EzCatDB: T00074
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DB codeT00074
RLCP classification1.13.30000.10 : Hydrolysis
CATH domainDomain 14.10.140.10 : Epsilon-Thrombin; Chain L
Domain 22.40.10.10 : Thrombin, subunit HCatalytic domain
Domain 32.40.10.10 : Thrombin, subunit HCatalytic domain
E.C.3.4.21.5

CATH domainRelated DB codes (homologues)
2.40.10.10 : Thrombin, subunit HM00139,D00214,M00167,D00426,M00133,D00428,D00429,D00430,D00431,D00432,D00433,D00434,D00435,M00227,M00209,D00194,D00197,D00211,D00212,D00216,M00212,D00224,D00497,M00217,M00216,D00528,D00848,D00850,D00851,D00852,D00855,M00152,M00155,M00157,M00181,M00315,M00316,M00317,M00348,M00349,T00410,T00411

Enzyme Name
UniProtKBKEGG

P00734P00735
Protein nameProthrombinProthrombinthrombin
fibrinogenase
thrombase
thrombofort
topical
thrombin-C
tropostasin
activated blood-coagulation factor II
blood-coagulation factor IIa
factor IIa
E thrombin
beta-thrombin
gamma-thrombin
SynonymsEC 3.4.21.5
Coagulation factor II
EC 3.4.21.5
Coagulation factor II
ContainsActivation peptide fragment 1
Activation peptide fragment 2
Thrombin light chain
Thrombin heavy chain
Activation peptide fragment 1
Activation peptide fragment 2
Thrombin light chain
Thrombin heavy chain
RefSeqNP_000497.1 (Protein)
NM_000506.3 (DNA/RNA sequence)
NP_776302.1 (Protein)
NM_173877.1 (DNA/RNA sequence)
MEROPSS01.217 (Serine)
S01.217 (Serine)
PfamPF00594 (Gla)
PF00051 (Kringle)
PF09396 (Thrombin_light)
PF00089 (Trypsin)
[Graphical view]
PF00594 (Gla)
PF00051 (Kringle)
PF09396 (Thrombin_light)
PF00089 (Trypsin)
[Graphical view]


UniProtKB:Accession NumberP00734P00735
Entry nameTHRB_HUMANTHRB_BOVIN
ActivitySelective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Subunit

Subcellular locationSecreted, extracellular space.Secreted, extracellular space.
Cofactor


Compound table: links to PDB-related databases & PoSSuM

SubstratesProductsintermediates
KEGG-idC00012C00393C00001C00290C00952C02404
CompoundPeptideFibrinogenH2OFibrinFibrinopeptide AFibrinopeptide B
Typepeptide/proteinpeptide/proteinH2Oamine group,peptide/proteinpeptide/proteinpeptide/protein
ChEBI

