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CATH domain | Related DB codes (homologues) |
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3.40.192.10 : Leucine Dehydrogenase; Chain A, domain 1 | D00458,D00032,D00033,D00035,D00605,D00845,D00857,D00858,M00210,T00010,T00011 | 3.40.50.720 : Rossmann fold | S00543,S00551,S00552,S00553,S00602,S00604,S00605,S00608,S00610,S00625,S00319,S00328,S00329,S00330,S00331,S00332,D00456,D00457,D00458,S00324,S00320,S00325,S00326,S00327,D00459,S00335,S00336,S00334,T00219,S00339,D00513,D00001,D00002,D00003,D00005,D00007,D00008,D00010,D00012,D00017,D00018,D00023,D00027,D00028,D00031,D00032,D00033,D00034,D00035,D00037,D00048,D00071,D00476,D00481,D00482,D00490,D00492,D00494,D00545,D00601,D00603,D00604,D00605,D00615,D00845,D00857,D00858,M00161,M00171,M00210,T00002,T00010,T00011,T00015,T00227,T00247,T00408,D00827,D00262,D00274,D00275,M00035,T00109 |
KEGG pathways | MAP code | Pathways |
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MAP00400 | Phenylalanine, tyrosine and tryptophan biosynthesis |
UniProtKB:Accession Number | Q97KM0 |
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Entry name | Q97KM0_CLOAB |
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Activity | Shikimate + NADP+ = 3-dehydroshikimate + NADPH. |
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Subunit |
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Subcellular location |
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Cofactor |
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References for Catalytic Mechanism | References | Sections | No. of steps in catalysis |
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[3] | p.19470-19471 |
| [5] | Fig.5, p.7168-7169 |
| [6] | p.17105-17107 |
| [8] | p.7791-7794 |
| [9] | Fig.4, p.9519-9521 |
| [10] | Fig.8, p.432-435 |
| [13] | p.4-6 |
| [14] | Fig.4, p.1130-1132, p.1136 |
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references | [1] |
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Comments | X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH NADP, SUBUNIT. |
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PubMed ID | 12837789 |
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Journal | J Bacteriol |
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Year | 2003 |
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Volume | 185 |
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Pages | 4144-51 |
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Authors | Ye S, Von Delft F, Brooun A, Knuth MW, Swanson RV, McRee DE |
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Title | The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode. |
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Related PDB | 1p74,1p77 |
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Related UniProtKB | P43876 |
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[2] |
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Comments | X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEX WITH NAD, FUNCTION, SUBUNIT. |
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PubMed ID | 12624088 |
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Journal | J Biol Chem |
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Year | 2003 |
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Volume | 278 |
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Pages | 19176-82 |
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Authors | Benach J, Lee I, Edstrom W, Kuzin AP, Chiang Y, Acton TB, Montelione GT, Hunt JF |
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Title | The 2.3-A crystal structure of the shikimate 5-dehydrogenase orthologue YdiB from Escherichia coli suggests a novel catalytic environment for an NAD-dependent dehydrogenase. |
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Related PDB | 1npd |
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Related UniProtKB | P0A6D5 |
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[3] |
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Comments | X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH NADP, SUBUNIT. , X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH NAD, CATALYTIC ACTIVITY, SUBUNIT. |
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PubMed ID | 12637497 |
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Journal | J Biol Chem |
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Year | 2003 |
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Volume | 278 |
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Pages | 19463-72 |
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Authors | Michel G, Roszak AW, Sauve V, Maclean J, Matte A, Coggins JR, Cygler M, Lapthorn AJ |
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Title | Structures of shikimate dehydrogenase AroE and its Paralog YdiB. A common structural framework for different activities. |
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Related PDB | 1nyt,1o9b |
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Related UniProtKB | P15770,P0A6D5 |
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[4] |
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Comments | X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) IN COMPLEX WITH NADP, SUBUNIT. |
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PubMed ID | 12906831 |
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Journal | Structure |
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Year | 2003 |
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Volume | 11 |
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Pages | 1005-13 |
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Authors | Padyana AK, Burley SK |
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Title | Crystal structure of shikimate 5-dehydrogenase (SDH) bound to NADP: insights into function and evolution. |
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Related PDB | 1nvt |
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Related UniProtKB | Q58484 |
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[5] |
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PubMed ID | 15596430 |
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Journal | J Biol Chem |
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Year | 2005 |
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Volume | 280 |
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Pages | 7162-9 |
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Authors | Lindner HA, Nadeau G, Matte A, Michel G, Menard R, Cygler M |
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Title | Site-directed mutagenesis of the active site region in the quinate/shikimate 5-dehydrogenase YdiB of Escherichia coli. |
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[6] |
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Comments | X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS), FUNCTION, MUTAGENESIS OF LYS-67 AND ASP-103, SUBUNIT. |
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PubMed ID | 15735308 |
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Journal | J Biol Chem |
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Year | 2005 |
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Volume | 280 |
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Pages | 17101-8 |
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Authors | Singh S, Korolev S, Koroleva O, Zarembinski T, Collart F, Joachimiak A, Christendat D |
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Title | Crystal structure of a novel shikimate dehydrogenase from Haemophilus influenzae. |
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Related PDB | 1npy |
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Related UniProtKB | P44774 |
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[7] |
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Comments | X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 2-288 IN COMPLEX WITH NAD. |
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PubMed ID | 16021622 |
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Journal | Proteins |
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Year | 2005 |
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Volume | 60 |
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Pages | 787-96 |
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Authors | Badger J, Sauder JM, Adams JM, Antonysamy S, Bain K, Bergseid MG, Buchanan SG, Buchanan MD, Batiyenko Y, Christopher JA, Emtage S, Eroshkina A, Feil I, Furlong EB, Gajiwala KS, Gao X, He D, Hendle J, Huber A, Hoda K, Kearins P, Kissinger C, Laubert B, Lewis HA, Lin J, Loomis K, Lorimer D, Louie G, Maletic M, Marsh CD, Miller I, Molinari J, Muller-Dieckmann HJ, Newman JM, Noland BW, Pagarigan B, Park F, Peat TS, Post KW, Radojicic S, Ramos A, Romero R, Rutter ME, Sanderson WE, Schwinn KD, Tresser J, Winhoven J, Wright TA, Wu L, Xu J, Harris TJ |
