EzCatDB: T00206
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DB codeT00206
CATH domainDomain 13.10.450.40 : Nuclear Transport Factor 2; Chain
Domain 23.10.450.40 : Nuclear Transport Factor 2; Chain
Domain 32.70.98.20 : Beta-galactosidase; Chain A, domain 5Catalytic domain
E.C.1.4.3.21

CATH domainRelated DB codes (homologues)
2.70.98.20 : Beta-galactosidase; Chain A, domain 5M00103,M00202,T00250,T00251
3.10.450.40 : Nuclear Transport Factor 2; ChainM00103,M00202,T00250,T00251

Enzyme Name
UniProtKBKEGG

P46881P12807
Protein namePhenylethylamine oxidasePeroxisomal primary amine oxidaseprimary-amine oxidase
amine oxidase (ambiguous)
amine oxidase (copper-containing)
amine oxidase (pyridoxal containing) (incorrect)
benzylamine oxidase (incorrect)
CAO (ambiguous)
copper amine oxidase (ambiguous)
Cu-amine oxidase (ambiguous)
Cu-containing amine oxidase (ambiguous)
diamine oxidase (incorrect)
diamino oxhydrase (incorrect)
histamine deaminase (ambiguous)
histamine oxidase (ambiguous)
monoamine oxidase (ambiguous)
plasma monoamine oxidase (ambiguous)
polyamine oxidase (ambiguous)
semicarbazide-sensitive amine oxidase (ambiguous)
SSAO (ambiguous)
SynonymsEC 1.4.3.21
Primary amine oxidase
EC 1.4.3.21
Copper amine oxidase
Methylamine oxidase
PfamPF01179 (Cu_amine_oxid)
PF02728 (Cu_amine_oxidN3)
[Graphical view]
PF01179 (Cu_amine_oxid)
PF02727 (Cu_amine_oxidN2)
PF02728 (Cu_amine_oxidN3)
[Graphical view]

KEGG pathways
MAP codePathways
MAP00260Glycine, serine and threonine metabolism
MAP00350Tyrosine metabolism
MAP00360Phenylalanine metabolism
MAP00410beta-Alanine metabolism
MAP00960Alkaloid biosynthesis II

UniProtKB:Accession NumberP46881P12807
Entry namePAOX_ARTGOAMO_PICAN
ActivityRCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
SubunitHomodimer.Homodimer.
Subcellular location
Peroxisome.
CofactorBinds 1 copper ion per subunit.,Contains 1 topaquinone per subunit.Binds 1 copper ion per subunit.,Contains 1 topaquinone per subunit.

Compound table: links to PDB-related databases & PoSSuM

CofactorsSubstratesProductsintermediates
KEGG-idC00070L00003C00375C00001C00007C00071C00014C00027I00021
I00022I00023I00024
CompoundCopperTopaquinoneRCH2NH2H2OOxygenAldehydeNH3H2O2Substrate Schiff-base (Iminoquinone=substrate)Carbanionic intermediateProduct Schiff-base (Aminoquinol=product)Aminoquinol/SemiquinoneIminoquinone
Typeheavy metalamino acids,aromatic ring (only carbon atom)amine groupH2Ootherscarbohydrateamine group,organic ionothers




