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CATH domain | Related DB codes (homologues) |
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3.30.70.260 : Alpha-Beta Plaits | D00496 | 3.40.50.720 : Rossmann fold | S00543,S00551,S00552,S00553,S00602,S00604,S00605,S00608,S00610,S00625,S00319,S00328,S00329,S00330,S00331,S00332,D00456,D00457,D00458,S00324,S00320,S00325,S00326,S00327,D00459,S00335,S00336,S00334,T00219,S00339,D00513,D00001,D00002,D00003,D00005,D00007,D00008,D00010,D00012,D00017,D00018,D00023,D00027,D00028,D00031,D00032,D00033,D00034,D00035,D00037,D00048,D00071,D00476,D00481,D00482,D00490,D00492,D00494,D00545,D00601,D00603,D00604,D00605,D00615,D00845,D00857,D00858,M00161,M00171,M00210,T00002,T00010,T00011,T00015,T00227,T00408,T00414,D00827,D00262,D00274,D00275,M00035,T00109 |
Enzyme Name | UniProtKB | KEGG |
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| P0A9T0 |
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Protein name | D-3-phosphoglycerate dehydrogenase | phosphoglycerate dehydrogenaseD-3-phosphoglycerate:NAD+ oxidoreductasealpha-phosphoglycerate dehydrogenase3-phosphoglycerate dehydrogenase3-phosphoglyceric acid dehydrogenaseD-3-phosphoglycerate dehydrogenaseglycerate 3-phosphate dehydrogenaseglycerate-1,3-phosphate dehydrogenasephosphoglycerate oxidoreductasephosphoglyceric acid dehydrogenaseSerA3-phosphoglycerate:NAD+ 2-oxidoreductaseSerA 3PG dehydrogenase3PHP reductasealphaKG reductaseD- and L-HGA |
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Synonyms | PGDHEC 1.1.1.95 |
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RefSeq | NP_417388.1 (Protein) NC_000913.2 (DNA/RNA sequence) YP_491113.1 (Protein) NC_007779.1 (DNA/RNA sequence)
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Pfam | PF00389 (2-Hacid_dh) PF02826 (2-Hacid_dh_C) PF01842 (ACT) [Graphical view]
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KEGG pathways | MAP code | Pathways |
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MAP00260 | Glycine, serine and threonine metabolism |
UniProtKB:Accession Number | P0A9T0 |
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Entry name | SERA_ECOLI |
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Activity | 3-phospho-D-glycerate + NAD(+) = 3- phosphonooxypyruvate + NADH.,2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH. |
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Subunit | Homotetramer. |
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Subcellular location |
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Cofactor |
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References for Catalytic Mechanism | References | Sections | No. of steps in catalysis |
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[7] | p.73 |
| [25] | p.3456-3458 |
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references | [1] |
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PubMed ID | 7049261 |
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Journal | Biosci Rep |
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Year | 1981 |
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Volume | 1 |
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Pages | 733-41 |
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Authors | vGrant GA, Zapp ML |
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Title | D-3-phosphoglycerate dehydrogenase from Escherichia coli: isolation by affinity chromatography and sequence comparison to other dehydrogenases. |
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[2] |
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PubMed ID | 3800969 |
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Journal | Biochem J |
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Year | 1986 |
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Volume | 238 |
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Pages | 919-22 |
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Authors | Lund K, Merrill DK, Guynn RW |
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Title | Purification and subunit structure of phosphoglycerate dehydrogenase from rabbit liver. |
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[3] |
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PubMed ID | 3017965 |
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Journal | J Biol Chem |
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Year | 1986 |
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Volume | 261 |
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Pages | 12179-83 |
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Authors | Tobey KL, Grant GA |
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Title | The nucleotide sequence of the serA gene of Escherichia coli and the amino acid sequence of the encoded protein, D-3-phosphoglycerate dehydrogenase. |
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[4] |
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PubMed ID | 2692566 |
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Journal | Biochem Biophys Res Commun |
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Year | 1989 |
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Volume | 165 |
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Pages | 1371-4 |
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Authors | Grant GA |
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Title | A new family of 2-hydroxyacid dehydrogenases. |
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[5] |
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PubMed ID | 2681152 |
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Journal | J Bacteriol |
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Year | 1989 |
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Volume | 171 |
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Pages | 6084-92 |
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Authors | Schoenlein PV, Roa BB, Winkler ME |
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Title | Divergent transcription of pdxB and homology between the pdxB and serA gene products in Escherichia coli K-12. |
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[6] |
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PubMed ID | 1567457 |
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Journal | Biochem Biophys Res Commun |
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Year | 1992 |
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Volume | 184 |
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Pages | 60-6 |
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Authors | Kochhar S, Hunziker PE, Leong-Morgenthaler P, Hottinger H |
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Title | Evolutionary relationship of NAD(+)-dependent D-lactate dehydrogenase: comparison of primary structure of 2-hydroxy acid dehydrogenases. |
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[7] |
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Comments | X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS). |
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PubMed ID | 7719856 |