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Title | Structural analysis of a set of proteins resulting from a bacterial genomics project. |
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Related PDB | 1vi2 |
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Related UniProtKB | P0A6D5 |
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[8] |
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Comments | X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 90-603 IN COMPLEX WITH SHIKIMATE AND TARTRATE, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF SER-336; SER-338; LYS-385; ASP-423 AND TYR-550. |
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PubMed ID | 16784230 |
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Journal | Biochemistry |
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Year | 2006 |
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Volume | 45 |
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Pages | 7787-96 |
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Authors | Singh SA, Christendat D |
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Title | Structure of Arabidopsis dehydroquinate dehydratase-shikimate dehydrogenase and implications for metabolic channeling in the shikimate pathway. |
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Related PDB | 2gpt |
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Related UniProtKB | Q9SQT8 |
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[9] |
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Comments | X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS). |
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PubMed ID | 17649975 |
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Journal | Biochemistry |
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Year | 2007 |
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Volume | 46 |
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Pages | 9513-22 |
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Authors | Gan J, Wu Y, Prabakaran P, Gu Y, Li Y, Andrykovitch M, Liu H, Gong Y, Yan H, Ji X |
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Title | Structural and biochemical analyses of shikimate dehydrogenase AroE from Aquifex aeolicus: implications for the catalytic mechanism. |
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Related PDB | 2hk7,2hk8,2hk9 |
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[10] |
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Comments | X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS). |
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PubMed ID | 17825835 |
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Journal | J Mol Biol |
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Year | 2007 |
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Volume | 373 |
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Pages | 424-38 |
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Authors | Bagautdinov B, Kunishima N |
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Title | Crystal structures of shikimate dehydrogenase AroE from Thermus thermophilus HB8 and its cofactor and substrate complexes: insights into the enzymatic mechanism. |
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Related PDB | 1wxd,2cy0,2d5c,2ev9 |
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Related UniProtKB | Q5SJF8 |
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[11] |
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Comments | X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS), FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT, REACTION MECHANISM. |
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PubMed ID | 18566515 |
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Journal | Acta Crystallogr D Biol Crystallogr |
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Year | 2008 |
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Volume | D64 |
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Pages | 803-9 |
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Authors | Schoepe J, Niefind K, Schomburg D |
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Title | 1.6 angstroms structure of an NAD+-dependent quinate dehydrogenase from Corynebacterium glutamicum. |
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Related PDB | 2ez3,2nlo |
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Related UniProtKB | Q9X5C9 |
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[12] |
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PubMed ID | 18669580 |
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Journal | Mol Biol Evol |
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Year | 2008 |
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Volume | 25 |
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Pages | 2221-32 |
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Authors | Singh S, Stavrinides J, Christendat D, Guttman DS |
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Title | A phylogenomic analysis of the shikimate dehydrogenases reveals broadscale functional diversification and identifies one functionally distinct subclass. |
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[13] |
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PubMed ID | 19917104 |
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Journal | BMC Res Notes |
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Year | 2009 |
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Volume | 2 |
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Pages | 227 |
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Authors | Rodrigues VS Jr, Breda A, Santos DS, Basso LA |
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Title | The conserved Lysine69 residue plays a catalytic role in Mycobacterium tuberculosis shikimate dehydrogenase. |
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[14] |
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Comments | X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS). |
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PubMed ID | 19215302 |
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Journal | FEBS J |
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Year | 2009 |
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Volume | 276 |
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Pages | 1125-39 |
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Authors | Han C, Hu T, Wu D, Qu S, Zhou J, Ding J, Shen X, Qu D, Jiang H |
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Title | X-ray crystallographic and enzymatic analyses of shikimate dehydrogenase from Staphylococcus epidermidis. |
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Related PDB | 3don,3doo |
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[15] |
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PubMed ID | 19043750 |
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Journal | J Mol Model |
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Year | 2009 |
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Volume | 15 |
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Pages | 147-55 |
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Authors | Barcellos GB, Caceres RA, de Azevedo WF Jr |
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Title | Structural studies of shikimate dehydrogenase from Bacillus anthracis complexed with cofactor NADP. |
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comments | This enzyme is composed of N-terminal chorismate mutase domain (EC 5.4.99.5) and C-terminal shikimate dehydrogenase domains (EC 1.1.1.25). Although the tertiary structure of the C-terminal shikimate dehydrogenase domains have been solved, that of the N-terminal domain has not been elucidated. The C-terminal enzyme belongs to the superfamily of NAD(P)H-dependent shikimate dehydrogenase. This superfamily had been previously subdivided into four groups (1) AroE, EC=1.1.1.25, Shikimate dehydrogenases; (2) YdiB, EC=1.1.1.282, Shikimate/quinate dehydrogenases; (3) SdhL;EC=1.1.1.25, Shikimate dehydrogenase-like protein; (4) RifI, EC=1.1.1.25, Shikimate dehydrogenase (literature [12]). The C-terminal domain corresponds to AroE, which has a similar active site as that of the homologous enzyme (D00845 in EzCatDB). Thus, its catalytic mechanism must be also similar to that of the homologue.
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created | updated |
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2011-07-28 | 2011-08-03 |
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