ChEBI28694
30052
36077
68431

15377
27140
26689
15379

16134
16240





PubChem23978


962
22247451
977

222
784
22326046





                     
1av4A01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1avkA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1avlA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1iqxA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1iqxB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1iqyA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1iqyB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1iu7A01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1iu7B01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ivuA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ivuB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ivvA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ivvB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ivwA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ivwB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ivxA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ivxB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1rjoA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1sihA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1siiA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ui7A01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ui7B01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ui8A01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ui8B01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1w4nA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1w4nB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1w5zA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1w6cA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1w6gA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1wmnA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1wmnB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1wmoA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1wmoB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1wmpA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1wmpB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2bt3A01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cfdA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cfdB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cfgA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cfgB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cfkA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cflA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cfwA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cg0A01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cg1A01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cwtA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cwtB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cwuA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cwuB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cwvA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cwvB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2d1wA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2d1wB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2e2tA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2e2uA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2e2uB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2e2vA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2e2vB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1a2vA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1a2vB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1a2vC01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1a2vD01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1a2vE01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1a2vF01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ekmA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ekmB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ekmC01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oovA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oovB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oovC01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oovD01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oovE01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oovF01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oqeA01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oqeB01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oqeC01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oqeD01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oqeE01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oqeF01UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1av4A02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1avkA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1avlA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1iqxA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1iqxB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1iqyA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1iqyB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1iu7A02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1iu7B02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ivuA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ivuB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ivvA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ivvB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ivwA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ivwB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ivxA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ivxB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1rjoA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1sihA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1siiA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ui7A02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ui7B02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ui8A02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ui8B02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1w4nA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1w4nB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1w5zA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1w6cA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1w6gA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1wmnA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1wmnB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1wmoA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1wmoB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1wmpA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1wmpB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2bt3A02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cfdA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cfdB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cfgA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cfgB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cfkA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cflA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cfwA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cg0A02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cg1A02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cwtA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cwtB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cwuA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cwuB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cwvA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2cwvB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2d1wA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2d1wB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2e2tA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2e2uA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2e2uB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2e2vA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2e2vB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1a2vA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1a2vB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1a2vC02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1a2vD02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1a2vE02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1a2vF02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ekmA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ekmB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1ekmC02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oovA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oovB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oovC02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oovD02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oovE02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oovF02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oqeA02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oqeB02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oqeC02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oqeD02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oqeE02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
2oqeF02UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1av4A03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1avkA03UnboundUnboundUnbound UnboundUnboundUnboundUnbound     
1avlA03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1iqxA03Analogue:_COBound:TPQUnbound UnboundUnboundUnboundUnbound     
1iqxB03Analogue:_COBound:TPQUnbound UnboundUnboundUnboundUnbound     
1iqyA03Analogue:_NIBound:TPQUnbound UnboundUnboundUnboundUnbound     
1iqyB03Analogue:_NIBound:TPQUnbound UnboundUnboundUnboundUnbound     
1iu7A03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1iu7B03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1ivuA03Bound:_CUUnboundUnbound UnboundUnboundUnboundUnbound     
1ivuB03Bound:_CUUnboundUnbound UnboundUnboundUnboundUnbound     
1ivvA03Bound:_CUAnalogue:DAHUnbound UnboundUnboundUnboundUnbound     
1ivvB03Bound:_CUAnalogue:DAHUnbound UnboundUnboundUnboundUnbound     
1ivwA03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1ivwB03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1ivxA03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1ivxB03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1rjoA03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1sihA03Bound:_CUAnalogue:MBQUnbound UnboundUnboundUnboundUnbound  Intermediate-analogue:MBQ  
1siiA03Bound:_CUAnalogue:NBQUnbound UnboundUnboundUnboundUnbound  Intermediate-analogue:NBQ  
1ui7A03Bound:_CUUnboundUnbound UnboundUnboundUnboundUnbound     
1ui7B03Bound:_CUUnboundUnbound UnboundUnboundUnboundUnbound     
1ui8A03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1ui8B03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1w4nA03Bound:_CUAnalogue:TCQUnbound UnboundUnboundUnboundUnboundIntermediate-analogue:TCQ    
1w4nB03Bound:_CUAnalogue:TCQUnbound UnboundUnboundUnboundUnboundIntermediate-analogue:TCQ    
1w5zA03Bound:_CUAnalogue:3TYUnbound UnboundUnboundUnboundUnboundIntermediate-analogue:3TY    
1w6cA03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1w6gA03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1wmnA03Analogue:_COBound:TPQUnbound UnboundUnboundUnboundUnbound     
1wmnB03Analogue:_COBound:TPQUnbound UnboundUnboundUnboundUnbound     
1wmoA03Analogue:_NIBound:TPQUnbound UnboundUnboundUnboundUnbound     
1wmoB03Analogue:_NIBound:TPQUnbound UnboundUnboundUnboundUnbound     
1wmpA03Analogue:_COUnboundUnbound UnboundUnboundUnboundUnbound     
1wmpB03Analogue:_COUnboundUnbound UnboundUnboundUnboundUnbound     
2bt3A03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2cfdA03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2cfdB03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2cfgA03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2cfgB03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2cfkA03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2cflA03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2cfwA03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2cg0A03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2cg1A03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2cwtA03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2cwtB03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2cwuA03Bound:_CUAnalogue:1TYUnbound UnboundUnboundUnboundUnboundIntermediate-analogue:1TY    
2cwuB03Bound:_CUAnalogue:1TYUnbound UnboundUnboundUnboundUnboundIntermediate-analogue:1TY    
2cwvA03Bound:_CUAnalogue:2TYUnbound UnboundUnboundUnboundUnbound  Intermediate-analogue:2TY  
2cwvB03Bound:_CUAnalogue:2TYUnbound UnboundUnboundUnboundUnbound  Intermediate-analogue:2TY  
2d1wA03Bound:_CUAnalogue:TTSUnbound UnboundUnboundUnboundUnboundIntermediate-analogue:TTS    
2d1wB03Bound:_CUAnalogue:TTSUnbound UnboundUnboundUnboundUnboundIntermediate-analogue:TTS    
2e2tA03Bound:_CUAnalogue:OTYUnbound UnboundUnboundUnboundUnboundIntermediate-analogue:OTY-PHZ    
2e2uA03Bound:_CUAnalogue:OTYUnbound UnboundUnboundUnboundUnboundIntermediate-analogue:OTY-4HL    
2e2uB03Bound:_CUAnalogue:OTYUnbound UnboundUnboundUnboundUnboundIntermediate-analogue:OTY-4HL    
2e2vA03Bound:_CUAnalogue:OTYUnbound UnboundUnboundUnboundUnboundIntermediate-analogue:OTY-BZZ    
2e2vB03Bound:_CUAnalogue:OTYUnbound UnboundUnboundUnboundUnboundIntermediate-analogue:OTY-BZZ    
1a2vA03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1a2vB03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1a2vC03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1a2vD03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1a2vE03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1a2vF03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
1ekmA03Analogue:_ZNUnboundUnbound UnboundUnboundUnboundUnbound     
1ekmB03Analogue:_ZNUnboundUnbound UnboundUnboundUnboundUnbound     
1ekmC03Analogue:_ZNUnboundUnbound UnboundUnboundUnboundUnbound     
2oovA03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2oovB03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2oovC03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2oovD03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2oovE03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2oovF03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2oqeA03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2oqeB03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2oqeC03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2oqeD03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2oqeE03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     
2oqeF03Bound:_CUBound:TPQUnbound UnboundUnboundUnboundUnbound     