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Journal | Nat Struct Biol |
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Year | 1995 |
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Volume | 2 |
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Pages | 69-76 |
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Authors | Schuller DJ, Grant GA, Banaszak LJ |
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Title | The allosteric ligand site in the Vmax-type cooperative enzyme phosphoglycerate dehydrogenase. |
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Related PDB | 1psd |
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Related UniProtKB | P0A9T0 |
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[8] |
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PubMed ID | 8662776 |
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Journal | J Biol Chem |
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Year | 1996 |
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Volume | 271 |
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Pages | 13013-7 |
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Authors | Al-Rabiee R, Lee EJ, Grant GA |
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Title | The mechanism of velocity modulated allosteric regulation in D-3-phosphoglycerate dehydrogenase. Cross-linking adjacent regulatory domains with engineered disulfides mimics effector binding. |
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[9] |
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PubMed ID | 8798520 |
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Journal | J Biol Chem |
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Year | 1996 |
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Volume | 271 |
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Pages | 23235-8 |
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Authors | Al-Rabiee R, Zhang Y, Grant GA |
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Title | The mechanism of velocity modulated allosteric regulation in D-3-phosphoglycerate dehydrogenase. Site-directed mutagenesis of effector binding site residues. |
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[10] |
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PubMed ID | 8771194 |
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Journal | Protein Sci |
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Year | 1996 |
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Volume | 5 |
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Pages | 34-41 |
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Authors | Grant GA, Schuller DJ, Banaszak LJ |
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Title | A model for the regulation of D-3-phosphoglycerate dehydrogenase, a Vmax-type allosteric enzyme. |
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[11] |
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PubMed ID | 9163325 |
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Journal | Biochem J |
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Year | 1997 |
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Volume | 323 |
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Pages | 365-70 |
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Authors | Achouri Y, Rider MH, Schaftingen EV, Robbi M |
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Title | Cloning, sequencing and expression of rat liver 3-phosphoglycerate dehydrogenase. |
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[12] |
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PubMed ID | 9712860 |
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Journal | J Biol Chem |
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Year | 1998 |
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Volume | 273 |
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Pages | 22389-94 |
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Authors | Grant GA, Xu XL |
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Title | Probing the regulatory domain interface of D-3-phosphoglycerate dehydrogenase with engineered tryptophan residues. |
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[13] |
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PubMed ID | 10600116 |
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Journal | Biochemistry |
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Year | 1999 |
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Volume | 38 |
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Pages | 16548-52 |
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Authors | Grant GA, Xu XL, Hu Z, Purvis AR |
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Title | Phosphate ion partially relieves the cooperativity of effector binding in D-3-phosphoglycerate dehydrogenase without altering the cooperativity of inhibition. |
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[14] |
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PubMed ID | 10026144 |
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Journal | J Biol Chem |
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Year | 1999 |
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Volume | 274 |
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Pages | 5357-61 |
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Authors | Grant GA, Kim SJ, Xu XL, Hu Z |
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Title | The contribution of adjacent subunits to the active sites of D-3-phosphoglycerate dehydrogenase. |
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[15] |
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PubMed ID | 10595555 |
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Journal | Protein Sci |
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Year | 1999 |
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Volume | 8 |
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Pages | 2501-5 |
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Authors | Grant GA, Xu XL, Hu Z |
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Title | The relationship between effector binding and inhibition of activity in D-3-phosphoglycerate dehydrogenase. |
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[16] |
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PubMed ID | 10683264 |
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Journal | Arch Biochem Biophys |
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Year | 2000 |
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Volume | 375 |
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Pages | 171-4 |
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Authors | Grant GA, Xu XL, Hu Z |
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Title | Removal of the tryptophan 139 side chain in Escherichia coli D-3-phosphoglycerate dehydrogenase produces a dimeric enzyme without cooperative effects. |
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[17] |
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PubMed ID | 10852732 |
