EzCatDB: U00001
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DB codeU00001
CATH domainDomain 1-.-.-.-
Domain 21.10.1200.10 : Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain ACatalytic domain
E.C.-.-.-.-

CATH domainRelated DB codes (homologues)
1.10.1200.10 : Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain AM00347

Enzyme Name
UniProtKBKEGG

O77077O77470P07854
Protein nameAcyl carrier proteinAcyl carrier proteinAcyl carrier protein 1, chloroplasticAcyl carrier protein
ACP
SynonymsNoneNoneAcyl carrier protein I
ACP I
RefSeq
XP_002365498.1 (Protein)
XM_002365457.1 (DNA/RNA sequence)

PfamPF00550 (PP-binding)
[Graphical view]
PF00550 (PP-binding)
[Graphical view]
PF00550 (PP-binding)
[Graphical view]

KEGG pathways
MAP codePathways
MAP00061Fatty acid biosynthesis
MAP01056Biosynthesis of type II polyketide backbone
MAP01057Biosynthesis of type II polyketide products
MAP01066Biosynthesis of alkaloids derived from terpenoid and polyketide

UniProtKB:Accession NumberO77077O77470P07854
Entry nameO77077_PLAFAO77470_TOXGOACP1_SPIOL
Activity


Subunit


Subcellular location

Plastid, chloroplast.
Cofactor



Compound table: links to PDB-related databases & PoSSuM

CofactorsSubstratesProducts
KEGG-idC01134C00229C00173
CompoundPantetheine 4'-phosphateAcyl-carrier proteinAcyl-[acyl-carrier protein]
Typecarbohydrate,peptide/protein,phosphate group/phosphate ion,sulfhydryl groupcarbohydrate,peptide/protein,phosphate group/phosphate ion,sulfhydryl groupcarbohydrate,peptide/protein,phosphate group/phosphate ion,sulfide group
ChEBI4222


PubChem115254


           
2fq0A00Bound:PNS Unbound
2fq2A00Bound:PNS Unbound
3gzlA00Bound:PNS Unbound
3gzmA00Bound:PNS Unbound
3gzmB00Bound:PNS Unbound
2qnwA00Unbound Unbound
2avaA00Unbound Unbound
2fvaA00Bound:PNS Bound:STE
2fveA00Unbound Unbound
2fvfA00Bound:PNS Bound:DKA
2xz0D00Unbound Unbound
2xz1C00Analogue:PNY Unbound
2xz1D00Unbound Unbound

Active-site residues
pdbCofactor-binding residuesModified residues
          
2fq0A00SER 37(Phosphopantetheine binding)
      
2fq2A00SER 37(Phosphopantetheine binding)
      
3gzlA00SER 39(Phosphopantetheine binding)
      
3gzmA00SER 39(Phosphopantetheine binding)
      
3gzmB00SER 39(Phosphopantetheine binding)
      
2qnwA00SER 41(Phosphopantetheine binding)
      
2avaA00SER 38(Phosphopantetheine binding)
      
2fvaA00SER 38(Phosphopantetheine binding)
      
2fveA00SER 38(Phosphopantetheine binding)
      
2fvfA00SER 38(Phosphopantetheine binding)
      
2xz0D00                                  
SEP 38
2xz1C00                                  
SEP 38
2xz1D00                                  
SEP 38


references
[1]
PubMed ID16618110
JournalBiochemistry
Year2006
Volume45
Pages5217-27
AuthorsZornetzer GA, Fox BG, Markley JL
TitleSolution structures of spinach acyl carrier protein with decanoate and stearate.
Related PDB2ava,2fva,2fve,2fvf
[2]
PubMed ID16734426
JournalBiochemistry
Year2006
Volume45
Pages6904-16
AuthorsSharma AK, Sharma SK, Surolia A, Surolia N, Sarma SP
TitleSolution structures of conformationally equilibrium forms of holo-acyl carrier protein (PfACP) from Plasmodium falciparum provides insight into the mechanism of activation of ACPs.
Related PDB2fq0,2fq2
[3]
PubMed ID19768685
JournalProteins
Year2010
Volume78
Pages575-88
AuthorsGallagher JR, Prigge ST
TitlePlasmodium falciparum acyl carrier protein crystal structures in disulfide-linked and reduced states and their prevalence during blood stage growth.
Related PDB3gzl,3gzm

comments
Although this protein is not an enzyme, it is involved in various kinds of enzyme reactions as the following substrates/products.
C00173 Acyl-[acyl-carrier protein]
C00229 [acyl-carrier-protein], Acyl-carrier protein
C00685 3-Oxoacyl-[acyl-carrier protein]
C00693 trans-2,3-Dehydroacyl-[acyl-carrier protein]
C01203 Oleoyl-[acyl-carrier protein]
C01209 malonyl-[acyl-carrier protein], malonyl-[acyl-carrier-protein], Malonyl-[acyl-carrier protein]
C01271 (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C04088 Stearoyl-[acyl-carrier protein]
C04180 3-Decanoyl-[acyl-carrier protein]
C04619 (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04688 (R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05744 acetoacetyl-[acyl-carrier protein]
C05754 trans-Dec-2-enoyl-[acyl-carrier protein]
C05757 (R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758 trans-Dodec-2-enoyl-[acyl-carrier protein]
L00039 (Z)-hexadec-11-enoyl-[acyl-carrier protein]
L00040 (Z)-3-oxooctadec-13-enoyl-[acyl-carrier protein]
Thus, this protein is very important in fatty acid metabolism and polyketide synthesis and so on.

createdupdated
2012-07-132012-07-17


Copyright: Nozomi Nagano, JST & CBRC-AIST
Funded by PRESTO/Japan Science and Technology Corporation (JST) (December 2001 - November 2004)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2006)
Funded by Grant-in-Aid for Scientific Research (B)/Japan Society for the Promotion of Science (JSPS) (April 2005 - March 2008)
Funded by BIRD/Japan Science and Technology Corporation (JST) (September 2005 - September 2008)
Funded by BIRD/Japan Science and Technology Corporation (JST) (October 2007 - September 2010)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2011 - March 2012)
Funded by Grant-in-Aid for Publication of Scientific Research Results/Japan Society for the Promotion of Science (JSPS) (April 2012 - March 2013)
Supported by the commission for the Development of Artificial Gene Synthesis Technology for Creating Innovative Biomaterial from the Ministry of Economy, Trade and Industry (METI) (October 2012 - )
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