Active-site residues
resource
Swiss-prot;Q43077, P12807, P46881
pdbCatalytic residuesCofactor-binding residuesModified residuescomment
            
1av4A01 
 
 
 
1avkA01 
 
 
 
1avlA01 
 
 
 
1iqxA01 
 
 
 
1iqxB01 
 
 
 
1iqyA01 
 
 
 
1iqyB01 
 
 
 
1iu7A01 
 
 
 
1iu7B01 
 
 
 
1ivuA01 
 
 
 
1ivuB01 
 
 
 
1ivvA01 
 
 
 
1ivvB01 
 
 
 
1ivwA01 
 
 
 
1ivwB01 
 
 
 
1ivxA01 
 
 
 
1ivxB01 
 
 
 
1rjoA01 
 
 
 
1sihA01 
 
 
 
1siiA01 
 
 
 
1ui7A01 
 
 
 
1ui7B01 
 
 
 
1ui8A01 
 
 
 
1ui8B01 
 
 
 
1w4nA01 
 
 
 
1w4nB01 
 
 
 
1w5zA01 
 
 
 
1w6cA01 
 
 
 
1w6gA01 
 
 
 
1wmnA01 
 
 
 
1wmnB01 
 
 
 
1wmoA01 
 
 
 
1wmoB01 
 
 
 
1wmpA01 
 
 
 
1wmpB01 
 
 
 
2bt3A01 
 
 
 
2cfdA01 
 
 
 
2cfdB01 
 
 
 
2cfgA01 
 
 
 
2cfgB01 
 
 
 
2cfkA01 
 
 
 