15377
5054



PubChem

962
22247451
439199



               
1a2cLUnboundUnbound UnboundUnboundUnboundUnbound
1a3bLUnboundUnbound UnboundUnboundUnboundUnbound
1a3eLUnboundUnbound UnboundUnboundUnboundUnbound
1a46LUnboundUnbound UnboundUnboundUnboundUnbound
1a4wLUnboundUnbound UnboundUnboundUnboundUnbound
1a5gLUnboundUnbound UnboundUnboundUnboundUnbound
1a61LUnboundUnbound UnboundUnboundUnboundUnbound
1abiLUnboundUnbound UnboundUnboundUnboundUnbound
1abjLUnboundUnbound UnboundUnboundUnboundUnbound
1ad8LUnboundUnbound UnboundUnboundUnboundUnbound
1ae8LUnboundUnbound UnboundUnboundUnboundUnbound
1afeLUnboundUnbound UnboundUnboundUnboundUnbound
1ahtLUnboundUnbound UnboundUnboundUnboundUnbound
1ai8LUnboundUnbound UnboundUnboundUnboundUnbound
1aixLUnboundUnbound UnboundUnboundUnboundUnbound
1avgLUnboundUnbound UnboundUnboundUnboundUnbound
1awfLUnboundUnbound UnboundUnboundUnboundUnbound
1awhAUnboundUnbound UnboundUnboundUnboundUnbound
1awhBUnboundUnbound UnboundUnboundUnboundUnbound
1ay6LUnboundUnbound UnboundUnboundUnboundUnbound
1b5gLUnboundUnbound UnboundUnboundUnboundUnbound
1b7xAUnboundUnbound UnboundUnboundUnboundUnbound
1ba8AUnboundUnbound UnboundUnboundUnboundUnbound
1bb0AUnboundUnbound UnboundUnboundUnboundUnbound
1bbrJUnboundUnbound UnboundUnboundUnboundUnbound
1bbrLUnboundUnbound UnboundUnboundUnboundUnbound
1bbrMUnboundUnbound UnboundUnboundUnboundUnbound
1bcuLUnboundUnbound UnboundUnboundUnboundUnbound
1bhxAUnboundUnbound UnboundUnboundUnboundUnbound
1bmmLUnboundUnbound UnboundUnboundUnboundUnbound
1bmnLUnboundUnbound UnboundUnboundUnboundUnbound
1bthLUnboundUnbound UnboundUnboundUnboundUnbound
1bthJUnboundUnbound UnboundUnboundUnboundUnbound
1c1uLUnboundUnbound UnboundUnboundUnboundUnbound
1c1vLUnboundUnbound UnboundUnboundUnboundUnbound
1c1wLUnboundUnbound UnboundUnboundUnboundUnbound
1c4u1UnboundUnbound UnboundUnboundUnboundUnbound
1c4v1UnboundUnbound UnboundUnboundUnboundUnbound
1c4y1UnboundUnbound UnboundUnboundUnboundUnbound
1c5lLUnboundUnbound UnboundUnboundUnboundUnbound
1c5nLUnboundUnbound UnboundUnboundUnboundUnbound
1c5oLUnboundUnbound UnboundUnboundUnboundUnbound
1ca8AUnboundUnbound UnboundUnboundUnboundUnbound
1d3dAUnboundUnbound UnboundUnboundUnboundUnbound
1d3pAUnboundUnbound UnboundUnboundUnboundUnbound
1d3qAUnboundUnbound UnboundUnboundUnboundUnbound
1d3tAUnboundUnbound UnboundUnboundUnboundUnbound
1d4pAUnboundUnbound UnboundUnboundUnboundUnbound
1de7LUnboundUnbound UnboundUnboundUnboundUnbound
1de7KUnboundUnbound UnboundUnboundUnboundUnbound
1ditLUnboundUnbound UnboundUnboundUnboundUnbound
1dwcLUnboundUnbound UnboundUnboundUnboundUnbound
1dwdLUnboundUnbound UnboundUnboundUnboundUnbound
1dweLUnboundUnbound UnboundUnboundUnboundUnbound
1dx5AUnboundUnbound UnboundUnboundUnboundUnbound
1dx5BUnboundUnbound UnboundUnboundUnboundUnbound
1dx5CUnboundUnbound UnboundUnboundUnboundUnbound
1dx5DUnboundUnbound UnboundUnboundUnboundUnbound
1etrLUnboundUnbound UnboundUnboundUnboundUnbound
1etsLUnboundUnbound UnboundUnboundUnboundUnbound
1ettLUnboundUnbound UnboundUnboundUnboundUnbound
1fpcLUnboundUnbound UnboundUnboundUnboundUnbound
1fphLUnboundUnbound UnboundUnboundUnboundUnbound
1h8dLUnboundUnbound UnboundUnboundUnboundUnbound
1h8iLUnboundUnbound UnboundUnboundUnboundUnbound
1hahLUnboundUnbound UnboundUnboundUnboundUnbound
1haiLUnboundUnbound UnboundUnboundUnboundUnbound
1haoLUnboundUnbound UnboundUnboundUnboundUnbound
1hapLUnboundUnbound UnboundUnboundUnboundUnbound
1hbtLUnboundUnbound UnboundUnboundUnboundUnbound
1hdtLUnboundUnbound UnboundUnboundUnboundUnbound
1hgtLUnboundUnbound UnboundUnboundUnboundUnbound
1hltLUnboundUnbound UnboundUnboundUnboundUnbound
1hltJUnboundUnbound UnboundUnboundUnboundUnbound
1hrtLUnboundUnbound UnboundUnboundUnboundUnbound
1hutLUnboundUnbound UnboundUnboundUnboundUnbound
1hxeLUnboundUnbound UnboundUnboundUnboundUnbound
1hxfLUnboundUnbound UnboundUnboundUnboundUnbound
1ihsLUnboundUnbound UnboundUnboundUnboundUnbound
1ihtLUnboundUnbound UnboundUnboundUnboundUnbound
1lhcLUnboundUnbound UnboundUnboundUnboundUnbound
1lhdLUnboundUnbound UnboundUnboundUnboundUnbound
1lheLUnboundUnbound UnboundUnboundUnboundUnbound
1lhfLUnboundUnbound UnboundUnboundUnboundUnbound
1lhgLUnboundUnbound UnboundUnboundUnboundUnbound
1mkwLUnboundUnbound UnboundUnboundUnboundUnbound
1mkxLUnboundUnbound UnboundUnboundUnboundUnbound