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Journal | Biochemistry |
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Year | 2000 |
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Volume | 39 |
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Pages | 7316-9 |
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Authors | Grant GA, Xu XL, Hu Z |
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Title | Role of an interdomain Gly-Gly sequence at the regulatory-substrate domain interface in the regulation of Escherichia coli. D-3-phosphoglycerate dehydrogenase. |
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[18] |
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PubMed ID | 11155166 |
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Journal | Oral Microbiol Immunol |
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Year | 2000 |
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Volume | 15 |
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Pages | 58-62 |
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Authors | Kawabata S, Terao Y, Hamada S |
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Title | Molecular cloning, sequence and characterization of a novel streptococcal phosphoglycerate dehydrogenase gene. |
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[19] |
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PubMed ID | 11050089 |
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Journal | J Biol Chem |
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Year | 2001 |
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Volume | 276 |
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Pages | 1078-83 |
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Authors | Grant GA, Hu Z, Xu XL |
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Title | Specific interactions at the regulatory domain-substrate binding domain interface influence the cooperativity of inhibition and effector binding in Escherichia coli D-3-phosphoglycerate dehydrogenase. |
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[20] |
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PubMed ID | 11278587 |
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Journal | J Biol Chem |
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Year | 2001 |
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Volume | 276 |
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Pages | 17844-50 |
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Authors | Grant GA, Hu Z, Xu XL |
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Title | Amino acid residue mutations uncouple cooperative effects in Escherichia coli D-3-phosphoglycerate dehydrogenase. |
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[21] |
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PubMed ID | 12466884 |
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Journal | Appl Microbiol Biotechnol |
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Year | 2002 |
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Volume | 60 |
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Pages | 437-41 |
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Authors | Peters-Wendisch P, Netzer R, Eggeling L, Sahm H |
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Title | 3-Phosphoglycerate dehydrogenase from Corynebacterium glutamicum: the C-terminal domain is not essential for activity but is required for inhibition by L-serine. |
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[22] |
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PubMed ID | 12199695 |
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Journal | Eur J Biochem |
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Year | 2002 |
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Volume | 269 |
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Pages | 4176-84 |
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Authors | Bell JK, Pease PJ, Bell JE, Grant GA, Banaszak LJ |
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Title | De-regulation of D-3-phosphoglycerate dehydrogenase by domain removal. Eur J Biochem. 2002 Sep;269(17):4176-84. |
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[23] |
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PubMed ID | 12183470 |
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Journal | J Biol Chem |
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Year | 2002 |
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Volume | 277 |
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Pages | 39548-53 |
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Authors | Grant GA, Hu Z, Xu XL |
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Title | Cofactor binding to Escherichia coli D-3-phosphoglycerate dehydrogenase induces multiple conformations which alter effector binding. |
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[24] |
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PubMed ID | 12644455 |
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Journal | J Biol Chem |
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Year | 2003 |
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Volume | 278 |
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Pages | 18170-6 |
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Authors | Grant GA, Hu Z, Xu XL |
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Title | Hybrid tetramers reveal elements of cooperativity in Escherichia coli D-3-phosphoglycerate dehydrogenase. |
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[25] |
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PubMed ID | 15035616 |
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Journal | Biochemistry |
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Year | 2004 |
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Volume | 43 |
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Pages | 3450-8 |
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Authors | Bell JK, Grant GA, Banaszak LJ |
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Title | Multiconformational states in phosphoglycerate dehydrogenase. |
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Related PDB | 1sc6 |
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[26] |
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PubMed ID | 14718528 |
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Journal | J Biol Chem |
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Year | 2004 |
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Volume | 279 |
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Pages | 13452-60 |
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Authors | Grant GA, Xu XL, Hu Z |
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Title | Quantitative relationships of site to site interaction in Escherichia coli D-3-phosphoglycerate dehydrogenase revealed by asymmetric hybrid tetramers. |
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created | updated |
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2004-03-16 | 2009-02-26 |
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