2cflA01 
 
 
 
2cfwA01 
 
 
 
2cg0A01 
 
 
 
2cg1A01 
 
 
 
2cwtA01 
 
 
 
2cwtB01 
 
 
 
2cwuA01 
 
 
 
2cwuB01 
 
 
 
2cwvA01 
 
 
 
2cwvB01 
 
 
 
2d1wA01 
 
 
 
2d1wB01 
 
 
 
2e2tA01 
 
 
 
2e2uA01 
 
 
 
2e2uB01 
 
 
 
2e2vA01 
 
 
 
2e2vB01 
 
 
 
1a2vA01 
 
 
 
1a2vB01 
 
 
 
1a2vC01 
 
 
 
1a2vD01 
 
 
 
1a2vE01 
 
 
 
1a2vF01 
 
 
 
1ekmA01 
 
 
 
1ekmB01 
 
 
 
1ekmC01 
 
 
 
2oovA01 
 
 
 
2oovB01 
 
 
 
2oovC01 
 
 
 
2oovD01 
 
 
 
2oovE01 
 
 
 
2oovF01 
 
 
 
2oqeA01 
 
 
 
2oqeB01 
 
 
 
2oqeC01 
 
 
 
2oqeD01 
 
 
 
2oqeE01 
 
 
 
2oqeF01 
 
 
 
1av4A02 
 
 
 
1avkA02 
 
 
 
1avlA02 
 
 
 
1iqxA02 
 
 
 
1iqxB02 
 
 
 
1iqyA02 
 
 
 
1iqyB02 
 
 
 
1iu7A02 
 
 
 
1iu7B02 
 
 
 
1ivuA02 
 
 
 
1ivuB02 
 
 
 
1ivvA02 
 
 
 
1ivvB02 
 
 
 
1ivwA02 
 
 
 
1ivwB02 
 
 
 
1ivxA02 
 
 
 
1ivxB02 
 
 
 
1rjoA02 
 
 
 
1sihA02 
 
 
 
1siiA02 
 
 
 
1ui7A02 
 
 
 
1ui7B02 
 
 
 
1ui8A02 
 
 
 
1ui8B02 
 
 
 
1w4nA02 
 
 
 
1w4nB02 
 
 
 
1w5zA02 
 
 
 
1w6cA02 
 
 
 
1w6gA02 
 
 
 
1wmnA02 
 
 
 
1wmnB02 
 
 
 
1wmoA02 
 
 
 
1wmoB02 
 
 
 
1wmpA02 
 
 
 
1wmpB02 
 
 
 
2bt3A02 
 
 
 
2cfdA02 
 
 
 
2cfdB02 
 
 
 
2cfgA02 
 
 
 
2cfgB02 
 
 
 
2cfkA02 
 
 
 
2cflA02 
 
 
 
2cfwA02 
 
 
 
2cg0A02 
 
 
 
2cg1A02 
 
 
 
2cwtA02 
 
 
 
2cwtB02 
 
 
 
2cwuA02 
 
 
 
2cwuB02 
 
 
 
2cwvA02 
 
 
 
2cwvB02 
 
 
 
2d1wA02 
 
 
 
2d1wB02 
 
 
 
2e2tA02 
 
 
 
2e2uA02 
 
 
 
2e2uB02 
 
 
 
2e2vA02 
 
 
 
2e2vB02 
 
 
 
1a2vA02 
 
 
 
1a2vB02 
 
 
 
1a2vC02 
 
 
 
1a2vD02 
 
 
 
1a2vE02 
 
 
 
1a2vF02 
 
 
 
1ekmA02 
 
 
 
1ekmB02 
 
 
 
1ekmC02 
 
 
 
2oovA02 
 
 
 
2oovB02 
 
 
 
2oovC02 
 
 
 
2oovD02 
 
 
 
2oovE02 
 
 
 
2oovF02 
 
 
 
2oqeA02 
 
 
 
2oqeB02 
 
 
 
2oqeC02 
 
 
 
2oqeD02 
 
 
 
2oqeE02 
 
 
 
2oqeF02 
 
 
 