1nrpLUnboundUnbound UnboundUnboundUnboundUnbound
1nrrLUnboundUnbound UnboundUnboundUnboundUnbound
1nrsLUnboundUnbound UnboundUnboundUnboundUnbound
1ppbLUnboundUnbound UnboundUnboundUnboundUnbound
1qbvLUnboundUnbound UnboundUnboundUnboundUnbound
1qhrAUnboundUnbound UnboundUnboundUnboundUnbound
1qj1AUnboundUnbound UnboundUnboundUnboundUnbound
1qj6AUnboundUnbound UnboundUnboundUnboundUnbound
1qj7AUnboundUnbound UnboundUnboundUnboundUnbound
1tbrJUnboundUnbound UnboundUnboundUnboundUnbound
1tbrLUnboundUnbound UnboundUnboundUnboundUnbound
1tbzLUnboundUnbound UnboundUnboundUnboundUnbound
1thpAUnboundUnbound UnboundUnboundUnboundUnbound
1thrLUnboundUnbound UnboundUnboundUnboundUnbound
1thsLUnboundUnbound UnboundUnboundUnboundUnbound
1tmbLUnboundUnbound UnboundUnboundUnboundUnbound
1tmuLUnboundUnbound UnboundUnboundUnboundUnbound
1tomLUnboundUnbound UnboundUnboundUnboundUnbound
1ucyJUnboundUnbound UnboundUnboundUnboundUnbound
1ucyLUnboundUnbound UnboundUnboundUnboundUnbound
1ucyMUnboundUnbound UnboundUnboundUnboundUnbound
1umaLUnboundUnbound UnboundUnboundUnboundUnbound
1uvsLUnboundUnbound UnboundUnboundUnboundUnbound
1uvtLUnboundUnbound UnboundUnboundUnboundUnbound
1uvuLUnboundUnbound UnboundUnboundUnboundUnbound
1ycpJUnboundUnbound UnboundUnboundUnboundUnbound
1ycpLUnboundUnbound UnboundUnboundUnboundUnbound
2hatLUnboundUnbound UnboundUnboundUnboundUnbound
2hgtLUnboundUnbound UnboundUnboundUnboundUnbound
2thfAUnboundUnbound UnboundUnboundUnboundUnbound
3hatLUnboundUnbound UnboundUnboundUnboundUnbound
4htcLUnboundUnbound UnboundUnboundUnboundUnbound
4thnLUnboundUnbound UnboundUnboundUnboundUnbound
5gdsLUnboundUnbound UnboundUnboundUnboundUnbound
7kmeLUnboundUnbound UnboundUnboundUnboundUnbound
8kme1UnboundUnbound UnboundUnboundUnboundUnbound
1a2cH01UnboundUnbound UnboundAnalogue:ENO-2AC-RPH-OAR(chain R)UnboundUnbound
1a3bH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:T29
1a3eH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:T16
1a46H01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:BIC-LYS-OHO(chain R)
1a4wH01Analogue:ANS-ARG-2EP-KTH(chain R)Unbound UnboundUnboundUnboundUnbound
1a5gH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:BIC-ARG-EOA(chain R)
1a61H01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:BIC-ARG-LOM(chain R)
1abiH01Analogue:HMR 3-GLY 4(chain I)Unbound UnboundUnboundUnboundUnbound
1abjH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:PHE-PRO-ARG-CH2(chain I)
1ad8H01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:MDL
1ae8H01Analogue:AZLUnbound UnboundUnboundUnboundUnbound
1afeH01Analogue:ALZUnbound UnboundUnboundUnboundUnbound
1ahtH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:APA
1ai8H01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:T42
1aixH01Analogue:T19Unbound UnboundUnboundUnboundUnbound
1avgH01UnboundUnbound UnboundUnboundUnboundUnbound
1awfH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:GR4
1awhB01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:GR3
1awhD01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:GR3
1ay6H01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:HMF-PRO-ARG-HHO(chain I)
1b5gH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:BCC-ARG-THZ(chain I)
1b7xB01UnboundUnbound UnboundUnboundUnboundIntermediate-bound:PHE-PRO-ARG(chain C)
1ba8B01UnboundUnbound UnboundUnboundUnboundIntermediate-bound:PMS-NVA-GLY-ARG(chain D)
1bb0B01Analogue:PMS-NVA-GLY-3GA(chain D)Unbound UnboundUnboundUnboundUnbound
1bbrEUnboundUnbound UnboundBound:ARG 318(chain F)UnboundUnbound
1bbrK01UnboundUnbound UnboundBound:ARG 318(chain G)UnboundUnbound
1bbrN01UnboundUnbound UnboundBound:ARG 318(chain I)UnboundUnbound
1bcuH01UnboundUnbound UnboundUnboundUnboundUnbound
1bhxFAnalogue:R56Unbound UnboundUnboundUnboundUnbound
1bmmH01Analogue:BM2Unbound UnboundUnboundUnboundUnbound
1bmnH01Analogue:BM9Unbound UnboundUnboundUnboundUnbound
1bthH01Analogue:LYS 15-ALA 16(chain P)Unbound UnboundUnboundUnboundUnbound
1bthK01Analogue:LYS 15-ALA 16(chain Q)Unbound UnboundUnboundUnboundUnbound
1c1uH01Analogue:BAIUnbound UnboundUnboundUnboundUnbound
1c1vH01Analogue:BABUnbound UnboundUnboundUnboundUnbound
1c1wH01Analogue:BAHUnbound UnboundUnboundUnboundUnbound
1c4u201Analogue:IH1Unbound UnboundUnboundUnboundUnbound
1c4v201Analogue:IH2Unbound UnboundUnboundUnboundUnbound
1c4y201Analogue:IH3Unbound UnboundUnboundUnboundUnbound
