TitleAn electrical potential in the access channel of catalases enhances catalysis.
Related PDB1p7y,1p7z,1p80,1p81,1qws
[18]
PubMed ID14745498
JournalCell Mol Life Sci
Year2004
Volume61
Pages192-208
AuthorsChelikani P, Fita I, Loewen PC
TitleDiversity of structures and properties among catalases.

comments
There are three types of catalases, which are monofunctional catalases, bifunctional catalase-peroxidases and manganese-containing catalases. This enzyme corresponds to monofunctional catalases.
This enzyme catalyzes the following reactions:
(1) Enzyme(Por-Fe(III)) + H2O2 -> Compound I(Por(+)-Fe(IV)=O) + H2O
(2) Compound I(Por(+)-Fe(IV)=O) + H2O2 -> Enzyme(Por-Fe(III)) + H2O + O2
During catalysis, a covalent bond between the ND o the imidazole ring of His392 and the CB of Tyr415 is formed, according to the literature [9]. Moreover, heme group also self-catalyzes to facilitate spirolactone cyclization (see [9]).

createdupdated
2005-05-192009-02-26


Copyright: Nozomi Nagano, JST & CBRC-AIST
Funded by PRESTO/Japan Science and Technology Corporation (JST) (December 2001 - November 2004)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
Funded by BIRD/Japan Science and Technology Corporation (JST) (September 2005 - September 2008)
Funded by BIRD/Japan Science and Technology Corporation (JST) (October 2007 - September 2010)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - )
© Biotechnology Research Institute for Drug Discovery, AIST, 2015-2016 All Rights Reserved.
© Computational Biology Research Center, AIST, 2004-2016 All Rights Reserved.