1av4A03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1avkA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
       
no-modification Y382
1avlA03TYR 284;ASP 298
TPQ 382;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1iqxA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1iqxB03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1iqyA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1iqyB03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1iu7A03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1iu7B03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1ivuA03TYR 284;ASP 298
TYR 382;HIS 431;HIS 433;HIS 592(Copper binding)
       
no-modification Y382
1ivuB03TYR 284;ASP 298
TYR 382;HIS 431;HIS 433;HIS 592(Copper binding)
       
no-modification Y382
1ivvA03TYR 284;ASP 298
DAH 382;HIS 431;HIS 433;HIS 592(Copper binding)
DAH 382
TPQ analogue DAH382
1ivvB03TYR 284;ASP 298
DAH 382;HIS 431;HIS 433;HIS 592(Copper binding)
DAH 382
TPQ analogue DAH382
1ivwA03TYR 284;ASP 298
TPQ 382;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1ivwB03TYR 284;ASP 298
TPQ 382;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1ivxA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1ivxB03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1rjoA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1sihA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
MBQ 382
TPQ analogue MBQ382
1siiA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
NBQ 382
TPQ analogue NBQ382
1ui7A03TYR 284;ASP 298
TYR 382;HIS 431;       ;HIS 592(Copper binding)
       
mutant H433A, no-modification Y382
1ui7B03TYR 284;ASP 298
TYR 382;HIS 431;       ;HIS 592(Copper binding)
       
mutant H433A, no-modification Y382
1ui8A03TYR 284;ASP 298
TPQ 382;HIS 431;HIS 433;       (Copper binding)
TPQ 382
mutant H592A
1ui8B03TYR 284;ASP 298
TPQ 382;HIS 431;HIS 433;       (Copper binding)
TPQ 382
mutant H592A
1w4nA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TCQ 382
TPQ analogue TCQ382
1w4nB03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TCQ 382
TPQ analogue TCQ382
1w5zA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
3TY 382
TPQ analogue 3TY382
1w6cA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1w6gA03TYR 284;ASP 298
TPQ 382;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1wmnA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1wmnB03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1wmoA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1wmoB03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
1wmpA03TYR 284;ASP 298
TYR 382;HIS 431;HIS 433;HIS 592(Copper binding)
       
no-modification Y382
1wmpB03TYR 284;ASP 298
TYR 382;HIS 431;HIS 433;HIS 592(Copper binding)
       
no-modification Y382
2bt3A03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
2cfdA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
2cfdB03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
2cfgA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
2cfgB03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
2cfkA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
2cflA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
2cfwA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
2cg0A03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
2cg1A03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
 
2cwtA03TYR 284;       
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
mutant D298A
2cwtB03TYR 284;       
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TPQ 382
mutant D298A
2cwuA03TYR 284;       
       ;HIS 431;HIS 433;HIS 592(Copper binding)
1TY 382
mutant D298A, TPQ analogue 1TY382
2cwuB03TYR 284;       
       ;HIS 431;HIS 433;HIS 592(Copper binding)
1TY 382
mutant D298A, TPQ analogue 1TY382
2cwvA03TYR 284;       
       ;HIS 431;HIS 433;HIS 592(Copper binding)
2TY 382
mutant D298A, TPQ analogue 2TY382
2cwvB03TYR 284;       
       ;HIS 431;HIS 433;HIS 592(Copper binding)
2TY 382
mutant D298A, TPQ analogue 2TY382
2d1wA03TYR 284;       
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TTS 382
mutant D298A, TPQ analogue TTS382
2d1wB03TYR 284;       
       ;HIS 431;HIS 433;HIS 592(Copper binding)
TTS 382
mutant D298A, TPQ analogue TTS382
2e2tA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
OTY 382
TPQ analogue OTY382
2e2uA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
OTY 382
TPQ analogue OTY382
2e2uB03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
OTY 382
TPQ analogue OTY382
2e2vA03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
OTY 382
TPQ analogue OTY382
2e2vB03TYR 284;ASP 298
       ;HIS 431;HIS 433;HIS 592(Copper binding)
OTY 382
TPQ analogue OTY382
1a2vA03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 
1a2vB03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 
1a2vC03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 
1a2vD03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 
1a2vE03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 
1a2vF03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 
1ekmA03TYR 305;ASP 319
TYR 405;HIS 456;HIS 458;HIS 624(Copper binding)
       