1c5lH01UnboundUnbound UnboundUnboundUnboundUnbound
1c5nH01UnboundUnbound UnboundUnboundUnboundUnbound
1c5oH01UnboundUnbound UnboundUnboundUnboundUnbound
1ca8B01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:PMS-NVA-GLY-3GA(chain D)
1d3dB01Analogue:BZTUnbound UnboundUnboundUnboundUnbound
1d3pB01Analogue:BT3Unbound UnboundUnboundUnboundUnbound
1d3qB01Analogue:BT2Unbound UnboundUnboundUnboundUnbound
1d3tB01Analogue:BT1Unbound UnboundUnboundUnboundUnbound
1d4pB01Analogue:BPPUnbound UnboundUnboundUnboundUnbound
1d6wA01Analogue:AIM-HMM-SMLUnbound UnboundUnboundUnboundUnbound
1d9iA01Analogue:CHN-HMM-SMLUnbound UnboundUnboundUnboundUnbound
1de7H01UnboundUnbound UnboundUnboundUnboundIntermediate-bound:PRO 36-ARG 37(chain A)
1de7K01UnboundUnbound UnboundUnboundUnboundIntermediate-bound:THR-VAL-GLU-LEU-GLN-GLY-VAL-VAL-PRO-ARG(chain B)
1ditH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:ARG 4-FMT 5(chain P)
1dojA01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:CH3-DPN-PRO-AR2(chain I)
1dwcH01UnboundUnbound UnboundAnalogue:MITUnboundUnbound
1dwdH01Analogue:MIDUnbound UnboundUnboundUnboundUnbound
1dweH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:PHE-PRO-ARG-CH2(chain P)
1dx5M01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:GLU-GLY-ARM(chain E)
1dx5N01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:GLU-GLY-ARM(chain F)
1dx5O01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:GLU-GLY-ARM(chain G)
1dx5P01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:GLU-GLY-ARM(chain H)
1eojA01Analogue:CPI 3-TIH 4(chain B)Unbound UnboundUnboundUnboundUnbound
1eolA01Analogue:CPI 3-NLE 4(chain B)Unbound UnboundUnboundUnboundUnbound
1etrH01UnboundUnbound UnboundAnalogue:MQI-ARG-MCP(chain M)UnboundUnbound
1etsH01Analogue:NAS-GLY-APH-PIP(chain N)Unbound UnboundUnboundUnboundUnbound
1ettH01Analogue:TOS-APH-PIP(chain T)Unbound UnboundUnboundUnboundUnbound
1fpcH01Analogue:ANS-ARG-EPI(chain R)Unbound UnboundUnboundUnboundUnbound
1fphH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:ARG 16-CH2 17(chain F)
1h8dH01UnboundUnbound UnboundAnalogue:PHWUnboundUnbound
1h8iH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:PHW
1hagE01UnboundUnbound UnboundUnboundUnboundUnbound
1hahH01UnboundUnbound UnboundUnboundUnboundUnbound
1haiH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:PHE-PRO-ARG-CH2(chain I)
1haoH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:PHE-PRO-ARG-CH2(chain P)
1hapH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:PHE-PRO-ARG-CH2(chain P)
1hbtH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:ARG 3-PAA 3(chain I)
1hdtH01Analogue:ALG-PHE-ALO-PHE-CH3(chain I)Unbound UnboundUnboundUnboundUnbound
1hgtH01UnboundUnbound UnboundUnboundUnboundUnbound
1hltH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:PHE-PRO-ARG-CH2(chain I)
1hltK01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:PHE-PRO-ARG-CH2(chain M)
1hrtH01UnboundUnbound UnboundUnboundUnboundUnbound
1hutH01UnboundUnbound UnboundAnalogue:PHE-PRO-ARG-CH2(chain I)UnboundUnbound
1hxeH01UnboundUnbound UnboundUnboundUnboundUnbound
1hxfH01UnboundUnbound UnboundUnboundUnboundUnbound
1ihsH01Analogue:ARG 3-CBG 3(chain I)Unbound UnboundUnboundUnboundUnbound
1ihtH01Analogue:ARG 3-PTL 3(chain I)Unbound UnboundUnboundUnboundUnbound
1lhcH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:DP7
1lhdH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:DI2
1lheH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:DI3
1lhfH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:DI4
1lhgH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:DI5
1mkwH01UnboundUnbound UnboundUnboundUnboundUnbound
1mkwK01UnboundUnbound UnboundUnboundUnboundUnbound
1mkxH01UnboundUnbound UnboundUnboundUnboundUnbound
1mkxK01UnboundUnbound UnboundUnboundUnboundUnbound
1nrpH01Analogue:LEU-ASP-PRO-HMR-SERUnbound UnboundUnboundUnboundUnbound
1nrrH01UnboundUnbound UnboundAnalogue:PHE-PRO-ARG-CH2(chain P)UnboundUnbound
1nrsH01UnboundUnbound UnboundBound:LEU-ASP-PRO-ARG(chain R)UnboundUnbound
1ppbH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:PHE-PRO-ARG-CH2(chain I)
1qbvH01Analogue:PPXUnbound UnboundUnboundUnboundUnbound
1qhrB01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:157
1qj1B01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:166
1qj6B01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:167
1qj7B01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:GR1
1tbrH01Analogue:HIS 10-ALA 11(chain R)Unbound UnboundUnboundUnboundUnbound
1tbrK01Analogue:HIS 10-ALA 11(chain S)Unbound UnboundUnboundUnboundUnbound
1tbzH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:DPN-PRO-ARG-THZ(chain R)
1thpB01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:PHE-PRO-ARG-CH2(chain C)
1thrH01UnboundUnbound UnboundUnboundUnboundUnbound
1thsH01UnboundUnbound UnboundUnboundUnboundUnbound
1tmbH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:FOR-ALA-PRO-ARG-FOR-PHE-AHT(chain T)
1tmtH01UnboundUnbound UnboundBound:PHE-PRO-ARG(chain I)UnboundUnbound
1tmuH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:PHE-PRO-ARG-CH2(chain I)
1tomH01Analogue:MINUnbound UnboundUnboundUnboundUnbound
1ucyEAnalogue:OPR 16(chain F)Unbound UnboundUnboundUnboundUnbound
1ucyK01Analogue:OPR 16(chain G)Unbound UnboundUnboundUnboundUnbound
1ucyN01Analogue:OPR 16(chain I)Unbound UnboundUnboundUnboundUnbound
1umaH01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:IN2
1uvsH01Analogue:I11Unbound UnboundUnboundUnboundUnbound
1uvtH01Analogue:I48Unbound UnboundUnboundUnboundUnbound
1uvuH01UnboundUnbound UnboundUnboundUnboundUnbound
1ycpH01Bound:GLY-VAL-ARG-GLY-PRO(chain F)Unbound UnboundUnboundUnboundUnbound
1ycpMBound:GLY-VAL-ARG-GLY-PRO(chain N)Unbound UnboundUnboundUnboundUnbound
2hatH01UnboundUnbound UnboundAnalogue:MBN-ABN-RNG-GLY-VAL-ARG-CH3(chain T)UnboundUnbound
2hgtH01UnboundUnbound UnboundBound:PHE-PRO-ARG(chain I)UnboundUnbound
2thfB01UnboundUnbound UnboundUnboundUnboundIntermediate-analogue:PHE-PRO-ARG-CH2(chain C)
3hatH01UnboundUnbound UnboundBound:RNG-GLY-VAL-ARG(chain T)UnboundUnbound
4htcH01UnboundUnbound UnboundUnboundUnboundUnbound
4thnH01UnboundUnbound UnboundUnboundUnboundUnbound
5gdsH01UnboundUnbound UnboundUnboundUnboundUnbound
7kmeH01UnboundUnbound UnboundUnboundUnboundUnbound
8kme201UnboundUnbound UnboundUnboundUnboundUnbound
1a2cH02UnboundUnbound UnboundUnboundUnboundUnbound
1a3bH02UnboundUnbound UnboundUnboundUnboundUnbound
1a3eH02UnboundUnbound UnboundUnboundUnboundUnbound
1a46H02UnboundUnbound UnboundUnboundUnboundUnbound
1a4wH02UnboundUnbound UnboundUnboundUnboundUnbound
1a5gH02UnboundUnbound UnboundUnboundUnboundUnbound
1a61H02UnboundUnbound UnboundUnboundUnboundUnbound
1abiH02UnboundUnbound UnboundUnboundUnboundUnbound
1abjH02UnboundUnbound UnboundUnboundUnboundUnbound
1ad8H02UnboundUnbound UnboundUnboundUnboundUnbound
1ae8H02UnboundUnbound UnboundUnboundUnboundUnbound
1afeH02UnboundUnbound UnboundUnboundUnboundUnbound
1ahtH02UnboundUnbound UnboundUnboundUnboundUnbound
1ai8H02UnboundUnbound UnboundUnboundUnboundUnbound
1aixH02UnboundUnbound UnboundUnboundUnboundUnbound
1avgH02UnboundUnbound UnboundUnboundUnboundUnbound
1awfH02UnboundUnbound UnboundUnboundUnboundUnbound
1awhB02UnboundUnbound UnboundUnboundUnboundUnbound
1awhD02UnboundUnbound UnboundUnboundUnboundUnbound
1ay6H02UnboundUnbound UnboundUnboundUnboundUnbound
1b5gH02UnboundUnbound UnboundUnboundUnboundUnbound
1b7xB02UnboundUnbound UnboundUnboundUnboundUnbound
1ba8B02UnboundUnbound UnboundUnboundUnboundUnbound
1bb0B02UnboundUnbound UnboundUnboundUnboundUnbound
1bbrHUnboundUnbound UnboundUnboundUnboundUnbound
1bbrK02UnboundUnbound UnboundUnboundUnboundUnbound
1bbrN02UnboundUnbound UnboundUnboundUnboundUnbound
1bcuH02UnboundUnbound UnboundUnboundUnboundUnbound
1bhxBUnboundUnbound UnboundUnboundUnboundUnbound
1bmmH02UnboundUnbound UnboundUnboundUnboundUnbound
1bmnH02UnboundUnbound UnboundUnboundUnboundUnbound
1bthH02UnboundUnbound UnboundUnboundUnboundUnbound
1bthK02UnboundUnbound UnboundUnboundUnboundUnbound
1c1uH02UnboundUnbound UnboundUnboundUnboundUnbound
1c1vH02UnboundUnbound UnboundUnboundUnboundUnbound
1c1wH02UnboundUnbound UnboundUnboundUnboundUnbound
1c4u202UnboundUnbound UnboundUnboundUnboundUnbound
1c4v202UnboundUnbound UnboundUnboundUnboundUnbound
1c4y202UnboundUnbound UnboundUnboundUnboundUnbound
1c5lH02UnboundUnbound UnboundUnboundUnboundUnbound
1c5nH02UnboundUnbound UnboundUnboundUnboundUnbound
1c5oH02UnboundUnbound UnboundUnboundUnboundUnbound
1ca8B02UnboundUnbound UnboundUnboundUnboundUnbound
1d3dB02UnboundUnbound UnboundUnboundUnboundUnbound
1d3pB02UnboundUnbound UnboundUnboundUnboundUnbound
1d3qB02UnboundUnbound UnboundUnboundUnboundUnbound
1d3tB02UnboundUnbound UnboundUnboundUnboundUnbound