no-modification Y405
1ekmB03TYR 305;ASP 319
TYR 405;HIS 456;HIS 458;HIS 624(Copper binding)
       
no-modification Y405
1ekmC03TYR 305;ASP 319
TYR 405;HIS 456;HIS 458;HIS 624(Copper binding)
       
no-modification Y405
2oovA03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 
2oovB03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 
2oovC03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 
2oovD03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 
2oovE03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 
2oovF03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 
2oqeA03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 
2oqeB03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 
2oqeC03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 
2oqeD03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 
2oqeE03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 
2oqeF03TYR 305;ASP 319
       ;HIS 456;HIS 458;HIS 624(Copper binding)
TPQ 405
 

References for Catalytic Mechanism
ReferencesSectionsNo. of steps in catalysis
[1]Fig. 3, p.263
[5]Scheme 2, p.16121-16124, p.16131-16132
[6]Scheme 1, p.16596-16599
[7]Fig.1, p.297-298, p.303-304
[8]Scheme 2, p.3691-3693
[9]Fig.2, p.1725-1728
[10]Scheme 1, p.9713-9716
[12]Scheme 1, Scheme 2, Scheme 3, p.147-154
[13]Fig.1, Fig.7, p.15793-15796
[14]Scheme 1, Scheme 2, p.2958-2960
[15]Fig.4, Fig.5, p.668-672
[16]Scheme 1, Scheme 2, Scheme 4, p.10582-10584
[18]Scheme 1, p.3645-3646
[20]Scheme 1, Scheme 3, Scheme 4, p.1050-1055
[22]Scheme 3, p.27-30
[24]Scheme 1