1d4pB02UnboundUnbound UnboundUnboundUnboundUnbound
1d6wA02UnboundUnbound UnboundUnboundUnboundUnbound
1d9iA02UnboundUnbound UnboundUnboundUnboundUnbound
1de7H02UnboundUnbound UnboundUnboundUnboundUnbound
1de7K02UnboundUnbound UnboundUnboundUnboundUnbound
1ditH02UnboundUnbound UnboundUnboundUnboundUnbound
1dojA02UnboundUnbound UnboundUnboundUnboundUnbound
1dwcH02UnboundUnbound UnboundUnboundUnboundUnbound
1dwdH02UnboundUnbound UnboundUnboundUnboundUnbound
1dweH02UnboundUnbound UnboundUnboundUnboundUnbound
1dx5M02UnboundUnbound UnboundUnboundUnboundUnbound
1dx5N02UnboundUnbound UnboundUnboundUnboundUnbound
1dx5O02UnboundUnbound UnboundUnboundUnboundUnbound
1dx5P02UnboundUnbound UnboundUnboundUnboundUnbound
1eojA02UnboundUnbound UnboundUnboundUnboundUnbound
1eolA02UnboundUnbound UnboundUnboundUnboundUnbound
1etrH02UnboundUnbound UnboundUnboundUnboundUnbound
1etsH02UnboundUnbound UnboundUnboundUnboundUnbound
1ettH02UnboundUnbound UnboundUnboundUnboundUnbound
1fpcH02UnboundUnbound UnboundUnboundUnboundUnbound
1fphH02UnboundUnbound UnboundUnboundUnboundUnbound
1h8dH02UnboundUnbound UnboundUnboundUnboundUnbound
1h8iH02UnboundUnbound UnboundUnboundUnboundUnbound
1hagE02UnboundUnbound UnboundUnboundUnboundUnbound
1hahH02UnboundUnbound UnboundUnboundUnboundUnbound
1haiH02UnboundUnbound UnboundUnboundUnboundUnbound
1haoH02UnboundUnbound UnboundUnboundUnboundUnbound
1hapH02UnboundUnbound UnboundUnboundUnboundUnbound
1hbtH02UnboundUnbound UnboundUnboundUnboundUnbound
1hdtH02UnboundUnbound UnboundUnboundUnboundUnbound
1hgtH02UnboundUnbound UnboundUnboundUnboundUnbound
1hltH02UnboundUnbound UnboundUnboundUnboundUnbound
1hltK02UnboundUnbound UnboundUnboundUnboundUnbound
1hrtH02UnboundUnbound UnboundUnboundUnboundUnbound
1hutH02UnboundUnbound UnboundUnboundUnboundUnbound
1hxeH02UnboundUnbound UnboundUnboundUnboundUnbound
1hxfH02UnboundUnbound UnboundUnboundUnboundUnbound
1ihsH02UnboundUnbound UnboundUnboundUnboundUnbound
1ihtH02UnboundUnbound UnboundUnboundUnboundUnbound
1lhcH02UnboundUnbound UnboundUnboundUnboundUnbound
1lhdH02UnboundUnbound UnboundUnboundUnboundUnbound
1lheH02UnboundUnbound UnboundUnboundUnboundUnbound
1lhfH02UnboundUnbound UnboundUnboundUnboundUnbound
1lhgH02UnboundUnbound UnboundUnboundUnboundUnbound
1mkwH02UnboundUnbound UnboundUnboundUnboundUnbound
1mkwK02UnboundUnbound UnboundUnboundUnboundUnbound
1mkxH02UnboundUnbound UnboundUnboundUnboundUnbound
1mkxK02UnboundUnbound UnboundUnboundUnboundUnbound
1nrpH02UnboundUnbound UnboundUnboundUnboundUnbound
1nrrH02UnboundUnbound UnboundUnboundUnboundUnbound
1nrsH02UnboundUnbound UnboundUnboundUnboundUnbound
1ppbH02UnboundUnbound UnboundUnboundUnboundUnbound
1qbvH02UnboundUnbound UnboundUnboundUnboundUnbound
1qhrB02UnboundUnbound UnboundUnboundUnboundUnbound
1qj1B02UnboundUnbound UnboundUnboundUnboundUnbound
1qj6B02UnboundUnbound UnboundUnboundUnboundUnbound
1qj7B02UnboundUnbound UnboundUnboundUnboundUnbound
1tbrH02UnboundUnbound UnboundUnboundUnboundUnbound
1tbrK02UnboundUnbound UnboundUnboundUnboundUnbound
1tbzH02UnboundUnbound UnboundUnboundUnboundUnbound
1thpB02UnboundUnbound UnboundUnboundUnboundUnbound
1thrH02UnboundUnbound UnboundUnboundUnboundUnbound
1thsH02UnboundUnbound UnboundUnboundUnboundUnbound
1tmbH02UnboundUnbound UnboundUnboundUnboundUnbound
1tmtH02UnboundUnbound UnboundUnboundUnboundUnbound
1tmuH02UnboundUnbound UnboundUnboundUnboundUnbound
1tomH02UnboundUnbound UnboundUnboundUnboundUnbound
1ucyHUnboundUnbound UnboundUnboundUnboundUnbound
1ucyK02UnboundUnbound UnboundUnboundUnboundUnbound
1ucyN02UnboundUnbound UnboundUnboundUnboundUnbound
1umaH02UnboundUnbound UnboundUnboundUnboundUnbound
1uvsH02UnboundUnbound UnboundUnboundUnboundUnbound
1uvtH02UnboundUnbound UnboundUnboundUnboundUnbound
1uvuH02UnboundUnbound UnboundUnboundUnboundUnbound
1ycpH02UnboundUnbound UnboundUnboundUnboundUnbound
1ycpKUnboundUnbound UnboundUnboundUnboundUnbound
2hatH02UnboundUnbound UnboundUnboundUnboundUnbound
2hgtH02UnboundUnbound UnboundUnboundUnboundUnbound
2thfB02UnboundUnbound UnboundUnboundUnboundUnbound
3hatH02UnboundUnbound UnboundUnboundUnboundUnbound
4htcH02UnboundUnbound UnboundUnboundUnboundUnbound
4thnH02UnboundUnbound UnboundUnboundUnboundUnbound
5gdsH02UnboundUnbound UnboundUnboundUnboundUnbound
7kmeH02UnboundUnbound UnboundUnboundUnboundUnbound
8kme202UnboundUnbound UnboundUnboundUnboundUnbound