references
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[2]
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[3]
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Year1996
Volume271
Pages22598-603
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[4]
CommentsX-ray crystallography
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Year1997
Volume53
Pages364-70
AuthorsLi R, Chen L, Cai D, Klinman JP, Mathews FS
TitleCrystallographic Study of Yeast Copper Amine Oxidase.
Related PDB1a2v
[5]
CommentsX-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 9-628
Medline ID98070236
PubMed ID9405045
JournalBiochemistry
Year1997
Volume36
Pages16116-33
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TitleCrystal structures of the copper-containing amine oxidase from Arthrobacter globiformis in the holo and apo forms: implications for the biogenesis of topaquinone.
Related PDB1av4,1avk,1avl
Related UniProtKBP46881
[6]
PubMed ID9843426
JournalBiochemistry
Year1998
Volume37
Pages16591-600
AuthorsSchwartz B, Green EL, Sanders-Loehr J, Klinman JP
TitleRelationship between conserved consensus site residues and the productive conformation for the TPQ cofactor in a copper-containing amine oxidase from yeast.
[7]
CommentsX-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS)
Medline ID98212916
PubMed ID9551552
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Year1998
Volume6
Pages293-307
AuthorsLi R, Klinman JP, Mathews FS
TitleCopper amine oxidase from Hansenula polymorpha: the crystal structure determined at 2.4 A resolution reveals the active conformation.
Related UniProtKBP12807
[8]
PubMed ID10090756
JournalBiochemistry
Year1999
Volume38
Pages3683-93
AuthorsHevel JM, Mills SA, Klinman JP
TitleMutation of a strictly conserved, active-site residue alters substrate specificity and cofactor biogenesis in a copper amine oxidase.
[9]
CommentsX-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS)
Medline ID20045000
PubMed ID10576737
JournalScience
Year1999
Volume286
Pages1724-8
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TitleVisualization of dioxygen bound to copper during enzyme catalysis.
Related PDB1d6u,1d6y,1d6z
Related UniProtKBP46883
[10]
CommentsX-ray crystallography
PubMed ID10933787
JournalBiochemistry
Year2000
Volume39
Pages9709-17
AuthorsChen Z, Schwartz B, Williams NK, Li R, Klinman JP, Mathews FS
TitleCrystal structure at 2.5 A resolution of zinc-substituted copper amine oxidase of Hansenula polymorpha expressed in Escherichia coli.
Related PDB1ekm
[11]
PubMed ID10858309
JournalBiochemistry
Year2000
Volume39
Pages7589-94
AuthorsMelville CR, Green EL, Sanders-Loehr J, Klinman JP
TitleReassessment of the active site quino-cofactor proposed to occur in the Aspergillus niger amine oxidase AO-I from the properties of model compounds.
[12]
PubMed ID11665487
JournalAdv Protein Chem
Year2001
Volume58
Pages141-74
AuthorsDove JE, Klinman JP
TitleTrihydroxyphenylalanine quinone (TPQ) from copper amine oxidases and lysyl tyrosylquinone (LTQ) from lysyl oxidase.
[13]
PubMed ID11747456
JournalBiochemistry
Year2001
Volume40
Pages15789-96
AuthorsHirota S, Iwamoto T, Kishishita S, Okajima T, Yamauchi O, Tanizawa K
TitleSpectroscopic observation of intermediates formed during the oxidative half-reaction of copper/topa quinone-containing phenylethylamine oxidase.
[14]
PubMed ID11258907
JournalBiochemistry
Year2001
Volume40
Pages2954-63
AuthorsSchwartz B, Olgin AK, Klinman JP
TitleThe role of copper in topa quinone biogenesis and catalysis, as probed by azide inhibition of a copper amine oxidase from yeast.
[15]
PubMed ID11751046
JournalCurr Opin Struct Biol
Year2001
Volume11
Pages666-73
AuthorsDawkes HC, Phillips SE
TitleCopper amine oxidase: cunning cofactor and controversial copper.
[16]
PubMed ID12186541
JournalBiochemistry
Year2002
Volume41
Pages10577-84
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[17]
PubMed ID12427025
JournalBiochemistry
Year2002
Volume41
Pages13637-43
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TitleBinding of dioxygen to non-metal sites in proteins: exploration of the importance of binding site size versus hydrophobicity in the copper amine oxidase from Hansenula polymorpha.
[18]
PubMed ID12153561
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Year2002
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Pages3645-58
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TitleTowards the development of selective amine oxidase inhibitors. Mechanism-based inhibition of six copper containing amine oxidases.
[19]
CommentsX-ray crystallography
PubMed ID12134140
JournalNat Struct Biol
Year2002
Volume9
Pages591-6
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TitleX-ray snapshots of quinone cofactor biogenesis in bacterial copper amine oxidase.
Related PDB1ivu,1ivv,1ivw,1ivx
[20]
CommentsX-ray crystallography
PubMed ID12537504
JournalJ Am Chem Soc
Year2003
Volume125
Pages1041-55
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Related PDB1iqx,1iqy,1iu7
[21]
PubMed ID12673620
JournalYeast
Year2003
Volume20
Pages369-79
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[22]
PubMed ID15234266
JournalArch Biochem Biophys
Year2004
Volume428
Pages22-31
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TitleCopper-containing amine oxidases. Biogenesis and catalysis; a structural perspective.
[23]
CommentsX-ray crystallography
PubMed ID14979714
JournalBiochemistry
Year2004
Volume43
Pages2178-87
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TitleChemical rescue of a site-specific mutant of bacterial copper amine oxidase for generation of the topa quinone cofactor.
Related PDB1ui7,1ui8
[24]
CommentsX-ray crystallography
PubMed ID15323556
JournalBiochemistry
Year2004
Volume43
Pages10965-78
AuthorsO'Connell KM, Langley DB, Shepard EM, Duff AP, Jeon HB, Sun G, Freeman HC, Guss JM, Sayre LM, Dooley DM
TitleDifferential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation.
Related PDB1sih,1sii
[25]
PubMed ID15038754
JournalJ Am Chem Soc
Year2004
Volume126
Pages3996-4006
AuthorsPrabhakar R, Siegbahn PE
TitleA theoretical study of the mechanism for the biogenesis of cofactor topaquinone in copper amine oxidases.
[26]
CommentsX-ray crystallography
PubMed ID15533431
JournalJ Mol Biol
Year2004
Volume344
Pages599-607
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TitleUsing xenon as a probe for dioxygen-binding sites in copper amine oxidases.
Related PDB1w2z,1rjo,1rky
[27]
PubMed ID16157884
JournalProc Natl Acad Sci U S A
Year2005
Volume102
Pages13451-6
AuthorsContakes SM, Juda GA, Langley DB, Halpern-Manners NW, Duff AP, Dunn AR, Gray HB, Dooley DM, Guss JM, Freeman HC
TitleReversible inhibition of copper amine oxidase activity by channel-blocking ruthenium(II) and rhenium(I) molecular wires.
Related PDB2bt3
[28]
PubMed ID16142901
JournalBiochemistry
Year2005
Volume44
Pages12041-8
AuthorsOkajima T, Kishishita S, Chiu YC, Murakawa T, Kim M, Yamaguchi H, Hirota S, Kuroda S, Tanizawa K
TitleReinvestigation of metal ion specificity for quinone cofactor biogenesis in bacterial copper amine oxidase.
Related PDB1wmn,1wmo
[29]
PubMed ID17077478
JournalActa Crystallogr Sect F Struct Biol Cryst Commun
Year2006
Volume62
Pages1052-7
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[30]
PubMed ID16566584
JournalBiochemistry
Year2006
Volume45
Pages4105-20
AuthorsChiu YC, Okajima T, Murakawa T, Uchida M, Taki M, Hirota S, Kim M, Yamaguchi H, Kawano Y, Kamiya N, Kuroda S, Hayashi H, Yamamoto Y, Tanizawa K
TitleKinetic and structural studies on the catalytic role of the aspartic acid residue conserved in copper amine oxidase.
Related PDB2cwt,2cwu,2cwv
[31]
PubMed ID16487484
JournalBiochem Biophys Res Commun
Year2006
Volume342
Pages414-23
AuthorsMurakawa T, Okajima T, Kuroda S, Nakamoto T, Taki M, Yamamoto Y, Hayashi H, Tanizawa K
TitleQuantum mechanical hydrogen tunneling in bacterial copper amine oxidase reaction.
Related PDB2d1w
[32]
PubMed ID17409383
JournalJ Biol Chem
Year2007
Volume282
Pages17767-76
AuthorsJohnson BJ, Cohen J, Welford RW, Pearson AR, Schulten K, Klinman JP, Wilmot CM
TitleExploring molecular oxygen pathways in Hansenula polymorpha copper-containing amine oxidase.
Related PDB2oov,2oqe