Active-site residues
pdbCatalytic residuesMain-chain involved in catalysiscomment
           
1a2cL 
 
 
1a3bL 
 
 
1a3eL 
 
 
1a46L 
 
 
1a4wL 
 
 
1a5gL 
 
 
1a61L 
 
 
1abiL 
 
 
1abjL 
 
 
1ad8L 
 
 
1ae8L 
 
 
1afeL 
 
 
1ahtL 
 
 
1ai8L 
 
 
1aixL 
 
 
1avgL 
 
 
1awfL 
 
 
1awhA 
 
 
1awhB 
 
 
1ay6L 
 
 
1b5gL 
 
 
1b7xA 
 
 
1ba8A 
 
 
1bb0A 
 
 
1bbrJ 
 
 
1bbrL 
 
 
1bbrM 
 
 
1bcuL 
 
 
1bhxA 
 
 
1bmmL 
 
 
1bmnL 
 
 
1bthL 
 
 
1bthJ 
 
 
1c1uL 
 
 
1c1vL 
 
 
1c1wL 
 
 
1c4u1 
 
 
1c4v1 
 
 
1c4y1 
 
 
1c5lL 
 
 
1c5nL 
 
 
1c5oL 
 
 
1ca8A 
 
 
1d3dA 
 
 
1d3pA 
 
 
1d3qA 
 
 
1d3tA 
 
 
1d4pA 
 
 
1de7L 
 
 
1de7K 
 
 
1ditL 
 
 
1dwcL 
 
 
1dwdL 
 
 
1dweL 
 
 
1dx5A 
 
 
1dx5B 
 
 
1dx5C 
 
 
1dx5D 
 
 
1etrL 
 
 
1etsL 
 
 
1ettL 
 
 
1fpcL 
 
 
1fphL 
 
 
1h8dL 
 
 
1h8iL 
 
 
1hahL 
 
 
1haiL 
 
 
1haoL 
 
 
1hapL 
 
 
1hbtL 
 
 
1hdtL 
 
 
1hgtL 
 
 
1hltL 
 
 
1hltJ 
 
 
1hrtL 
 
 
1hutL 
 
 
1hxeL 
 
 
1hxfL 
 
 
1ihsL 
 
 
1ihtL 
 
 
1lhcL 
 
 
1lhdL 
 
 
1lheL 
 
 
1lhfL 
 
 
1lhgL 
 
 
1mkwL 
 
 
1mkxL 
 
 
1nrpL 
 
 
1nrrL 
 
 
1nrsL 
 
 
1ppbL 
 
 
1qbvL 
 
 
1qhrA 
 
 
1qj1A 
 
 
1qj6A 
 
 
1qj7A 
 
 
1tbrJ 
 
 
1tbrL 
 
 
1tbzL 
 
 
1thpA 
 
 
1thrL 
 
 
1thsL 
 
 
1tmbL 
 
 
1tmuL 
 
 
1tomL 
 
 
1ucyJ 
 
 
1ucyL 
 
 
1ucyM 
 
 
1umaL 
 
 
1uvsL 
 
 
1uvtL 
 
 
1uvuL 
 
 
1ycpJ 
 
 
1ycpL 
 
 
2hatL 
 
 
2hgtL 
 
 
2thfA 
 
 
3hatL 
 
 
4htcL 
 
 
4thnL 
 
 
5gdsL 
 
 
7kmeL 
 
 
8kme1 
 
 
1a2cH01SER 195
GLY 193;SER 195
 
1a3bH01SER 195
GLY 193;SER 195
 
1a3eH01SER 195
GLY 193;SER 195
 
1a46H01SER 195
GLY 193;SER 195
 
1a4wH01SER 195
GLY 193;SER 195
 
1a5gH01SER 195
GLY 193;SER 195
 
1a61H01SER 195
GLY 193;SER 195
 
1abiH01SER 195
GLY 193;SER 195
 
1abjH01SER 195
GLY 193;SER 195
 
1ad8H01SER 195
GLY 193;SER 195
 
1ae8H01SER 195
GLY 193;SER 195
 
1afeH01SER 195
GLY 193;SER 195
 
1ahtH01SER 195
GLY 193;SER 195
 
1ai8H01SER 195
GLY 193;SER 195
 
1aixH01SER 195
GLY 193;SER 195
 
1avgH01SER 195
GLY 193;SER 195
 
1awfH01SER 195
GLY 193;SER 195
 
1awhB01SER 195
GLY 193;SER 195
 
1awhD01SER 195
GLY 193;SER 195
 
1ay6H01SER 195
GLY 193;SER 195
 
1b5gH01SER 195
GLY 193;SER 195
 
1b7xB01SER 195
GLY 193;SER 195
mutant Y225I
1ba8B01SER 195
GLY 193;SER 195
 
1bb0B01SER 195
GLY 193;SER 195
 
1bbrESER 195
GLY 193;SER 195
 
1bbrK01SER 195
GLY 193;SER 195
 
1bbrN01SER 195
GLY 193;SER 195
 
1bcuH01SER 195
GLY 193;SER 195
 
1bhxFSER 195
GLY 193;SER 195
 
1bmmH01SER 195
GLY 193;SER 195
 
1bmnH01SER 195
GLY 193;SER 195
 
1bthH01SER 195
GLY 193;SER 195
mutant E192Q
1bthK01SER 195
GLY 193;SER 195
mutant E192Q
1c1uH01SER 201
GLY 199;SER 201
 