comments
The catalytic domain of this enzyme is homologous to those of counterpart enzymes from E. coli (M00103 in EzCatDB), from pea (T00250 in EzCatDB), from bovine (T00251 in EzCatDB), and membrane-protein from human (M00202 in EzCatDB).
Cofactor, topaquinone (2,4,5-trihydroxyphenylalanine), is a modified residue, generated from active site tyrosine residue (Tyr471) by self-catalysis (see [6] of M00103 in EzCatDB). Some literature described biogenesis of this residue, along with the catalytic mechanism.
According to the literature [24], and [9] (for its homologue), this enzyme catalyzes two half-reactions: (I) reductive half-reaction, and (II) oxidative half-reaction. These half-reactions can be subdivided into several basic reactions in terms of RLCP classification.
(I) Reductive half-reaction:
(A) Exchange of double-bonded atoms; Schiff-base formation; Substrate amine forms a Schiff-base with topaquinone, generating iminoquinone=substrate and H2O (dehydration):
(B) Isomerization from iminoquinone=substrate complex to aminoquinol=product complex (through a carbanionic intermediate):
(C) Exchange of double-bonded atoms; Schiff-base deformation; H2O reacts with the intermediate, generating aminoquinol and product aldehyde (hydration):
(II) Oxidative half-reaction:
(D) Reduction of dioxygen (O2) by aminoquinol, to produce hydrogen peroxide (H2O2) and iminoquinone (Hydride transfer):
(E) Exchange of double-bonded atoms; Schiff-base deformation; H2O reacts with the intermediate, generating topaquinone and product ammonia (hydration):

createdupdated
2005-05-262009-03-04


Copyright: Nozomi Nagano, JST & CBRC-AIST
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