1c1vH01SER 201
GLY 199;SER 201
 
1c1wH01SER 201
GLY 199;SER 201
 
1c4u201SER 195
GLY 193;SER 195
 
1c4v201SER 195
GLY 193;SER 195
 
1c4y201SER 195
GLY 193;SER 195
 
1c5lH01SER 195
GLY 193;SER 195
 
1c5nH01SER 195
GLY 193;SER 195
 
1c5oH01SER 195
GLY 193;SER 195
 
1ca8B01SER 195
GLY 193;SER 195
 
1d3dB01SER 241
GLY 239;SER 241
 
1d3pB01SER 241
GLY 239;SER 241
 
1d3qB01SER 241
GLY 239;SER 241
 
1d3tB01SER 241
GLY 239;SER 241
 
1d4pB01SER 241
GLY 239;SER 241
 
1d6wA01SER 195
GLY 193;SER 195
 
1d9iA01SER 195
GLY 193;SER 195
 
1de7H01SER 195
GLY 193;SER 195
 
1de7K01SER 195
GLY 193;SER 195
 
1ditH01SER 195
GLY 193;SER 195
 
1dojA01SER 195
GLY 193;SER 195
 
1dwcH01SER 195
GLY 193;SER 195
 
1dwdH01SER 195
GLY 193;SER 195
 
1dweH01SER 195
GLY 193;SER 195
 
1dx5M01SER 195
GLY 193;SER 195
 
1dx5N01SER 195
GLY 193;SER 195
 
1dx5O01SER 195
GLY 193;SER 195
 
1dx5P01SER 195
GLY 193;SER 195
 
1eojA01SER 195
GLY 193;SER 195
 
1eolA01SER 195
GLY 193;SER 195
 
1etrH01SER 195
GLY 193;SER 195
 
1etsH01SER 195
GLY 193;SER 195
 
1ettH01SER 195
GLY 193;SER 195
 
1fpcH01SER 195
GLY 193;SER 195
 
1fphH01SER 195
GLY 193;SER 195
 
1h8dH01SER 195
GLY 193;SER 195
 
1h8iH01SER 195
GLY 193;SER 195
 
1hagE01SER 195
GLY 193;SER 195
 
1hahH01SER 195
GLY 193;SER 195
 
1haiH01SER 195
GLY 193;SER 195
 
1haoH01SER 195
GLY 193;SER 195
 
1hapH01SER 195
GLY 193;SER 195
 
1hbtH01SER 195
GLY 193;SER 195
 
1hdtH01SER 195
GLY 193;SER 195
 
1hgtH01SER 195
GLY 193;SER 195
 
1hltH01SER 195
GLY 193;SER 195
 
1hltK01SER 195
GLY 193;SER 195
 
1hrtH01SER 195
GLY 193;SER 195
 
1hutH01SER 195
GLY 193;SER 195
 
1hxeH01SER 195
GLY 193;SER 195
 
1hxfH01SER 195
GLY 193;SER 195
 
1ihsH01SER 195
GLY 193;SER 195
 
1ihtH01SER 195
GLY 193;SER 195
 
1lhcH01SER 195
GLY 193;SER 195
 
1lhdH01SER 195
GLY 193;SER 195
 
1lheH01SER 195
GLY 193;SER 195
 
1lhfH01SER 195
GLY 193;SER 195
 
1lhgH01SER 195
GLY 193;SER 195
 
1mkwH01SER 195
GLY 193;SER 195
 
1mkwK01SER 195
GLY 193;SER 195
 
1mkxH01SER 195
GLY 193;SER 195
 
1mkxK01SER 195
GLY 193;SER 195
 
1nrpH01SER 195
GLY 193;SER 195
 
1nrrH01SER 195
GLY 193;SER 195
 
1nrsH01SER 195
GLY 193;SER 195
 
1ppbH01SER 195
GLY 193;SER 195
 
1qbvH01SER 195
GLY 193;SER 195
 
1qhrB01SER 195
GLY 193;SER 195
 
1qj1B01SER 195
GLY 193;SER 195
 
1qj6B01SER 195
GLY 193;SER 195
 
1qj7B01SER 195
GLY 193;SER 195
 
1tbrH01SER 195
GLY 193;SER 195
 
1tbrK01SER 195
GLY 193;SER 195
 
1tbzH01SER 195
GLY 193;SER 195
 
1thpB01SER 195
GLY 193;SER 195
mutant Y225P
1thrH01SER 195
GLY 193;SER 195
 
1thsH01SER 195
GLY 193;SER 195
 
1tmbH01SER 195
GLY 193;SER 195
 
1tmtH01SER 195
GLY 193;SER 195
 
1tmuH01SER 195
GLY 193;SER 195
 
1tomH01SER 195
GLY 193;SER 195
 
1ucyESER 195
GLY 193;SER 195
 
1ucyK01SER 195
GLY 193;SER 195
 
1ucyN01SER 195
GLY 193;SER 195
 
1umaH01SER 195
GLY 193;SER 195
 
1uvsH01SER 195
GLY 193;SER 195
 
1uvtH01SER 195
GLY 193;SER 195
 
1uvuH01SER 195
GLY 193;SER 195
 
1ycpH01SER 195
GLY 193;SER 195
 
1ycpMSER 195
GLY 193;SER 195
 
2hatH01SER 195
GLY 193;SER 195
 
2hgtH01SER 195
GLY 193;SER 195
 
2thfB01SER 195
GLY 193;SER 195
mutant Y225F
3hatH01SER 195
GLY 193;SER 195
 
4htcH01SER 195
GLY 193;SER 195
 
4thnH01SER 195
GLY 193;SER 195
 
5gdsH01SER 195
GLY 193;SER 195
 
7kmeH01SER 195
GLY 193;SER 195
 
8kme201SER 195
GLY 193;SER 195
 
1a2cH02HIS 57;ASP 102
 
 
1a3bH02HIS 57;ASP 102
 
 
1a3eH02HIS 57;ASP 102
 
 
1a46H02HIS 57;ASP 102
 
 
1a4wH02HIS 57;ASP 102
 
 
1a5gH02HIS 57;ASP 102
 
 
1a61H02HIS 57;ASP 102
 
 
1abiH02HIS 57;ASP 102
 
 
1abjH02HIS 57;ASP 102
 
 
1ad8H02HIS 57;ASP 102
 
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